Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity

Functional crosstalk between cell‐surface and intracellular ion channels plays important roles in excitable cells and is structurally supported by junctophilins (JPs) in muscle cells. Here, we report a novel form of channel crosstalk in cerebellar Purkinje cells (PCs). The generation of slow afterhy...

Full description

Saved in:

Bibliographic Details
Published in:	The EMBO journal Vol. 26; no. 7; pp. 1924 - 1933
Main Authors:	Kakizawa, Sho, Kishimoto, Yasushi, Hashimoto, Kouichi, Miyazaki, Taisuke, Furutani, Kazuharu, Shimizu, Hidemi, Fukaya, Masahiro, Nishi, Miyuki, Sakagami, Hiroyuki, Ikeda, Atsushi, Kondo, Hisatake, Kano, Masanobu, Watanabe, Masahiko, Iino, Masamitsu, Takeshima, Hiroshi
Format:	Journal Article
Language:	English
Published:	Chichester, UK John Wiley & Sons, Ltd 04-04-2007 Blackwell Publishing Ltd Nature Publishing Group
Subjects:	Action Potentials afterhyperpolarization Animals Brain Calcium Calcium - metabolism Histology Ion Channel Gating Learning long-term depression Long-Term Synaptic Depression Membrane Proteins - metabolism Membranes Mental depression Mice Mice, Knockout Motor Skills - physiology Neuronal Plasticity Neurosciences Purkinje cell Purkinje Cells - cytology Purkinje Cells - metabolism ryanodine receptor Ryanodine Receptor Calcium Release Channel - metabolism Signal transduction SK channel Small-Conductance Calcium-Activated Potassium Channels - metabolism Synapses - metabolism
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	Functional crosstalk between cell‐surface and intracellular ion channels plays important roles in excitable cells and is structurally supported by junctophilins (JPs) in muscle cells. Here, we report a novel form of channel crosstalk in cerebellar Purkinje cells (PCs). The generation of slow afterhyperpolarization (sAHP) following complex spikes in PCs required ryanodine receptor (RyR)‐mediated Ca2+‐induced Ca2+ release and the subsequent opening of small‐conductance Ca2+‐activated K+ (SK) channels in somatodendritic regions. Despite the normal expression levels of these channels, sAHP was abolished in PCs from mutant mice lacking neural JP subtypes (JP‐DKO), and this defect was restored by exogenously expressing JPs or enhancing SK channel activation. The stimulation paradigm for inducing long‐term depression (LTD) at parallel fiber–PC synapses adversely established long‐term potentiation in the JP‐DKO cerebellum, primarily due to the sAHP deficiency. Furthermore, JP‐DKO mice exhibited impairments of motor coordination and learning, although normal cerebellar histology was retained. Therefore, JPs support the Ca2+‐mediated communication between voltage‐gated Ca2+ channels, RyRs and SK channels, which modulates the excitability of PCs and is fundamental to cerebellar LTD and motor functions.
AbstractList	Functional crosstalk between cell‐surface and intracellular ion channels plays important roles in excitable cells and is structurally supported by junctophilins (JPs) in muscle cells. Here, we report a novel form of channel crosstalk in cerebellar Purkinje cells (PCs). The generation of slow afterhyperpolarization (sAHP) following complex spikes in PCs required ryanodine receptor (RyR)‐mediated Ca2+‐induced Ca2+ release and the subsequent opening of small‐conductance Ca2+‐activated K+ (SK) channels in somatodendritic regions. Despite the normal expression levels of these channels, sAHP was abolished in PCs from mutant mice lacking neural JP subtypes (JP‐DKO), and this defect was restored by exogenously expressing JPs or enhancing SK channel activation. The stimulation paradigm for inducing long‐term depression (LTD) at parallel fiber–PC synapses adversely established long‐term potentiation in the JP‐DKO cerebellum, primarily due to the sAHP deficiency. Furthermore, JP‐DKO mice exhibited impairments of motor coordination and learning, although normal cerebellar histology was retained. Therefore, JPs support the Ca2+‐mediated communication between voltage‐gated Ca2+ channels, RyRs and SK channels, which modulates the excitability of PCs and is fundamental to cerebellar LTD and motor functions. Functional crosstalk between cell-surface and intracellular ion channels plays important roles in excitable cells and is structurally supported by junctophilins (JPs) in muscle cells. Here, we report a novel form of channel crosstalk in cerebellar Purkinje cells (PCs). The generation of slow afterhyperpolarization (sAHP) following complex spikes in PCs required ryanodine receptor (RyR)-mediated Ca(2+)-induced Ca(2+) release and the subsequent opening of small-conductance Ca(2+)-activated K(+) (SK) channels in somatodendritic regions. Despite the normal expression levels of these channels, sAHP was abolished in PCs from mutant mice lacking neural JP subtypes (JP-DKO), and this defect was restored by exogenously expressing JPs or enhancing SK channel activation. The stimulation paradigm for inducing long-term depression (LTD) at parallel fiber-PC synapses adversely established long-term potentiation in the JP-DKO cerebellum, primarily due to the sAHP deficiency. Furthermore, JP-DKO mice exhibited impairments of motor coordination and learning, although normal cerebellar histology was retained. Therefore, JPs support the Ca(2+)-mediated communication between voltage-gated Ca(2+) channels, RyRs and SK channels, which modulates the excitability of PCs and is fundamental to cerebellar LTD and motor functions. Functional crosstalk between cell-surface and intracellular ion channels plays important roles in excitable cells and is structurally supported by junctophilins (JPs) in muscle cells. Here, we report a novel form of channel crosstalk in cerebellar Purkinje cells (PCs). The generation of slow afterhyperpolarization (sAHP) following complex spikes in PCs required ryanodine receptor (RyR)-mediated Ca 2+ -induced Ca 2+ release and the subsequent opening of small-conductance Ca 2+ -activated K + (SK) channels in somatodendritic regions. Despite the normal expression levels of these channels, sAHP was abolished in PCs from mutant mice lacking neural JP subtypes (JP-DKO), and this defect was restored by exogenously expressing JPs or enhancing SK channel activation. The stimulation paradigm for inducing long-term depression (LTD) at parallel fiber–PC synapses adversely established long-term potentiation in the JP-DKO cerebellum, primarily due to the sAHP deficiency. Furthermore, JP-DKO mice exhibited impairments of motor coordination and learning, although normal cerebellar histology was retained. Therefore, JPs support the Ca 2+ -mediated communication between voltage-gated Ca 2+ channels, RyRs and SK channels, which modulates the excitability of PCs and is fundamental to cerebellar LTD and motor functions. Functional crosstalk between cell-surface and intracellular ion channels plays important roles in excitable cells and is structurally supported by junctophilins (JPs) in muscle cells. Here, we report a novel form of channel crosstalk in cerebellar Purkinje cells (PCs). The generation of slow afterhyperpolarization (sAHP) following complex spikes in PCs required ryanodine receptor (RyR)-mediated Ca super(2+)-induced Ca super(2+) release and the subsequent opening of small-conductance Ca super(2+)-activated K super(+) (SK) channels in somatodendritic regions. Despite the normal expression levels of these channels, sAHP was abolished in PCs from mutant mice lacking neural JP subtypes (JP-DKO), and this defect was restored by exogenously expressing JPs or enhancing SK channel activation. The stimulation paradigm for inducing long-term depression (LTD) at parallel fiber-PC synapses adversely established long-term potentiation in the JP-DKO cerebellum, primarily due to the sAHP deficiency. Furthermore, JP- DKO mice exhibited impairments of motor coordination and learning, although normal cerebellar histology was retained. Therefore, JPs support the Ca super(2+)- mediated communication between voltage-gated Ca super(2+) channels, RyRs and SK channels, which modulates the excitability of PCs and is fundamental to cerebellar LTD and motor functions.
