WRAP-based nanoparticles for siRNA delivery: a SAR study and a comparison with lipid-based transfection reagents

Recently, we designed novel amphipathic cell-penetrating peptides, called WRAP, able to transfer efficiently siRNA molecules into cells. In order to gain more information about the relationship between amino acid composition, nanoparticle formation and cellular internalization of these peptides comp...

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Bibliographic Details
Published in:	Journal of nanobiotechnology Vol. 19; no. 1; p. 236
Main Authors:	Konate, Karidia, Josse, Emilie, Tasic, Milana, Redjatti, Karima, Aldrian, Gudrun, Deshayes, Sébastien, Boisguérin, Prisca, Vivès, Eric
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 11-08-2021 BioMed Central BMC
Subjects:	Amino acid composition Amino Acid Sequence Amino acids Analysis Cell Line, Tumor Cell-Penetrating Peptides Chemical properties Composition Compression Bandages Drug Delivery Systems Drugs Gene silencing Gene Silencing - drug effects Glioblastoma Health aspects Humans Indicators and Reagents - chemistry Internalization Investigations Leucine Life Sciences Lipids Lipids - chemistry Methods Nanoparticle Nanoparticles Nanoparticles - chemistry Peptides Plasmids Proline Reagents Residues RNA, Small Interfering - chemistry RNA, Small Interfering - pharmacology siRNA siRNA delivery Structure-Activity Relationship Structure-activity relationship (Pharmacology) Structure-activity relationships Toxicity Transfection Tryptophan France siRNA delivery Cell-penetrating peptides Nanoparticle Structure–activity relationship
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