The evolving roles of canonical WNT signaling in stem cells and tumorigenesis: implications in targeted cancer therapies
The canonical WNT/β-catenin signaling pathway governs a myriad of biological processes underlying the development and maintenance of adult tissue homeostasis, including regulation of stem cell self-renewal, cell proliferation, differentiation, and apoptosis. WNTs are secreted lipid-modified glycopro...
Saved in:
| Published in: | Laboratory investigation Vol. 96; no. 2; pp. 116 - 136 |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
New York
Elsevier Inc
01-02-2016
Nature Publishing Group US Nature Publishing Group |
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | The canonical WNT/β-catenin signaling pathway governs a myriad of biological processes underlying the development and maintenance of adult tissue homeostasis, including regulation of stem cell self-renewal, cell proliferation, differentiation, and apoptosis. WNTs are secreted lipid-modified glycoproteins that act as short-range ligands to activate receptor-mediated signaling pathways. The hallmark of the canonical pathway is the activation of β-catenin-mediated transcriptional activity. Canonical WNTs control the β-catenin dynamics as the cytoplasmic level of β-catenin is tightly regulated via phosphorylation by the ‘destruction complex', consisting of glycogen synthase kinase 3β (GSK3β), casein kinase 1α (CK1α), the scaffold protein AXIN, and the tumor suppressor adenomatous polyposis coli (APC). Aberrant regulation of this signaling cascade is associated with varieties of human diseases, especially cancers. Over the past decade, significant progress has been made in understanding the mechanisms of canonical WNT signaling. In this review, we focus on the current understanding of WNT signaling at the extracellular, cytoplasmic membrane, and intracellular/nuclear levels, including the emerging knowledge of cross-talk with other pathways. Recent progresses in developing novel WNT pathway-targeted therapies will also be reviewed. Thus, this review is intended to serve as a refresher of the current understanding about the physiologic and pathogenic roles of WNT/β-catenin signaling pathway, and to outline potential therapeutic opportunities by targeting the canonical WNT pathway. |
|---|---|
| AbstractList | The canonical WNT/β-catenin signaling pathway governs a myriad of biological processes underlying the development and maintenance of adult tissue homeostasis, including regulation of stem cell self-renewal, cell proliferation, differentiation, and apoptosis. WNTs are secreted lipid-modified glycoproteins that act as short-range ligands to activate receptor-mediated signaling pathways. The hallmark of the canonical pathway is the activation of β-catenin-mediated transcriptional activity. Canonical WNTs control the β-catenin dynamics as the cytoplasmic level of β-catenin is tightly regulated via phosphorylation by the 'destruction complex', consisting of glycogen synthase kinase 3β (GSK3β), casein kinase 1α (CK1α), the scaffold protein AXIN, and the tumor suppressor adenomatous polyposis coli (APC). Aberrant regulation of this signaling cascade is associated with varieties of human diseases, especially cancers. Over the past decade, significant progress has been made in understanding the mechanisms of canonical WNT signaling. In this review, we focus on the current understanding of WNT signaling at the extracellular, cytoplasmic membrane, and intracellular/nuclear levels, including the emerging knowledge of cross-talk with other pathways. Recent progresses in developing novel WNT pathway-targeted therapies will also be reviewed. Thus, this review is intended to serve as a refresher of the current understanding about the physiologic and pathogenic roles of WNT/β-catenin signaling pathway, and to outline potential therapeutic opportunities by targeting the canonical WNT pathway. The canonical WNT/ beta -catenin signaling pathway governs a myriad of biological processes underlying the development and maintenance of adult tissue homeostasis, including regulation of stem cell self-renewal, cell proliferation, differentiation, and apoptosis. WNTs are secreted lipid-modified glycoproteins that act as short-range ligands to activate receptor-mediated signaling pathways. The hallmark of the canonical pathway is the activation of beta -catenin-mediated transcriptional activity. Canonical WNTs control the beta -catenin dynamics as the cytoplasmic level of beta -catenin is tightly regulated via phosphorylation by the 'destruction complex', consisting of glycogen synthase kinase 3 beta (GSK3 beta ), casein kinase 1 alpha (CK1 alpha ), the scaffold protein AXIN, and the tumor suppressor adenomatous polyposis coli (APC). Aberrant regulation of this signaling cascade is associated with varieties of human diseases, especially cancers. Over the past decade, significant progress has been made in understanding the mechanisms of canonical WNT signaling. In this review, we focus on the current understanding of WNT signaling at the extracellular, cytoplasmic membrane, and intracellular/nuclear levels, including the emerging knowledge of cross-talk with other pathways. Recent progresses in developing novel WNT pathway-targeted therapies will also be reviewed. Thus, this review is intended to serve as a refresher of the current understanding about the physiologic and pathogenic roles of WNT/ beta -catenin signaling pathway, and to outline potential therapeutic opportunities by targeting the canonical WNT pathway. The canonical WNT/β-catenin signaling pathway governs a myriad of biological processes underlying development and maintenance of adult tissue homeostasis, including regulation of stem cell self-renewal, cell proliferation, differentiation, and apoptosis. WNTs are secreted lipid-modified glycoproteins that act as short-range ligands to activate receptor-mediated signaling pathways. The hallmark of the canonical pathway is the activation of β-catenin mediated transcriptional activity. Canonical WNTs control the β-catenin dynamics as the cytoplasmic level of β-catenin is tightly regulated via phosphorylation by the ‘destruction complex’, consisting of glycogen synthase kinase 3β (GSK3β), casein kinase 1α (CK1α), the scaffold protein AXIN, and the tumor suppressor adenomatous polyposis coli (APC). Aberrant regulation of this signaling cascade is associated with varieties of human diseases, especially cancers. Over the past decade, significant progress has been made in understanding the mechanisms of canonical WNT signaling. In this review, we focus on the current understanding of WNT signaling at the extracellular, cytoplasmic membrane, and intracellular/nuclear levels, including the emerging knowledge of crosstalk with other pathways. Recent progresses in developing novel WNT pathway-targeted therapies will also be reviewed. Thus, this review is intended to serve as a refresher of the current understanding about the physiologic and pathogenic roles of WNT/β-catenin signaling pathway, and to outline potential therapeutic opportunities by targeting the canonical WNT pathway. The canonical WNT/ β -catenin signaling pathway governs a myriad of biological processes underlying the development and maintenance of adult tissue homeostasis, including regulation of stem cell self-renewal, cell proliferation, differentiation, and apoptosis. WNTs are secreted lipid-modified glycoproteins that act as short-range ligands to activate receptor-mediated signaling pathways. The hallmark of the canonical pathway is the activation of β -catenin-mediated transcriptional activity. Canonical WNTs control the β -catenin dynamics as the cytoplasmic level of β -catenin is tightly regulated via phosphorylation by the ‘destruction complex’, consisting of glycogen synthase kinase 3 β (GSK3 β ), casein kinase 1α (CK1α), the scaffold protein AXIN, and the tumor suppressor adenomatous polyposis coli (APC). Aberrant regulation of this signaling cascade is associated with varieties of human diseases, especially cancers. Over the past decade, significant progress has been made in understanding the mechanisms of canonical WNT signaling. In this review, we focus on the current understanding of WNT signaling at the extracellular, cytoplasmic membrane, and intracellular/nuclear levels, including the emerging knowledge of cross-talk with other pathways. Recent progresses in developing novel WNT pathway-targeted therapies will also be reviewed. Thus, this review is intended to serve as a refresher of the current understanding about the physiologic and pathogenic roles of WNT/ β -catenin signaling pathway, and to outline potential therapeutic opportunities by targeting the canonical WNT pathway. |
| Author | Haydon, Rex C Bi, Yang He, Tong-Chuan Zhang, Fugui Yang, Ke Mohammed, Maryam K Wang, Xin Zhang, Hongmei Wang, Zhongliang Luu, Hue H Nan, Guoxin Li, Yasha |
| AuthorAffiliation | 3 Department of Surgery, West China Hospital, Sichuan University, Chengdu, China 2 Molecular Oncology Laboratory, The University of Chicago Medical Center, Chicago, IL 60637, USA 4 Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences, and the Affiliated Hospital of Stomatology of Chongqing Medical University, Chongqing, China 1 Stem Cell Biology and Therapy Laboratory, Ministry of Education Key Laboratory of Child Development and Disorders, The Children's Hospital, Chongqing Medical University; Chongqing, China |
| AuthorAffiliation_xml | – name: 2 Molecular Oncology Laboratory, The University of Chicago Medical Center, Chicago, IL 60637, USA – name: 3 Department of Surgery, West China Hospital, Sichuan University, Chengdu, China – name: 4 Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences, and the Affiliated Hospital of Stomatology of Chongqing Medical University, Chongqing, China – name: 1 Stem Cell Biology and Therapy Laboratory, Ministry of Education Key Laboratory of Child Development and Disorders, The Children's Hospital, Chongqing Medical University; Chongqing, China |
| Author_xml | – sequence: 1 givenname: Ke surname: Yang fullname: Yang, Ke organization: Stem Cell Biology and Therapy Laboratory, Ministry of Education Key Laboratory of Child Development and Disorders, The Children's Hospital, Chongqing Medical University, Chongqing, China – sequence: 2 givenname: Xin surname: Wang fullname: Wang, Xin organization: Molecular Oncology Laboratory, The University of Chicago Medical Center, Chicago, IL, USA – sequence: 3 givenname: Hongmei surname: Zhang fullname: Zhang, Hongmei organization: Molecular Oncology Laboratory, The University of Chicago Medical Center, Chicago, IL, USA – sequence: 4 givenname: Zhongliang surname: Wang fullname: Wang, Zhongliang organization: Stem Cell Biology and Therapy Laboratory, Ministry of Education Key Laboratory of Child Development and Disorders, The Children's Hospital, Chongqing Medical University, Chongqing, China – sequence: 5 givenname: Guoxin surname: Nan fullname: Nan, Guoxin organization: Stem Cell Biology and Therapy Laboratory, Ministry of Education Key Laboratory of Child Development and Disorders, The Children's Hospital, Chongqing Medical University, Chongqing, China – sequence: 6 givenname: Yasha surname: Li fullname: Li, Yasha organization: Stem Cell Biology and Therapy Laboratory, Ministry of Education Key Laboratory of Child Development and Disorders, The Children's Hospital, Chongqing Medical University, Chongqing, China – sequence: 7 givenname: Fugui surname: Zhang fullname: Zhang, Fugui organization: Molecular Oncology Laboratory, The University of Chicago Medical Center, Chicago, IL, USA – sequence: 8 givenname: Maryam K surname: Mohammed fullname: Mohammed, Maryam K organization: Molecular Oncology Laboratory, The University of Chicago Medical Center, Chicago, IL, USA – sequence: 9 givenname: Rex C surname: Haydon fullname: Haydon, Rex C organization: Molecular Oncology Laboratory, The University of Chicago Medical Center, Chicago, IL, USA – sequence: 10 givenname: Hue H surname: Luu fullname: Luu, Hue H organization: Molecular Oncology Laboratory, The University of Chicago Medical Center, Chicago, IL, USA – sequence: 11 givenname: Yang surname: Bi fullname: Bi, Yang email: yangbi1981@cqmu.edu.cn organization: Stem Cell Biology and Therapy Laboratory, Ministry of Education Key Laboratory of Child Development and Disorders, The Children's Hospital, Chongqing Medical University, Chongqing, China – sequence: 12 givenname: Tong-Chuan surname: He fullname: He, Tong-Chuan email: tche@uchicago.edu organization: Stem Cell Biology and Therapy Laboratory, Ministry of Education Key Laboratory of Child Development and Disorders, The Children's Hospital, Chongqing Medical University, Chongqing, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26618721$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kUtv1DAUhS1URKeFP8ACWWLDJoMfiZ0gVAlVvKQKNoNYWh77JuMqsQfbE8G_x2HKqLCoN17c75z7OBfozAcPCD2nZE0Jb1-Peuv8DCmvGaHNmtb1I7SiDScV4USeoRUhjFei5fIcXaR0S0hBRPMEnTMhaCsZXaGfmx1gmMM4Oz_gGEZIOPTY6NLLGT3i7182OLnB63EBnMcpw4QNjGPC2lucD1OIbgAPyaU32E37seiyCz4tdNZxgAx2cTQQcd5B1HsH6Sl63OsxwbO7_xJ9-_B-c_2puvn68fP1u5vKCCZyJangTU-kJY3uRGOJ6FrghhEutO1seaKXndbSUCl53TdW11vT9aIGSXrT80t0dfTdH7YTWAM-Rz2qfXSTjr9U0E79W_Fup4Ywq1pyylpeDF7dGcTw41CurSaXlv21h3BIajlky9uOs4K-_A-9DYdYTlcoKQiTNavrQrEjZWJIKUJ_GoYStQSrTsGqJVhF_4he3F_jJPmbZAH4EUil5AeI93o_ZPv2qIISweyKKhkHJSnrIpisbHAPyX8DIOjMgA |
