Synergistic effects of the dual release of stromal cell-derived factor-1 and bone morphogenetic protein-2 from hydrogels on bone regeneration

Abstract The objective of this study is to evaluate the activity of gelatin hydrogels incorporating combined stromal cell-derived factor-1 (SDF-1) and bone morphogenetic protein-2 (BMP-2) on the in vivo bone regeneration at an ulna critical-sized defect and subcutaneous site of rats, and compared wi...

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Bibliographic Details
Published in:	Biomaterials Vol. 32; no. 11; pp. 2797 - 2811
Main Authors:	Ratanavaraporn, Juthamas, Furuya, Hiroyuki, Kohara, Hiroshi, Tabata, Yasuhiko
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Ltd 01-04-2011
Subjects:	Advanced Basic Science Animals Bone Morphogenetic Protein 2 - chemistry Bone Morphogenetic Protein 2 - pharmacology Bone morphogenetic protein-2 (BMP-2) Bone regeneration Bone Regeneration - drug effects Cells, Cultured Chemokine CXCL12 - chemistry Chemokine CXCL12 - pharmacology Combined release Core Binding Factor Alpha 1 Subunit - metabolism Dentistry Female Flow Cytometry Gelatin - chemistry Gelatin hydrogels Hydrogels - chemistry Male Mice Mice, Inbred C57BL Osteocalcin - metabolism Rats Rats, Wistar Receptors, CXCR4 - metabolism Stromal cell-derived factor-1 (SDF-1) Tissue Engineering - methods X-Ray Microtomography Stromal cell-derived factor-1 (SDF-1) Combined release Gelatin hydrogels Bone morphogenetic protein-2 (BMP-2) Bone regeneration
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