Author	Takeshima, Hiroshi Miyazaki, Taisuke Sakagami, Hiroyuki Furutani, Kazuharu Iino, Masamitsu Fukaya, Masahiro Kano, Masanobu Watanabe, Masahiko Nishi, Miyuki Ikeda, Atsushi Hashimoto, Kouichi Kondo, Hisatake Kishimoto, Yasushi Shimizu, Hidemi Kakizawa, Sho
Author_xml	– sequence: 1 givenname: Sho surname: Kakizawa fullname: Kakizawa, Sho organization: Department of Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan – sequence: 2 givenname: Yasushi surname: Kishimoto fullname: Kishimoto, Yasushi organization: Department of Cellular Neuroscience, Graduate School of Medicine, Osaka University, Osaka, Japan – sequence: 3 givenname: Kouichi surname: Hashimoto fullname: Hashimoto, Kouichi organization: Department of Cellular Neuroscience, Graduate School of Medicine, Osaka University, Osaka, Japan – sequence: 4 givenname: Taisuke surname: Miyazaki fullname: Miyazaki, Taisuke organization: Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Sapporo, Japan – sequence: 5 givenname: Kazuharu surname: Furutani fullname: Furutani, Kazuharu organization: Department of Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan – sequence: 6 givenname: Hidemi surname: Shimizu fullname: Shimizu, Hidemi organization: Department of Anatomy, Hokkaido University Graduate School of Medicine, Sapporo, Japan – sequence: 7 givenname: Masahiro surname: Fukaya fullname: Fukaya, Masahiro organization: Department of Anatomy, Hokkaido University Graduate School of Medicine, Sapporo, Japan – sequence: 8 givenname: Miyuki surname: Nishi fullname: Nishi, Miyuki organization: Department of Biological Chemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Kyoto, Japan – sequence: 9 givenname: Hiroyuki surname: Sakagami fullname: Sakagami, Hiroyuki organization: Department of Cell Biology, Tohoku University Graduate School of Medicine, Sendai, Japan – sequence: 10 givenname: Atsushi surname: Ikeda fullname: Ikeda, Atsushi organization: Department of Biological Chemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Kyoto, Japan – sequence: 11 givenname: Hisatake surname: Kondo fullname: Kondo, Hisatake organization: Department of Cell Biology, Tohoku University Graduate School of Medicine, Sendai, Japan – sequence: 12 givenname: Masanobu surname: Kano fullname: Kano, Masanobu organization: Department of Cellular Neuroscience, Graduate School of Medicine, Osaka University, Osaka, Japan – sequence: 13 givenname: Masahiko surname: Watanabe fullname: Watanabe, Masahiko organization: Department of Anatomy, Hokkaido University Graduate School of Medicine, Sapporo, Japan – sequence: 14 givenname: Masamitsu surname: Iino fullname: Iino, Masamitsu organization: Department of Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan – sequence: 15 givenname: Hiroshi surname: Takeshima fullname: Takeshima, Hiroshi email: takeshim@pharm.kyoto-u.ac.jp organization: Department of Biological Chemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Kyoto, Japan
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/17347645$$D View this record in MEDLINE/PubMed
BookMark	eNqFUctu1DAUtVARnRb2bEARC3YZ7PgRZ4NUqrZQyksqGnaW49wwnmbsYCfA_D1uM5oBNvXmyjoPnXvPETpw3gFCTwmeE0zlq7iaw7r2q3kpMBG0eoBmhAmcF7jkB2iGC0FyRmR1iI5iXGGMuSzJI3RISspKwfgMXV-Ozgy-X9rOunwNjdUDNJlZauegy0zwMQ66u8kgRnCD1V3W-pAZCFBD1-mQxY3T_WBN1nc6pmmHzWP0sNVdhCfbeYy-np9dn77Nrz5dvDs9ucqNKGSVk0JjXmvGoaaFpFAWpNJQN6RgjJGWk7o1hFEOuhbQNOnbGCwYIU0lZCsNPUavJ99-rFN0kwIG3ak-2LUOG-W1Vf8izi7Vd_9TEZnWFzwZvNwaBP9jhDiotY3mdi8HfoyqxJSnh-8lFunUQkqaiC_-I678GFy6giIVLwTGTCYSnkh35w3Q7iITrG6LVXGl7opV22KT5Pnfq-4F2yYToZoIv2wHm3sN1dmHN5d782eT1ulhDLAT7_F8wm0c4PcO1uFGiZKWXC0-XqjF5y_y_D35phb0D4Viz54
CODEN	EMJODG
CitedBy_id	crossref_primary_10_1016_j_ceca_2007_10_006 crossref_primary_10_1016_j_omtm_2017_07_006 crossref_primary_10_1002_dneu_22139 crossref_primary_10_1161_CIRCHEARTFAILURE_110_958694 crossref_primary_10_1073_pnas_2403777121 crossref_primary_10_1002_syn_20887 crossref_primary_10_1523_JNEUROSCI_2680_07_2007 crossref_primary_10_1523_JNEUROSCI_2259_19_2019 crossref_primary_10_1007_s10038_007_0149_y crossref_primary_10_1016_j_neuron_2017_10_014 crossref_primary_10_1016_j_clinph_2021_08_026 crossref_primary_10_1523_JNEUROSCI_3203_10_2011 crossref_primary_10_1016_j_ebiom_2016_08_020 crossref_primary_10_3389_fnins_2020_00048 crossref_primary_10_26508_lsa_202101092 crossref_primary_10_1007_s00441_017_2579_y crossref_primary_10_1146_annurev_physiol_042022_014926 crossref_primary_10_1371_journal_pbio_3000596 crossref_primary_10_1038_s41598_020_71414_y crossref_primary_10_3390_ijms23041953 crossref_primary_10_1113_jphysiol_2007_141010 crossref_primary_10_1016_j_neurobiolaging_2010_04_016 crossref_primary_10_1111_j_1749_6632_2009_04995_x crossref_primary_10_1523_JNEUROSCI_2921_12_2013 crossref_primary_10_1007_s12311_008_0040_1 crossref_primary_10_1113_JP281331 crossref_primary_10_1016_j_celrep_2016_02_054 crossref_primary_10_1093_genetics_iyab063 crossref_primary_10_7554_eLife_64249 crossref_primary_10_1016_j_pharmthera_2008_11_004 crossref_primary_10_1073_pnas_0710131104 crossref_primary_10_1523_JNEUROSCI_3542_13_2014 crossref_primary_10_1080_03081079_2014_920999 crossref_primary_10_1371_journal_pbio_2004344 crossref_primary_10_1016_j_ceca_2015_01_007 crossref_primary_10_1111_j_1460_9568_2007_05829_x crossref_primary_10_1146_annurev_vision_091718_015000 crossref_primary_10_1007_s12104_022_10091_6 crossref_primary_10_3389_fncel_2017_00247 crossref_primary_10_1152_ajpendo_00342_2018 crossref_primary_10_1002_ajmg_a_36569 crossref_primary_10_1146_annurev_biochem_061516_044932 crossref_primary_10_1016_j_bbrc_2007_09_062 crossref_primary_10_1152_jn_00515_2019 crossref_primary_10_1523_JNEUROSCI_4759_12_2013 crossref_primary_10_3389_fnmol_2021_709390 crossref_primary_10_2142_biophys_50_195 crossref_primary_10_1073_pnas_0802175105 crossref_primary_10_1002_jcp_28405
Cites_doi	10.1002/(SICI)1096-9861(19980525)395:1<112::AID-CNE8>3.0.CO;2-3 10.1046/j.1460-9568.2002.02407.x 10.1016/S0028-3908(01)00067-3 10.1073/pnas.0401702101 10.1083/jcb.200105040 10.1146/annurev.ph.56.030194.002413 10.1016/j.mcn.2005.10.003 10.1113/jphysiol.2005.088799 10.1523/JNEUROSCI.4208-03.2004 10.1523/JNEUROSCI.2915-04.2004 10.1016/S0896-6273(01)80047-7 10.1046/j.1460-9568.2003.02698.x 10.1006/bbrc.2002.6649 10.1152/physrev.00004.2004 10.1523/JNEUROSCI.21-24-09701.2001 10.1126/science.1114816 10.1152/physrev.1997.77.3.699 10.1146/annurev.ne.18.030195.001535 10.1038/nrn1516 10.1038/nn1647 10.1016/S0143416002001823 10.1016/S0896-6273(03)00714-1 10.1016/j.neuron.2004.10.024 10.1074/jbc.M010001200 10.1016/0012-1606(92)90065-O 10.1016/S0304-3940(00)01046-6 10.1073/pnas.0504359103 10.1073/pnas.0600497103 10.1038/nrn962 10.1113/jphysiol.2002.027854 10.1523/JNEUROSCI.20-13-04954.2000 10.1126/science.1082915 10.1073/pnas.0509863103 10.1126/science.6701513 10.1016/S0070-2161(08)60768-6 10.1016/0092-8674(95)90147-7 10.1152/jn.1995.74.5.2184 10.1016/S0169-328X(03)00341-3 10.1523/JNEUROSCI.0182-04.2004
ContentType	Journal Article
Copyright	Copyright © 2007 European Molecular Biology Organization Copyright Nature Publishing Group Apr 4, 2007 Copyright © 2007, European Molecular Biology Organization 2007
Copyright_xml	– notice: Copyright © 2007 European Molecular Biology Organization – notice: Copyright Nature Publishing Group Apr 4, 2007 – notice: Copyright © 2007, European Molecular Biology Organization 2007
DBID	BSCLL CGR CUY CVF ECM EIF NPM AAYXX CITATION 3V. 7QG 7QL 7QP 7T5 7TK 7TM 7TO 7U9 7X7 7XB 88A 88E 8AO 8C1 8FD 8FE 8FH 8FI 8FJ 8FK 8G5 ABUWG AFKRA AZQEC BBNVY BENPR BHPHI BKSAR C1K CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ GUQSH H94 HCIFZ K9. LK8 M0S M1P M2O M7N M7P MBDVC P64 PCBAR PQEST PQQKQ PQUKI Q9U RC3 7X8 5PM
DOI	10.1038/sj.emboj.7601639
