Transition to chronic pain: opportunities for novel therapeutics

Although chronic pain is one of the most important medical problems facing society, there has been very limited progress in the development of novel therapies for this condition. Here, we discuss high-impact research priorities to reduce the number of people transitioning from acute to chronic intra...

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Published in:	Nature reviews. Neuroscience Vol. 19; no. 7; pp. 383 - 384
Main Authors:	Price, Theodore J., Basbaum, Allan I., Bresnahan, Jacqueline, Chambers, Jan F., De Koninck, Yves, Edwards, Robert R., Ji, Ru-Rong, Katz, Joel, Kavelaars, Annemieke, Levine, Jon D., Porter, Linda, Schechter, Neil, Sluka, Kathleen A., Terman, Gregory W., Wager, Tor D., Yaksh, Tony L., Dworkin, Robert H.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01-07-2018 Nature Publishing Group
Subjects:	631/378/1689/2610 631/378/2620/410 Acute Pain - physiopathology Animal Genetics and Genomics Animals Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Brain - physiopathology Chronic pain Chronic Pain - etiology Chronic Pain - physiopathology Clinical Trials as Topic Comment Disease Progression Humans Neurobiology Neurons - physiology Neurosciences Pain Pain Management Therapeutics
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Abstract	Although chronic pain is one of the most important medical problems facing society, there has been very limited progress in the development of novel therapies for this condition. Here, we discuss high-impact research priorities to reduce the number of people transitioning from acute to chronic intractable pain.
AbstractList	Although chronic pain is one of the most important medical problems facing society, there has been very limited progress in the development of novel therapies for this condition. Here, we discuss high-impact research priorities to reduce the number of people transitioning from acute to chronic intractable pain.
Audience	Academic
Author	Schechter, Neil Wager, Tor D. Bresnahan, Jacqueline Dworkin, Robert H. Chambers, Jan F. Yaksh, Tony L. De Koninck, Yves Ji, Ru-Rong Porter, Linda Terman, Gregory W. Kavelaars, Annemieke Edwards, Robert R. Levine, Jon D. Katz, Joel Basbaum, Allan I. Sluka, Kathleen A. Price, Theodore J.
AuthorAffiliation	2 University of California, San Francisco, San Francisco, CA, USA 6 Duke University, Durham, NC, USA 5 Harvard University, Boston, MA, USA 14 University of Rochester, Rochester, NY, USA 9 National Institutes of Health, Bethesda, MD, USA 4 Laval University & CERVO Brain Research Centre, Québec, QC, Canada 13 University of California, San Diego, San Diego, CA, USA 7 York University, Toronto, ON, Canada 12 University of Colorado, Boulder, CO, USA 1 The University of Texas at Dallas, Richardson, TX, USA 3 National Fibromyalgia and Chronic Pain Association, Logan, UT, USA 10 University of Iowa, Iowa City, IA, USA 11 University of Washington, Seattle, WA, USA 8 University of Texas MD Anderson Cancer Center, Houston, TX, USA
AuthorAffiliation_xml	– name: 5 Harvard University, Boston, MA, USA – name: 12 University of Colorado, Boulder, CO, USA – name: 13 University of California, San Diego, San Diego, CA, USA – name: 14 University of Rochester, Rochester, NY, USA – name: 7 York University, Toronto, ON, Canada – name: 8 University of Texas MD Anderson Cancer Center, Houston, TX, USA – name: 2 University of California, San Francisco, San Francisco, CA, USA – name: 11 University of Washington, Seattle, WA, USA – name: 1 The University of Texas at Dallas, Richardson, TX, USA – name: 10 University of Iowa, Iowa City, IA, USA – name: 9 National Institutes of Health, Bethesda, MD, USA – name: 4 Laval University & CERVO Brain Research Centre, Québec, QC, Canada – name: 3 National Fibromyalgia and Chronic Pain Association, Logan, UT, USA – name: 6 Duke University, Durham, NC, USA