| CitedBy_id | crossref_primary_10_18632_oncotarget_8834 crossref_primary_10_3390_jcm8101658 crossref_primary_10_1002_stem_2794 crossref_primary_10_1042_BST20220634 crossref_primary_10_1016_j_brainres_2017_02_006 crossref_primary_10_3389_fcell_2022_946706 crossref_primary_10_1016_j_biopha_2023_114822 crossref_primary_10_1016_j_clinre_2023_102086 crossref_primary_10_1016_j_gendis_2021_04_004 crossref_primary_10_1111_cas_13273 crossref_primary_10_3390_cancers14215468 crossref_primary_10_1016_j_gendis_2016_01_002 crossref_primary_10_1016_j_phrs_2016_06_018 crossref_primary_10_3390_cancers13225858 crossref_primary_10_3390_cells10051266 crossref_primary_10_1038_labinvest_2016_140 crossref_primary_10_1016_j_ejcb_2021_151168 crossref_primary_10_3892_ijo_2017_4129 crossref_primary_10_1016_j_lfs_2022_120613 crossref_primary_10_1186_s41983_024_00857_1 crossref_primary_10_18632_oncotarget_23250 crossref_primary_10_1038_s41416_023_02401_z crossref_primary_10_1093_toxsci_kfw094 crossref_primary_10_1016_j_archoralbio_2022_105469 crossref_primary_10_3390_cancers12030555 crossref_primary_10_3390_ijms22094613 crossref_primary_10_1002_mco2_216 crossref_primary_10_18632_oncotarget_15637 crossref_primary_10_1016_j_drup_2018_01_002 crossref_primary_10_18632_oncotarget_13850 crossref_primary_10_1038_s41598_023_35719_y crossref_primary_10_18632_oncotarget_11552 crossref_primary_10_1002_2211_5463_13696 crossref_primary_10_1007_s12022_020_09661_y crossref_primary_10_1021_acssynbio_9b00203 crossref_primary_10_1021_acsami_8b19094 crossref_primary_10_1038_labinvest_2016_110 crossref_primary_10_1152_ajpcell_00453_2021 crossref_primary_10_1186_s13287_019_1358_y crossref_primary_10_1016_j_gendis_2018_04_006 crossref_primary_10_3390_ijms22169033 crossref_primary_10_1007_s00223_016_0231_6 crossref_primary_10_1002_jcb_27593 crossref_primary_10_1007_s00210_024_03037_3 crossref_primary_10_1016_j_jep_2021_114044 crossref_primary_10_1016_j_ymthe_2022_01_019 crossref_primary_10_1021_acsbiomaterials_8b00179 crossref_primary_10_1186_s41232_024_00344_3 crossref_primary_10_3389_fnmol_2022_1017568 crossref_primary_10_3390_cells11010155 crossref_primary_10_3892_ol_2017_7030 crossref_primary_10_1016_j_gendis_2022_12_013 crossref_primary_10_1111_cas_13173 crossref_primary_10_1007_s00277_016_2766_z crossref_primary_10_3390_genes12010101 crossref_primary_10_1038_s41419_021_03739_z crossref_primary_10_1007_s00238_022_01958_x crossref_primary_10_18632_oncotarget_18655 crossref_primary_10_1016_j_gendis_2020_11_015 crossref_primary_10_1016_j_ijbiomac_2023_126311 crossref_primary_10_1021_acs_jafc_3c08473 crossref_primary_10_3389_fcell_2022_752326 crossref_primary_10_18632_oncotarget_25211 crossref_primary_10_1158_0008_5472_CAN_17_3006 crossref_primary_10_1186_s11658_022_00344_6 crossref_primary_10_3892_etm_2019_7180 crossref_primary_10_1016_j_biopha_2021_112376 crossref_primary_10_1016_j_gendis_2019_03_008 crossref_primary_10_3389_fonc_2023_1121787 crossref_primary_10_1088_1748_6041_11_2_025021 crossref_primary_10_1016_j_gendis_2023_01_030 crossref_primary_10_1016_j_trsl_2023_05_007 crossref_primary_10_3390_scipharm90020022 crossref_primary_10_3389_fgene_2023_1120185 crossref_primary_10_1016_j_gendis_2023_04_042 crossref_primary_10_1038_s41598_021_84695_8 crossref_primary_10_1016_j_celrep_2018_12_046 crossref_primary_10_3389_fgene_2022_1035099 crossref_primary_10_1016_j_gene_2018_06_053 crossref_primary_10_1007_s11055_022_01261_z crossref_primary_10_3390_ijms22094645 crossref_primary_10_1155_2016_9392132 crossref_primary_10_1016_j_gendis_2016_09_004 crossref_primary_10_3892_ijo_2018_4572 crossref_primary_10_1016_j_lfs_2020_117925 crossref_primary_10_1002_advs_202307554 crossref_primary_10_1089_scd_2019_0292 crossref_primary_10_1002_mc_22570 crossref_primary_10_1016_j_diff_2022_10_003 crossref_primary_10_1002_jmv_24863 crossref_primary_10_1007_s13577_020_00339_5 crossref_primary_10_1016_j_biopha_2021_112309 crossref_primary_10_1038_s41419_024_06687_6 crossref_primary_10_1038_s41598_017_00409_z crossref_primary_10_2174_1389450124666230719102112 crossref_primary_10_1002_jcb_27580 crossref_primary_10_18632_aging_102583 crossref_primary_10_1186_s12943_016_0541_3 crossref_primary_10_1038_s41388_017_0034_x crossref_primary_10_1007_s10565_022_09772_8 crossref_primary_10_3389_fimmu_2018_00563 crossref_primary_10_1016_j_cellsig_2021_110166 crossref_primary_10_18632_oncotarget_22915 crossref_primary_10_1007_s12032_023_02111_9 crossref_primary_10_1016_j_theriogenology_2020_11_014 crossref_primary_10_1038_s12276_020_0380_6 crossref_primary_10_1016_j_dld_2019_04_012 crossref_primary_10_3390_ijms23084092 crossref_primary_10_3390_ijms21207624 crossref_primary_10_3390_ncrna10010014 crossref_primary_10_1016_j_prp_2023_154566 crossref_primary_10_3390_ijms241814043 crossref_primary_10_4062_biomolther_2020_003 crossref_primary_10_52679_978_81_952885_6_4_9 crossref_primary_10_1038_s41598_019_43820_4 crossref_primary_10_1002_jcp_30561 crossref_primary_10_1080_00016489_2017_1351040 crossref_primary_10_1038_s41417_023_00647_6 crossref_primary_10_1186_s13148_021_01107_4 crossref_primary_10_1038_s41379_018_0070_2 crossref_primary_10_1097_j_pain_0000000000001738 crossref_primary_10_1111_iej_13877 crossref_primary_10_3390_cancers15072086 crossref_primary_10_3390_ijms22136879 crossref_primary_10_1007_s00432_020_03407_3 crossref_primary_10_3389_fimmu_2019_02872 crossref_primary_10_3390_cells8080840 crossref_primary_10_1016_j_tranon_2020_100747 crossref_primary_10_3389_fcell_2021_646032 crossref_primary_10_1016_j_biopha_2021_112187 crossref_primary_10_1016_j_yexcr_2022_113416 crossref_primary_10_1097_MOH_0000000000000336 crossref_primary_10_1002_mco2_401 crossref_primary_10_3389_fcell_2021_614988 crossref_primary_10_1016_j_gendis_2018_05_001 crossref_primary_10_1080_07391102_2020_1835718 crossref_primary_10_1007_s11033_024_09694_0 crossref_primary_10_1158_0008_5472_CAN_18_0316 crossref_primary_10_1002_cam4_1568 crossref_primary_10_1002_cbin_10959 crossref_primary_10_3390_app11146650 crossref_primary_10_14218_JCTH_2021_00065 crossref_primary_10_2174_1871520619666191019114321 crossref_primary_10_3389_fimmu_2018_00745 crossref_primary_10_3390_cancers13235993 crossref_primary_10_7717_peerj_11203 crossref_primary_10_1016_j_phymed_2020_153243 crossref_primary_10_1016_j_ymthe_2018_04_002 crossref_primary_10_1111_cbdd_14113 crossref_primary_10_3390_genes9020109 crossref_primary_10_1016_j_bmc_2018_09_016 crossref_primary_10_1002_ajmg_a_63173 crossref_primary_10_1016_j_yexcr_2017_04_006 crossref_primary_10_12688_f1000research_17801_1 crossref_primary_10_2174_1574892815666200713145931 crossref_primary_10_1016_j_bmcl_2018_11_022 crossref_primary_10_3390_cancers14153743 crossref_primary_10_1634_theoncologist_2019_0830 crossref_primary_10_1002_jhet_4715 crossref_primary_10_1002_pbc_27566 crossref_primary_10_1371_journal_pbio_2002054 crossref_primary_10_3389_fbioe_2023_1189225 |
| Cites_doi | 10.1038/nature01611 10.1038/nature03319 10.1053/j.gastro.2009.06.021 10.1002/path.2727 10.1016/j.tcb.2015.05.002 10.1091/mbc.e08-02-0187 10.1016/j.gastro.2005.06.007 10.1016/S0968-0004(99)01539-X 10.1073/pnas.0404875101 10.1146/annurev.cellbio.20.010403.113126 10.1073/pnas.1120407109 10.1186/1476-4598-8-76 10.1359/JBMR.040816 10.1126/science.1651563 10.1016/S1535-6108(03)00334-9 10.1038/nchembio.453 10.1042/BJ20061476 10.1083/jcb.200704152 10.1152/physrev.00005.2014 10.1172/JCI37175 10.1016/S0092-8674(02)00679-7 10.1074/jbc.M109.060319 10.1038/sj.emboj.7601667 10.1111/febs.12320 10.1111/j.1440-169X.2005.00821.x 10.1016/0092-8674(87)90038-9 10.1016/j.celrep.2015.03.007 10.1016/j.biomaterials.2014.11.007 10.1158/0008-5472.CAN-11-3336 10.1016/0092-8674(82)90409-3 10.1016/S0092-8674(00)80112-9 10.1073/pnas.0900427106 10.1038/sj.onc.1205947 10.1038/nrc2389 10.1016/j.ygyno.2014.04.005 10.1016/j.cell.2015.07.013 10.1016/j.devcel.2009.06.016 10.1016/j.gendis.2015.01.002 10.1038/emboj.2012.126 10.1038/nature10598 10.1074/jbc.M407810200 10.1111/j.1600-0854.2010.01076.x 10.1158/0008-5472.CAN-05-0824 10.1038/nrd4233 10.1126/science.1651562 10.1038/nrc3419 10.1073/pnas.150152697 10.1158/1535-7163.MCT-09-0147 10.1016/S1476-5586(04)80048-4 10.1016/j.ydbio.2012.02.019 10.1016/j.cell.2007.07.019 10.1073/pnas.1118857109 10.1002/dvdy.24149 10.1126/scisignal.2005189 10.1074/jbc.M508324200 10.1016/j.mod.2009.10.005 10.1016/S0959-8049(99)00333-0 10.1016/S0092-8674(02)01015-2 10.1038/cr.2009.43 10.1186/1471-2407-5-53 10.1126/science.1137065 10.1016/j.cell.2013.07.004 10.1038/emboj.2010.200 10.1038/labinvest.3700509 10.1186/1476-4598-10-16 10.1042/BC20060020 10.1074/jbc.M802376200 10.1126/science.284.5415.770 10.1038/ni1164 10.1002/prot.20955 10.1016/j.yexcr.2010.12.015 10.1101/gad.264515.115 10.1006/viro.1993.1245 10.1038/nrc1886 10.1046/j.1523-1747.2001.01315.x 10.1242/dev.126.20.4557 10.1074/jbc.M413274200 10.1002/bies.201100102 10.1038/nature10337 10.1158/0008-5472.CAN-09-1500 10.1038/sj.onc.1204123 10.1016/j.cell.2009.01.031 10.1126/stke.2001.100.pe31 10.1158/1078-0432.CCR-13-3296 10.3816/CCC.2003.n.018 10.1074/jbc.M407050200 10.1038/34848 10.1016/j.cell.2012.11.026 10.1158/0008-5472.CAN-09-0578 10.1111/cas.12471 10.1016/j.devcel.2009.03.010 10.1016/j.cellsig.2012.07.009 10.1016/B978-0-12-386035-4.00002-1 10.1002/dvdy.22541 10.1073/pnas.1106083108 10.1038/nature09727 10.1073/pnas.1208396109 10.1073/pnas.0904894106 10.1124/mol.110.068668 10.1128/MCB.00222-08 10.1038/nature05659 10.1038/nrm3470 10.1038/nrd1580 10.1002/path.1449 10.1242/dev.129.13.3045 10.1038/18884 10.1016/S0092-8674(05)80065-0 10.1128/MCB.22.4.1172-1183.2002 10.18632/oncoscience.172 10.1126/science.8259519 10.1073/pnas.1314239110 10.1182/blood-2010-09-305664 10.1210/en.2007-0869 10.1073/pnas.1311395111 10.1073/pnas.92.6.2268 10.1126/science.275.5307.1787 10.2174/1573406054864098 10.1158/0008-5472.CAN-06-2726 10.1182/blood-2009-05-220988 10.1002/ijc.10719 10.1021/bi201428h 10.1021/bi9009677 10.1089/scd.2013.0580 10.1242/jcs.00623 10.1371/journal.pone.0001155 10.1371/journal.pone.0029290 10.1177/1759720X12466608 10.1126/science.1218370 10.1210/me.2004-0208 10.1016/S0925-4773(98)00004-5 10.1038/nature10107 10.1073/pnas.90.2.740 10.1126/scitranslmed.3003808 10.1242/dev.013540 10.1158/0008-5472.CAN-10-3978 10.1186/1471-2407-9-159 10.1038/367080a0 10.1158/0008-5472.CAN-07-0266 10.1016/j.devcel.2006.06.014 10.1126/science.1248012 10.1083/jcb.152.1.87 10.1074/jbc.M800351200 10.1016/j.mod.2009.04.003 10.1242/dev.01724 10.1016/S0092-8674(00)81333-1 10.1101/cshperspect.a002915 10.1038/onc.2013.169 10.1158/0008-5472.CAN-07-2325 10.1126/science.1199010 10.1038/sj.onc.1204064 10.1038/18899 10.1016/j.devcel.2015.01.031 10.1038/nature11217 10.1073/pnas.261574498 10.1016/j.tcb.2012.04.006 10.1016/S0092-8674(00)81664-5 10.1016/j.molcel.2012.11.022 10.1007/s00018-014-1644-x 10.1038/nature756 10.1126/science.280.5366.1036 10.1016/j.gde.2006.12.007 10.1016/j.cell.2006.02.049 10.4161/cc.5.1.2305 10.1126/science.281.5382.1509 10.1016/j.jmb.2010.07.007 10.1158/1535-7163.MCT-13-0555 10.1038/287795a0 10.4161/cbt.5.9.3151 10.1016/j.stem.2008.06.019 10.1016/j.cell.2012.05.012 10.5966/sctm.2011-0033 10.1073/pnas.0701331104 10.2353/ajpath.2010.090657 10.1038/35077219 10.1016/j.bbrc.2004.12.151 10.2174/1874467211104010014 10.1074/jbc.M701927200 10.1093/carcin/bgu166 10.1083/jcb.200710050 10.1016/j.ejca.2010.02.036 10.1074/jbc.M513378200 10.1016/j.stem.2015.03.008 10.1016/j.devcel.2005.03.016 10.1038/26982 10.1073/pnas.0504600102 10.1074/jbc.M113.542845 10.1074/jbc.M201196200 10.1074/jbc.M800014200 10.1242/jcs.015958 10.1186/bcr1671 10.1158/0008-5472.CAN-12-4562 10.1016/j.ceb.2013.01.004 10.1242/dev.01236 10.1016/j.devcel.2014.11.016 10.1158/1078-0432.CCR-0707-03 10.1007/s00535-007-2087-z 10.1016/j.gendis.2014.09.001 10.1038/382225a0 10.1126/science.271.5257.1826 10.1038/ng1099 10.1128/MCB.26.8.2955-2964.2006 10.1016/j.devcel.2014.03.016 10.1038/onc.2008.293 10.1006/bbrc.1994.2631 10.1016/j.stem.2011.06.011 10.1073/pnas.93.15.7950 10.1038/ncb2903 10.3892/ijo.2010.858 10.1128/MCB.24.8.3404-3414.2004 10.1158/0008-5472.CAN-12-4384 10.1242/jcs.067546 10.1126/science.1350108 10.1002/path.2220 10.1038/emboj.2013.127 10.1089/107632704323061753 10.1128/MCB.22.4.1184-1193.2002 10.1038/26989 10.1016/j.canlet.2009.08.019 10.1002/pros.23015 10.1016/S0002-9440(10)61177-7 10.1242/dev.104976 10.1073/pnas.96.10.5522 10.1073/pnas.0803437105 10.1038/ncb2048 10.1016/j.cell.2009.04.030 10.1016/j.stem.2009.04.015 10.1371/journal.pone.0056644 10.1038/nature10408 10.1038/nrm1622 10.1016/j.semcancer.2014.04.012 10.1126/science.8259518 10.1002/emmm.201100186 10.1038/367076a0 10.1002/hep.21317 10.1038/ng.431 10.1016/j.jhep.2010.06.033 10.1242/dev.02644 10.1016/j.drudis.2010.11.007 10.1126/science.1222879 10.1242/dev.00674 10.1073/pnas.0600065103 10.1073/pnas.0500303102 10.1111/j.1600-0609.2008.01188.x 10.1038/sj.onc.1209859 10.1006/dbio.1999.9586 10.1038/nature11693 10.1038/35035110 10.1371/journal.pone.0004310 10.1053/j.gastro.2009.04.059 10.1038/onc.2010.432 10.1101/gad.10.24.3116 10.1016/j.tig.2015.04.005 10.1038/ng1304 10.1073/pnas.94.13.6770 10.1016/j.humpath.2008.07.022 10.1021/bi0512602 10.1016/S1535-6108(03)00135-1 10.1016/j.cell.2009.03.045 10.1242/dev.095471 10.1038/emboj.2012.146 10.1158/1078-0432.CCR-07-1750 10.1073/pnas.1321764111 10.1038/nature08356 10.1016/j.stem.2007.10.011 10.1074/jbc.C700185200 10.1016/j.gendis.2014.07.005 10.1101/gad.938601 10.1182/blood.V98.7.2091 10.1073/pnas.1121312110 10.1073/pnas.1110431108 10.1038/nm979 10.1111/j.1582-4934.2008.00569.x 10.1126/science.1180794 10.1016/j.devcel.2004.07.019 10.1182/blood-2008-06-163774 10.1002/stem.2083 10.1038/ng.192 10.1073/pnas.1017496108 10.1038/modpathol.2014.114 10.1016/j.molcel.2009.09.034 10.1080/08977190412331279890 10.1016/S0092-8674(01)00336-1 10.2174/156652311795684777 10.1083/jcb.118.3.681 10.1038/nature01593 10.1242/dev.01573 10.1126/science.275.5307.1784 10.1158/1078-0432.CCR-09-0336 10.1038/nchembio.137 10.1038/35001602 10.1016/j.ccr.2007.11.003 10.1158/1535-7163.MCT-13-0625 10.1038/nature11308 10.1038/modpathol.2009.45 10.1016/j.cell.2014.06.013 10.1016/j.canlet.2007.12.030 10.1101/gad.1249504 10.1002/ijc.28341 10.1126/science.1090922 10.1002/stem.1599 10.1038/382638a0 10.1016/j.bmcl.2009.07.070 10.1371/journal.pone.0075010 10.1002/hep.22856 10.1038/ncomms3610 10.1074/jbc.M504308200 10.2174/1568009615666150629132157 10.1016/j.cellsig.2014.01.021 10.1038/nature11019 10.1101/cshperspect.a008029 10.1016/S0304-3835(03)00013-2 10.1016/j.devcel.2006.10.003 10.1128/MCB.25.4.1475-1488.2005 10.1155/2014/162024 10.1038/nrm3758 10.1371/journal.pone.0115835 10.1038/bcj.2011.41 10.1242/dev.102376 10.1046/j.1365-2559.2000.00847.x 10.1038/73448 10.1074/jbc.M109.009647 10.1186/gb-2012-13-3-242 10.1016/j.cellsig.2014.02.018 10.1074/jbc.M305472200 10.1016/j.gendis.2014.12.002 10.1016/j.ccr.2011.08.016 10.1101/cshperspect.a007971 10.1016/j.stem.2008.08.017 10.1038/307131a0 10.1158/1535-7163.MCT-14-1038 |
| ContentType | Journal Article |
| Copyright | 2016 United States & Canadian Academy of Pathology United States & Canadian Academy of Pathology 2016 Copyright Nature Publishing Group Feb 2016 |
| Copyright_xml | – notice: 2016 United States & Canadian Academy of Pathology – notice: United States & Canadian Academy of Pathology 2016 – notice: Copyright Nature Publishing Group Feb 2016 |
| DBID | 6I. AAFTH CGR CUY CVF ECM EIF NPM AAYXX CITATION 3V. 7QL 7QP 7QR 7T5 7T7 7TK 7TM 7U9 7X7 7XB 88E 8AO 8C1 8FD 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI C1K CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. LK8 M0S M1P M7N M7P P64 PQEST PQQKQ PQUKI PRINS 7QO 5PM |
| DOI | 10.1038/labinvest.2015.144 |
| DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef ProQuest Central (Corporate) Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Immunology Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) Neurosciences Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts ProQuest Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database (Proquest) Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central ProQuest Central Essentials Biological Science Collection ProQuest Central ProQuest Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection (Proquest) (PQ_SDU_P3) ProQuest Health & Medical Complete (Alumni) ProQuest Biological Science Collection Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Biotechnology and BioEngineering Abstracts ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China Biotechnology Research Abstracts PubMed Central (Full Participant titles) |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef ProQuest Central Student Technology Research Database ProQuest Central Essentials Nucleic Acids Abstracts ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest Central Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Collection AIDS and Cancer Research Abstracts Chemoreception Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) ProQuest Medical Library (Alumni) ProQuest Public Health Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition Immunology Abstracts Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest Central (Alumni) Biotechnology Research Abstracts |
| DatabaseTitleList | MEDLINE Engineering Research Database ProQuest Central Student |
| Database_xml | – sequence: 1 dbid: ECM name: MEDLINE url: https://search.ebscohost.com/login.aspx?direct=true&db=cmedm&site=ehost-live sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1530-0307 |
| EndPage | 136 |
| ExternalDocumentID | 3933851991 10_1038_labinvest_2015_144 26618721 S0023683722023017 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NCI NIH HHS grantid: R01 CA106569 – fundername: NIAMS NIH HHS grantid: AR054381 – fundername: NCCIH NIH HHS grantid: AT004418 – fundername: NIAMS NIH HHS grantid: K08 AR050142 – fundername: NIAMS NIH HHS grantid: K08 AR054381 – fundername: NIAMS NIH HHS grantid: AR50142 – fundername: NCATS NIH HHS grantid: UL1 TR000430 – fundername: NCCIH NIH HHS grantid: P01 AT004418 |
