Bone sialoprotein-coated femoral implants are osteoinductive but mechanically compromised
Aseptic loosening of femoral implants in total hip replacement remains an unsolved orthopaedic problem. This paper investigates the potential role of bone sialoprotein (BSP) in enhancing bone-implant adherence. As BSP is osteoinductive in rat calvarial models, we investigated whether BSP is similarl...
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| Published in: | Journal of orthopaedic research Vol. 22; no. 3; pp. 641 - 646 |
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| Format: | Journal Article |
| Language: | English |
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| Abstract | Aseptic loosening of femoral implants in total hip replacement remains an unsolved orthopaedic problem. This paper investigates the potential role of bone sialoprotein (BSP) in enhancing bone-implant adherence. As BSP is osteoinductive in rat calvarial models, we investigated whether BSP is similarly osteoinductive when coated onto intramedullary femoral implants.
BSP-coated titanium implants were implanted into the femur of female `Wistar' rats (average weight 215 g) that were sacrificed at days 10, 20 and 30. Harvested femoral implants were subjected to pullout testing and then examined histologically.
BSP-coated implants demonstrate osteoinduction when examined histologically. Plugging the femoral canal with BSP prior to inserting the implant neither increased implant pullout strengths nor further increased osteoblastic activity.
This study has demonstrated for the first time that BSP is osteoinductive when coated onto femoral implants and inserted into bones subjected to mechanical loading. However, we found that pullout strengths are a function of implant surface topographical characteristics and are not affected by BSP coating or histological osteoinduction. |
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| AbstractList | Aseptic loosening of femoral implants in total hip replacement remains an unsolved orthopaedic problem. This paper investigates the potential role of bone sialoprotein (BSP) in enhancing bone‐implant adherence. As BSP is osteoinductive in rat calvarial models, we investigated whether BSP is similarly osteoinductive when coated onto intramedullary femoral implants.
BSP‐coated titanium implants were implanted into the femur of female “Wistar” rats (average weight 215 g) that were sacrificed at days 10, 20 and 30. Harvested femoral implants were subjected to pullout testing and then examined histologically.
BSP‐coated implants demonstrate osteoinduction when examined histologically. Plugging the femoral canal with BSP prior to inserting the implant neither increased implant pullout strengths nor further increased osteoblastic activity.
This study has demonstrated for the first time that BSP is osteoinductive when coated onto femoral implants and inserted into bones subjected to mechanical loading. However, we found that pullout strengths are a function of implant surface topographical characteristics and are not affected by BSP coating or histological osteoinduction. © 2003 Orthopaedic Research Society. Published by Elsevier Ltd. All rights reserved. Aseptic loosening of femoral implants in total hip replacement remains an unsolved orthopaedic problem. This paper investigates the potential role of bone sialoprotein (BSP) in enhancing bone-implant adherence. As BSP is osteoinductive in rat calvarial models, we investigated whether BSP is similarly osteoinductive when coated onto intramedullary femoral implants. BSP-coated titanium implants were implanted into the femur of female 'Wistar' rats (average weight 215 g) that were sacrificed at days 10, 20 and 30. Harvested femoral implants were subjected to pullout testing and then examined histologically. BSP-coated implants demonstrate osteoinduction when examined histologically. Plugging the femoral canal with BSP prior to inserting the implant neither increased implant pullout strengths nor further increased osteoblastic activity. This study has demonstrated for the first time that BSP is osteoinductive when coated onto femoral implants and inserted into bones subjected to mechanical loading. However, we found that pullout strengths are a function of implant surface topographical characteristics and are not affected by BSP coating or histological osteoinduction. Aseptic loosening of femoral implants in total hip replacement remains an unsolved orthopaedic problem. This paper investigates the potential role of bone sialoprotein (BSP) in enhancing bone-implant adherence. As BSP is osteoinductive in rat calvarial models, we investigated whether BSP is similarly osteoinductive when coated onto intramedullary femoral implants. BSP-coated titanium implants were implanted into the femur of female `Wistar' rats (average weight 215 g) that were sacrificed at days 10, 20 and 30. Harvested femoral implants were subjected to pullout testing and then examined histologically. BSP-coated implants demonstrate osteoinduction when examined histologically. Plugging the femoral canal with BSP prior to inserting the implant neither increased implant pullout strengths nor further increased osteoblastic activity. This study has demonstrated for the first time that BSP is osteoinductive when coated onto femoral implants and inserted into bones subjected to mechanical loading. However, we found that pullout strengths are a function of implant surface topographical characteristics and are not affected by BSP coating or histological osteoinduction. |
| Author | O'Toole, Gary C. Gallagher, C. O'Rourke, S. K. O'Higgins, N. Salih, E. FitzPatrick, D. |