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References	Braz (CR5) 2012; 74 Denk, McMahon, Tracey (CR3) 2014; 17 Gewandter (CR6) 2015; 156 Skolnick, Volkow (CR4) 2016; 92 Apkarian, Baliki, Farmer (CR2) 2013; 26 Ji, Chamessian, Zhang (CR1) 2016; 354 JS Gewandter (12_CR6) 2015; 156 F Denk (12_CR3) 2014; 17 P Skolnick (12_CR4) 2016; 92 AV Apkarian (12_CR2) 2013; 26 JM Braz (12_CR5) 2012; 74 RR Ji (12_CR1) 2016; 354
References_xml	– volume: 74 start-page: 663 year: 2012 end-page: 675 ident: CR5 article-title: Forebrain GABAergic neuron precursors integrate into adult spinal cord and reduce injury-induced neuropathic pain publication-title: Neuron doi: 10.1016/j.neuron.2012.02.033 contributor: fullname: Braz – volume: 92 start-page: 294 year: 2016 end-page: 297 ident: CR4 article-title: Re-energizing the development of pain therapeutics in light of the opioid epidemic publication-title: Neuron doi: 10.1016/j.neuron.2016.09.051 contributor: fullname: Volkow – volume: 354 start-page: 572 year: 2016 end-page: 577 ident: CR1 article-title: Pain regulation by non-neuronal cells and inflammation publication-title: Science doi: 10.1126/science.aaf8924 contributor: fullname: Zhang – volume: 17 start-page: 192 year: 2014 end-page: 200 ident: CR3 article-title: Pain vulnerability: a neurobiological perspective publication-title: Nat. Neurosci. doi: 10.1038/nn.3628 contributor: fullname: Tracey – volume: 156 start-page: 1184 year: 2015 end-page: 1197 ident: CR6 article-title: Research design considerations for chronic pain prevention clinical trials: IMMPACT recommendations publication-title: Pain doi: 10.1097/j.pain.0000000000000191 contributor: fullname: Gewandter – volume: 26 start-page: 360 year: 2013 end-page: 367 ident: CR2 article-title: Predicting transition to chronic pain publication-title: Curr. Opin. Neurol. doi: 10.1097/WCO.0b013e32836336ad contributor: fullname: Farmer – volume: 74 start-page: 663 year: 2012 ident: 12_CR5 publication-title: Neuron doi: 10.1016/j.neuron.2012.02.033 contributor: fullname: JM Braz – volume: 17 start-page: 192 year: 2014 ident: 12_CR3 publication-title: Nat. Neurosci. doi: 10.1038/nn.3628 contributor: fullname: F Denk – volume: 156 start-page: 1184 year: 2015 ident: 12_CR6 publication-title: Pain doi: 10.1097/j.pain.0000000000000191 contributor: fullname: JS Gewandter – volume: 26 start-page: 360 year: 2013 ident: 12_CR2 publication-title: Curr. Opin. Neurol. doi: 10.1097/WCO.0b013e32836336ad contributor: fullname: AV Apkarian – volume: 354 start-page: 572 year: 2016 ident: 12_CR1 publication-title: Science doi: 10.1126/science.aaf8924 contributor: fullname: RR Ji – volume: 92 start-page: 294 year: 2016 ident: 12_CR4 publication-title: Neuron doi: 10.1016/j.neuron.2016.09.051 contributor: fullname: P Skolnick
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SubjectTerms	631/378/1689/2610 631/378/2620/410 Acute Pain - physiopathology Animal Genetics and Genomics Animals Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Brain - physiopathology Chronic pain Chronic Pain - etiology Chronic Pain - physiopathology Clinical Trials as Topic Comment Disease Progression Humans Neurobiology Neurons - physiology Neurosciences Pain Pain Management Therapeutics
Title	Transition to chronic pain: opportunities for novel therapeutics
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