| GroupedDBID | --- -Q- -~X .55 .GJ 0R~ 1KJ 29L 2WC 36B 39C 3V. 4.4 53G 5GY 5RE 6I. 70F 7X7 88E 8AO 8C1 8FI 8FJ 8R4 8R5 8WZ A6W AADWK AAFTH AANZL AAWBL AAXUO AAYFA AAYJO AAZLF ABAWZ ABCQX ABGIJ ABJNI ABLJU ABUWG ACBMV ACBRV ACBYP ACGFO ACGFS ACIGE ACIWK ACKTT ACPRK ACRQY ACTTH ACVWB ACZOJ ADBBV ADHDB ADMDM ADQMX ADYYL AEDAW AEFTE AEJRE AENEX AEXYK AFFNX AFKRA AFOSN AFRAH AFSHS AGAYW AGEZK AGGBP AGHAI AHMBA AHPSJ AHSBF AILAN AJDOV AJRNO ALFFA ALMA_UNASSIGNED_HOLDINGS AMRAJ AMRJV AMYLF ASPBG AVWKF AXYYD AZFZN BAWUL BBNVY BENPR BHPHI BKKNO BPHCQ BVXVI CAG CCPQU COF CS3 DIK DNIVK DU5 E3Z EBLON EBS EE. EIOEI EJD EMB F5P FDB FDQFY FEDTE FERAY FIZPM FSGXE FYUFA GX1 HCIFZ HMCUK HVGLF HZ~ IH2 IWAJR JSO JZLTJ KQ8 M1P M7P MVM NAO NQJWS NYICJ O9- OK1 P2P P6G PQQKQ PROAC PSQYO Q2X RNS RNT RNTTT ROL S10 SNX SNYQT SOHCF SRMVM SV3 SWTZT TAOOD TBHMF TDRGL TR2 TSG TWZ UKHRP X7M Y6R YFH YKV YOC YQI YQT ZA5 ZGI ZXP 0SF AALRI ADVLN AFJKZ AITUG AKRWK ALIPV CGR CUY CVF ECM EIF NPM AAYXX CITATION 7QL 7QP 7QR 7T5 7T7 7TK 7TM 7U9 7XB 8FD 8FE 8FH 8FK AZQEC C1K DWQXO FR3 GNUQQ H94 K9. LK8 M7N P64 PQEST PQUKI PRINS 7QO 5PM |
| ID | FETCH-LOGICAL-c626t-71635f07d05a965d0698e3c2036ad9dddd6f79aa7c17734f5da4bc9f64e70fcf3 |
| ISSN | 0023-6837 |
| IngestDate | Tue Sep 17 21:10:21 EDT 2024 Fri Oct 25 05:48:50 EDT 2024 Thu Oct 10 22:17:25 EDT 2024 Thu Sep 26 16:59:55 EDT 2024 Wed Oct 16 00:40:54 EDT 2024 Fri Oct 11 20:48:12 EDT 2024 Fri Feb 23 02:39:28 EST 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Language | English |
| License | This article is made available under the Elsevier license. Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c626t-71635f07d05a965d0698e3c2036ad9dddd6f79aa7c17734f5da4bc9f64e70fcf3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://pubmed.ncbi.nlm.nih.gov/PMC4731283 |
| PMID | 26618721 |
| PQID | 1760274244 |
| PQPubID | 25033 |
| PageCount | 21 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_4731283 proquest_miscellaneous_1872838932 proquest_journals_1760274244 crossref_primary_10_1038_labinvest_2015_144 pubmed_primary_26618721 springer_journals_10_1038_labinvest_2015_144 elsevier_sciencedirect_doi_10_1038_labinvest_2015_144 |
| PublicationCentury | 2000 |
| PublicationDate | 2016-02-01 |
| PublicationDateYYYYMMDD | 2016-02-01 |
| PublicationDate_xml | – month: 02 year: 2016 text: 2016-02-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | New York |
| PublicationPlace_xml | – name: New York – name: United States |
| PublicationSubtitle | Advancing the understanding of human and experimental disease |
| PublicationTitle | Laboratory investigation |
| PublicationTitleAbbrev | Lab Invest |
| PublicationTitleAlternate | Lab Invest |
| PublicationYear | 2016 |
| Publisher | Elsevier Inc Nature Publishing Group US Nature Publishing Group |
| Publisher_xml | – name: Elsevier Inc – name: Nature Publishing Group US – name: Nature Publishing Group |
| References | Wang, Green, Wang (bib124) 2014; 1 Letamendia, Labbe, Attisano (bib133) 2001; 83-A Suppl 1 Chiou, Wang, Huang (bib257) 2014; 35 Rastegar, Shenaq, Huang (bib195) 2010; 2 Pai, Dunlap, Qing (bib118) 2008; 68 Tang, Liu, Zhao (bib141) 2008; 283 Moreno (bib159) 2010; 176 Satoh, Daigo, Furukawa (bib244) 2000; 24 Teo, Ma, Nguyen (bib65) 2005; 102 Dumont, Arteaga (bib122) 2003; 3 Li, Zhang, Kang (bib95) 2005; 280 Wolf, Rodova, Miska (bib67) 2002; 277 Verkaar, Zaman (bib275) 2011; 16 Mikami, You, He (bib283) 2005; 5 Fortini (bib145) 2009; 16 Varelas (bib178) 2014; 141 Liu, Farmer (bib202) 2004; 279 Rijsewijk, Schuermann, Wagenaar (bib4) 1987; 50 Gough (bib24) 2012; 5 Nam, Turcotte, Smith (bib76) 2006; 281 Cathcart, Pulkoski-Gross, Cao (bib264) 2015; 2 Desbois-Mouthon, Cadoret, Blivet-Van Eggelpoel (bib107) 2001; 20 Augustin, Goidts, Bongers (bib253) 2012; 4 Gang, Hsieh, Pham (bib319) 2014; 33 Dihlmann, Siermann, von Knebel Doeberitz (bib323) 2001; 20 de Lau, Barker, Low (bib81) 2011; 476 Kinzler, Vogelstein (bib240) 1998; 280 Wei, Chua, Grepper (bib284) 2009; 8 Kikuchi, Yamamoto, Sato (bib61) 2011; 291 Liu, Pan, Hsieh (bib301) 2013; 110 Willert, Epping, Pollack (bib60) 2002; 2 Tetsu, McCormick (bib55) 1999; 398 Galceran, Sustmann, Hsu (bib148) 2004; 18 van Den Heuvel (bib164) 2001; 2001 Wang, Zhang, Li (bib93) 2008; 283 Semenov, Tamai, He (bib96) 2005; 280 Joesting, Perrin, Elenbaas (bib288) 2005; 65 Haydon, Deyrup, Ishikawa (bib249) 2002; 102 Kandyba, Kobielak (bib235) 2014; 32 van der Flier, van Gijn, Hatzis (bib214) 2009; 136 Schulenburg, Cech, Herbacek (bib274) 2007; 213 Liu, Lou, Armstrong (bib341) 2015; 75 Nguyen, Merrill, Polak (bib231) 2009; 41 Tian, Biehs, Warming (bib208) 2011; 478 Hoffmeyer, Raggioli, Rudloff (bib250) 2012; 336 Zhao, Blum, Chen (bib219) 2007; 12 Day, Guo, Garrett-Beal (bib196) 2005; 8 Wei, Chua, Grepper (bib290) 2011; 10 Koo, Spit, Jordens (bib83) 2012; 488 Varnat, Zacchetti, Ruiz i Altaba (bib171) 2010; 127 Bastide, Darido, Pannequin (bib213) 2007; 178 Cai, Maitra, Anders (bib186) 2015; 29 Gan, Wang, Xi (bib62) 2008; 180 Szeto, Kimelman (bib131) 2004; 131 Mehlen, Puisieux (bib261) 2006; 6 Ayyanan, Civenni, Ciarloni (bib161) 2006; 103 Lluis, Pedone, Pepe (bib193) 2008; 3 Lamouille, Xu, Derynck (bib266) 2014; 15 Zhong, Zylstra-Diegel, Schumacher (bib41) 2012; 109 Roose, Molenaar, Peterson (bib46) 1998; 395 Yang, Xia, Ji (bib105) 2011; 480 Arimura, Matsunaga, Kitamura (bib173) 2009; 137 Funa, Schachter, Lerdrup (bib73) 2015; 16 Luis, Weerkamp, Naber (bib218) 2009; 113 Clements, Lowy, Groden (bib241) 2003; 3 Levy, Wei, Labalette (bib68) 2004; 24 Carmon, Gong, Lin (bib80) 2011; 108 Gurbuxani, Xu, Keerthivasan (bib223) 2005; 102 Lau, Chan, Callow (bib299) 2013; 73 Both, Krijgsman, Bras (bib256) 2014; 9 Finch, He, Kelley (bib85) 1997; 94 Yang, Tang, Kong (bib270) 2015; 33 Molejon, Tellechea, Moutardier (bib273) 2015; 2 Wang, Li, Lee (bib64) 2015; 32 Nguyen, Chiang, Zhang (bib268) 2009; 138 Metcalfe, Mendoza-Topaz, Mieszczanek (bib50) 2010; 123 Logan, Nusse (bib17) 2004; 20 Grossmann, Yeh, Bowman (bib312) 2012; 109 Verras, Sun (bib111) 2005; 19 Polakis (bib245) 2007; 17 Eguchi, Nguyen, Lee (bib314) 2005; 1 Wend, Fang, Zhu (bib318) 2013; 32 Fuchs (bib227) 2007; 445 Yu, Chia, Canning (bib38) 2014; 29 Satyamoorthy, Li, Vaidya (bib110) 2001; 61 Wang, Ye, Deng (bib181) 2014; 1 Duan, Yao, Wu (bib156) 2006; 98 Kansara, Tsang, Kodjabachian (bib252) 2009; 119 Arend, Londono-Joshi, Samant (bib340) 2014; 134 Kramps, Peter, Brunner (bib51) 2002; 109 Clements, Kim, Ong (bib224) 2011; 474 Nishisho, Nakamura, Miyoshi (bib14) 1991; 253 Hsieh, Kodjabachian, Rebbert (bib88) 1999; 398 Zhang, Wang, Deng (bib201) 2015; 39 Thorne, Hanson, Schneider (bib336) 2010; 6 Lepourcelet, Chen, France (bib303) 2004; 5 Siegfried, Wilder, Perrimon (bib8) 1994; 367 Kim, Crooks, Dracheva (bib127) 2002; 62 Xie, Xie (bib247) 2015; 2 Coghlin, Murray (bib262) 2010; 222 Azzolin, Panciera, Soligo (bib185) 2014; 158 Lien, Polak, Lin (bib232) 2014; 16 Huelsken, Vogel, Erdmann (bib230) 2001; 105 Minke, Staib, Puetter (bib305) 2009; 82 Kim, Zhao, Andarmani (bib75) 2006; 5 Wei, Yokota, Semenov (bib79) 2007; 282 Marson, Foreman, Chevalier (bib317) 2008; 3 Lu, Lin, Li (bib335) 2014; 26 Kawano, Kypta (bib86) 2003; 116 Sato, Meijer, Skaltsounis (bib191) 2004; 10 Wei, Chua, Grepper (bib304) 2010; 126 Rasola, Fassetta, De Bacco (bib102) 2007; 26 Batlle, Henderson, Beghtel (bib215) 2002; 111 Hu, Rosenblum (bib136) 2005; 132 Zhang, Wei, Gong (bib74) 2011; 20 Li, Zhang, Polakiewicz (bib120) 2008; 283 Han, Li, Liang (bib139) 2006; 11 Taipaleenmaki, Abdallah, AlDahmash (bib203) 2011; 317 Janda, Waghray, Levin (bib29) 2012; 337 Anastas, Moon (bib26) 2013; 13 Itasaki, Hoppler (bib143) 2010; 239 Mullighan, Zhang, Kasper (bib259) 2011; 471 Chen, Guttridge, You (bib281) 2001; 152 He, Gao, Zhang (bib333) 2011; 79 Gonzalez, Medici (bib267) 2014; 7 Willert, Brown, Danenberg (bib28) 2003; 423 Gehart, Clevers (bib210) 2015; 31 Vermeulen, De Sousa, van der Heijden (bib265) 2010; 12 Hao, Xie, Zhang (bib82) 2012; 485 He, Gao, Luo (bib332) 2011; 38 Yan, Chia, Li (bib209) 2012; 109 Morin, Vogelstein, Kinzler (bib280) 1996; 93 Liu, Lou, Zhu (bib342) 2014; 20 Miller, Rutherford, Johnson (bib71) 2010; 401 Hoppler, Moon (bib128) 1998; 71 Zhu, Zhu, Zhang (bib42) 2012; 365 Ingham, McMahon (bib163) 2001; 15 Heallen, Zhang, Wang (bib184) 2011; 332 Christensen, Schreck, Burrows (bib325) 2003; 63 Pendas-Franco, Aguilera, Pereira (bib327) 2008; 28 Roccaro, Leleu, Sacco (bib331) 2008; 14 Bhowmick, Chytil, Plieth (bib137) 2004; 303 Ramocki, Wilkins, Magness (bib109) 2008; 149 Su, Kinzler, Vogelstein (bib242) 1992; 256 Piccolo, Dupont, Cordenonsi (bib180) 2014; 94 Gregorieff, Pinto, Begthel (bib211) 2005; 129 Stewart, James, McCluggage (bib258) 2015; 28 Fre, Pallavi, Huyghe (bib157) 2009; 106 Kim, Zhang, Rieger-Christ (bib329) 2006; 281 Monga, Mars, Pediaditakis (bib100) 2002; 62 Birdsey, Shah, Dufton (bib112) 2015; 32 Cavallo, Cox, Moline (bib45) 1998; 395 Yao, Ashihara, Strovel (bib310) 2011; 1 Zhang, Chang, Fong (bib194) 2014; 289 Sakai, Tanaka, Endo (bib135) 2005; 47 Huang, Mishina, Liu (bib296) 2009; 461 Singbrant, Karlsson, Ehinger (bib226) 2010; 115 Nostro, Cheng, Keller (bib217) 2008; 2 Previdi, Maroni, Matteucci (bib269) 2010; 46 Takada, Zhu, Bird (bib311) 2012; 4 Franch-Marro, Wendler, Griffith (bib30) 2008; 121 Zhou, An, Haydon (bib324) 2003; 193 Fu, Ivy Yu, Maruyama (bib43) 2011; 240 DeAlmeida, Miao, Ernst (bib289) 2007; 67 Wagner, Zhu, Zhang (bib22) 2011; 4 Miyoshi, Iwao, Nagasawa (bib243) 1998; 58 Bhanot, Brink, Samos (bib11) 1996; 382 Kim, Wagle, Tran (bib78) 2008; 19 Alfaro, Pagni, Vincent (bib205) 2008; 105 Wissmann, Wild, Kaiser (bib251) 2003; 201 Hansen, Moroishi, Guan (bib179) 2015; 25 Sun, Watanabe, Fallahi (bib233) 2014; 111 Nusse, Varmus (bib2) 2012; 31 Hooper, Scott (bib166) 2005; 6 Johnson, Harnish, Nusse (bib97) 2004; 19 Gonsalves, Klein, Carson (bib307) 2011; 108 Itasaki, Jones, Mercurio (bib94) 2003; 130 Peifer, McCrea, Green (bib6) 1992; 118 Korinek, Barker, Morin (bib237) 1997; 275 Chen, Venkatesan, Dehnhardt (bib306) 2009; 19 Voloshanenko, Erdmann, Dubash (bib255) 2013; 4 Kim, Liu, Wang (bib98) 2013; 5 De Boer, Wang, Van Blitterswijk (bib206) 2004; 10 Yu, Ting, Stott (bib248) 2012; 487 Chocarro-Calvo, Garcia-Martinez, Ardila-Gonzalez (bib69) 2013; 49 Labbe, Letamendia, Attisano (bib129) 2000; 97 Lim, Nusse (bib228) 2013; 5 He, Xu, Xu (bib320) 2014; 134 Smith, Hawcroft, Hull (bib322) 2000; 36 Nicolas, Wolfer, Raj (bib154) 2003; 33 Yang, Andl, Grachtchouk (bib168) 2008; 40 Shtutman, Zhurinsky, Simcha (bib56) 1999; 96 Fujii, You, Xu (bib294) 2007; 67 Collu, Brennan (bib160) 2007; 9 Yanai, Nakamura, Akiyoshi (bib176) 2008; 263 Bilic, Huang, Davidson (bib48) 2007; 316 Semenov, Zhang, He (bib92) 2008; 283 Chen, Dodge, Tang (bib297) 2009; 5 Nambotin, Lefrancois, Sainsily (bib291) 2011; 54 Li, Sutter, Parker (bib52) 2007; 26 Lu, Lin, Roberts (bib338) 2011; 6 Shan, Shi, Wang (bib293) 2005; 44 Kahn (bib278) 2014; 13 Merrill (bib190) 2012; 4 Artavanis-Tsakonas, Rand, Lake (bib144) 1999; 284 Ellwanger, Saito, Clement-Lacroix (bib91) 2008; 28 Clevers, Loh, Nusse (bib27) 2014; 346 Banziger, Soldini, Schutt (bib35) 2006; 125 He, Chan, Vogelstein (bib53) 1999; 99 DasGupta, Fuchs (bib229) 1999; 126 Edlund, Lee, Grimsby (bib140) 2005; 25 Sasaki, Hwang, Nguyen (bib66) 2013; 8 Ochiai, Akimoto, Kanai (bib104) 1994; 205 Longato, de la Monte, Kuzushita (bib108) 2009; 49 Kinzler, Nilbert, Su (bib13) 1991; 253 Kinzler, Vogelstein (bib239) 1996; 87 Port, Basler (bib37) 2010; 11 Luther, Wagner, Zhu (bib125) 2011; 11 Noubissi, Goswami, Sanek (bib170) 2009; 69 Reya, Duncan, Ailles (bib221) 2003; 423 Ramos, Camargo (bib182) 2012; 22 Kazanskaya, Glinka, del Barco Barrantes (bib77) 2004; 7 Chen, Wang, Lu (bib337) 2009; 48 Lavergne, Hendaoui, Coulouarn (bib285) 2011; 30 Abu-Remaileh, Gerson, Farago (bib192) 2010; 29 Chen, Zhao, Mundy (bib121) 2004; 22 Apte, Zeng, Muller (bib99) 2006; 44 Loeffler, Kokkaliaris, Schroeder (bib225) 2011; 9 Rosenbluh, Nijhawan, Cox (bib260) 2012; 151 Baryawno, Sveinbjornsson, Eksborg (bib326) 2010; 70 Theil, Aydin, Koch (bib134) 2002; 129 Arce, Pate, Waterman (bib47) 2009; 9 Li, Clevers (bib212) 2010; 327 Londono-Joshi, Arend, Aristizabal (bib343) 2014; 13 Galli, Szabo, Li (bib44) 2014; 243 Noordermeer, Klingensmith, Perrimon (bib5) 1994; 367 Si, Kang, Luu (bib198) 2006; 26 Shackleford, MacArthur, Kwan (bib119) 1993; 90 Niehrs (bib25) 2012; 13 Hanna, Markoulaki, Mitalipova (bib189) 2009; 4 Klaus, Birchmeier (bib19) 2008; 8 Nakopoulou, Gakiopoulou, Keramopoulos (bib101) 2000; 36 Yamamoto, Awada, Hanaki (bib40) 2013; 126 Bisson, Prowse (bib272) 2009; 19 van den Bosch, Blom, van Lent (bib72) 2014; 26 Munoz-Descalzo, de Navascues, Arias (bib151) 2012; 34 Yan, Wiesmann, Rohan (bib57) 2001; 98 Jamieson, Sharma, Henderson (bib277) 2014; 27 Liao, Nan, Yan (bib344) 2015; 15 Su, Vogelstein, Kinzler (bib16) 1993; 262 Estrach, Ambler, Lo Celso (bib162) 2006; 133 Kabiri, Greicius, Madan (bib302) 2014; 141 He, Sparks, Rago (bib54) 1998; 281 Pasca di Magliano, Biankin, Heiser (bib174) 2007; 2 Holland, Klaus, Garratt (bib188) 2013; 25 Trosset, Dalvit, Knapp (bib308) 2006; 64 Clausse, Baines, Moore (bib114) 1993; 194 Hofmann ( Li, Placencio, Iturregui (CR138) 2008; 27 Taipale, Beachy (CR165) 2001; 411 Alfaro, Pagni, Vincent (CR205) 2008; 105 Hayward, Brennan, Sanders (CR152) 2005; 132 Arce, Pate, Waterman (CR47) 2009; 9 Merrill (CR190) 2012; 4 Christensen, Schreck, Burrows (CR325) 2003; 63 Dumont, Arteaga (CR122) 2003; 3 Madan, Virshup (CR279) 2015; 14 Londono-Joshi, Arend, Aristizabal (CR343) 2014; 13 Day, Guo, Garrett-Beal (CR196) 2005; 8 Hansen, Moroishi, Guan (CR179) 2015; 25 Ramocki, Wilkins, Magness (CR109) 2008; 149 van den Brink, Bleuming, Hardwick (CR175) 2004; 36 He, Chan, Vogelstein (CR53) 1999; 99 Varelas (CR178) 2014; 141 Bhanot, Brink, Samos (CR11) 1996; 382 Gough (CR24) 2012; 5 Lee, Lane, Kuo (CR116) 1995; 92 Kim, Crooks, Dracheva (CR127) 2002; 62 Liu, Pan, Hsieh (CR301) 2013; 110 Luo, Kang, Si (CR197) 2004; 279 Kadowaki, Wilder, Klingensmith (CR33) 1996; 10 Theil, Aydin, Koch (CR134) 2002; 129 Apte, Zeng, Muller (CR99) 2006; 44 Yang, Xia, Ji (CR105) 2011; 480 Lavergne, Hendaoui, Coulouarn (CR285) 2011; 30 Hofmann (CR32) 2000; 25 Ladher, Church, Allen (CR87) 2000; 218 Li, Zhang, Kang (CR95) 2005; 280 Anastas, Moon (CR26) 2013; 13 Wehrli, Dougan, Caldwell (CR12) 2000; 407 DasGupta, Fuchs (CR229) 1999; 126 He, You, Uematsu (CR282) 2004; 6 Tian, Han, Yan (CR309) 2012; 51 Siegfried, Wilder, Perrimon (CR8) 1994; 367 Bonifas, Pennypacker, Chuang (CR167) 2001; 116 Yamamoto, Awada, Hanaki (CR40) 2013; 126 Munoz-Descalzo, de Navascues, Arias (CR151) 2012; 34 Satoh, Daigo, Furukawa (CR244) 2000; 24 Takada, Satomi, Kurata (CR34) 2006; 11 Schulenburg, Cech, Herbacek (CR274) 2007; 213 Verras, Sun (CR111) 2005; 19 Klaus, Birchmeier (CR19) 2008; 8 Gonzalez, Medici (CR267) 2014; 7 Li, Zhang, Polakiewicz (CR120) 2008; 283 Nambotin, Lefrancois, Sainsily (CR291) 2011; 54 Moreno (CR159) 2010; 176 Clevers, Loh, Nusse (CR27) 2014; 346 Cavallo, Cox, Moline (CR45) 1998; 395 Collu, Hidalgo-Sastre, Brennan (CR150) 2014; 71 Ellwanger, Saito, Clement-Lacroix (CR91) 2008; 28 Chen, Zhao, Mundy (CR121) 2004; 22 Dong, Feldmann, Huang (CR177) 2007; 130 Hanna, Markoulaki, Mitalipova (CR189) 2009; 4 Nusse, van Ooyen, Cox (CR236) 1984; 307 Satyamoorthy, Li, Vaidya (CR110) 2001; 61 Coghlin, Murray (CR262) 2010; 222 Duncan, Rattis, DiMascio (CR147) 2005; 6 Wei, Chua, Grepper (CR290) 2011; 10 Gonsalves, Klein, Carson (CR307) 2011; 108 Yan, Wiesmann, Rohan (CR57) 2001; 98 Wang, Zhang, Zhang (CR200) 2014; 23 Luis, Weerkamp, Naber (CR218) 2009; 113 Nguyen, Chiang, Zhang (CR268) 2009; 138 Waaler, Machon, Tumova (CR298) 2012; 72 Reya, Clevers (CR18) 2005; 434 Kessler, Hausmann, Basler (CR70) 2009; 126 Kinzler, Nilbert, Su (CR13) 1991; 253 Kinzler, Vogelstein (CR239) 1996; 87 Shackleford, MacArthur, Kwan (CR119) 1993; 90 Nam, Turcotte, Smith (CR76) 2006; 281 De Boer, Wang, Van Blitterswijk (CR206) 2004; 10 Li, Clevers (CR212) 2010; 327 Kansara, Tsang, Kodjabachian (CR252) 2009; 119 Azzolin, Panciera, Soligo (CR185) 2014; 158 Abu-Remaileh, Gerson, Farago (CR192) 2010; 29 Hoppler, Moon (CR128) 1998; 71 Kabiri, Greicius, Madan (CR302) 2014; 141 Kurayoshi, Yamamoto, Izumi (CR31) 2007; 402 Luther, Wagner, Zhu (CR125) 2011; 11 van Den Heuvel (CR164) 2001; 2001 Tumova, Pombinho, Vojtechova (CR346) 2014; 13 Lehtio, Chi, Krauss (CR300) 2013; 280 Roccaro, Leleu, Sacco (CR331) 2008; 14 Polakis (CR276) 2012; 31 Ramos, Camargo (CR182) 2012; 22 Grandy, Shan, Zhang (CR295) 2009; 284 Semenov, Tamai, He (CR96) 2005; 280 Zhang, Morris, Yan (CR246) 2013; 73 Kopan, Ilagan (CR146) 2009; 137 Both, Krijgsman, Bras (CR256) 2014; 9 Funa, Schachter, Lerdrup (CR73) 2015; 16 Koo, Spit, Jordens (CR83) 2012; 488 Galceran, Sustmann, Hsu (CR148) 2004; 18 Gregorieff, Pinto, Begthel (CR211) 2005; 129 Nakamura, Tsuchiya, Watanabe (CR149) 2007; 42 Jaiswal, Marlow, Gupta (CR328) 2002; 21 Kim, Choi (CR172) 2009; 137 Pasca di Magliano, Biankin, Heiser (CR174) 2007; 2 Loeffler, Kokkaliaris, Schroeder (CR225) 2011; 9 Hsieh, Kodjabachian, Rebbert (CR88) 1999; 398 Jho, Zhang, Domon (CR59) 2002; 22 Fu, Jiang, Mirando (CR36) 2009; 106 Park, Kim, Yu (CR187) 2015; 162 Peifer, McCrea, Green (CR6) 1992; 118 Tang, Liu, Zhao (CR141) 2008; 283 Yanai, Nakamura, Akiyoshi (CR176) 2008; 263 Yu, Chia, Canning (CR38) 2014; 29 Fre, Pallavi, Huyghe (CR157) 2009; 106 Zhang, Chang, Fong (CR194) 2014; 289 Szeto, Kimelman (CR131) 2004; 131 Artavanis-Tsakonas, Rand, Lake (CR144) 1999; 284 Banziger, Soldini, Schutt (CR35) 2006; 125 He, Xu, Xu (CR320) 2014; 134 Longato, de la Monte, Kuzushita (CR108) 2009; 49 Korinek, Barker, Morin (CR237) 1997; 275 Clevers (CR207) 2013; 154 Rasola, Fassetta, De Bacco (CR102) 2007; 26 Jamieson, Sharma, Henderson (CR277) 2014; 27 Chen, Guttridge, You (CR281) 2001; 152 Clements, Lowy, Groden (CR241) 2003; 3 Pendas-Franco, Aguilera, Pereira (CR327) 2008; 28 Nicholes, Guillet, Tomlinson (CR117) 2002; 160 Mehlen, Puisieux (CR261) 2006; 6 Miyabayashi, Teo, Yamamoto (CR315) 2007; 104 Metcalfe, Mendoza-Topaz, Mieszczanek (CR50) 2010; 123 DeAlmeida, Miao, Ernst (CR289) 2007; 67 Edlund, Lee, Grimsby (CR140) 2005; 25 Liu, Lou, Armstrong (CR341) 2015; 75 Lopez-Terrada, Gunaratne, Adesina (CR158) 2009; 40 Xie, Xie (CR247) 2015; 2 Previdi, Maroni, Matteucci (CR269) 2010; 46 Wolf, Rodova, Miska (CR67) 2002; 277 Shin, Kim, Lee (CR292) 2012; 40 Smith, Hawcroft, Hull (CR322) 2000; 36 Wang, Li, Lee (CR64) 2015; 32 Stewart, James, McCluggage (CR258) 2015; 28 Wend, Fang, Zhu (CR318) 2013; 32 Labbe, Letamendia, Attisano (CR129) 2000; 97 Kawaguchi-Ihara, Murohashi, Nara (CR271) 2008; 28 Lau, Chan, Callow (CR299) 2013; 73 Rubinfeld, Souza, Albert (CR15) 1993; 262 Su, Kinzler, Vogelstein (CR242) 1992; 256 Niehrs (CR25) 2012; 13 Arend, Londono-Joshi, Samant (CR340) 2014; 134 Gan, Wang, Xi (CR62) 2008; 180 Gang, Hsieh, Pham (CR319) 2014; 33 Yao, Ashihara, Strovel (CR310) 2011; 1 Varnat, Zacchetti, Ruiz i Altaba (CR171) 2010; 127 Batlle, Henderson, Beghtel (CR215) 2002; 111 Hoffmeyer, Raggioli, Rudloff (CR250) 2012; 336 Sasaki, Hwang, Nguyen (CR66) 2013; 8 Si, Kang, Luu (CR198) 2006; 26 Li, Sutter, Parker (CR52) 2007; 26 Vermeulen, De Sousa, van der Heijden (CR265) 2010; 12 Yang, Tang, Kong (CR270) 2015; 33 de Lau, Snel, Clevers (CR84) 2012; 13 Reya, Duncan, Ailles (CR221) 2003; 423 Baryawno, Sveinbjornsson, Eksborg (CR326) 2010; 70 Yan, Chia, Li (CR209) 2012; 109 Behrens, von Kries, Kuhl (CR9) 1996; 382 Lamplot, Qin, Nan (CR126) 2013; 2 Hussein, Duff, Sirard (CR132) 2003; 278 Hooper, Scott (CR166) 2005; 6 Siegfried, Chou, Perrimon (CR7) 1992; 71 Yingling, Blanchard, Sawyer (CR123) 2004; 3 Trosset, Dalvit, Knapp (CR308) 2006; 64 Lu, Choi, Yu (CR345) 2011; 108 Fu, Ivy Yu, Maruyama (CR43) 2011; 240 Wagner, Zhu, Zhang (CR22) 2011; 4 Thorne, Hanson, Schneider (CR336) 2010; 6 Sato, Meijer, Skaltsounis (CR191) 2004; 10 Hao, Xie, Zhang (CR82) 2012; 485 Liao, Nan, Yan (CR344) 2015; 15 Kazanskaya, Glinka, del Barco Barrantes (CR77) 2004; 7 Carmon, Gong, Lin (CR80) 2011; 108 Yu, Ting, Stott (CR248) 2012; 487 Wang, Green, Wang (CR124) 2014; 1 Kikuchi, Yamamoto, Sato (CR61) 2011; 291 Zhou, An, Haydon (CR324) 2003; 193 Nusse, Varmus (CR2) 2012; 31 Rastegar, Shenaq, Huang (CR195) 2010; 2 Willert, Epping, Pollack (CR60) 2002; 2 Nakopoulou, Gakiopoulou, Keramopoulos (CR101) 2000; 36 Hasegawa, Yasuda, Teo (CR316) 2012; 1 Kramps, Peter, Brunner (CR51) 2002; 109 Schaniel, Sirabella, Qiu (CR220) 2011; 118 Gao, Guo, Jiang (CR204) 2014; 2014 Willert, Brown, Danenberg (CR28) 2003; 423 Molejon, Tellechea, Moutardier (CR273) 2015; 2 Park, Chang, Hahm (CR330) 2005; 328 Collu, Brennan (CR160) 2007; 9 Chocarro-Calvo, Garcia-Martinez, Ardila-Gonzalez (CR69) 2013; 49 Estrach, Ambler, Lo Celso (CR162) 2006; 133 Haydon, Deyrup, Ishikawa (CR249) 2002; 102 Katoh, Katoh (CR115) 2006; 5 Kawano, Kypta (CR86) 2003; 116 Tang, Song, Luo (CR199) 2009; 13 Janda, Waghray, Levin (CR29) 2012; 337 Port, Basler (CR37) 2010; 11 Arimura, Matsunaga, Kitamura (CR173) 2009; 137 Mullighan, Zhang, Kasper (CR259) 2011; 471 Kim, Zhang, Rieger-Christ (CR329) 2006; 281 Glinka, Wu, Delius (CR89) 1998; 391 Ingham, McMahon (CR163) 2001; 15 Singbrant, Karlsson, Ehinger (CR226) 2010; 115 Nishisho, Nakamura, Miyoshi (CR14) 1991; 253 Lluis, Pedone, Pepe (CR193) 2008; 3 Rubin, Guo, Tu (CR286) 2010; 9 Verkaar, Zaman (CR275) 2011; 16 Luo, Chen, Deng (CR21) 2007; 87 Nguyen, Merrill, Polak (CR231) 2009; 41 Barry, Morikawa, Butler (CR183) 2013; 493 Duan, Yao, Wu (CR156) 2006; 98 Zhang, Wang, Deng (CR201) 2015; 39 Molenaar, van de Wetering, Oosterwegel (CR10) 1996; 86 Lu, Lin, Roberts (CR338) 2011; 6 van der Flier, van Gijn, Hatzis (CR214) 2009; 136 Morin, Sparks, Korinek (CR238) 1997; 275 Lu, Lin, King (CR334) 2012; 24 Wei, Chua, Grepper (CR304) 2010; 126 Zeng, Huang, Tamai (CR49) 2008; 135 Kim, Zhao, Andarmani (CR75) 2006; 5 Birdsey, Shah, Dufton (CR112) 2015; 32 Rosenbluh, Nijhawan, Cox (CR260) 2012; 151 Taipaleenmaki, Abdallah, AlDahmash (CR203) 2011; 317 Heallen, Zhang, Wang (CR184) 2011; 332 He, Gao, Zhang (CR333) 2011; 79 Rijsewijk, Schuermann, Wagenaar (CR4) 1987; 50 Morin, Vogelstein, Kinzler (CR280) 1996; 93 Ochiai, Akimoto, Kanai (CR104) 1994; 205 Lu, Lin, Li (CR335) 2014; 26 Zhao, Blum, Chen (CR219) 2007; 12 Chen, Venkatesan, Dehnhardt (CR306) 2009; 19 Wang, Zhang, Li (CR93) 2008; 283 Chen, Dodge, Tang (CR297) 2009; 5 Augustin, Goidts, Bongers (CR253) 2012; 4 Shan, Shi, Wang (CR293) 2005; 44 Maruyama, Yu, Jiang (CR254) 2013; 8 Nicolas, Wolfer, Raj (CR154) 2003; 33 Heuberger, Birchmeier (CR263) 2010; 2 Finch, He, Kelley (CR85) 1997; 94 van den Bosch, Blom, van Lent (CR72) 2014; 26 Naik, Dothager, Marasa (CR113) 2009; 15 Itasaki, Jones, Mercurio (CR94) 2003; 130 Han, Li, Liang (CR139) 2006; 11 Voloshanenko, Erdmann, Dubash (CR255) 2013; 4 Bisson, Prowse (CR272) 2009; 19 Sakai, Tanaka, Endo (CR135) 2005; 47 Hu, Rosenblum (CR136) 2005; 132 Wang, Ye, Deng (CR181) 2014; 1 Levy, Wei, Labalette (CR68) 2004; 24 Grossmann, Yeh, Bowman (CR312) 2012; 109 Lenz, Kahn (CR321) 2014; 105 Noordermeer, Klingensmith, Perrimon (CR5) 1994; 367 Pai, Dunlap, Qing (CR118) 2008; 68 de Lau, Barker, Low (CR81) 2011; 476 Zhang, Wei, Gong (CR74) 2011; 20 Kim, Liu, Wang (CR98) 2013; 5 Noubissi, Goswami, Sanek (CR170) 2009; 69 Zhong, Zylstra-Diegel, Schumacher (CR41) 2012; 109 Marson, Foreman, Chevalier (CR317) 2008; 3 Fujii, You, Xu (CR294) 2007; 67 Semenov, Zhang, He Munoz-Descalzo (10.1038/labinvest.2015.144_bib151) 2012; 34 Luis (10.1038/labinvest.2015.144_bib218) 2009; 113 Hoppler (10.1038/labinvest.2015.144_bib128) 1998; 71 Ellwanger (10.1038/labinvest.2015.144_bib91) 2008; 28 He (10.1038/labinvest.2015.144_bib53) 1999; 99 Hao (10.1038/labinvest.2015.144_bib82) 2012; 485 Willert (10.1038/labinvest.2015.144_bib60) 2002; 2 Anastas (10.1038/labinvest.2015.144_bib26) 2013; 13 Finch (10.1038/labinvest.2015.144_bib85) 1997; 94 Lenz (10.1038/labinvest.2015.144_bib321) 2014; 105 Satyamoorthy (10.1038/labinvest.2015.144_bib110) 2001; 61 Bhowmick (10.1038/labinvest.2015.144_bib137) 2004; 303 Sato (10.1038/labinvest.2015.144_bib191) 2004; 10 Chen (10.1038/labinvest.2015.144_bib337) 2009; 48 Noubissi (10.1038/labinvest.2015.144_bib170) 2009; 69 Nicolas (10.1038/labinvest.2015.144_bib154) 2003; 33 Bommer (10.1038/labinvest.2015.144_bib106) 2010; 285 Molenaar (10.1038/labinvest.2015.144_bib10) 1996; 86 Trosset (10.1038/labinvest.2015.144_bib308) 2006; 64 Li (10.1038/labinvest.2015.144_bib52) 2007; 26 Abu-Remaileh (10.1038/labinvest.2015.144_bib192) 2010; 29 Galceran (10.1038/labinvest.2015.144_bib148) 2004; 18 Wang (10.1038/labinvest.2015.144_bib200) 2014; 23 van Den Heuvel (10.1038/labinvest.2015.144_bib164) 2001; 2001 Liao (10.1038/labinvest.2015.144_bib169) 2009; 22 Nostro (10.1038/labinvest.2015.144_bib217) 2008; 2 Grossmann (10.1038/labinvest.2015.144_bib312) 2012; 109 Naik (10.1038/labinvest.2015.144_bib113) 2009; 15 De Boer (10.1038/labinvest.2015.144_bib206) 2004; 10 Kansara (10.1038/labinvest.2015.144_bib252) 2009; 119 Huang (10.1038/labinvest.2015.144_bib296) 2009; 461 Siegfried (10.1038/labinvest.2015.144_bib8) 1994; 367 Funa (10.1038/labinvest.2015.144_bib73) 2015; 16 Hansen (10.1038/labinvest.2015.144_bib179) 2015; 25 Gregorieff (10.1038/labinvest.2015.144_bib211) 2005; 129 Kim (10.1038/labinvest.2015.144_bib329) 2006; 281 Zhu (10.1038/labinvest.2015.144_bib42) 2012; 365 Ramos (10.1038/labinvest.2015.144_bib182) 2012; 22 Zeng (10.1038/labinvest.2015.144_bib49) 2008; 135 Willert (10.1038/labinvest.2015.144_bib28) 2003; 423 Fujii (10.1038/labinvest.2015.144_bib294) 2007; 67 Han (10.1038/labinvest.2015.144_bib139) 2006; 11 Li (10.1038/labinvest.2015.144_bib212) 2010; 327 Heuberger (10.1038/labinvest.2015.144_bib263) 2010; 2 Cavallo (10.1038/labinvest.2015.144_bib45) 1998; 395 Kikuchi (10.1038/labinvest.2015.144_bib61) 2011; 291 Lluis (10.1038/labinvest.2015.144_bib193) 2008; 3 Letamendia (10.1038/labinvest.2015.144_bib133) 2001; 83-A Suppl 1 Polakis (10.1038/labinvest.2015.144_bib245) 2007; 17 Kramps (10.1038/labinvest.2015.144_bib51) 2002; 109 Kinzler (10.1038/labinvest.2015.144_bib240) 1998; 280 Franch-Marro (10.1038/labinvest.2015.144_bib30) 2008; 121 Moreno (10.1038/labinvest.2015.144_bib159) 2010; 176 Lehtio (10.1038/labinvest.2015.144_bib300) 2013; 280 Merrill (10.1038/labinvest.2015.144_bib190) 2012; 4 Rubinfeld (10.1038/labinvest.2015.144_bib15) 1993; 262 Arimura (10.1038/labinvest.2015.144_bib173) 2009; 137 Piccolo (10.1038/labinvest.2015.144_bib180) 2014; 94 Morin (10.1038/labinvest.2015.144_bib280) 1996; 93 Tumova (10.1038/labinvest.2015.144_bib346) 2014; 13 Luo (10.1038/labinvest.2015.144_bib197) 2004; 279 Pendas-Franco (10.1038/labinvest.2015.144_bib327) 2008; 28 Niehrs (10.1038/labinvest.2015.144_bib25) 2012; 13 Kurayoshi (10.1038/labinvest.2015.144_bib31) 2007; 402 Zhong (10.1038/labinvest.2015.144_bib41) 2012; 109 Mao (10.1038/labinvest.2015.144_bib90) 2002; 417 Yang (10.1038/labinvest.2015.144_bib270) 2015; 33 Kawaguchi-Ihara (10.1038/labinvest.2015.144_bib271) 2008; 28 Chen (10.1038/labinvest.2015.144_bib121) 2004; 22 DeAlmeida (10.1038/labinvest.2015.144_bib289) 2007; 67 Itasaki (10.1038/labinvest.2015.144_bib94) 2003; 130 Bisson (10.1038/labinvest.2015.144_bib272) 2009; 19 Verkaar (10.1038/labinvest.2015.144_bib275) 2011; 16 Bilic (10.1038/labinvest.2015.144_bib48) 2007; 316 Ramocki (10.1038/labinvest.2015.144_bib109) 2008; 149 Ayyanan (10.1038/labinvest.2015.144_bib161) 2006; 103 Kim (10.1038/labinvest.2015.144_bib75) 2006; 5 Desbois-Mouthon (10.1038/labinvest.2015.144_bib107) 2001; 20 Shin (10.1038/labinvest.2015.144_bib292) 2012; 40 Lepourcelet (10.1038/labinvest.2015.144_bib303) 2004; 5 Lu (10.1038/labinvest.2015.144_bib335) 2014; 26 Wang (10.1038/labinvest.2015.144_bib124) 2014; 1 Kopan (10.1038/labinvest.2015.144_bib146) 2009; 137 Gehart (10.1038/labinvest.2015.144_bib210) 2015; 31 Hayward (10.1038/labinvest.2015.144_bib152) 2005; 132 Rosenbluh (10.1038/labinvest.2015.144_bib260) 2012; 151 He (10.1038/labinvest.2015.144_bib54) 1998; 281 Monga (10.1038/labinvest.2015.144_bib100) 2002; 62 Yang (10.1038/labinvest.2015.144_bib105) 2011; 480 Revet (10.1038/labinvest.2015.144_bib155) 2010; 289 Mikami (10.1038/labinvest.2015.144_bib283) 2005; 5 Itasaki (10.1038/labinvest.2015.144_bib143) 2010; 239 Wagner (10.1038/labinvest.2015.144_bib22) 2011; 4 Clements (10.1038/labinvest.2015.144_bib241) 2003; 3 Kazanskaya (10.1038/labinvest.2015.144_bib77) 2004; 7 Wei (10.1038/labinvest.2015.144_bib304) 2010; 126 Chocarro-Calvo (10.1038/labinvest.2015.144_bib69) 2013; 49 Gonsalves (10.1038/labinvest.2015.144_bib307) 2011; 108 Fre (10.1038/labinvest.2015.144_bib157) 2009; 106 Levy (10.1038/labinvest.2015.144_bib68) 2004; 24 Taipaleenmaki (10.1038/labinvest.2015.144_bib203) 2011; 317 Li (10.1038/labinvest.2015.144_bib138) 2008; 27 Kandyba (10.1038/labinvest.2015.144_bib235) 2014; 32 Minke (10.1038/labinvest.2015.144_bib305) 2009; 82 Su (10.1038/labinvest.2015.144_bib242) 1992; 256 Lu (10.1038/labinvest.2015.144_bib345) 2011; 108 Roose (10.1038/labinvest.2015.144_bib46) 1998; 395 Pasca di Magliano (10.1038/labinvest.2015.144_bib174) 2007; 2 Polakis (10.1038/labinvest.2015.144_bib276) 2012; 31 Xie (10.1038/labinvest.2015.144_bib247) 2015; 2 Bonifas (10.1038/labinvest.2015.144_bib167) 2001; 116 Baryawno (10.1038/labinvest.2015.144_bib326) 2010; 70 Estrach (10.1038/labinvest.2015.144_bib162) 2006; 133 Wei (10.1038/labinvest.2015.144_bib284) 2009; 8 Varnat (10.1038/labinvest.2015.144_bib171) 2010; 127 Peifer (10.1038/labinvest.2015.144_bib6) 1992; 118 Liu (10.1038/labinvest.2015.144_bib202) 2004; 279 Voloshanenko (10.1038/labinvest.2015.144_bib255) 2013; 4 Liu (10.1038/labinvest.2015.144_bib301) 2013; 110 Both (10.1038/labinvest.2015.144_bib256) 2014; 9 Mehlen (10.1038/labinvest.2015.144_bib261) 2006; 6 Londono-Joshi (10.1038/labinvest.2015.144_bib343) 2014; 13 Kahn (10.1038/labinvest.2015.144_bib278) 2014; 13 Singbrant (10.1038/labinvest.2015.144_bib226) 2010; 115 Jaiswal (10.1038/labinvest.2015.144_bib328) 2002; 21 Fukuda (10.1038/labinvest.2015.144_bib222) 2001; 98 Jiang (10.1038/labinvest.2015.144_bib39) 2013; 140 Haydon (10.1038/labinvest.2015.144_bib249) 2002; 102 Cai (10.1038/labinvest.2015.144_bib186) 2015; 29 Nishita (10.1038/labinvest.2015.144_bib130) 2000; 403 Song (10.1038/labinvest.2015.144_bib142) 2014; 111 Noordermeer (10.1038/labinvest.2015.144_bib5) 1994; 367 Johnson (10.1038/labinvest.2015.144_bib97) 2004; 19 Miller (10.1038/labinvest.2015.144_bib71) 2010; 401 Miyoshi (10.1038/labinvest.2015.144_bib243) 1998; 58 Nusse (10.1038/labinvest.2015.144_bib236) 1984; 307 Semenov (10.1038/labinvest.2015.144_bib92) 2008; 283 Wei (10.1038/labinvest.2015.144_bib290) 2011; 10 Barry (10.1038/labinvest.2015.144_bib183) 2013; 493 Previdi (10.1038/labinvest.2015.144_bib269) 2010; 46 Sun (10.1038/labinvest.2015.144_bib233) 2014; 111 Taipale (10.1038/labinvest.2015.144_bib165) 2001; 411 Bhanot (10.1038/labinvest.2015.144_bib11) 1996; 382 Wolf (10.1038/labinvest.2015.144_bib67) 2002; 277 Liu (10.1038/labinvest.2015.144_bib341) 2015; 75 Duan (10.1038/labinvest.2015.144_bib156) 2006; 98 Wissmann (10.1038/labinvest.2015.144_bib251) 2003; 201 Reya (10.1038/labinvest.2015.144_bib221) 