Factors predictive of relapse in adult bacterial osteomyelitis of long bones

• Published in: BMC infectious diseases Vol. 18; no. 1; p. 635
• Main Authors: Garcia Del Pozo, E, Collazos, J, Carton, J A, Camporro, D, Asensi, V
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 07-12-2018; BioMed Central; BMC
• Subjects: Adults; Antibiotics; Antiinfectives and antibacterials; Biocompatibility; Biomedical materials; Bone surgery; Bones; Care and treatment; CAT scans; Debridement; Demographics; Development and progression; Exposure; Fractures; Health aspects; Infectious diseases; Muscles; Muscular flap; NMR; Nuclear magnetic resonance; Osteomyelitis; Patients; Regression analysis; Relapse; Risk analysis; Risk factors; Severity factors; Sinuses; Staphylococcus infections; Surgery; Therapy; Tibia; Trauma; Taiwan; Osteomyelitis; Severity factors; Debridement; Relapse; Antibiotics; Muscular flap
• ISSN: 1471-2334; 1471-2334
• DOI: 10.1186/s12879-018-3550-6

Osteomyelitis is a difficult-to-cure infection with a high relapse rate despite combined medical and surgical therapies. Some severity factors, duration of antimicrobial therapy and type of surgical procedure might influence osteomyelitis relapse.
116 patients with osteomyelitis were followed for ≥1 year after hospital discharge. Demographic, microbiological and clinical data, eight severity factors and treatment (surgical and antibiotic) were analyzed.
Mean age was 53 years and 74.1% were men. Tibia (62.1%) and S. aureus (58.5%) were the most commonly involved bone and bacteria, respectively. Mean follow-up was 67.1 months. Forty-six patients underwent bone debridement, 61 debridement plus flap coverage and 9 antimicrobial therapy only. Twenty-six patients (22.4%) relapsed, at a mean of 11.2 months since hospital discharge. Duration > 3 months (p = 0.025), number of severity factors (P = 0.02) and absence of surgery (P = 0.004) were associated with osteomyelitis relapse in the univariate analysis. In the Cox regression analysis, osteomyelitis duration > 3 months (P = 0.012), bone exposure (P = 0.0003) and type of surgery (P < 0.0001) were associated with relapse. Regarding the surgical modalities, bone debridement with muscle flap was associated with better osteomyelitis outcomes, as compared with no surgery (P < 0.0001) and debridement only (P = 0.004).
Osteomyelitis extending for > 3 months, bone exposure and treatment other than surgical debridement with muscular flap are risk factors for osteomyelitis relapse.