Integrative genome-wide association analysis of cytoarchitectural abnormalities in the prefrontal cortex of psychiatric disorders

Cytoarchitectural abnormalities have been described in the prefrontal cortex (PFC) of subjects with psychiatric disorders. We explored the possible genetic causalities that may underlie the cytoarchitectural abnormalities of calbindin-containing γ-aminobutyric acid (GABA)ergic neurons and perineuron...

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Bibliographic Details
Published in:	Molecular psychiatry Vol. 16; no. 4; pp. 452 - 461
Main Authors:	Kim, S, Webster, M J
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01-04-2011 Nature Publishing Group
Subjects:	631/208/205 631/378/1457/1945 692/699/476 Adult Adult and adolescent clinical studies Amino Acid Transport System A - genetics Apoptosis Association analysis Behavioral Sciences Biological and medical sciences Biological Psychology Bipolar disorder Bipolar disorders Brain research Calbindin Calbindins Causality Databases, Genetic Development and progression Etiology Female gamma-Aminobutyric Acid - genetics Gene expression Gene Expression Profiling Genetic aspects Genetic Predisposition to Disease Genetic susceptibility Genome-Wide Association Study Genomes Genotype Humans Male Medical research Medical sciences Medicine Medicine & Public Health Mental depression Mental disorders Mental Disorders - genetics Mental Disorders - pathology Middle Aged Mood disorders Neurons Neurosciences Oligodendrocytes Oligodendroglia - pathology Oligonucleotide Array Sequence Analysis original-article Pharmacotherapy Physiological aspects Polymorphism Polymorphism, Single Nucleotide - genetics Prefrontal cortex Prefrontal Cortex - pathology Protein Phosphatase 2 - genetics Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Quality control rab2 GTP-Binding Protein - genetics Research centers Risk factors S100 Calcium Binding Protein G - genetics Schizophrenia Single-nucleotide polymorphism γ-Aminobutyric acid United States United States > US GABAergic neuron bipolar disorder schizophrenia SNP expression profile oligodendrocyte Mood disorder Neuroglia Central nervous system Schizophrenia Bipolar disorder Prefrontal cortex Encephalon Psychosis Oligodendrocyte Mental disorder Gabaergic neuron
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