Tocilizumab in HIV patient with severe COVID-19: case report

A 73-year-old male patient who had a history of Human Immunodeficiency Virus (HIV) infection for over 20 years was diagnosed with SARS-CoV-2 infection. The patient was admitted to the Intensive Care Unit (ICU), where he remained for 25 days, due to a severe condition. Intubation, hemodialysis, and t...

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Published in:	AIDS research and therapy Vol. 18; no. 1; p. 73
Main Authors:	Bertozzi, Pedro Vieira, de Oliveira Vicente, Amanda, Pereira, Amanda Siqueira, de Sant'Ana, Joao Pedro Espinha, Mano, Rafaela Braga Cabrera, Jorge, Luciana Souza, da Silva Sardenberg, Rodrigo Afonso
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 16-10-2021 BioMed Central BMC
Subjects:	Aged Analysis Antibodies, Monoclonal, Humanized - therapeutic use Antiretroviral agents Care and treatment Case Report Case reports Coinfection Comorbidity Coronaviruses COVID-19 COVID-19 Drug Treatment Diagnosis Health aspects Hemodialysis Highly active antiretroviral therapy HIV HIV Infections - complications HIV Infections - drug therapy HIV patients Homeostasis Human immunodeficiency virus Humans Hypertension Immune response Immune system Intubation Lymphocytes Male Males Monoclonal antibodies Mortality Patients Recovery Risk analysis Risk factors Ritonavir Severe acute respiratory syndrome coronavirus 2 Tocilizumab Tracheostomy Viral diseases Brazil COVID-19 Case report Coinfection HIV Tocilizumab
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Abstract	A 73-year-old male patient who had a history of Human Immunodeficiency Virus (HIV) infection for over 20 years was diagnosed with SARS-CoV-2 infection. The patient was admitted to the Intensive Care Unit (ICU), where he remained for 25 days, due to a severe condition. Intubation, hemodialysis, and tracheostomy were necessary to maintain homeostasis. In addition to regular treatment with etravirine, dolutegravir, darunavir, and ritonavir for highly active antiretroviral therapy, the patient received tocilizumab, which showed a great recovery in the patient's condition. The patient had several risk factors, such as male gender, age > 70 years, and arterial hypertension. The use of tocilizumab was of great importance in the patient's recovery since the drug increased his immune response, which is deficient, due to HIV infection.
AbstractList	Background A 73-year-old male patient who had a history of Human Immunodeficiency Virus (HIV) infection for over 20 years was diagnosed with SARS-CoV-2 infection. Case presentation The patient was admitted to the Intensive Care Unit (ICU), where he remained for 25 days, due to a severe condition. Intubation, hemodialysis, and tracheostomy were necessary to maintain homeostasis. In addition to regular treatment with etravirine, dolutegravir, darunavir, and ritonavir for highly active antiretroviral therapy, the patient received tocilizumab, which showed a great recovery in the patient's condition. Conclusion The patient had several risk factors, such as male gender, age > 70 years, and arterial hypertension. The use of tocilizumab was of great importance in the patient's recovery since the drug increased his immune response, which is deficient, due to HIV infection. Keywords: COVID-19, HIV, Tocilizumab, Coinfection, Case report Background A 73-year-old male patient who had a history of Human Immunodeficiency Virus (HIV) infection for over 20 years was diagnosed with SARS-CoV-2 infection. Case presentation The patient was admitted to the Intensive Care Unit (ICU), where he remained for 25 days, due to a severe condition. Intubation, hemodialysis, and tracheostomy were necessary to maintain homeostasis. In addition to regular treatment with etravirine, dolutegravir, darunavir, and ritonavir for highly active antiretroviral therapy, the patient received tocilizumab, which showed a great recovery in the patient’s condition. Conclusion The patient had several risk factors, such as male gender, age > 70 years, and arterial hypertension. The use of tocilizumab was of great importance in the patient’s recovery since the drug increased his immune response, which is deficient, due to HIV infection. BACKGROUNDA 73-year-old male patient who had a history of Human Immunodeficiency Virus (HIV) infection for over 20 years was diagnosed with SARS-CoV-2 infection.CASE PRESENTATIONThe patient was admitted to the Intensive Care Unit (ICU), where he remained for 25 days, due to a severe