DatabaseName	Istex Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Immunology Abstracts Neurosciences Abstracts Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Virology and AIDS Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Research Library (Alumni Edition) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection ProQuest Databases ProQuest Natural Science Collection Earth, Atmospheric & Aquatic Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student Research Library Prep AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) Research Library Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Research Library (Corporate) Biotechnology and BioEngineering Abstracts Earth, Atmospheric & Aquatic Science Database ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central Basic Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles)
DatabaseTitle	MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Research Library Prep ProQuest Central Student Oncogenes and Growth Factors Abstracts ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection Environmental Sciences and Pollution Management Health Research Premium Collection Natural Science Collection Biological Science Collection ProQuest Medical Library (Alumni) Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Earth, Atmospheric & Aquatic Science Database ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts Technology Research Database ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College Research Library (Alumni Edition) ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Biology Journals (Alumni Edition) ProQuest Central Earth, Atmospheric & Aquatic Science Collection Genetics Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) AIDS and Cancer Research Abstracts ProQuest Research Library ProQuest Public Health ProQuest Central Basic ProQuest SciTech Collection ProQuest Medical Library Animal Behavior Abstracts Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	Research Library Prep MEDLINE Neurosciences Abstracts MEDLINE - Academic
Database_xml	– sequence: 1 dbid: ECM name: MEDLINE url: https://search.ebscohost.com/login.aspx?direct=true&db=cmedm&site=ehost-live sourceTypes: Index Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Chemistry Biology
DocumentTitleAlternate	Junctophilin-mediated cerebellar channel crosstalk
EISSN	1460-2075
EndPage	1933
ExternalDocumentID	1252214731 10_1038_sj_emboj_7601639 17347645 EMBJ7601639 7601639 ark_67375_WNG_WPQ8FK1X_W
Genre	article Research Support, Non-U.S. Gov't Journal Article
GroupedDBID	--- -DZ -Q- -~X 0R~ 123 1OC 24P 29G 2WC 33P 36B 39C 3O- 3V. 4.4 53G 5VS 70F 7X7 88A 88E 8AO 8C1 8CJ 8FE 8FH 8FI 8FJ 8G5 8R4 8R5 A8Z AAESR AAEVG AAHBH AAHHS AAIHA AANLZ AASGY AAXRX AAZKR ABCUV ABJNI ABLJU ABUWG ACAHQ ACBWZ ACCFJ ACCZN ACGFO ACGFS ACNCT ACPOU ACPRK ACSMW ACXBN ACXQS ADBBV ADEOM ADKYN ADMGS ADOZA ADXAS ADZMN AEEZP AEGXH AEIGN AENEX AEQDE AEUYR AFBPY AFFNX AFGKR AFKRA AFPWT AFRAH AFZJQ AHMBA AIAGR AIURR AIWBW AJBDE ALAGY ALIPV ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB AOIJS ASPBG AUFTA AVWKF AZFZN AZQEC AZVAB BAWUL BBNVY BDRZF BENPR BFHJK BHPHI BKSAR BMNLL BMXJE BPHCQ BRXPI BSCLL BTFSW BVXVI C1A C6C CAG CCPQU COF CS3 D1J DCZOG DIK DPXWK DRFUL DRSTM DU5 DWQXO E3Z EBD EBLON EBS EJD EMB EMOBN ESTFP F5P FEDTE FYUFA G-S GNUQQ GODZA GROUPED_DOAJ GUQSH GX1 H13 HCIFZ HH5 HK~ HMCUK HVGLF HYE KQ8 LATKE LEEKS LH4 LITHE LK8 LOXES LUTES LW6 LYRES M0L M1P M2O M7P MEWTI MRFUL MRSTM MSFUL MSSTM MVM MXFUL MXSTM MY~ O9- OK1 P2P P2W PCBAR PQQKQ PROAC PSQYO Q2X RHF RHI RIG RNS ROL RPM RZO SV3 TN5 TR2 UKHRP WBKPD WH7 WIH WIK WIN WOHZO WXSBR WYJ YSK ZCA ZZTAW ~KM - 0R ABFLS ABHUG ABPTK ABZEH ADACO ADAWD ADDAD AEUQT AFVGU AGJLS BBAFP DZ HK KM MY PADUT PQEST PQUKI PRINS Q- SUPJJ X XFK ZA5 CGR CUY CVF ECM EIF NPM AAYXX CITATION 7QG 7QL 7QP 7T5 7TK 7TM 7TO 7U9 7XB 8FD 8FK C1K FR3 H94 K9. M7N MBDVC P64 Q9U RC3 7X8 5PM
ID	FETCH-LOGICAL-c6289-12a05ba45eb3283e7219aebd124441f51bfc1435eab6edd1bfdc06411d968f8c3
IEDL.DBID	RPM
ISSN	0261-4189
IngestDate	Tue Sep 17 21:17:46 EDT 2024 Fri Oct 25 08:39:14 EDT 2024 Sun Sep 29 07:32:13 EDT 2024 Wed Nov 06 08:55:38 EST 2024 Fri Nov 22 00:11:01 EST 2024 Sat Sep 28 07:57:16 EDT 2024 Sat Aug 24 00:44:50 EDT 2024 Thu Oct 07 20:37:46 EDT 2021 Wed Oct 30 09:50:46 EDT 2024
IsDoiOpenAccess	false
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	7
Language	English
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c6289-12a05ba45eb3283e7219aebd124441f51bfc1435eab6edd1bfdc06411d968f8c3
Notes	istex:75B833B0D9427F3A2DFA29AADF7472295DEC0BCA ArticleID:EMBJ7601639 Supplementary Figure 1Supplementary Figure 2Supplementary Figure 3Supplementary Figure 4Supplementary Figure 5Supplementary Figure 6Supplementary Figure 7Supplementary Table ISupplementary Information ark:/67375/WNG-WPQ8FK1X-W ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
OpenAccessLink	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1847665
PMID	17347645
PQID	195260048
PQPubID	35985
PageCount	10
ParticipantIDs	pubmedcentral_primary_oai_pubmedcentral_nih_gov_1847665 proquest_miscellaneous_70355550 proquest_miscellaneous_20266883 proquest_journals_195260048 crossref_primary_10_1038_sj_emboj_7601639 pubmed_primary_17347645 wiley_primary_10_1038_sj_emboj_7601639_EMBJ7601639 nature_primary_7601639 istex_primary_ark_67375_WNG_WPQ8FK1X_W
ProviderPackageCode	-Q- 70F
PublicationCentury	2000
PublicationDate	April 4, 2007
PublicationDateYYYYMMDD	2007-04-04
PublicationDate_xml	– month: 04 year: 2007 text: April 4, 2007 day: 04
PublicationDecade	2000
PublicationPlace	Chichester, UK
PublicationPlace_xml	– name: Chichester, UK – name: England – name: Heidelberg
PublicationTitle	The EMBO journal
PublicationTitleAlternate	EMBO J
PublicationYear	2007
Publisher	John Wiley & Sons, Ltd Blackwell Publishing Ltd Nature Publishing Group
Publisher_xml	– name: John Wiley & Sons, Ltd – name: Blackwell Publishing Ltd – name: Nature Publishing Group
References	Kano M, Hashimoto K, Chen C, Abeliovich A, Aiba A, Kurihara H, Watanabe M, Inoue Y, Tonegawa S (1995) Impaired synapse elimination during cerebellar development in PKC gamma mutant mice. Cell 83: 1223-1231 Kishimoto Y, Fujimichi R, Araishi K, Kawahara S, Kano M, Aiba A, Kirino Y (2002) mGluR1 in cerebellar Purkinje cells is required for normal association of temporally contiguous stimuli in classical conditioning. Eur J Neurosci 16: 2416-2424 Hashimoto K, Ichikawa R, Takechi H, Inoue Y, Aiba A, Sakimura K, Mishina M, Hashikawa T, Konnerth A, Watanabe M, Kano M (2001) Roles of glutamate receptor delta 2 subunit (GluR delta 2) and metabotropic glutamate receptor subtype 1 (mGluR1) in climbing fiber synapse elimination during postnatal cerebellar development. J Neurosci 21: 9701-9712 Nishi M, Sakagami H, Komazaki S, Kondo H, Takeshima H (2003) Coexpression of junctophilin type 3 and type 4 in brain. Mol Brain Res 118: 102-110 Bloodgood BL, Sabatini BL (2005) Neuronal activity regulates diffusion across the neck of dendritic spines. Science 310: 866-869 Kakizawa S, Yamasaki M, Watanabe M, Kano M (2000) Critical period for activity-dependent synapse elimination in developing cerebellum. J Neurosci 20: 4954-4961 Pedarzani P, Mosbacher J, Rivard A, Cingolani LA, Oliver D, Stocker M, Adelman JP, Fakler B (2001) Control of electrical activity in central neurons by modulating the gating of small conductance Ca2+-activated K+ channels. J Biol Chem 276: 9762-9769 Ito M (2002) The molecular organization of cerebellar long-term depression. Nat Rev Neurosci 3: 896-902 Mori F, Fukaya M, Abe H, Wakabayashi K, Watanabe M (2000) Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain. Neurosci Lett 285: 57-60 Bond CT, Herson PS, Strassmaier T, Hammond R, Stackman R, Maylie J, Adelman JP (2004) Small conductance Ca2+-activated K+ channel knock-out mice reveal the identity of calcium-dependent afterhyperpolarization currents. J Neurosci 24: 5301-5306 Leitges M, Kovac J, Plomann M, Linden DJ (2004) A unique PDZ ligand in PKC alpha confers induction of cerebellar