Neurogenesis and generalization: a new approach to stratify and treat anxiety disorders

In this review, the authors examine the link between adult hippocampal neurogenesis and anxiety and depression. They propose that impaired pattern separation underlies the overgeneralization often seen in anxiety disorders. Although an influence of adult neurogenesis in mediating some of the effects...

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Bibliographic Details
Published in:	Nature neuroscience Vol. 15; no. 12; pp. 1613 - 1620
Main Authors:	Kheirbek, Mazen A, Klemenhagen, Kristen C, Sahay, Amar, Hen, René
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01-12-2012 Nature Publishing Group
Subjects:	631/378/1689/1300 631/378/368/2431 Animal Genetics and Genomics Animals Antidepressants Anxiety Anxiety Disorders - pathology Anxiety Disorders - psychology Anxiety Disorders - therapy Behavioral Sciences Biological Techniques Biomedicine Care and treatment Diagnosis Generalization (Psychology) - physiology Health aspects Hippocampus - cytology Hippocampus - physiology Humans Neurobiology Neurogenesis Neurogenesis - physiology Neurons Neurosciences Panic attacks Panic disorders Post-traumatic stress disorder Properties review-article Treatment Outcome United States
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