Variation in tau isoform expression in different brain regions and disease states

Abstract Progressive supranuclear palsy (PSP) is the most common atypical parkinsonian disorder. Abnormal tau inclusions, in selected regions of the brain, are a hallmark of the disease and the H1 haplotype of MAPT , the gene encoding tau, is the major risk factor in PSP. A 3-repeat and 4-repeat (4R...

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Bibliographic Details
Published in:	Neurobiology of aging Vol. 34; no. 7; pp. 1922.e7 - 1922.e12
Main Authors:	Majounie, Elisa, Cross, William, Newsway, Victoria, Dillman, Allissa, Vandrovcova, Jana, Morris, Christopher M, Nalls, Michael A, Ferrucci, Luigi, Owen, Michael J, O'Donovan, Michael C, Cookson, Mark R, Singleton, Andrew B, de Silva, Rohan, Morris, Huw R
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-07-2013
Subjects:	Adolescent Adult Aged Aged, 80 and over Aging Brain Chemistry - genetics Case-Control Studies Female Gene Expression Regulation Globus Pallidus - metabolism Globus Pallidus - pathology Humans Internal Medicine Male MAPT Middle Aged Neurology Progressive supranuclear palsy Protein Isoforms - biosynthesis Protein Isoforms - genetics Supranuclear Palsy, Progressive - diagnosis Supranuclear Palsy, Progressive - genetics Supranuclear Palsy, Progressive - metabolism tau Proteins - biosynthesis tau Proteins - genetics Tauopathies Young Adult Tauopathies Progressive supranuclear palsy MAPT
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