long-term synaptic depression. Neuron 44: 585-594 Nakagawa S, Watanabe M, Isobe T, Kondo H, Inoue Y (1998) Cytological compartmentalization in the staggerer cerebellum, as revealed by calbindin immunohistochemistry for Purkinje cells. J Comp Neurol 395: 112-120 Nishi M, Hashimoto K, Kuriyama K, Komazaki S, Kano M, Shibata S, Takeshima H (2002) Motor discoordination in mutant mice lacking junctophilin type 3. Biochem Biophys Res Commun 292: 318-324 Endo M (1985) Calcium release from sarcoplasmic-reticulum. Curr Topics Memb Trans 25: 181-230 Flucher BE (1992) Structural-analysis of muscle development-transverse tubules, sarcoplasmic-reticulum, and the triad. Dev Biol 154: 245-260 Moriguchi S, Nishi M, Komazaki S, Sakagami H, Miyazaki T, Masumiya H, Saito SY, Watanabe M, Kondo H, Yawo H, Fukunaga K, Takeshima H (2006) Functional uncoupling between Ca2+ release and afterhyperpolarization in mutant hippocampal neurons lacking junctophilins. Proc Natl Acad Sci USA 103: 10811-10816 Edgerton JR, Reinhart PH (2003) Distinct contributions of small and large conductance Ca2+-activated K+ channels to rat Purkinje neuron function. J Physiol-London 548: 53-69 Miyazaki T, Fukaya M, Shimizu H, Watanabe M (2003) Subtype switching of vesicular glutamate transporters at parallel fibre-Purkinje cell synapses in developing mouse cerebellum. Eur J Neurosc 17: 2563-2572 Takeshima H, Komazaki S, Nishi M, Iino M, Kangawa K (2000) Junctophilins: a novel family of junctional membrane complex proteins. Mol Cell 6: 11-22 Namiki S, Kakizawa S, Hirose K, Iino M (2005) NO signalling decodes frequency of neuronal activity and generates synapse-specific plasticity in mouse cerebellum. J Physiol-London 566: 849-863 Berridge MJ (2002) The endoplasmic reticulum: a multifunctional signaling organelle. Cell Calcium 32: 235-249 FranziniArmstrong C, Protasi F (1997) Ryanodine receptors of striated muscles: a complex channel capable of multiple interactions. Physiol Rev 77: 699-729 Womack MD, Chevez C, Khodakhah K (2004) Calcium-activated potassium channels are selectively coupled to P/Q-type calcium channels in cerebellar Purkinje neurons. J Neurosci 24: 8818-8822 Levitan IB (2006) Signaling protein complexes associated with neuronal ion channels. Nat Neurosci 9: 305-310 Kohda K, Inoue T, Mikoshiba K (1995) Ca2+ release from Ca2+ stores, particularly from ryanodine-sensitive Ca2+ stores, is required for the induction of ltd in cultured cerebellar Purkinje-cells. J Neurophysiol 74: 2184-2188 McCormick DA, Thompson RF (1984) Cerebellum-essential involvement in the classically-conditioned eyelid response. Science 223: 296-299 Meissner G (1994) Ryanodine receptor Ca2+ release channels and their regulation by endogenous effectors. Annu Rev Physiol 56: 485-508 Miyazaki T, Hashimoto K, Shin HS, Kano M, Watanabe M (2004) P/Q-type Ca2+ channel alpha 1A regulates synaptic competition on developing cerebellar Purkinje cells. J Neurosci 24: 1734-1743 Kakizawa S, Miyazaki T, Yanagihara D, Iino M, Watanabe M, Kano M (2005) Maintenance of presynaptic function by AMPA receptor-mediated excitatory postsynaptic activity in adult brain. Proc Natl Acad Sci USA 102: 19180-19185 Stocker M (2004) Ca2+-activated K+ channels: molecular determinants and function of the SK family. Nat Rev Neurosci 5: 758-770 Finlayson K, McLuckie J, Hern J, Aramori I, Olverman HJ, Kelly JS (2001) Characterisation of I-125-apamin binding sites in rat brain membranes and HEK293 cells transfected with SK channel subtypes. Neuropharmacology 41: 341-350 Kano M, Hashimoto K, Kurihara H, Watanabe M, Inoue Y, Aiba A, Tonegawa S (1997) Persistent multiple climbing fiber innervation of cerebellar Purkinje cells in mice lacking mGluR1. Neuron 18: 71-79 Chung HJ, Steinberg JP, Huganir RL, Linden DJ (2003) Requirement of AMPA receptor GluR2 phosphorylation for cerebellar long-term depression. Science 300: 1751-1755 Sausbier M, Hu H, Arntz C, Feil S, Kamm S, Adelsberger H, Sausbier U, Sailer CA, Feil R, Hofmann F, Korth M, Shipston MJ, Knaus HG, Wolfer DP, Pedroarena CM, Storm JF, Ruth P (2004) Cerebellar ataxia and Purkinje cell dysfunction caused by Ca2+-activated K+ channel deficiency. Proc Natl Acad Sci USA 101: 9474-9478 Furutani K, Okubo Y, Kakizawa S, Iino M (2006) Postsynaptic inositol 1,4,5-trisphosphate signaling maintains presynaptic function of parallel fiber-Purkinje cell synapses via BDNF. Proc Natl Acad Sci USA 103: 8528-8533 Ito K, Komazaki S, Sasamoto K, Yoshida M, Nishi M, Kitamura K, Takeshima H (2001) Deficiency of triad junction and contraction in mutant skeletal muscle lacking junctophilin type 1. J Cell Biol 154: 1059-1067 Tohgo A, Eiraku M, Miyazaki T, Miura E, Kawaguchi S, Nishi M, Watanabe M, Hirano T, Kengaku M, Takeshima H (2006) Impaired cerebellar functions in mutant mice lacking DNER. Mol Cell Neurosci 31: 326-333 Goldberg JH, Tamas G, Aronov D, Yuste R (2003) Calcium microdomains in aspiny dendrites. Neuron 40: 807-821 Linden DJ, Connor JA (1995) Long-term synaptic depression. Annu Rev Neurosci 18: 319-357 Verkhratsky A (2005) Physiology and pathophysiology of the calcium store in the endoplasmic reticulum of neurons. Physiol Rev 85: 201-279 Pedarzani, P, Mosbacher, J, Rivard, A, Cingolani, LA, Oliver, D, Stocker, M, Adelman, JP, Fakler, B (b34) 2001; 276 Kakizawa, S, Miyazaki, T, Yanagihara, D, Iino, M, Watanabe, M, Kano, M (b15) 2005; 102 Flucher, BE (b8) 1992; 154 Nishi, M, Sakagami, H, Komazaki, S, Kondo, H, Takeshima, H (b33) 2003; 118 FranziniArmstrong, C, Protasi, F (b9) 1997; 77 Meissner, G (b25) 1994; 56 Stocker, M (b36) 2004; 5 Moriguchi, S, Nishi, M, Komazaki, S, Sakagami, H, Miyazaki, T, Masumiya, H, Saito, SY, Watanabe, M, Kondo, H, Yawo, H, Fukunaga, K, Takeshima, H (b29) 2006; 103 Levitan, IB (b22) 2006; 9 Linden, DJ, Connor, JA (b23) 1995; 18 Nishi, M, Hashimoto, K, Kuriyama, K, Komazaki, S, Kano, M, Shibata, S, Takeshima, H (b32) 2002; 292 Verkhratsky, A (b39) 2005; 85 Kakizawa, S, Yamasaki, M, Watanabe, M, Kano, M (b16) 2000; 20 Kano, M, Hashimoto, K, Chen, C, Abeliovich, A, Aiba, A, Kurihara, H, Watanabe, M, Inoue, Y, Tonegawa, S (b17) 1995; 83 Kano, M, Hashimoto, K, Kurihara, H, Watanabe, M, Inoue, Y, Aiba, A, Tonegawa, S (b18) 1997; 18 Endo, M (b6) 1985; 25 Miyazaki, T, Hashimoto, K, Shin, HS, Kano, M, Watanabe, M (b27) 2004; 24 Womack, MD, Chevez, C, Khodakhah, K (b40) 2004; 24 Furutani, K, Okubo, Y, Kakizawa, S, Iino, M (b10) 2006; 103 Goldberg, JH, Tamas, G, Aronov, D, Yuste, R (b11) 2003; 40 Ito, K, Komazaki, S, Sasamoto, K, Yoshida, M, Nishi, M, Kitamura, K, Takeshima, H (b13) 2001; 154 Kishimoto, Y, Fujimichi, R, Araishi, K, Kawahara, S, Kano, M, Aiba, A, Kirino, Y (b19) 2002; 16 Bond, CT, Herson, PS, Strassmaier, T, Hammond, R, Stackman, R, Maylie, J, Adelman, JP (b3) 2004; 24 Chung, HJ, Steinberg, JP, Huganir, RL, Linden, DJ (b4) 2003; 300 Berridge, MJ (b1) 2002; 32 McCormick, DA, Thompson, RF (b24) 1984; 223 Leitges, M, Kovac, J, Plomann, M, Linden, DJ (b21) 2004; 44 Namiki, S, Kakizawa, S, Hirose, K, Iino, M (b31) 2005; 566 Ito, M (b14) 2002; 3 Nakagawa, S, Watanabe, M, Isobe, T, Kondo, H, Inoue, Y (b30) 1998; 395 Miyazaki, T, Fukaya, M, Shimizu, H, Watanabe, M (b26) 2003; 17 Kohda, K, Inoue, T, Mikoshiba, K (b20) 1995; 74 Takeshima, H, Komazaki, S, Nishi, M, Iino, M, Kangawa, K (b37) 2000; 6 Hashimoto, K, Ichikawa, R, Takechi, H, Inoue, Y, Aiba, A, Sakimura, K, Mishina, M, Hashikawa, T, Konnerth, A, Watanabe, M, Kano, M (b12) 2001; 21 Finlayson, K, McLuckie, J, Hern, J, Aramori, I, Olverman, HJ, Kelly, JS (b7) 2001; 41 Edgerton, JR, Reinhart, PH (b5) 2003; 548 Tohgo, A, Eiraku, M, Miyazaki, T, Miura, E, Kawaguchi, S, Nishi, M, Watanabe, M, Hirano, T, Kengaku, M, Takeshima, H (b38) 2006; 31 Mori, F, Fukaya, M, Abe, H, Wakabayashi, K, Watanabe, M (b28) 2000; 285 Sausbier, M, Hu, H, Arntz, C, Feil, S, Kamm, S, Adelsberger, H, Sausbier, U, Sailer, CA, Feil, R, Hofmann, F, Korth, M, Shipston, MJ, Knaus, HG, Wolfer, DP, Pedroarena, CM, Storm, JF, Ruth, P (b35) 2004; 101 Bloodgood, BL, Sabatini, BL (b2) 2005; 310 2002; 16 2004; 101 1995; 74 2004; 44 2002; 292 2003; 118 2006; 31 2000; 6 1984; 223 2005; 310 2002; 32 2006; 9 2004; 24 2000; 20 2005; 85 2002; 3 2004; 5 2003; 17 1995; 18 2001; 41 1998; 395 1985; 25 2001; 21 2001; 276 2001; 154 1995; 83 2003; 548 1997; 77 1992; 154 2005; 102 2005; 566 1994; 56 1997; 18 2000; 285 2003; 300 2003; 40 2006; 103 15541307 - Neuron. 