2003; 423 Dihlmann (10.1038/labinvest.2015.144_bib323) 2001; 20 Wang (10.1038/labinvest.2015.144_bib181) 2014; 1 Wei (10.1038/labinvest.2015.144_bib79) 2007; 282 Lee (10.1038/labinvest.2015.144_bib116) 1995; 92 Gough (10.1038/labinvest.2015.144_bib24) 2012; 5 Nambotin (10.1038/labinvest.2015.144_bib291) 2011; 54 Clevers (10.1038/labinvest.2015.144_bib23) 2012; 149 Rijsewijk (10.1038/labinvest.2015.144_bib4) 1987; 50 Lien (10.1038/labinvest.2015.144_bib232) 2014; 16 Edlund (10.1038/labinvest.2015.144_bib140) 2005; 25 Nishisho (10.1038/labinvest.2015.144_bib14) 1991; 253 Janda (10.1038/labinvest.2015.144_bib29) 2012; 337 Lustig (10.1038/labinvest.2015.144_bib58) 2002; 22 Verras (10.1038/labinvest.2015.144_bib111) 2005; 19 Smith (10.1038/labinvest.2015.144_bib322) 2000; 36 Kim (10.1038/labinvest.2015.144_bib78) 2008; 19 Theil (10.1038/labinvest.2015.144_bib134) 2002; 129 Hussein (10.1038/labinvest.2015.144_bib132) 2003; 278 Birdsey (10.1038/labinvest.2015.144_bib112) 2015; 32 Tetsu (10.1038/labinvest.2015.144_bib55) 1999; 398 Chiou (10.1038/labinvest.2015.144_bib257) 2014; 35 Gan (10.1038/labinvest.2015.144_bib62) 2008; 180 Louie (10.1038/labinvest.2015.144_bib63) 2009; 4 Pai (10.1038/labinvest.2015.144_bib118) 2008; 68 Tian (10.1038/labinvest.2015.144_bib208) 2011; 478 Gurbuxani (10.1038/labinvest.2015.144_bib223) 2005; 102 Wang (10.1038/labinvest.2015.144_bib93) 2008; 283 Hofmann (10.1038/labinvest.2015.144_bib32) 2000; 25 Apte (10.1038/labinvest.2015.144_bib99) 2006; 44 Duncan (10.1038/labinvest.2015.144_bib147) 2005; 6 Tian (10.1038/labinvest.2015.144_bib309) 2012; 51 Kim (10.1038/labinvest.2015.144_bib127) 2002; 62 Arce (10.1038/labinvest.2015.144_bib47) 2009; 9 Coghlin (10.1038/labinvest.2015.144_bib262) 2010; 222 Alfaro (10.1038/labinvest.2015.144_bib205) 2008; 105 Molejon (10.1038/labinvest.2015.144_bib273) 2015; 2 Siegfried (10.1038/labinvest.2015.144_bib7) 1992; 71 Szeto (10.1038/labinvest.2015.144_bib131) 2004; 131 Fu (10.1038/labinvest.2015.144_bib43) 2011; 240 Chen (10.1038/labinvest.2015.144_bib281) 2001; 152 Ingham (10.1038/labinvest.2015.144_bib163) 2001; 15 Li (10.1038/labinvest.2015.144_bib120) 2008; 283 Nicholes (10.1038/labinvest.2015.144_bib117) 2002; 160 Yamamoto (10.1038/labinvest.2015.144_bib40) 2013; 126 Nusse (10.1038/labinvest.2015.144_bib1) 1982; 31 Holland (10.1038/labinvest.2015.144_bib188) 2013; 25 Kawano (10.1038/labinvest.2015.144_bib86) 2003; 116 Yang (10.1038/ |
| References_xml | – volume: 395 start-page: 604 year: 1998 end-page: 608 ident: bib45 article-title: Drosophila Tcf and Groucho interact to repress Wingless signalling activity publication-title: Nature contributor: fullname: Moline – volume: 126 start-page: 2931 year: 2013 end-page: 2943 ident: bib40 article-title: The apical and basolateral secretion of Wnt11 and Wnt3a in polarized epithelial cells is regulated by different mechanisms publication-title: J Cell Sci contributor: fullname: Hanaki – volume: 5 start-page: 100 year: 2009 end-page: 107 ident: bib297 article-title: Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer publication-title: Nat Chem Biol contributor: fullname: Tang – volume: 19 start-page: 2588 year: 2008 end-page: 2596 ident: bib78 article-title: R-Spondin family members regulate the Wnt pathway by a common mechanism publication-title: Mol Biol Cell contributor: fullname: Tran – volume: 149 start-page: 1192 year: 2012 end-page: 1205 ident: bib23 article-title: Wnt/beta-catenin signaling and disease publication-title: Cell contributor: fullname: Nusse – volume: 423 start-page: 448 year: 2003 end-page: 452 ident: bib28 article-title: Wnt proteins are lipid-modified and can act as stem cell growth factors publication-title: Nature contributor: fullname: Danenberg – volume: 180 start-page: 1087 year: 2008 end-page: 1100 ident: bib62 article-title: Nuclear Dvl, c-Jun, beta-catenin, and TCF form a complex leading to stabilization of beta-catenin-TCF interaction publication-title: J Cell Biol contributor: fullname: Xi – volume: 116 start-page: 739 year: 2001 end-page: 742 ident: bib167 article-title: Activation of expression of hedgehog target genes in basal cell carcinomas publication-title: J Invest Dermatol contributor: fullname: Chuang – volume: 16 start-page: 35 year: 2011 end-page: 41 ident: bib275 article-title: New avenues to target Wnt/beta-catenin signaling publication-title: Drug Discov Today contributor: fullname: Zaman – volume: 14 start-page: 1849 year: 2008 end-page: 1858 ident: bib331 article-title: Resveratrol exerts antiproliferative activity and induces apoptosis in Waldenstrom's macroglobulinemia publication-title: Clin Cancer Res contributor: fullname: Sacco – volume: 2014 start-page: 162024 year: 2014 ident: bib204 article-title: A cocktail method for promoting cardiomyocyte differentiation from bone marrow-derived mesenchymal stem cells publication-title: Stem Cells Int contributor: fullname: Jiang – volume: 41 start-page: 1068 year: 2009 end-page: 1075 ident: bib231 article-title: Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia publication-title: Nat Genet contributor: fullname: Polak – volume: 111 start-page: 10215 year: 2014 end-page: 10220 ident: bib233 article-title: Pygo2 regulates beta-catenin-induced activation of hair follicle stem/progenitor cells and skin hyperplasia publication-title: Proc Natl Acad Sci USA contributor: fullname: Fallahi – volume: 395 start-page: 608 year: 1998 end-page: 612 ident: bib46 article-title: The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors publication-title: Nature contributor: fullname: Peterson – volume: 108 start-page: 11452 year: 2011 end-page: 11457 ident: bib80 article-title: R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling publication-title: Proc Natl Acad Sci USA contributor: fullname: Lin – volume: 279 start-page: 55958 year: 2004 end-page: 55968 ident: bib197 article-title: Connective tissue growth factor (CTGF) is regulated by Wnt and bone morphogenetic proteins signaling in osteoblast differentiation of mesenchymal stem cells publication-title: J Biol Chem contributor: fullname: Si – volume: 9 start-page: 731 year: 2010 end-page: 741 ident: bib286 article-title: Wnt inhibitory factor 1 decreases tumorigenesis and metastasis in osteosarcoma publication-title: Mol Cancer Ther contributor: fullname: Tu – volume: 101 start-page: 12682 year: 2004 end-page: 12687 ident: bib313 article-title: A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected] publication-title: Proc Natl Acad Sci USA contributor: fullname: Ma – volume: 38 start-page: 437 year: 2011 end-page: 445 ident: bib332 article-title: Ginsenoside Rg3 inhibits colorectal tumor growth through the down-regulation of Wnt/ss-catenin signaling publication-title: Int J Oncol contributor: fullname: Luo – volume: 178 start-page: 635 year: 2007 end-page: 648 ident: bib213 article-title: Sox9 regulates cell proliferation and is required for Paneth cell differentiation in the intestinal epithelium publication-title: J Cell Biol contributor: fullname: Pannequin – volume: 28 start-page: 4875 year: 2008 end-page: 4882 ident: bib91 article-title: Targeted disruption of the Wnt regulator Kremen induces limb defects and high bone density publication-title: Mol Cell Biol contributor: fullname: Clement-Lacroix – volume: 307 start-page: 131 year: 1984 end-page: 136 ident: bib236 article-title: Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15 publication-title: Nature contributor: fullname: Cox – volume: 98 start-page: 14973 year: 2001 end-page: 14978 ident: bib57 article-title: Elevated expression of axin2 and hnkd mRNA provides evidence that Wnt/beta -catenin signaling is activated in human colon tumors publication-title: Proc Natl Acad Sci USA contributor: fullname: Rohan – volume: 25 start-page: 499 year: 2015 end-page: 513 ident: bib179 article-title: YAP and TAZ: a nexus for Hippo signaling and beyond publication-title: Trends Cell Biol contributor: fullname: Guan – volume: 94 start-page: 1287 year: 2014 end-page: 1312 ident: bib180 article-title: The biology of YAP/TAZ: hippo signaling and beyond publication-title: Physiol Rev contributor: fullname: Cordenonsi – volume: 279 start-page: 45020 year: 2004 end-page: 45027 ident: bib202 article-title: Regulating the balance between peroxisome proliferator-activated receptor gamma and beta-catenin signaling during adipogenesis. A glycogen synthase kinase 3beta phosphorylation-defective mutant of beta-catenin inhibits expression of a subset of adipogenic genes publication-title: J Biol Chem contributor: fullname: Farmer – volume: 13 start-page: 767 year: 2012 end-page: 779 ident: bib25 article-title: The complex world of WNT receptor signalling publication-title: Nat Rev Mol Cell Biol contributor: fullname: Niehrs – volume: 284 start-page: 770 year: 1999 end-page: 776 ident: bib144 article-title: Notch signaling: cell fate control and signal integration in development publication-title: Science contributor: fullname: Lake – volume: 281 start-page: 13247 year: 2006 end-page: 13257 ident: bib76 article-title: Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression publication-title: J Biol Chem contributor: fullname: Smith – volume: 105 start-page: 18366 year: 2008 end-page: 18371 ident: bib205 article-title: The Wnt modulator sFRP2 enhances mesenchymal stem cell engraftment, granulation tissue formation and myocardial repair publication-title: Proc Natl Acad Sci USA contributor: fullname: Vincent – volume: 125 start-page: 509 year: 2006 end-page: 522 ident: bib35 article-title: Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells publication-title: Cell contributor: fullname: Schutt – volume: 382 start-page: 638 year: 1996 end-page: 642 ident: bib9 article-title: Functional interaction of beta-catenin with the transcription factor LEF-1 publication-title: Nature contributor: fullname: Kuhl – volume: 283 start-page: 23956 year: 2008 end-page: 23963 ident: bib141 article-title: Smad7 stabilizes beta-catenin binding to E-cadherin complex and promotes cell-cell adhesion publication-title: J Biol Chem contributor: fullname: Zhao – volume: 29 start-page: 3236 year: 2010 end-page: 3248 ident: bib192 article-title: Oct-3/4 regulates stem cell identity and cell fate decisions by modulating Wnt/beta-catenin signalling publication-title: EMBO J contributor: fullname: Farago – volume: 30 start-page: 423 year: 2011 end-page: 433 ident: bib285 article-title: Blocking Wnt signaling by SFRP-like molecules inhibits publication-title: Oncogene contributor: fullname: Coulouarn – volume: 129 start-page: 3045 year: 2002 end-page: 3054 ident: bib134 article-title: Wnt and Bmp signalling cooperatively regulate graded Emx2 expression in the dorsal telencephalon publication-title: Development contributor: fullname: Koch – volume: 46 start-page: 1679 year: 2010 end-page: 1691 ident: bib269 article-title: Interaction between human-breast cancer metastasis and bone microenvironment through activated hepatocyte growth factor/Met and beta-catenin/Wnt pathways publication-title: Eur J Cancer contributor: fullname: Matteucci – volume: 135 start-page: 367 year: 2008 end-page: 375 ident: bib49 article-title: Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions publication-title: Development contributor: fullname: Tamai – volume: 289 start-page: 9221 year: 2014 end-page: 9232 ident: bib194 article-title: Regulation of induced pluripotent stem (iPS) cell induction by Wnt/beta-catenin signaling publication-title: J Biol Chem contributor: fullname: Fong – volume: 12 start-page: 528 year: 2007 end-page: 541 ident: bib219 article-title: Loss of beta-catenin impairs the renewal of normal and CML stem cells publication-title: Cancer Cell contributor: fullname: Chen – volume: 10 start-page: 3116 year: 1996 end-page: 3128 ident: bib33 article-title: The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing publication-title: Genes Dev contributor: fullname: Klingensmith – volume: 83-A Suppl 1 start-page: S31 year: 2001 end-page: S39 ident: bib133 article-title: Transcriptional regulation by Smads: cross-talk between the TGF-beta and Wnt pathways publication-title: J Bone Joint Surg Am contributor: fullname: Attisano – volume: 140 start-page: 3589 year: 2013 end-page: 3594 ident: bib39 article-title: Gpr177 regulates pulmonary vasculature development publication-title: Development contributor: fullname: Fu – volume: 160 start-page: 2295 year: 2002 end-page: 2307 ident: bib117 article-title: A mouse model of hepatocellular carcinoma: ectopic expression of fibroblast growth factor 19 in skeletal muscle of transgenic mice publication-title: Am J Pathol contributor: fullname: Tomlinson – volume: 69 start-page: 8572 year: 2009 end-page: 8578 ident: bib170 article-title: Wnt signaling stimulates transcriptional outcome of the Hedgehog pathway by stabilizing GLI1 mRNA publication-title: Cancer Res contributor: fullname: Sanek – volume: 26 start-page: 1303 year: 2014 end-page: 1309 ident: bib335 article-title: Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/beta-catenin and mTORC1 signaling in prostate and breast cancer cells publication-title: Cell Signal contributor: fullname: Li – volume: 8 start-page: e75010 year: 2013 ident: bib66 article-title: The small molecule Wnt signaling modulator ICG-001 improves contractile function in chronically infarcted rat myocardium publication-title: PLoS One contributor: fullname: Nguyen – volume: 137 start-page: 216 year: 2009 end-page: 233 ident: bib146 article-title: The canonical Notch signaling pathway: unfolding the activation mechanism publication-title: Cell contributor: fullname: Ilagan – volume: 36 start-page: 277 year: 2004 end-page: 282 ident: bib175 article-title: Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation publication-title: Nat Genet contributor: fullname: Hardwick – volume: 282 start-page: 15903 year: 2007 end-page: 15911 ident: bib79 article-title: R-spondin1 is a high affinity ligand for LRP6 and induces LRP6 phosphorylation and beta-catenin signaling publication-title: J Biol Chem contributor: fullname: Semenov – volume: 16 start-page: 179 year: 2014 end-page: 190 ident: bib232 article-title: transcriptional governance of hair follicle stem cells by canonical Wnt regulators publication-title: Nat Cell Biol contributor: fullname: Lin – volume: 105 start-page: 1087 year: 2014 end-page: 1092 ident: bib321 article-title: Safely targeting cancer stem cells via selective catenin coactivator antagonism publication-title: Cancer Sci contributor: fullname: Kahn – volume: 13 start-page: 513 year: 2014 end-page: 532 ident: bib278 article-title: Can we safely target the WNT pathway? publication-title: Nat Rev Drug Discov contributor: fullname: Kahn – volume: 86 start-page: 391 year: 1996 end-page: 399 ident: bib10 article-title: XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos publication-title: Cell contributor: fullname: Oosterwegel – volume: 48 start-page: 10267 year: 2009 end-page: 10274 ident: bib337 article-title: The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling publication-title: Biochemistry contributor: fullname: Lu – volume: 193 start-page: 161 year: 2003 end-page: 170 ident: bib324 article-title: Tyrosine kinase inhibitor STI-571/Gleevec down-regulates the beta-catenin signaling activity publication-title: Cancer Lett contributor: fullname: Haydon – volume: 277 start-page: 25562 year: 2002 end-page: 25567 ident: bib67 article-title: Acetylation of beta-catenin by CREB-binding protein (CBP) publication-title: J Biol Chem contributor: fullname: Miska – volume: 141 start-page: 1614 year: 2014 end-page: 1626 ident: bib178 article-title: The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease publication-title: Development contributor: fullname: Varelas – volume: 474 start-page: 220 year: 2011 end-page: 224 ident: bib224 article-title: A somitic Wnt16/Notch pathway specifies haematopoietic stem cells publication-title: Nature contributor: fullname: Ong – volume: 16 start-page: 639 year: 2015 end-page: 652 ident: bib73 article-title: Beta-catenin regulates primitive streak induction through collaborative interactions with SMAD2/SMAD3 and OCT4 publication-title: Cell Stem Cell contributor: fullname: Lerdrup – volume: 365 start-page: 328 year: 2012 end-page: 338 ident: bib42 article-title: Wls-mediated Wnts differentially regulate distal limb patterning and tissue morphogenesis publication-title: Dev Biol contributor: fullname: Zhang – volume: 73 start-page: 4909 year: 2013 end-page: 4922 ident: bib246 article-title: Canonical wnt signaling is required for pancreatic carcinogenesis publication-title: Cancer Res contributor: fullname: Yan – volume: 205 start-page: 73 year: 1994 end-page: 78 ident: bib104 article-title: c-erbB-2 gene product associates with catenins in human cancer cells publication-title: Biochem Biophys Res Commun contributor: fullname: Kanai – volume: 5 start-page: a008029 year: 2013 ident: bib228 article-title: Wnt signaling in skin development, homeostasis, and disease publication-title: Cold Spring Harb Perspect Biol contributor: fullname: Nusse – volume: 27 start-page: 7118 year: 2008 end-page: 7130 ident: bib138 article-title: Prostate tumor progression is mediated by a paracrine TGF-beta/Wnt3a signaling axis publication-title: Oncogene contributor: fullname: Iturregui – volume: 493 start-page: 106 year: 2013 end-page: 110 ident: bib183 article-title: Restriction of intestinal stem cell expansion and the regenerative response by YAP publication-title: Nature contributor: fullname: Butler – volume: 132 start-page: 1819 year: 2005 end-page: 1830 ident: bib152 article-title: Notch modulates Wnt signalling by associating with Armadillo/beta-catenin and regulating its transcriptional activity publication-title: Development contributor: fullname: Sanders – volume: 68 start-page: 5086 year: 2008 end-page: 5095 ident: bib118 article-title: Inhibition of fibroblast growth factor 19 reduces tumor growth by modulating beta-catenin signaling publication-title: Cancer Res contributor: fullname: Qing – volume: 9 start-page: 2 year: 2011 end-page: 4 ident: bib225 article-title: Wnt to notch relay signaling induces definitive hematopoiesis publication-title: Cell Stem Cell contributor: fullname: Schroeder – volume: 119 start-page: 837 year: 2009 end-page: 851 ident: bib252 article-title: Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice publication-title: J Clin Invest contributor: fullname: Kodjabachian – volume: 22 start-page: 1172 year: 2002 end-page: 1183 ident: bib59 article-title: Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway publication-title: Mol Cell Biol contributor: fullname: Domon – volume: 402 start-page: 515 year: 2007 end-page: 523 ident: bib31 article-title: Post-translational palmitoylation and glycosylation of Wnt-5a are necessary for its signalling publication-title: Biochem J contributor: fullname: Izumi – volume: 332 start-page: 458 year: 2011 end-page: 461 ident: bib184 article-title: Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size publication-title: Science contributor: fullname: Wang – volume: 4 start-page: a007971 year: 2012 ident: bib190 article-title: Wnt pathway regulation of embryonic stem cell self-renewal publication-title: Cold Spring Harb Perspect Biol contributor: fullname: Merrill – volume: 4 start-page: e4310 year: 2009 ident: bib63 article-title: Modulation of the beta-catenin signaling pathway by the dishevelled-associated protein Hipk1 publication-title: PLoS One contributor: fullname: Conrad – volume: 487 start-page: 510 year: 2012 end-page: 513 ident: bib248 article-title: RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis publication-title: Nature contributor: fullname: Stott – volume: 280 start-page: 19883 year: 2005 end-page: 19887 ident: bib95 article-title: Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling publication-title: J Biol Chem contributor: fullname: Kang – volume: 176 start-page: 518 year: 2010 end-page: 527 ident: bib159 article-title: The Sex-determining region Y-box 4 and homeobox C6 transcriptional networks in prostate cancer progression: cros-stalk with the Wnt, Notch, and PI3K pathways publication-title: Am J Pathol contributor: fullname: Moreno – volume: 29 start-page: 1493 year: 2015 end-page: 1506 ident: bib186 article-title: beta-Catenin destruction complex-independent regulation of Hippo-YAP signaling by APC in intestinal tumorigenesis publication-title: Genes Dev contributor: fullname: Anders – volume: 3 start-page: 113 year: 2003 end-page: 120 ident: bib241 article-title: Adenomatous polyposis coli/beta-catenin interaction and downstream targets: altered gene expression in gastrointestinal tumors publication-title: Clin Colorectal Cancer contributor: fullname: Groden – volume: 13 start-page: 800 year: 2014 end-page: 811 ident: bib343 article-title: Effect of niclosamide on basal-like breast cancers publication-title: Mol Cancer Ther contributor: fullname: Aristizabal – volume: 130 start-page: 4295 year: 2003 end-page: 4305 ident: bib94 article-title: Wise, a context-dependent activator and inhibitor of Wnt signalling publication-title: Development contributor: fullname: Mercurio – volume: 8 start-page: 76 year: 2009 ident: bib284 article-title: Blockade of Wnt-1 signaling leads to anti-tumor effects in hepatocellular carcinoma cells publication-title: Mol Cancer contributor: fullname: Grepper – volume: 29 start-page: 277 year: 2014 end-page: 291 ident: bib38 article-title: WLS retrograde transport to the endoplasmic reticulum during Wnt secretion publication-title: Dev Cell contributor: fullname: Canning – volume: 15 start-page: 7529 year: 2009 end-page: 7537 ident: bib113 article-title: Vascular endothelial growth factor receptor-1 is synthetic lethal to aberrant {beta}-catenin activation in colon cancer publication-title: Clin Cancer Res contributor: fullname: Marasa – volume: 480 start-page: 118 year: 2011 end-page: 122 ident: bib105 article-title: Nuclear PKM2 regulates beta-catenin transactivation upon EGFR activation publication-title: Nature contributor: fullname: Ji – volume: 253 start-page: 661 year: 1991 end-page: 665 ident: bib13 article-title: Identification of FAP locus genes from chromosome 5q21 publication-title: Science contributor: fullname: Su – volume: 5 start-page: 13 year: 2013 end-page: 31 ident: bib98 article-title: Wnt signaling in bone formation and its therapeutic potential for bone diseases publication-title: Ther Adv Musculoskelet Dis contributor: fullname: Wang – volume: 15 start-page: 178 year: 2014 end-page: 196 ident: bib266 article-title: Molecular mechanisms of epithelial-mesenchymal transition publication-title: Nat Rev Mol Cell Biol contributor: fullname: Derynck – volume: 11 start-page: 791 year: 2006 end-page: 801 ident: bib34 article-title: Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion publication-title: Dev Cell contributor: fullname: Kurata – volume: 31 start-page: 2670 year: 2012 end-page: 2684 ident: bib2 article-title: Three decades of Wnts: a personal perspective on how a scientific field developed publication-title: Embo J contributor: fullname: Varmus – volume: 283 start-page: 21427 year: 2008 end-page: 21432 ident: bib92 article-title: DKK1 antagonizes Wnt signaling without promotion of LRP6 internalization and degradation publication-title: J Biol Chem contributor: fullname: He – volume: 51 start-page: 724 year: 2012 end-page: 731 ident: bib309 article-title: Structure-based discovery of a novel inhibitor targeting the beta-catenin/Tcf4 interaction publication-title: Biochemistry contributor: fullname: Yan – volume: 11 start-page: 301 year: 2006 end-page: 312 ident: bib139 article-title: Smad7-induced beta-catenin degradation alters epidermal appendage development publication-title: Dev Cell contributor: fullname: Liang – volume: 316 start-page: 1619 year: 2007 end-page: 1622 ident: bib48 article-title: Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation publication-title: Science contributor: fullname: Davidson – volume: 92 start-page: 2268 year: 1995 end-page: 2272 ident: bib116 article-title: Insertional mutagenesis identifies a member of the Wnt gene family as a candidate oncogene in the mammary epithelium of int-2/Fgf-3 transgenic mice publication-title: Proc Natl Acad Sci USA contributor: fullname: Kuo – volume: 1 start-page: 18 year: 2012 end-page: 28 ident: bib316 article-title: Wnt signaling orchestration with a small molecule DYRK inhibitor provides long-term xeno-free human pluripotent cell expansion publication-title: Stem Cells Transl Med contributor: fullname: Teo – volume: 9 start-page: 105 year: 2007 ident: bib160 article-title: Cooperation between Wnt and Notch signalling in human breast cancer publication-title: Breast Cancer Res contributor: fullname: Brennan – volume: 3 start-page: 531 year: 2003 end-page: 536 ident: bib122 article-title: Targeting the TGF beta signaling network in human neoplasia publication-title: Cancer Cell contributor: fullname: Arteaga – volume: 5 start-page: 1059 year: 2006 end-page: 1064 ident: bib115 article-title: Cross-talk of WNT and FGF signaling pathways at GSK3beta to regulate beta-catenin and SNAIL signaling cascades publication-title: Cancer Biol Ther contributor: fullname: Katoh – volume: 99 start-page: 335 year: 1999 end-page: 345 ident: bib53 article-title: PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs publication-title: Cell contributor: fullname: Vogelstein – volume: 158 start-page: 157 year: 2014 end-page: 170 ident: bib185 article-title: YAP/TAZ incorporation in the beta-catenin destruction complex orchestrates the Wnt response publication-title: Cell contributor: fullname: Soligo – volume: 108 start-page: 13253 year: 2011 end-page: 13257 ident: bib345 article-title: Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells publication-title: Proc Natl Acad Sci USA contributor: fullname: Yu – volume: 130 start-page: 1120 year: 2007 end-page: 1133 ident: bib177 article-title: Elucidation of a universal size-control mechanism in Drosophila and mammals publication-title: Cell contributor: fullname: Huang – volume: 23 start-page: 1405 year: 2014 end-page: 1416 ident: bib200 article-title: Bone morphogenetic protein-9 effectively induces osteo/odontoblastic differentiation of the reversibly immortalized stem cells of dental apical papilla publication-title: Stem Cells Dev contributor: fullname: Zhang – volume: 281 start-page: 10865 year: 2006 end-page: 10875 ident: bib329 article-title: Suppression of Wnt signaling by the green tea compound (-)-epigallocatechin 3-gallate (EGCG) in invasive breast cancer cells. Requirement of the transcriptional repressor HBP1 publication-title: J Biol Chem contributor: fullname: Rieger-Christ – volume: 102 start-page: 338 year: 2002 end-page: 342 ident: bib249 article-title: Cytoplasmic and/or nuclear accumulation of the beta-catenin protein is a frequent event in human osteosarcoma publication-title: Int J Cancer contributor: fullname: Ishikawa – volume: 127 start-page: 73 year: 2010 end-page: 81 ident: bib171 article-title: Hedgehog pathway activity is required for the lethality and intestinal phenotypes of mice with hyperactive Wnt signaling publication-title: Mech Dev contributor: fullname: Ruiz i Altaba – volume: 33 start-page: 2913 year: 2015 end-page: 2924 ident: bib270 article-title: LGR5 promotes breast cancer progression and maintains stem-like cells through activation of Wnt/beta-catenin signaling publication-title: Stem Cells contributor: fullname: Kong – volume: 63 start-page: 7345 year: 2003 end-page: 7355 ident: bib325 article-title: A selective small molecule inhibitor of c-Met kinase inhibits c-Met-dependent phenotypes publication-title: Cancer Res contributor: fullname: Burrows – volume: 11 start-page: 229 year: 2011 end-page: 240 ident: bib125 article-title: BMP-9 induced osteogenic differentiation of mesenchymal stem cells: molecular mechanism and therapeutic potential publication-title: Curr Gene Ther contributor: fullname: Zhu – volume: 222 start-page: 1 year: 2010 end-page: 15 ident: bib262 article-title: Current and emerging concepts in tumour metastasis publication-title: J Pathol contributor: fullname: Murray – volume: 9 start-page: 159 year: 2009 ident: bib47 article-title: Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression publication-title: BMC Cancer contributor: fullname: Waterman – volume: 75 start-page: 1341 year: 2015 end-page: 1353 ident: bib341 article-title: Niclosamide suppresses cell migration and invasion in enzalutamide resistant prostate cancer cells via Stat3-AR axis inhibition publication-title: Prostate contributor: fullname: Armstrong – volume: 13 start-page: 242 year: 2012 ident: bib84 article-title: The R-spondin protein family publication-title: Genome Biol contributor: fullname: Clevers – volume: 111 start-page: 251 year: 2002 end-page: 263 ident: bib215 article-title: Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB publication-title: Cell contributor: fullname: Beghtel – volume: 398 start-page: 422 year: 1999 end-page: 426 ident: bib55 article-title: Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells publication-title: Nature contributor: fullname: McCormick – volume: 411 start-page: 349 year: 2001 end-page: 354 ident: bib165 article-title: The Hedgehog and Wnt signalling pathways in cancer publication-title: Nature contributor: fullname: Beachy – volume: 6 start-page: 306 year: 2005 end-page: 317 ident: bib166 article-title: Communicating with Hedgehogs publication-title: Nat Rev Mol Cell Biol contributor: fullname: Scott – volume: 262 start-page: 1731 year: 1993 end-page: 1734 ident: bib15 article-title: Association of the APC gene product with beta-catenin publication-title: Science contributor: fullname: Albert – volume: 44 start-page: 15495 year: 2005 end-page: 15503 ident: bib293 article-title: Identification of a specific inhibitor of the dishevelled PDZ domain publication-title: Biochemistry contributor: fullname: Wang – volume: 15 start-page: 3059 year: 2001 end-page: 3087 ident: bib163 article-title: Hedgehog signaling in animal development: paradigms and principles publication-title: Genes Dev contributor: fullname: McMahon – volume: 6 start-page: 449 year: 2006 end-page: 458 ident: bib261 article-title: Metastasis: a question of life or death publication-title: Nat Rev Cancer contributor: fullname: Puisieux – volume: 108 start-page: 5954 year: 2011 end-page: 5963 ident: bib307 article-title: An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway publication-title: Proc Natl Acad Sci USA contributor: fullname: Carson – volume: 17 start-page: 9 year: 2009 end-page: 26 ident: bib20 article-title: Wnt/beta-catenin signaling: components, mechanisms, and diseases publication-title: Dev Cell contributor: fullname: He – volume: 398 start-page: 431 year: 1999 end-page: 436 ident: bib88 article-title: A new secreted protein that binds to Wnt proteins and inhibits their activities publication-title: Nature contributor: fullname: Rebbert – volume: 10 start-page: 55 year: 2004 end-page: 63 ident: bib191 article-title: Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor publication-title: Nat Med contributor: fullname: Skaltsounis – volume: 284 start-page: 16256 year: 2009 end-page: 16263 ident: bib295 article-title: Discovery and characterization of a small molecule inhibitor of the PDZ domain of dishevelled publication-title: J Biol Chem contributor: fullname: Zhang – volume: 109 start-page: 17942 year: 2012 end-page: 17947 ident: bib312 article-title: Inhibition of oncogenic Wnt signaling through direct targeting of beta-catenin publication-title: Proc Natl Acad Sci USA contributor: fullname: Bowman – volume: 137 start-page: 629 year: 2009 end-page: 638 ident: bib173 article-title: Reduced level of smoothened suppresses intestinal tumorigenesis by down-regulation of Wnt signaling publication-title: Gastroenterology contributor: fullname: Kitamura – volume: 5 start-page: 91 year: 2004 end-page: 102 ident: bib303 article-title: Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex publication-title: Cancer Cell contributor: fullname: France – volume: 71 start-page: 3553 year: 2014 end-page: 3567 ident: bib150 article-title: Wnt-Notch signalling cross-talk in development and disease publication-title: Cell Mol Life Sci contributor: fullname: Brennan – volume: 3 start-page: 493 year: 2008 end-page: 507 ident: bib193 article-title: Periodic activation of Wnt/beta-catenin signaling enhances somatic cell reprogramming mediated by cell fusion publication-title: Cell Stem Cell contributor: fullname: Pepe – volume: 111 start-page: 7337 year: 2014 end-page: 7342 ident: bib142 article-title: Smad1 transcription factor integrates BMP2 and Wnt3a signals in migrating cardiac progenitor cells publication-title: Proc Natl Acad Sci USA contributor: fullname: Camp – volume: 218 start-page: 183 year: 2000 end-page: 198 ident: bib87 article-title: Cloning and expression of the Wnt antagonists Sfrp-2 and Frzb during chick development publication-title: Dev Biol contributor: fullname: Allen – volume: 102 start-page: 11480 year: 2005 end-page: 11485 ident: bib223 article-title: Differential requirements for survivin in hematopoietic cell development publication-title: Proc Natl Acad Sci USA contributor: fullname: Keerthivasan – volume: 129 start-page: 626 year: 2005 end-page: 638 ident: bib211 article-title: Expression pattern of Wnt signaling components in the adult intestine publication-title: Gastroenterology contributor: fullname: Begthel – volume: 64 start-page: 60 year: 2006 end-page: 67 ident: bib308 article-title: Inhibition of protein-protein interactions: the discovery of druglike beta-catenin inhibitors by combining virtual and biophysical screening publication-title: Proteins contributor: fullname: Knapp – volume: 28 start-page: 2613 year: 2008 end-page: 2623 ident: bib327 article-title: Vitamin D and Wnt/beta-catenin pathway in colon cancer: role and regulation of DICKKOPF genes publication-title: Anticancer Res contributor: fullname: Pereira – volume: 13 start-page: 2448 year: 2009 end-page: 2464 ident: bib199 article-title: BMP-9-induced osteogenic differentiation of mesenchymal progenitors requires functional canonical Wnt/beta-catenin signalling publication-title: J Cell Mol Med contributor: fullname: Luo – volume: 2 start-page: a002915 year: 2010 ident: bib263 article-title: Interplay of cadherin-mediated cell adhesion and canonical Wnt signaling publication-title: Cold Spring Harb Perspect Biol contributor: fullname: Birchmeier – volume: 20 start-page: 3198 year: 2014 end-page: 3210 ident: bib342 article-title: Niclosamide inhibits androgen receptor variants expression and overcomes enzalutamide resistance in castration-resistant prostate cancer publication-title: Clin Cancer Res contributor: fullname: Zhu – volume: 25 start-page: 254 year: 2013 end-page: 264 ident: bib188 article-title: Wnt signaling in stem and cancer stem cells publication-title: Curr Opin Cell Biol contributor: fullname: Garratt – volume: 31 start-page: 344 year: 2015 end-page: 351 ident: bib210 article-title: Repairing organs: lessons from intestine and liver publication-title: Trends Genet contributor: fullname: Clevers – volume: 445 start-page: 834 year: 2007 end-page: 842 ident: bib227 article-title: Scratching the surface of skin development publication-title: Nature contributor: fullname: Fuchs – volume: 93 start-page: 7950 year: 1996 end-page: 7954 ident: bib280 article-title: Apoptosis and APC in colorectal tumorigenesis publication-title: Proc Natl Acad Sci USA contributor: fullname: Kinzler – volume: 90 start-page: 740 year: 1993 end-page: 744 ident: bib119 article-title: Mouse mammary tumor virus infection accelerates mammary carcinogenesis in Wnt-1 transgenic mice by insertional activation of int-2/Fgf-3 and hst/Fgf-4 publication-title: Proc Natl Acad Sci USA contributor: fullname: Kwan – volume: 118 start-page: 681 year: 1992 end-page: 691 ident: bib6 article-title: The vertebrate adhesive junction proteins beta-catenin and plakoglobin and the Drosophila segment polarity gene armadillo form a multigene family with similar properties publication-title: J Cell Biol contributor: fullname: Green – volume: 62 start-page: 2064 year: 2002 end-page: 2071 ident: bib100 article-title: Hepatocyte growth factor induces Wnt-independent nuclear translocation of beta-catenin after Met-beta-catenin dissociation in hepatocytes publication-title: Cancer Res contributor: fullname: Pediaditakis – volume: 49 start-page: 1935 year: 2009 end-page: 1943 ident: bib108 article-title: Overexpression of insulin receptor substrate-1 and hepatitis Bx genes causes premalignant alterations in the liver publication-title: Hepatology contributor: fullname: Kuzushita – volume: 62 start-page: 2744 year: 2002 end-page: 2748 ident: bib127 article-title: Oncogenic beta-catenin is required for bone morphogenetic protein 4 expression in human cancer cells publication-title: Cancer Res contributor: fullname: Dracheva – volume: 94 start-page: 6770 year: 1997 end-page: 6775 ident: bib85 article-title: Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action publication-title: Proc Natl Acad Sci USA contributor: fullname: Kelley – volume: 133 start-page: 4427 year: 2006 end-page: 4438 ident: bib162 article-title: Jagged 1 is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis publication-title: Development contributor: fullname: Lo Celso – volume: 382 start-page: 225 year: 1996 end-page: 230 ident: bib11 article-title: A new member of the frizzled family from Drosophila functions as a Wingless receptor publication-title: Nature contributor: fullname: Samos – volume: 20 start-page: 252 year: 2001 end-page: 259 ident: bib107 article-title: Insulin and IGF-1 stimulate the beta-catenin pathway through two signalling cascades involving GSK-3beta inhibition and Ras activation publication-title: Oncogene contributor: fullname: Blivet-Van Eggelpoel – volume: 162 start-page: 780 year: 2015 end-page: 794 ident: bib187 article-title: Alternative Wnt signaling activates YAP/TAZ publication-title: Cell contributor: fullname: Yu – volume: 152 start-page: 87 year: 2001 end-page: 96 ident: bib281 article-title: Wnt-1 signaling inhibits apoptosis by activating beta-catenin/T cell factor-mediated transcription publication-title: J Cell Biol contributor: fullname: You – volume: 27 start-page: 20 year: 2014 end-page: 29 ident: bib277 article-title: Targeting the beta-catenin nuclear transport pathway in cancer publication-title: Semin Cancer Biol contributor: fullname: Henderson – volume: 2 start-page: 8 year: 2002 ident: bib60 article-title: A transcriptional response to Wnt protein in human embryonic carcinoma cells. BMC publication-title: Dev Biol contributor: fullname: Pollack – volume: 263 start-page: 145 year: 2008 end-page: 156 ident: bib176 article-title: Cross-talk of hedgehog and Wnt pathways in gastric cancer publication-title: Cancer Lett contributor: fullname: Akiyoshi – volume: 256 start-page: 668 year: 1992 end-page: 670 ident: bib242 article-title: Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene publication-title: Science contributor: fullname: Vogelstein – volume: 13 start-page: 11 year: 2013 end-page: 26 ident: bib26 article-title: WNT signalling pathways as therapeutic targets in cancer publication-title: Nat Rev Cancer contributor: fullname: Moon – volume: 20 start-page: 427 year: 2011 end-page: 442 ident: bib74 article-title: FoxM1 promotes beta-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis publication-title: Cancer Cell contributor: fullname: Gong – volume: 10 start-page: 615 year: 2004 end-page: 625 ident: bib287 article-title: Membranous expression of secreted frizzled-related protein 4 predicts for good prognosis in localized prostate cancer and inhibits PC3 cellular proliferation publication-title: Clin Cancer Res contributor: fullname: Kench – volume: 36 start-page: 547 year: 2009 end-page: 559 ident: bib103 article-title: EGF-induced ERK activation promotes CK2-mediated disassociation of alpha-Catenin from beta-Catenin and transactivation of beta-Catenin publication-title: Mol Cell contributor: fullname: Nika – volume: 262 start-page: 1734 year: 1993 end-page: 1737 ident: bib16 article-title: Association of the APC tumor suppressor protein with catenins publication-title: Science contributor: fullname: Kinzler – volume: 42 start-page: 705 year: 2007 end-page: 710 ident: bib149 article-title: Cross-talk between Wnt and Notch signaling in intestinal epithelial cell fate decision publication-title: J Gastroenterol contributor: fullname: Watanabe – volume: 24 start-page: 3404 year: 2004 end-page: 3414 ident: bib68 article-title: Acetylation of beta-catenin by p300 regulates beta-catenin-Tcf4 interaction publication-title: Mol Cell Biol contributor: fullname: Labalette – volume: 24 start-page: 2291 year: 2012 end-page: 2296 ident: bib334 article-title: Silibinin inhibits Wnt/beta-catenin signaling by suppressing Wnt co-receptor LRP6 expression in human prostate and breast cancer cells publication-title: Cell Signal contributor: fullname: King – volume: 109 start-page: 47 year: 2002 end-page: 60 ident: bib51 article-title: Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex publication-title: Cell contributor: fullname: Brunner – volume: 97 start-page: 8358 year: 2000 end-page: 8363 ident: bib129 article-title: Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways publication-title: Proc Natl Acad Sci USA contributor: fullname: Attisano – volume: 109 start-page: 466 year: 2012 end-page: 471 ident: bib209 article-title: The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations publication-title: Proc Natl Acad Sci USA contributor: fullname: Li – volume: 98 start-page: 479 year: 2006 end-page: 490 ident: bib156 article-title: Growth suppression induced by Notch1 activation involves Wnt-beta-catenin down-regulation in human tongue carcinoma cells publication-title: Biol Cell contributor: fullname: Wu – volume: 201 start-page: 204 year: 2003 end-page: 212 ident: bib251 article-title: WIF1, a component of the Wnt pathway, is down-regulated in prostate, breast, lung, and bladder cancer publication-title: J Pathol contributor: fullname: Kaiser – volume: 3 start-page: 132 year: 2008 end-page: 135 ident: bib317 article-title: Wnt signaling promotes reprogramming of somatic cells to pluripotency publication-title: Cell Stem Cell contributor: fullname: Chevalier – volume: 32 start-page: 82 year: 2015 end-page: 96 ident: bib112 article-title: The endothelial transcription factor ERG promotes vascular stability and growth through Wnt/beta-catenin signaling publication-title: Dev Cell contributor: fullname: Dufton – volume: 40 start-page: 783 year: 2009 end-page: 794 ident: bib158 article-title: Histologic subtypes of hepatoblastoma are characterized by differential canonical Wnt and Notch pathway activation in DLK+ precursors publication-title: Hum Pathol contributor: fullname: Adesina – volume: 1 start-page: 87 year: 2014 end-page: 105 ident: bib124 article-title: Bone morphogenetic protein (BMP) signaling in development and human diseases publication-title: Genes Dis contributor: fullname: Wang – volume: 2001 start-page: pe31 year: 2001 ident: bib164 article-title: Fat hedgehogs, slower or richer? publication-title: Sci STKE contributor: fullname: van Den Heuvel – volume: 6 start-page: 829 year: 2010 end-page: 836 ident: bib336 article-title: Small-molecule inhibition of Wnt signaling through activation of casein kinase 1alpha publication-title: Nat Chem Biol contributor: fullname: Schneider – volume: 33 start-page: 2169 year: 2014 end-page: 2178 ident: bib319 article-title: Small-molecule inhibition of CBP/catenin interactions eliminates drug-resistant clones in acute lymphoblastic leukemia publication-title: Oncogene contributor: fullname: Pham – volume: 283 start-page: 23371 year: 2008 end-page: 23375 ident: bib93 article-title: Characterization of the Kremen-binding site on Dkk1 and elucidation of the role of Kremen in Dkk-mediated Wnt antagonism publication-title: J Biol Chem contributor: fullname: Li – volume: 280 start-page: 1036 year: 1998 end-page: 1037 ident: bib240 article-title: Landscaping the cancer terrain publication-title: Science contributor: fullname: Vogelstein – volume: 283 start-page: 12686 year: 2008 end-page: 12690 ident: bib120 article-title: HDAC6 is required for epidermal growth factor-induced beta-catenin nuclear localization publication-title: J Biol Chem contributor: fullname: Polakiewicz – volume: 11 start-page: 33 year: 2015 end-page: 42 ident: bib216 article-title: Opposing activities of Notch and Wnt signaling regulate intestinal stem cells and gut homeostasis publication-title: Cell Rep contributor: fullname: Chiu – volume: 71 start-page: 4172 year: 2011 end-page: 4182 ident: bib339 article-title: Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations publication-title: Cancer Res contributor: fullname: Yang – volume: 4 start-page: 38 year: 2012 end-page: 51 ident: bib253 article-title: The Wnt secretion protein Evi/Gpr177 promotes glioma tumourigenesis publication-title: EMBO Mol Med contributor: fullname: Bongers – volume: 22 start-page: 233 year: 2004 end-page: 241 ident: bib121 article-title: Bone morphogenetic proteins publication-title: Growth Factors contributor: fullname: Mundy – volume: 289 start-page: 195 year: 2010 end-page: 207 ident: bib155 article-title: MSX1 induces the Wnt pathway antagonist genes DKK1, DKK2, DKK3, and SFRP1 in neuroblastoma cells, but does not block Wnt3 and Wnt5A signalling to DVL3 publication-title: Cancer Lett contributor: fullname: Koster – volume: 98 start-page: 2091 year: 2001 end-page: 2100 ident: bib222 article-title: Regulation of the inhibitor-of-apoptosis family member survivin in normal cord blood and bone marrow CD34(+) cells by hematopoietic growth factors: implication of survivin expression in normal hematopoiesis publication-title: Blood contributor: fullname: Pelus – volume: 19 start-page: 1749 year: 2004 end-page: 1757 ident: bib97 article-title: LRP5 and Wnt signaling: a union made for bone publication-title: J Bone Miner Res contributor: fullname: Nusse – volume: 8 start-page: 739 year: 2005 end-page: 750 ident: bib196 article-title: Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis publication-title: Dev Cell contributor: fullname: Garrett-Beal – volume: 33 start-page: 416 year: 2003 end-page: 421 ident: bib154 article-title: Notch1 functions as a tumor suppressor in mouse skin publication-title: Nat Genet contributor: fullname: Raj – volume: 31 start-page: 2737 year: 2012 end-page: 2746 ident: bib276 article-title: Drugging Wnt signalling in cancer publication-title: Embo J contributor: fullname: Polakis – volume: 4 start-page: 148ra117 year: 