Myocyte Death, Growth, and Regeneration in Cardiac Hypertrophy and Failure

ABSTRACT—The accepted paradigm considers the adult mammalian heart as a postmitotic organ, which possesses a relatively constant number of myocytes from shortly after birth to adulthood and senescence. This notion is questioned by the demonstration that although most adult myocytes are terminally di...

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Bibliographic Details
Published in:	Circulation research Vol. 92; no. 2; pp. 139 - 150
Main Authors:	Nadal-Ginard, Bernardo, Kajstura, Jan, Leri, Annarosa, Anversa, Piero
Format:	Journal Article
Language:	English
Published:	Hagerstown, MD American Heart Association, Inc 07-02-2003 Lippincott Lippincott Williams & Wilkins Ovid Technologies
Subjects:	Animals Biological and medical sciences Bone Marrow Transplantation Cardiology. Vascular system Cardiomegaly - pathology Cardiomegaly - therapy Cell Death Cell Division Cellular Senescence Heart Heart Failure - pathology Heart Failure - therapy Heart failure, cardiogenic pulmonary edema, cardiac enlargement Humans Medical sciences Myocardium - pathology Myocytes, Cardiac - pathology Regeneration - physiology Stem Cells Heart Human Heart failure Cell proliferation stem cells Pathophysiology Stem cell Cardiovascular disease Review Myocyte Necrosis Regeneration myocyte regeneration Heart disease Animal Circulatory system myocyte apoptosis and necrosis Apoptosis Hypertrophy
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