2004 Nov 18;44(4):585-94 15618481 - Physiol Rev. 2005 Jan;85(1):201-79 16709674 - Proc Natl Acad Sci U S A. 2006 May 30;103(22):8528-33 15919714 - J Physiol. 2005 Aug 1;566(Pt 3):849-63 12805550 - Science. 2003 Jun 13;300(5626):1751-5 14559359 - Brain Res Mol Brain Res. 2003 Oct 21;118(1-2):102-10 7516645 - Annu Rev Physiol. 1994;56:485-508 16809425 - Proc Natl Acad Sci U S A. 2006 Jul 11;103(28):10811-6 9590549 - J Comp Neurol. 1998 May 25;395(1):112-20 12415297 - Nat Rev Neurosci. 2002 Nov;3(11):896-902 11739579 - J Neurosci. 2001 Dec 15;21(24):9701-12 1426638 - Dev Biol. 1992 Dec;154(2):245-60 15470147 - J Neurosci. 2004 Oct 6;24(40):8818-22 11134030 - J Biol Chem. 2001 Mar 30;276(13):9762-9 14973254 - J Neurosci. 2004 Feb 18;24(7):1734-43 11522325 - Neuropharmacology. 2001 Sep;41(3):341-50 16498425 - Nat Neurosci. 2006 Mar;9(3):305-10 16272125 - Science. 2005 Nov 4;310(5749):866-9 9234963 - Physiol Rev. 1997 Jul;77(3):699-729 10788707 - Neurosci Lett. 2000 May 5;285(1):57-60 15190101 - J Neurosci. 2004 Jun 9;24(23):5301-6 8592207 - J Neurophysiol. 1995 Nov;74(5):2184-8 12492436 - Eur J Neurosci. 2002 Dec;16(12):2416-24 10864953 - J Neurosci. 2000 Jul 1;20(13):4954-61 12543086 - Cell Calcium. 2002 Nov-Dec;32(5-6):235-49 12823463 - Eur J Neurosci. 2003 Jun;17(12):2563-72 11906164 - Biochem Biophys Res Commun. 2002 Mar 29;292(2):318-24 12576503 - J Physiol. 2003 Apr 1;548(Pt 1):53-69 7605065 - Annu Rev Neurosci. 1995;18:319-57 14622584 - Neuron. 2003 Nov 13;40(4):807-21 6701513 - Science. 1984 Jan 20;223(4633):296-9 10949023 - Mol Cell. 2000 Jul;6(1):11-22 15378036 - Nat Rev Neurosci. 2004 Oct;5(10):758-70 9010206 - Neuron. 1997 Jan;18(1):71-9 16298139 - Mol Cell Neurosci. 2006 Feb;31(2):326-33 11535622 - J Cell Biol. 2001 Sep 3;154(5):1059-67 8548808 - Cell. 1995 Dec 29;83(7):1223-31 15194823 - Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9474-8 16357208 - Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19180-5 Kano M (7601639-b17) 1995; 83 Berridge MJ (7601639-b1) 2002; 32 Kakizawa S (7601639-b15) 2005; 102 Edgerton JR (7601639-b5) 2003; 548 Sausbier M (7601639-b35) 2004; 101 Tohgo A (7601639-b38) 2006; 31 Bloodgood BL (7601639-b2) 2005; 310 Miyazaki T (7601639-b27) 2004; 24 Bond CT (7601639-b3) 2004; 24 Takeshima H (7601639-b37) 2000; 6 Finlayson K (7601639-b7) 2001; 41 Ito K (7601639-b13) 2001; 154 Womack MD (7601639-b40) 2004; 24 Furutani K (7601639-b10) 2006; 103 Levitan IB (7601639-b22) 2006; 9 Nishi M (7601639-b32) 2002; 292 Linden DJ (7601639-b23) 1995; 18 Nishi M (7601639-b33) 2003; 118 Pedarzani P (7601639-b34) 2001; 276 FranziniArmstrong C (7601639-b9) 1997; 77 McCormick DA (7601639-b24) 1984; 223 Endo M (7601639-b6) 1985; 25 Kakizawa S (7601639-b16) 2000; 20 Kishimoto Y (7601639-b19) 2002; 16 Goldberg JH (7601639-b11) 2003; 40 Meissner G (7601639-b25) 1994; 56 Hashimoto K (7601639-b12) 2001; 21 Namiki S (7601639-b31) 2005; 566 Nakagawa S (7601639-b30) 1998; 395 Kano M (7601639-b18) 1997; 18 Kohda K (7601639-b20) 1995; 74 Stocker M (7601639-b36) 2004; 5 Flucher BE (7601639-b8) 1992; 154 Ito M (7601639-b14) 2002; 3 Leitges M (7601639-b21) 2004; 44 Verkhratsky A (7601639-b39) 2005; 85 Mori F (7601639-b28) 2000; 285 Moriguchi S (7601639-b29) 2006; 103 Miyazaki T (7601639-b26) 2003; 17 Chung HJ (7601639-b4) 2003; 300
References_xml	– volume: 32 start-page: 235 year: 2002 end-page: 249 ident: b1 publication-title: Cell Calcium contributor: fullname: Berridge, MJ – volume: 21 start-page: 9701 year: 2001 end-page: 9712 ident: b12 publication-title: J Neurosci contributor: fullname: Kano, M – volume: 6 start-page: 11 year: 2000 end-page: 22 ident: b37 publication-title: Mol Cell contributor: fullname: Kangawa, K – volume: 31 start-page: 326 year: 2006 end-page: 333 ident: b38 publication-title: Mol Cell Neurosci contributor: fullname: Takeshima, H – volume: 285 start-page: 57 year: 2000 end-page: 60 ident: b28 publication-title: Neurosci Lett contributor: fullname: Watanabe, M – volume: 18 start-page: 71 year: 1997 end-page: 79 ident: b18 publication-title: Neuron contributor: fullname: Tonegawa, S – volume: 56 start-page: 485 year: 1994 end-page: 508 ident: b25 publication-title: Annu Rev Physiol contributor: fullname: Meissner, G – volume: 300 start-page: 1751 year: 2003 end-page: 1755 ident: b4 publication-title: Science contributor: fullname: Linden, DJ – volume: 395 start-page: 112 year: 1998 end-page: 120 ident: b30 publication-title: J Comp Neurol contributor: fullname: Inoue, Y – volume: 276 start-page: 9762 year: 2001 end-page: 9769 ident: b34 publication-title: J Biol Chem contributor: fullname: Fakler, B – volume: 77 start-page: 699 year: 1997 end-page: 729 ident: b9 publication-title: Physiol Rev contributor: fullname: Protasi, F – volume: 83 start-page: 1223 year: 1995 end-page: 1231 ident: b17 publication-title: Cell contributor: fullname: Tonegawa, S – volume: 9 start-page: 305 year: 2006 end-page: 310 ident: b22 publication-title: Nat Neurosci contributor: fullname: Levitan, IB – volume: 154 start-page: 245 year: 1992 end-page: 260 ident: b8 publication-title: Dev Biol contributor: fullname: Flucher, BE – volume: 101 start-page: 9474 year: 2004 end-page: 9478 ident: b35 publication-title: Proc Natl Acad Sci USA contributor: fullname: Ruth, P – volume: 3 start-page: 896 year: 2002 end-page: 902 ident: b14 publication-title: Nat Rev Neurosci contributor: fullname: Ito, M – volume: 40 start-page: 807 year: 2003 end-page: 821 ident: b11 publication-title: Neuron contributor: fullname: Yuste, R – volume: 85 start-page: 201 year: 2005 end-page: 279 ident: b39 publication-title: Physiol Rev contributor: fullname: Verkhratsky, A – volume: 18 start-page: 319 year: 1995 end-page: 357 ident: b23 publication-title: Annu Rev Neurosci contributor: fullname: Connor, JA – volume: 16 start-page: 2416 year: 2002 end-page: 2424 ident: b19 publication-title: Eur J Neurosci contributor: fullname: Kirino, Y – volume: 24 start-page: 1734 year: 2004 end-page: 1743 ident: b27 publication-title: J Neurosci contributor: fullname: Watanabe, M – volume: 25 start-page: 181 year: 1985 end-page: 230 ident: b6 publication-title: Curr Topics Memb Trans contributor: fullname: Endo, M – volume: 223 start-page: 296 year: 1984 end-page: 299 ident: b24 publication-title: Science contributor: fullname: Thompson, RF – volume: 41 start-page: 341 year: 2001 end-page: 350 ident: b7 publication-title: Neuropharmacology contributor: fullname: Kelly, JS – volume: 154 start-page: 1059 year: 2001 end-page: 1067 ident: b13 publication-title: J Cell Biol contributor: fullname: Takeshima, H – volume: 292 start-page: 318 year: 2002 end-page: 324 ident: b32 publication-title: Biochem Biophys Res Commun contributor: fullname: Takeshima, H – volume: 44 start-page: 585 year: 2004 end-page: 594 ident: b21 publication-title: Neuron contributor: fullname: Linden, DJ – volume: 118 start-page: 102 year: 2003 end-page: 110 ident: b33 publication-title: Mol Brain Res contributor: fullname: Takeshima, H – volume: 102 start-page: 19180 year: 2005 end-page: 19185 ident: b15 publication-title: Proc Natl Acad Sci USA contributor: fullname: Kano, M – volume: 24 start-page: 5301 year: 2004 end-page: 5306 ident: b3 publication-title: J Neurosci contributor: fullname: Adelman, JP – volume: 74 start-page: 2184 year: 1995 end-page: 2188 ident: b20 publication-title: J Neurophysiol contributor: fullname: Mikoshiba, K – volume: 103 start-page: 10811 year: 2006 end-page: 10816 ident: b29 publication-title: Proc Natl Acad Sci USA contributor: fullname: Takeshima, H – volume: 20 start-page: 4954 year: 2000 end-page: 4961 ident: b16 publication-title: J Neurosci contributor: fullname: Kano, M – volume: 17 start-page: 2563 year: 2003 end-page: 2572 ident: b26 publication-title: Eur J Neurosc contributor: fullname: Watanabe, M – volume: 548 start-page: 53 year: 2003 end-page: 69 ident: b5 publication-title: J Physiol-London contributor: fullname: Reinhart, PH – volume: 566 start-page: 849 year: 2005 end-page: 863 ident: b31 publication-title: J Physiol-London contributor: fullname: Iino, M – volume: 310 start-page: 866 year: 2005 end-page: 869 ident: b2 publication-title: Science contributor: fullname: Sabatini, BL – volume: 103 start-page: 8528 year: 2006 end-page: 8533 ident: b10 publication-title: Proc Natl Acad Sci USA contributor: fullname: Iino, M – volume: 5 start-page: 758 year: 2004 end-page: 770 ident: b36 publication-title: Nat Rev Neurosci contributor: fullname: Stocker, M – volume: 24 start-page: 8818 year: 2004 end-page: 8822 ident: b40 publication-title: J Neurosci contributor: fullname: Khodakhah, K – volume: 300 start-page: 1751 year: 2003 end-page: 1755 article-title: Requirement of AMPA receptor GluR2 phosphorylation for cerebellar long‐term depression publication-title: Science – volume: 102 start-page: 19180 year: 2005 end-page: 19185 article-title: Maintenance of presynaptic function by AMPA receptor‐mediated excitatory postsynaptic activity in adult brain publication-title: Proc Natl Acad Sci USA – volume: 3 start-page: 896 year: 2002 end-page: 902 article-title: The molecular organization of cerebellar long‐term depression publication-title: Nat Rev Neurosci – volume: 292 start-page: 318 year: 2002 end-page: 324 article-title: Motor discoordination in mutant mice lacking junctophilin type 3 publication-title: Biochem Biophys Res Commun – volume: 154 start-page: 1059 year: 2001 end-page: 1067 article-title: Deficiency of triad junction and contraction in mutant skeletal muscle lacking junctophilin type 1 publication-title: J Cell Biol – volume: 21 start-page: 9701 year: 2001 end-page: 9712 article-title: Roles of glutamate receptor delta 2 subunit (GluR delta 2) and metabotropic glutamate receptor subtype 1 (mGluR1) in climbing fiber synapse elimination during postnatal cerebellar development publication-title: J Neurosci – volume: 85 start-page: 201 year: 2005 end-page: 279 article-title: Physiology and pathophysiology of the calcium store in the endoplasmic reticulum of neurons publication-title: Physiol Rev – volume: 41 start-page: 341 year: 2001 end-page: 350 article-title: Characterisation of I‐125‐apamin binding sites in rat brain membranes and HEK293 cells transfected with SK channel subtypes publication-title: Neuropharmacology – volume: 83 start-page: 1223 year: 1995 end-page: 1231 article-title: Impaired synapse elimination during cerebellar development in PKC gamma mutant mice publication-title: Cell – volume: 18 start-page: 319 year: 1995 end-page: 357 article-title: Long‐term synaptic depression publication-title: Annu Rev Neurosci – volume: 25 start-page: 181 year: 1985 end-page: 230 article-title: Calcium release from sarcoplasmic‐reticulum publication-title: Curr Topics Memb Trans – volume: 101 start-page: 9474 year: 2004 end-page: 9478 article-title: Cerebellar ataxia and Purkinje cell dysfunction caused by Ca ‐activated K channel deficiency publication-title: Proc Natl Acad Sci USA – volume: 310 start-page: 866 year: 2005 end-page: 869 article-title: Neuronal activity regulates diffusion across the neck of dendritic spines publication-title: Science – volume: 548 start-page: 53 year: 2003 end-page: 69 article-title: Distinct contributions of small and large conductance Ca ‐activated K channels to rat Purkinje neuron function publication-title: J Physiol‐London – volume: 44 start-page: 585 year: 2004 end-page: 594 article-title: A unique PDZ ligand in PKC alpha confers induction of cerebellar long‐term synaptic depression publication-title: Neuron – volume: 24 start-page: 8818 year: 2004 end-page: 8822 article-title: Calcium‐activated potassium channels are selectively coupled to P/Q‐type calcium channels in cerebellar Purkinje neurons publication-title: J Neurosci – volume: 40 start-page: 807 year: 2003 end-page: 821 article-title: Calcium microdomains in aspiny dendrites publication-title: Neuron – volume: 56 start-page: 485 year: 1994 end-page: 508 article-title: Ryanodine receptor Ca release channels and their regulation by endogenous effectors publication-title: Annu Rev Physiol – volume: 5 start-page: 758 year: 2004 end-page: 770 article-title: Ca ‐activated K channels: molecular determinants and function of the SK family publication-title: Nat Rev Neurosci – volume: 9 start-page: 305 year: 2006 end-page: 310 article-title: Signaling protein complexes associated with neuronal ion channels publication-title: Nat Neurosci – volume: 24 start-page: 5301 year: 2004 end-page: 5306 article-title: Small conductance Ca ‐activated K channel knock‐out mice reveal the identity of calcium‐dependent afterhyperpolarization currents publication-title: J Neurosci – volume: 77 start-page: 699 year: 1997 end-page: 729 article-title: Ryanodine receptors of striated muscles: a complex channel capable of multiple interactions publication-title: Physiol Rev – volume: 223 start-page: 296 year: 1984 end-page: 299 article-title: Cerebellum—essential involvement in the classically‐conditioned eyelid response publication-title: Science – volume: 103 start-page: 10811 year: 2006 end-page: 10816 article-title: Functional uncoupling between Ca release and afterhyperpolarization in mutant hippocampal neurons lacking junctophilins publication-title: Proc Natl Acad Sci USA – volume: 32 start-page: 235 year: 2002 end-page: 249 article-title: The endoplasmic reticulum: a multifunctional signaling organelle publication-title: Cell Calcium – volume: 118 start-page: 102 year: 2003 end-page: 110 article-title: Coexpression of junctophilin type 3 and type 4 in brain publication-title: Mol Brain Res – volume: 24 start-page: 1734 year: 2004 end-page: 1743 article-title: P/Q‐type Ca channel alpha 1A regulates synaptic competition on developing cerebellar Purkinje cells publication-title: J Neurosci – volume: 18 start-page: 71 year: 1997 end-page: 79 article-title: Persistent multiple climbing fiber innervation of cerebellar Purkinje cells in mice lacking mGluR1 publication-title: Neuron – volume: 20 start-page: 4954 year: 2000 end-page: 4961 article-title: Critical period for activity‐dependent synapse elimination in developing cerebellum publication-title: J Neurosci – volume: 6 start-page: 11 year: 2000 end-page: 22 article-title: Junctophilins: a novel family of junctional membrane complex proteins publication-title: Mol Cell – volume: 276 start-page: 9762 year: 2001 end-page: 9769 article-title: Control of electrical activity in central neurons by modulating the gating of small conductance Ca ‐activated K channels publication-title: J Biol Chem – volume: 154 start-page: 245 year: 1992 end-page: 260 article-title: Structural‐analysis of muscle development—transverse tubules, sarcoplasmic‐reticulum, and the triad publication-title: Dev Biol – volume: 31 start-page: 326 year: 2006 end-page: 333 article-title: Impaired cerebellar functions in mutant mice lacking DNER publication-title: Mol Cell Neurosci – volume: 74 start-page: 2184 year: 1995 end-page: 2188 article-title: Ca release from Ca stores, particularly from ryanodine‐sensitive Ca stores, is required for the induction of ltd in cultured cerebellar Purkinje‐cells publication-title: J Neurophysiol – volume: 566 start-page: 849 year: 2005 end-page: 863 article-title: NO signalling