| Author_xml | – sequence: 1 givenname: Gary C surname: O'Toole fullname: O'Toole, Gary C email: garyotoole@ireland.com organization: Department of Surgery, St. Vincent's University Hospital, Dublin 4, Ireland – sequence: 2 givenname: E surname: Salih fullname: Salih, E organization: Laboratory for the Study of Skeletal Disorders, Harvard University & The Children's Hospital, Boston, MA 02115, USA – sequence: 3 givenname: C surname: Gallagher fullname: Gallagher, C organization: Department of Surgery, St. Vincent's University Hospital, Dublin 4, Ireland – sequence: 4 givenname: D surname: FitzPatrick fullname: FitzPatrick, D organization: Department of Engineering, University College Dublin, Dublin 4, Ireland – sequence: 5 givenname: N surname: O'Higgins fullname: O'Higgins, N organization: Department of Surgery, St. Vincent's University Hospital, Dublin 4, Ireland – sequence: 6 givenname: S.K surname: O'Rourke fullname: O'Rourke, S.K organization: Department of Surgery, St. Vincent's University Hospital, Dublin 4, Ireland |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/15099646$$D View this record in MEDLINE/PubMed |
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| Copyright | 2003 Orthopaedic Research Society Copyright © 2003 Orthopaedic Research Society Copyright Journal of Bone and Joint Surgery, Inc. May 2004 |
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| References_xml | – volume: 258 start-page: 12723 year: 1983 end-page: 12727 ident: BIB8 article-title: Matrix sialoprotein of developing bone publication-title: J. Biol. Chem. contributor: fullname: Termine – volume: 11 start-page: 391 year: 1998 end-page: 401 ident: BIB4 article-title: Mechanisms of endosseous integration publication-title: Int. J. Prosthodont. contributor: fullname: Davies – start-page: 99 year: 1990 end-page: 125 ident: BIB6 article-title: Reactions of tissue to calcium phosphate ceramics publication-title: Osseo-integrated implants: implants in oral and ENT surgery contributor: fullname: Donath – start-page: 31 year: 1999 end-page: 41 ident: BIB9 article-title: Particulate debris and osteolysis publication-title: Revision total knee arthroplasty contributor: fullname: Harowitz – volume: 23 start-page: 1007 year: 1998 end-page: 1008 ident: BIB20 article-title: Novel bioactive property of purified native bone sialoprotein in bone repair of calvarial defect publication-title: Trans. Orthop. Res. Soc. contributor: fullname: Salih – volume: 22 start-page: 621 year: 1998 end-page: 628 ident: BIB19 article-title: Expression of bone microsomal casein kinase II, bone sialoprotein and osteopontin during the repair of calvarial defects publication-title: Bone contributor: fullname: Salih – volume: 69 start-page: 1 year: 1998 end-page: 4 ident: BIB1 article-title: Fluid pressure may cause periprosthetic osteolysis publication-title: Acta Orthop. Scan. contributor: fullname: van der Vis – volume: 265 start-page: 2347 year: 1990 end-page: 2351 ident: BIB7 article-title: Matrix sialoprotein of developing bone publication-title: J. Biol. Chem. contributor: fullname: Young – volume: 75-A start-page: 802 year: 1993 end-page: 813 ident: BIB11 article-title: Studies of the mechanism by which the mechanical failure of polymethylmethacrylate leads to bone resorption publication-title: J. Bone Joint Surg. contributor: fullname: Burnstein – volume: 29 start-page: 127 year: 1995 end-page: 131 ident: BIB2 article-title: Isolation of predominantly submicron-sized UHMWPE wear particles from periprosthetic tissues publication-title: J. Biomed. Mater. Res. contributor: fullname: Amstutz – volume: 74-A start-page: 995 year: 1992 end-page: 1008 ident: BIB3 article-title: Early clinical experience with hydroxyapatite-coated femoral implants publication-title: J. Bone Joint Surg. contributor: fullname: Amnlet – volume: 162 start-page: 272 year: 1982 end-page: 275 ident: BIB16 article-title: A bovine low molecular weight bone morphogenetic protein fraction publication-title: Clin. Orthop. Rel. Res. contributor: fullname: Urist – volume: 19 start-page: 875 year: 1985 end-page: 901 ident: BIB15 publication-title: J. Biomed Mat. Res. contributor: fullname: Cook – volume: 31 start-page: 91 year: 1996 end-page: 96 ident: BIB10 article-title: Pharmacologic inhibition of particulate-induced bone resorption publication-title: J. Biomed. Mater. Res. contributor: fullname: Purdon – volume: 50 start-page: 1392 year: 1971 end-page: 1406 ident: BIB18 article-title: Bone morphogenetic protein publication-title: J. Dent. Res. contributor: fullname: Strates – volume: 150 start-page: 893 year: 1965 end-page: 900 ident: BIB17 article-title: Bone formation by osteoinduction publication-title: Science contributor: fullname: Urist – volume: 952 start-page: 22 year: 1999 ident: BIB21 article-title: Novel bioactive property of purified native bone sialoprotein in bone repair of calvarial defect publication-title: Orthop. 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| Snippet | Aseptic loosening of femoral implants in total hip replacement remains an unsolved orthopaedic problem. This paper investigates the potential role of bone... |
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| SubjectTerms | Animals Arthroplasty, Replacement, Hip Biomechanical Phenomena Bone sialoprotein Coated Materials, Biocompatible - pharmacology Female Femur - physiology Femur - surgery Integrin-Binding Sialoprotein Osteogenesis - drug effects Osteoinduction Rats Rats, Wistar Sialoglycoproteins - pharmacology |
| Title | Bone sialoprotein-coated femoral implants are osteoinductive but mechanically compromised |
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