condition. Intubation, hemodialysis, and tracheostomy were necessary to maintain homeostasis. In addition to regular treatment with etravirine, dolutegravir, darunavir, and ritonavir for highly active antiretroviral therapy, the patient received tocilizumab, which showed a great recovery in the patient's condition.CONCLUSIONThe patient had several risk factors, such as male gender, age > 70 years, and arterial hypertension. The use of tocilizumab was of great importance in the patient's recovery since the drug increased his immune response, which is deficient, due to HIV infection. A 73-year-old male patient who had a history of Human Immunodeficiency Virus (HIV) infection for over 20 years was diagnosed with SARS-CoV-2 infection. The patient had several risk factors, such as male gender, age > 70 years, and arterial hypertension. The use of tocilizumab was of great importance in the patient's recovery since the drug increased his immune response, which is deficient, due to HIV infection. Abstract Background A 73-year-old male patient who had a history of Human Immunodeficiency Virus (HIV) infection for over 20 years was diagnosed with SARS-CoV-2 infection. Case presentation The patient was admitted to the Intensive Care Unit (ICU), where he remained for 25 days, due to a severe condition. Intubation, hemodialysis, and tracheostomy were necessary to maintain homeostasis. In addition to regular treatment with etravirine, dolutegravir, darunavir, and ritonavir for highly active antiretroviral therapy, the patient received tocilizumab, which showed a great recovery in the patient’s condition. Conclusion The patient had several risk factors, such as male gender, age > 70 years, and arterial hypertension. The use of tocilizumab was of great importance in the patient’s recovery since the drug increased his immune response, which is deficient, due to HIV infection. A 73-year-old male patient who had a history of Human Immunodeficiency Virus (HIV) infection for over 20 years was diagnosed with SARS-CoV-2 infection. The patient was admitted to the Intensive Care Unit (ICU), where he remained for 25 days, due to a severe condition. Intubation, hemodialysis, and tracheostomy were necessary to maintain homeostasis. In addition to regular treatment with etravirine, dolutegravir, darunavir, and ritonavir for highly active antiretroviral therapy, the patient received tocilizumab, which showed a great recovery in the patient's condition. The patient had several risk factors, such as male gender, age > 70 years, and arterial hypertension. The use of tocilizumab was of great importance in the patient's recovery since the drug increased his immune response, which is deficient, due to HIV infection.
ArticleNumber	73
Audience	Academic
Author	Pereira, Amanda Siqueira Mano, Rafaela Braga Cabrera Jorge, Luciana Souza de Sant'Ana, Joao Pedro Espinha Bertozzi, Pedro Vieira da Silva Sardenberg, Rodrigo Afonso de Oliveira Vicente, Amanda
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Cites_doi	10.1089/apc.2020.29005.com 10.1001/jama.2020.17021 10.1038/s41569-020-0360-5 10.1038/s41586-020-2521-4 10.1016/j.ijid.2020.04.060 10.1093/cid/ciaa1198 10.1093/cid/ciaa1605 10.1056/NEJMoa2030340 10.1002/jmv.25955 10.1016/S2352-3018(20)30164-8 10.1007/s00228-014-1775-x 10.1681/ASN.2020030276 10.1016/S2352-3018(20)30111-9 10.3390/jof6040211 10.1056/NEJMoa2021436 10.1001/jamanetworkopen.2020.37069 10.1016/S2213-2600(20)30116-8 10.24875/AIDSRev.M20000031 10.2147/DDDT.S164515
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Snippet	A 73-year-old male patient who had a history of Human Immunodeficiency Virus (HIV) infection for over 20 years was diagnosed with SARS-CoV-2 infection. The... Background A 73-year-old male patient who had a history of Human Immunodeficiency Virus (HIV) infection for over 20 years was diagnosed with SARS-CoV-2... A 73-year-old male patient who had a history of Human Immunodeficiency Virus (HIV) infection for over 20 years was diagnosed with SARS-CoV-2 infection. The... BACKGROUNDA 73-year-old male patient who had a history of Human Immunodeficiency Virus (HIV) infection for over 20 years was diagnosed with SARS-CoV-2... Abstract Background A 73-year-old male patient who had a history of Human Immunodeficiency Virus (HIV) infection for over 20 years was diagnosed with...
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Title	Tocilizumab in HIV patient with severe COVID-19: case report
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