decodes frequency of neuronal activity and generates synapse‐specific plasticity in mouse cerebellum publication-title: J Physiol‐London – volume: 285 start-page: 57 year: 2000 end-page: 60 article-title: Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain publication-title: Neurosci Lett – volume: 395 start-page: 112 year: 1998 end-page: 120 article-title: Cytological compartmentalization in the staggerer cerebellum, as revealed by calbindin immunohistochemistry for Purkinje cells publication-title: J Comp Neurol – volume: 17 start-page: 2563 year: 2003 end-page: 2572 article-title: Subtype switching of vesicular glutamate transporters at parallel fibre–Purkinje cell synapses in developing mouse cerebellum publication-title: Eur J Neurosc – volume: 103 start-page: 8528 year: 2006 end-page: 8533 article-title: Postsynaptic inositol 1,4,5‐trisphosphate signaling maintains presynaptic function of parallel fiber‐Purkinje cell synapses via BDNF publication-title: Proc Natl Acad Sci USA – volume: 16 start-page: 2416 year: 2002 end-page: 2424 article-title: mGluR1 in cerebellar Purkinje cells is required for normal association of temporally contiguous stimuli in classical conditioning publication-title: Eur J Neurosci – volume: 395 start-page: 112 year: 1998 ident: 7601639-b30 publication-title: J Comp Neurol doi: 10.1002/(SICI)1096-9861(19980525)395:1<112::AID-CNE8>3.0.CO;2-3 contributor: fullname: Nakagawa S – volume: 16 start-page: 2416 year: 2002 ident: 7601639-b19 publication-title: Eur J Neurosci doi: 10.1046/j.1460-9568.2002.02407.x contributor: fullname: Kishimoto Y – volume: 41 start-page: 341 year: 2001 ident: 7601639-b7 publication-title: Neuropharmacology doi: 10.1016/S0028-3908(01)00067-3 contributor: fullname: Finlayson K – volume: 101 start-page: 9474 year: 2004 ident: 7601639-b35 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0401702101 contributor: fullname: Sausbier M – volume: 154 start-page: 1059 year: 2001 ident: 7601639-b13 publication-title: J Cell Biol doi: 10.1083/jcb.200105040 contributor: fullname: Ito K – volume: 56 start-page: 485 year: 1994 ident: 7601639-b25 publication-title: Annu Rev Physiol doi: 10.1146/annurev.ph.56.030194.002413 contributor: fullname: Meissner G – volume: 31 start-page: 326 year: 2006 ident: 7601639-b38 publication-title: Mol Cell Neurosci doi: 10.1016/j.mcn.2005.10.003 contributor: fullname: Tohgo A – volume: 566 start-page: 849 year: 2005 ident: 7601639-b31 publication-title: J Physiol-London doi: 10.1113/jphysiol.2005.088799 contributor: fullname: Namiki S – volume: 24 start-page: 1734 year: 2004 ident: 7601639-b27 publication-title: J Neurosci doi: 10.1523/JNEUROSCI.4208-03.2004 contributor: fullname: Miyazaki T – volume: 24 start-page: 8818 year: 2004 ident: 7601639-b40 publication-title: J Neurosci doi: 10.1523/JNEUROSCI.2915-04.2004 contributor: fullname: Womack MD – volume: 18 start-page: 71 year: 1997 ident: 7601639-b18 publication-title: Neuron doi: 10.1016/S0896-6273(01)80047-7 contributor: fullname: Kano M – volume: 17 start-page: 2563 year: 2003 ident: 7601639-b26 publication-title: Eur J Neurosc doi: 10.1046/j.1460-9568.2003.02698.x contributor: fullname: Miyazaki T – volume: 292 start-page: 318 year: 2002 ident: 7601639-b32 publication-title: Biochem Biophys Res Commun doi: 10.1006/bbrc.2002.6649 contributor: fullname: Nishi M – volume: 85 start-page: 201 year: 2005 ident: 7601639-b39 publication-title: Physiol Rev doi: 10.1152/physrev.00004.2004 contributor: fullname: Verkhratsky A – volume: 21 start-page: 9701 year: 2001 ident: 7601639-b12 publication-title: J Neurosci doi: 10.1523/JNEUROSCI.21-24-09701.2001 contributor: fullname: Hashimoto K – volume: 310 start-page: 866 year: 2005 ident: 7601639-b2 publication-title: Science doi: 10.1126/science.1114816 contributor: fullname: Bloodgood BL – volume: 77 start-page: 699 year: 1997 ident: 7601639-b9 publication-title: Physiol Rev doi: 10.1152/physrev.1997.77.3.699 contributor: fullname: FranziniArmstrong C – volume: 18 start-page: 319 year: 1995 ident: 7601639-b23 publication-title: Annu Rev Neurosci doi: 10.1146/annurev.ne.18.030195.001535 contributor: fullname: Linden DJ – volume: 5 start-page: 758 year: 2004 ident: 7601639-b36 publication-title: Nat Rev Neurosci doi: 10.1038/nrn1516 contributor: fullname: Stocker M – volume: 9 start-page: 305 year: 2006 ident: 7601639-b22 publication-title: Nat Neurosci doi: 10.1038/nn1647 contributor: fullname: Levitan IB – volume: 32 start-page: 235 year: 2002 ident: 7601639-b1 publication-title: Cell Calcium doi: 10.1016/S0143416002001823 contributor: fullname: Berridge MJ – volume: 40 start-page: 807 year: 2003 ident: 7601639-b11 publication-title: Neuron doi: 10.1016/S0896-6273(03)00714-1 contributor: fullname: Goldberg JH – volume: 44 start-page: 585 year: 2004 ident: 7601639-b21 publication-title: Neuron doi: 10.1016/j.neuron.2004.10.024 contributor: fullname: Leitges M – volume: 276 start-page: 9762 year: 2001 ident: 7601639-b34 publication-title: J Biol Chem doi: 10.1074/jbc.M010001200 contributor: fullname: Pedarzani P – volume: 154 start-page: 245 year: 1992 ident: 7601639-b8 publication-title: Dev Biol doi: 10.1016/0012-1606(92)90065-O contributor: fullname: Flucher BE – volume: 285 start-page: 57 year: 2000 ident: 7601639-b28 publication-title: Neurosci Lett doi: 10.1016/S0304-3940(00)01046-6 contributor: fullname: Mori F – volume: 102 start-page: 19180 year: 2005 ident: 7601639-b15 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0504359103 contributor: fullname: Kakizawa S – volume: 103 start-page: 8528 year: 2006 ident: 7601639-b10 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0600497103 contributor: fullname: Furutani K – volume: 3 start-page: 896 year: 2002 ident: 7601639-b14 publication-title: Nat Rev Neurosci doi: 10.1038/nrn962 contributor: fullname: Ito M – volume: 548 start-page: 53 year: 2003 ident: 7601639-b5 publication-title: J Physiol-London doi: 10.1113/jphysiol.2002.027854 contributor: fullname: Edgerton JR – volume: 20 start-page: 4954 year: 2000 ident: 7601639-b16 publication-title: J Neurosci doi: 10.1523/JNEUROSCI.20-13-04954.2000 contributor: fullname: Kakizawa S – volume: 300 start-page: 1751 year: 2003 ident: 7601639-b4 publication-title: Science doi: 10.1126/science.1082915 contributor: fullname: Chung HJ – volume: 103 start-page: 10811 year: 2006 ident: 7601639-b29 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0509863103 contributor: fullname: Moriguchi S – volume: 223 start-page: 296 year: 1984 ident: 7601639-b24 publication-title: Science doi: 10.1126/science.6701513 contributor: fullname: McCormick DA – volume: 25 start-page: 181 year: 1985 ident: 7601639-b6 publication-title: Curr Topics Memb Trans doi: 10.1016/S0070-2161(08)60768-6 contributor: fullname: Endo M – volume: 83 start-page: 1223 year: 1995 ident: 7601639-b17 publication-title: Cell doi: 10.1016/0092-8674(95)90147-7 contributor: fullname: Kano M – volume: 74 start-page: 2184 year: 1995 ident: 7601639-b20 publication-title: J Neurophysiol doi: 10.1152/jn.1995.74.5.2184 contributor: fullname: Kohda K – volume: 6 start-page: 11 year: 2000 ident: 7601639-b37 publication-title: Mol Cell contributor: fullname: Takeshima H – volume: 118 start-page: 102 year: 2003 ident: 7601639-b33 publication-title: Mol Brain Res doi: 10.1016/S0169-328X(03)00341-3 contributor: fullname: Nishi M – volume: 24 start-page: 5301 year: 2004 ident: 7601639-b3 publication-title: J Neurosci doi: 10.1523/JNEUROSCI.0182-04.2004 contributor: fullname: Bond CT
SSID	ssj0005871
Score	2.1703188
Snippet	Functional crosstalk between cell‐surface and intracellular ion channels plays important roles in excitable cells and is structurally supported by... Functional crosstalk between cell-surface and intracellular ion channels plays important roles in excitable cells and is structurally supported by...
