Contemporary views on the genetics of anorexia nervosa

• Published in: European neuropsychopharmacology Vol. 26; no. 4; pp. 663 - 673
• Main Authors: Shih, Pei-an Betty, Woodside, D. Blake
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01-04-2016
• Subjects: Anorexia nervosa; Anorexia Nervosa - diet therapy; Anorexia Nervosa - drug therapy; Anorexia Nervosa - genetics; DNA Methylation; Family Health; Gene Expression; Gene-Environment Interaction; Genetic Predisposition to Disease - genetics; Genetics; Genome-Wide Association Study; Humans; Internal Medicine; Nutrigenetics; Nutrigenomics; Nutritional Physiological Phenomena - genetics; Pharmacogenetics; Precision Medicine; Psychiatry; Review; Genetics; Nutrigenomics; Nutrigenetics; Anorexia nervosa; Review
• ISSN: 0924-977X; 1873-7862
• DOI: 10.1016/j.euroneuro.2016.02.008

Abstract Anorexia nervosa (AN) is a serious mental illness characterized by severe dietary restriction that leads to high rates of morbidity, chronicity, and mortality. Unfortunately, effective treatment is lacking and few options are available. High rates of familial aggregation and significant heritability suggested that the complex etiology of AN is affected by both genetic and environmental factors. In this paper, we review studies that reported common and rare genetic variation that influence susceptibility of AN through candidate gene studies, genome-wide association studies, and sequencing-based studies. We also discuss gene expression, methylation, imaging genetics, and pharmacogenetics to demonstrate that these studies have collectively advanced our knowledge of how genetic variation contributes to AN susceptibility and clinical course. Lastly, we highlight the importance of gene by environment interactions (G×E) and share our enthusiasm for the use of nutritional genomic approaches to elucidate the interaction among nutrients, metabolic intermediates, and genetic variation in AN. A deeper understanding of how nutrition alters genome stability, how genetic variation influences uptake and metabolism of nutrients, and how response to food components affects disordered eating, will lead to personalized dietary interventions and effective nutraceutical and pharmacological treatments for AN.