SourceID	pubmedcentral proquest crossref pubmed wiley nature istex
SourceType	Open Access Repository Aggregation Database Index Database Publisher
StartPage	1924
SubjectTerms	Action Potentials afterhyperpolarization Animals Brain Calcium Calcium - metabolism Histology Ion Channel Gating Learning long-term depression Long-Term Synaptic Depression Membrane Proteins - metabolism Membranes Mental depression Mice Mice, Knockout Motor Skills - physiology Neuronal Plasticity Neurosciences Purkinje cell Purkinje Cells - cytology Purkinje Cells - metabolism ryanodine receptor Ryanodine Receptor Calcium Release Channel - metabolism Signal transduction SK channel Small-Conductance Calcium-Activated Potassium Channels - metabolism Synapses - metabolism
SummonAdditionalLinks	– databaseName: Wiley-Blackwell dbid: 33P link: http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwEB5BEYILj0IhLQ8fEBKHlDhxEudYyi5VEVURj-3Nsh1HdNtmq01X6t74CfzG_hJmnGzKFiEkRE4bxfHG43l8Y8-MAV4g6HYuyXXIqyIKhTESZa7MwpjMcVppYyNKFN75lO8dyLcDKpPT58K09SH6BTeSDK-vScC1abo0cQpcb8ab7sRMxpsU1YF2FtUwOgs-iyPZv4zykN7n8sssgsui26nELl5f7WDJMt0gIp9fra-5hD9_D6P8Fd56-zS8-z9Gdg_udOiUbbXsdB-uuXoVbrbnVc5X4db24ni4B_B1Fy0iVSU4xD-8-P7Dp6AgfGWUSoxfwPwoEdofMSpPXqMmOWaIkJl1U0e7HXrKmnmtUWVZdooYnsK7z-YP4ctw8Hl7J-wOaQhths5ayGMdpUaLFL1yhCoOPcpCO1MSbhC8SrmpLGEyp03myhJvS4swiPOyyGQlbbIGK_Wkdo-BFVVM9tJFWlSiymlNKtY2sUgFa5A0AbxaTJA6bWtxKL-HnkjVjJWnmepoFsBLP4N9Qz09ohi2PFWjvXdqtP9RDt_zAzUKYK2d4r5l38PGYspVJ9eN4kVKFf0Ffsvz_ikSnnZZdO0ms0bFyGuZlMmfW6CSTfGKAnjUMtDlaPJE5JlIA8iXWKtvQMXAl5_Uh998UXD01PMswzdjz1p_JZAafHiz2_1e_5eXNuB2u85NgUxPYOVsOnNP4XpTzp55EfwJZ3U3aA priority: 102 providerName: Wiley-Blackwell
Title	Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity
URI	https://api.istex.fr/ark:/67375/WNG-WPQ8FK1X-W/fulltext.pdf http://dx.doi.org/10.1038/sj.emboj.7601639 https://onlinelibrary.wiley.com/doi/abs/10.1038%2Fsj.emboj.7601639 https://www.ncbi.nlm.nih.gov/pubmed/17347645 https://www.proquest.com/docview/195260048 https://search.proquest.com/docview/20266883 https://search.proquest.com/docview/70355550 https://pubmed.ncbi.nlm.nih.gov/PMC1847665
Volume	26
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
link	http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwED_RIQQvaAw2wtjIA0LiIW2-4zxC1zI2bSpiqHuzbMcR7dq0alaJ_vfcOR9bhxASfaga2Urcu3Pud_bdzwDvEXRrHSTC8fLUdUIpGc65LHZ8csdRLqRyqVD49Htyec1OBkSTEzW1MCZpX8lJt5jNu8Xkp8mtXM5Vr8kT640u-hiVJHEc9TrQQWzYhOhNXgczUZZZWAk9ltZ7k27AeuW0q-dyMe1SIgi6ZmIMTQK8FxUz3XNLj0nCvx6Sa26Bzz9zKO9jW-OchrvwvEaV9qdq9C_gkS724El1zuRmD572m2PdXsLVGXoyYhOYIMB0TOEIgk6bCoALPbPN8BCQ39hEKl7g_J_ZiGttpVea9ijEyi43hcAXjbKXiLwpKft28wp-DAdX_VOnPlrBUTGGWI7nCzeSIowwlkaAoTEOTIWWGXn70MsjT-aKkJQWMtZZhpeZQvDieVkas5ypYB92ikWhX4Od5j55Oe2KMA_zhFaSfKEChSJWEqVuwcdGsnxZMWhws_MdMF5OuVEIrxViwQcj-rajWN1Q5lkS8fHlFz4efWPDc--ajy3Yr3TT9mzvcNjoitezseReGhEPf4hjede2othpb0QUerEuuY_2EjMW_L0Hvhoj_LgWHFSav_s3tQ1ZkGzZRNuBKLy3W9CyDZV3bckW-MZ6_ikgPrj4fFb_fvPfjzuEZ9USNeUgvYWd29VaH0GnzNbH0AmCEX6ffD0_NvPqN8B4JQs
link.rule.ids	230,315,729,782,786,887,1408,27933,27934,46064,46488,53800,53802
linkProvider	National Library of Medicine
linkToHtml	http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1fb9MwED-xTWi8bDAYCwOWB4TEQ0b-OInzCKWl7E81xKB7s2zHEeu2dGpWib7xEfYZ-STcOWlGhxASIk-N4rjx-c73u_PdGeAFgm5jolR6QZH5HlOKo8zliReSOo4LqbRPicL9T-nghL_rUpmczjwXpq4P0TrcSDLsek0CTg7pJk-cIter0a65UOPRLoV1oKJdghWWID9SHkd0dBPnwa3VZR0tLOBZs1eJfby-3cOCblohMn-7XWFzAYH-Hkj5K8C1Gqq3_l_Gdh_WGoDqvqk56gHcMeUG3K2PrJxtwGpnfkLcQ_iyh0qRChOc4j_--H5ts1AQwbqUTYyf4NphIro_c6lCeYmLybmLINnVZmJow0NO3GpWSly1tHuJMJ4ivK9mj-Bzr3vc6XvNOQ2eTtBe84JQ-rGSLEbDHNGKQaMyk0blBB1YUMSBKjTBMiNVYvIcb3ONSCgI8izhBdfRJiyX49JsgZsVIalM40tWsCIlt1QodaSRClohaRx4NZ8hcVmX4xB2Gz3iohoJSzPR0MyBl3YK24ZyckZhbGkshoP3Ynj0kff2gxMxdGCznuO2ZdvD9nzORSPalQiymIr6M_yWnfYpEp42WmRpxtNKhMhsCefRn1vgOhvj5TvwuOagm9GkEUsTFjuQLvBW24DqgS8-KU-_2rrgaKynSYJvhpa3_kog0T18u9f8fvIvL-3Aav_48EAcfBjsb8O92u1NcU1PYflqMjXPYKnKp8-tPP4E43s7kA
linkToPdf	http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwEB7RVjwuPAqFUKA5ICQOKXk4iXOEdpfSwmoRj-3Nsh1bdAvZ1aYrsTd-Ar-RX8KMk03ZIoSEyGmjON54Hp5v7JkxwGME3cYkuQwiW4QBU4qjzpVZEJM5Tq1UOqRE4YN3-eCY7_eoTE6XC9PUh-gW3Egz3HxNCj4tbZsmToHr9XjXfFGT8S5FdaCdXYMNhmic6ucnyfA8zIM7p8uts7CIF-1WJfbx7GIPK6Zpg6j89WKBzRUA-nsc5a_41hmo_o3_MbSbcL2Fp_7zRp5uwSVTbcLl5sDKxSZc3VueD3cbPh6iSaSyBCf4hz--fXc5KIhffcolxi_w3SgR25_6VJ-8wqnks48Q2ddmZmi7Q878elFJnLO0P0UQT_HdZ4s78KHfe793ELSnNAQ6Q28tiGIZpkqyFN1yxCoGXcpCGlUScGCRTSNlNYEyI1VmyhJvS41siqKyyLjlOtmC9WpSmXvgFzYmg2lCySyzOS1KxVInGqmgFZLGg6dLBolpU4xDuE30hIt6LBzNREszD544DnYN5eyUgtjyVIwGL8Vo-Jb3j6JjMfJgq2Fx17LrYXvJctEqdi2iIqWS_gy_Zad7ioSnbRZZmcm8FjHKWsZ58ucWOMumeIUe3G0E6Hw0ecLyjKUe5Cui1TWgauCrT6qTT64qOLrqeZbhm7ETrb8SSPTevDhsf9__l5d24Mpwvy9evxocbcO1Zs2bgpoewPrZbG4ewlpdzh85bfwJ6Xs6Ng
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Junctophilin%E2%80%90mediated+channel+crosstalk+essential+for+cerebellar+synaptic+plasticity&rft.jtitle=The+EMBO+journal&rft.au=Kakizawa%2C+Sho&rft.au=Kishimoto%2C+Yasushi&rft.au=Hashimoto%2C+Kouichi&rft.au=Miyazaki%2C+Taisuke&rft.date=2007-04-04&rft.pub=John+Wiley+%26+Sons%2C+Ltd&rft.issn=0261-4189&rft.eissn=1460-2075&rft.volume=26&rft.issue=7&rft.spage=1924&rft.epage=1933&rft_id=info:doi/10.1038%2Fsj.emboj.7601639&rft.externalDBID=10.1038%252Fsj.emboj.7601639&rft.externalDocID=EMBJ7601639
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0261-4189&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0261-4189&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0261-4189&client=summon