2012 ident: bib311 article-title: Targeted disruption of the BCL9/beta-catenin complex inhibits oncogenic Wnt signaling publication-title: Sci Transl Med contributor: fullname: Bird – volume: 16 start-page: 633 year: 2009 end-page: 647 ident: bib145 article-title: Notch signaling: the core pathway and its posttranslational regulation publication-title: Dev Cell contributor: fullname: Fortini – volume: 28 start-page: 2701 year: 2008 end-page: 2704 ident: bib271 article-title: Promotion of the self-renewal capacity of human acute leukemia cells by Wnt3A publication-title: Anticancer Res contributor: fullname: Nara – volume: 8 start-page: e56644 year: 2013 ident: bib254 article-title: Gpr177 deficiency impairs mammary development and prohibits Wnt-induced tumorigenesis publication-title: PLoS One contributor: fullname: Jiang – volume: 367 start-page: 80 year: 1994 end-page: 83 ident: bib5 article-title: Dishevelled and armadillo act in the wingless signalling pathway in Drosophila publication-title: Nature contributor: fullname: Perrimon – volume: 14 start-page: 1087 year: 2015 end-page: 1094 ident: bib279 article-title: Targeting Wnts at the source—new mechanisms, new biomarkers, new drugs publication-title: Mol Cancer Ther contributor: fullname: Virshup – volume: 67 start-page: 5371 year: 2007 end-page: 5379 ident: bib289 article-title: The soluble wnt receptor Frizzled8CRD-hFc inhibits the growth of teratocarcinomas publication-title: Cancer Res contributor: fullname: Ernst – volume: 434 start-page: 843 year: 2005 end-page: 850 ident: bib18 article-title: Wnt signalling in stem cells and cancer publication-title: Nature contributor: fullname: Clevers – volume: 26 start-page: 1078 year: 2007 end-page: 1087 ident: bib102 article-title: A positive feedback loop between hepatocyte growth factor receptor and beta-catenin sustains colorectal cancer cell invasive growth publication-title: Oncogene contributor: fullname: De Bacco – volume: 24 start-page: 245 year: 2000 end-page: 250 ident: bib244 article-title: AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1 publication-title: Nat Genet contributor: fullname: Furukawa – volume: 4 start-page: 14 year: 2011 end-page: 25 ident: bib22 article-title: The therapeutic potential of the Wnt signaling pathway in bone disorders publication-title: Curr Mol Pharmacol contributor: fullname: Zhang – volume: 417 start-page: 664 year: 2002 end-page: 667 ident: bib90 article-title: Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling publication-title: Nature contributor: fullname: Davidson – volume: 151 start-page: 1457 year: 2012 end-page: 1473 ident: bib260 article-title: beta-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis publication-title: Cell contributor: fullname: Cox – volume: 126 start-page: 4557 year: 1999 end-page: 4568 ident: bib229 article-title: Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation publication-title: Development contributor: fullname: Fuchs – volume: 39 start-page: 145 year: 2015 end-page: 154 ident: bib201 article-title: Canonical Wnt signaling acts synergistically on BMP9-induced osteo/odontoblastic differentiation of stem cells of dental apical papilla (SCAPs) publication-title: Biomaterials contributor: fullname: Deng – volume: 6 start-page: 314 year: 2005 end-page: 322 ident: bib147 article-title: Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance publication-title: Nat Immunol contributor: fullname: DiMascio – volume: 58 start-page: 2524 year: 1998 end-page: 2527 ident: bib243 article-title: Activation of the beta-catenin gene in primary hepatocellular carcinomas by somatic alterations involving exon 3 publication-title: Cancer Res contributor: fullname: Nagasawa – volume: 72 start-page: 2822 year: 2012 end-page: 2832 ident: bib298 article-title: A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice publication-title: Cancer Res contributor: fullname: Tumova – volume: 243 start-page: 1095 year: 2014 end-page: 1105 ident: bib44 article-title: Concentration-dependent effects of WNTLESS on WNT1/3A signaling publication-title: Dev Dyn contributor: fullname: Li – volume: 401 start-page: 969 year: 2010 end-page: 984 ident: bib71 article-title: Allosteric remodelling of the histone H3 binding pocket in the Pygo2 PHD finger triggered by its binding to the B9L/BCL9 co-factor publication-title: J Mol Biol contributor: fullname: Johnson – volume: 40 start-page: 1533 year: 2012 end-page: 1542 ident: bib292 article-title: Change in gene expression profiles of secreted frizzled-related proteins (SFRPs) by sodium butyrate in gastric cancers: induction of promoter demethylation and histone modification causing inhibition of Wnt signaling publication-title: Int J Oncol contributor: fullname: Lee – volume: 19 start-page: 683 year: 2009 end-page: 697 ident: bib272 article-title: WNT signaling regulates self-renewal and differentiation of prostate cancer cells with stem cell characteristics publication-title: Cell Res contributor: fullname: Prowse – volume: 336 start-page: 1549 year: 2012 end-page: 1554 ident: bib250 article-title: Wnt/beta-catenin signaling regulates telomerase in stem cells and cancer cells publication-title: Science contributor: fullname: Rudloff – volume: 423 start-page: 409 year: 2003 end-page: 414 ident: bib221 article-title: A role for Wnt signalling in self-renewal of haematopoietic stem cells publication-title: Nature contributor: fullname: Ailles – volume: 141 start-page: 2206 year: 2014 end-page: 2215 ident: bib302 article-title: Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts publication-title: Development contributor: fullname: Madan – volume: 10 start-page: 393 year: 2004 end-page: 401 ident: bib206 article-title: Effects of Wnt signaling on proliferation and differentiation of human mesenchymal stem cells publication-title: Tissue Eng contributor: fullname: Van Blitterswijk – volume: 87 start-page: 97 year: 2007 end-page: 103 ident: bib21 article-title: Wnt signaling and human diseases: what are the therapeutic implications? publication-title: Lab Invest contributor: fullname: Deng – volume: 403 start-page: 781 year: 2000 end-page: 785 ident: bib130 article-title: Interaction between Wnt and TGF-beta signalling pathways during formation of Spemann's organizer publication-title: Nature contributor: fullname: Ogata – volume: 25 start-page: 1475 year: 2005 end-page: 1488 ident: bib140 article-title: Interaction between Smad7 and beta-catenin: importance for transforming growth factor beta-induced apoptosis publication-title: Mol Cell Biol contributor: fullname: Grimsby – volume: 49 start-page: 474 year: 2013 end-page: 486 ident: bib69 article-title: Glucose-induced beta-catenin acetylation enhances Wnt signaling in cancer publication-title: Mol Cell contributor: fullname: Ardila-Gonzalez – volume: 303 start-page: 848 year: 2004 end-page: 851 ident: bib137 article-title: TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia publication-title: Science contributor: fullname: Plieth – volume: 126 start-page: 2426 year: 2010 end-page: 2436 ident: bib304 article-title: Small molecule antagonists of Tcf4/beta-catenin complex inhibit the growth of HCC cells publication-title: Int J Cancer contributor: fullname: Grepper – volume: 2 start-page: 67 year: 2010 end-page: 80 ident: bib195 article-title: Mesenchymal stem cells: Molecular characteristics and clinical applications. World J publication-title: Stem Cells contributor: fullname: Huang – volume: 253 start-page: 665 year: 1991 end-page: 669 ident: bib14 article-title: Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients publication-title: Science contributor: fullname: Miyoshi – volume: 36 start-page: 313 year: 2000 end-page: 325 ident: bib101 article-title: c-met tyrosine kinase receptor expression is associated with abnormal beta-catenin expression and favourable prognostic factors in invasive breast carcinoma publication-title: Histopathology contributor: fullname: Keramopoulos – volume: 317 start-page: 745 year: 2011 end-page: 756 ident: bib203 article-title: Wnt signalling mediates the cross-talk between bone marrow derived pre-adipocytic and pre-osteoblastic cell populations publication-title: Exp Cell Res contributor: fullname: AlDahmash – volume: 40 start-page: 1130 year: 2008 end-page: 1135 ident: bib168 article-title: Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/beta3-catenin signaling publication-title: Nat Genet contributor: fullname: Grachtchouk – volume: 134 start-page: 112 year: 2014 end-page: 120 ident: bib340 article-title: Inhibition of Wnt/beta-catenin pathway by niclosamide: a therapeutic target for ovarian cancer publication-title: Gynecol Oncol contributor: fullname: Samant – volume: 154 start-page: 274 year: 2013 end-page: 284 ident: bib207 article-title: The intestinal crypt, a prototype stem cell compartment publication-title: Cell contributor: fullname: Clevers – volume: 240 start-page: 365 year: 2011 end-page: 371 ident: bib43 article-title: Gpr177/mouse Wntless is essential for Wnt-mediated craniofacial and brain development publication-title: Dev Dyn contributor: fullname: Maruyama – volume: 26 start-page: 2955 year: 2006 end-page: 2964 ident: bib198 article-title: CCN1/Cyr61 is regulated by the canonical Wnt signal and plays an important role in Wnt3A-induced osteoblast differentiation of mesenchymal stem cells publication-title: Mol Cell Biol contributor: fullname: Luu – volume: 328 start-page: 227 year: 2005 end-page: 234 ident: bib330 article-title: Quercetin, a potent inhibitor against beta-catenin/Tcf signaling in SW480 colon cancer cells publication-title: Biochem Biophys Res Commun contributor: fullname: Hahm – volume: 13 start-page: 812 year: 2014 end-page: 822 ident: bib346 article-title: Monensin inhibits canonical Wnt signaling in human colorectal cancer cells and suppresses tumor growth in multiple intestinal neoplasia mice publication-title: Mol Cancer Ther contributor: fullname: Vojtechova – volume: 291 start-page: 21 year: 2011 end-page: 71 ident: bib61 article-title: New insights into the mechanism of Wnt signaling pathway activation publication-title: Int Rev Cell Mol Biol contributor: fullname: Sato – volume: 82 start-page: 165 year: 2009 end-page: 175 ident: bib305 article-title: Small molecule inhibitors of WNT signaling effectively induce apoptosis in acute myeloid leukemia cells publication-title: Eur J Haematol contributor: fullname: Puetter – volume: 21 start-page: 8414 year: 2002 end-page: 8427 ident: bib328 article-title: Beta-catenin-mediated transactivation and cell-cell adhesion pathways are important in curcumin (diferuylmethane)-induced growth arrest and apoptosis in colon cancer cells publication-title: Oncogene contributor: fullname: Gupta – volume: 15 start-page: 726 year: 2015 end-page: 738 ident: bib344 article-title: The anthelmintic drug niclosamide inhibits the proliferative activity of human osteosarcoma cells by targeting multiple signal pathways publication-title: Curr Cancer Drug Targets contributor: fullname: Yan – volume: 5 start-page: eg2 year: 2012 ident: bib24 article-title: Focus issue: Wnt and beta-catenin signaling in development and disease publication-title: Sci Signal contributor: fullname: Gough – volume: 1 start-page: 467 year: 2005 end-page: 472 ident: bib314 article-title: ICG-001, a novel small molecule regulator of TCF/beta-catenin transcription publication-title: Med Chem contributor: fullname: Lee – volume: 281 start-page: 1509 year: 1998 end-page: 1512 ident: bib54 article-title: Identification of c-MYC as a target of the APC pathway publication-title: Science contributor: fullname: Rago – volume: 132 start-page: 215 year: 2005 end-page: 225 ident: bib136 article-title: Smad1, beta-catenin and Tcf4 associate in a molecular complex with the Myc promoter in dysplastic renal tissue and cooperate to control Myc transcription publication-title: Development contributor: fullname: Rosenblum – volume: 1 start-page: 127 year: 2014 end-page: 128 ident: bib181 article-title: Wnt Hippo: A balanced act or dynamic duo? publication-title: Genes Dis contributor: fullname: Deng – volume: 123 start-page: 1588 year: 2010 end-page: 1599 ident: bib50 article-title: Stability elements in the LRP6 cytoplasmic tail confer efficient signalling upon DIX-dependent polymerization publication-title: J Cell Sci contributor: fullname: Mieszczanek – volume: 126 start-page: 752 year: 2009 end-page: 759 ident: bib70 article-title: The PHD domain is required to link Drosophila Pygopus to Legless/beta-catenin and not to histone H3 publication-title: Mech Dev contributor: fullname: Basler – volume: 488 start-page: 665 year: 2012 end-page: 669 ident: bib83 article-title: Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors publication-title: Nature contributor: fullname: Jordens – volume: 461 start-page: 614 year: 2009 end-page: 620 ident: bib296 article-title: Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling publication-title: Nature contributor: fullname: Liu – volume: 391 start-page: 357 year: 1998 end-page: 362 ident: bib89 article-title: Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction publication-title: Nature contributor: fullname: Delius – volume: 12 start-page: 468 year: 2010 end-page: 476 ident: bib265 article-title: Wnt activity defines colon cancer stem cells and is regulated by the microenvironment publication-title: Nat Cell Biol contributor: fullname: van der Heijden – volume: 2 start-page: 26 year: 2015 end-page: 34 ident: bib264 article-title: Targeting matrix metalloproteinases in cancer: bringing new life to old ideas publication-title: Genes Dis contributor: fullname: Cao – volume: 278 start-page: 48805 year: 2003 end-page: 48814 ident: bib132 article-title: Smad4 and beta-catenin co-activators functionally interact with lymphoid-enhancing factor to regulate graded expression of Msx2 publication-title: J Biol Chem contributor: fullname: Sirard – volume: 478 start-page: 255 year: 2011 end-page: 259 ident: bib208 article-title: A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable publication-title: Nature contributor: fullname: Warming – volume: 104 start-page: 5668 year: 2007 end-page: 5673 ident: bib315 article-title: Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency publication-title: Proc Natl Acad Sci USA contributor: fullname: Yamamoto – volume: 28 start-page: 428 year: 2015 end-page: 436 ident: bib258 article-title: Analysis of wntless (WLS) expression in gastric, ovarian, and breast cancers reveals a strong association with HER2 overexpression publication-title: Mod Pathol contributor: fullname: McCluggage – volume: 19 start-page: 391 year: 2005 end-page: 398 ident: bib111 article-title: Beta-catenin is involved in insulin-like growth factor 1-mediated transactivation of the androgen receptor publication-title: Mol Endocrinol contributor: fullname: Sun – volume: 118 start-page: 2420 year: 2011 end-page: 2429 ident: bib220 article-title: Wnt-inhibitory factor 1 dysregulation of the bone marrow niche exhausts hematopoietic stem cells publication-title: Blood contributor: fullname: Qiu – volume: 1 start-page: e43 year: 2011 ident: bib310 article-title: AV-65, a novel Wnt/beta-catenin signal inhibitor, successfully suppresses progression of multiple myeloma in a mouse model publication-title: Blood Cancer J contributor: fullname: Strovel – volume: 280 start-page: 26770 year: 2005 end-page: 26775 ident: bib96 article-title: SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor publication-title: J Biol Chem contributor: fullname: He – volume: 17 start-page: 45 year: 2007 end-page: 51 ident: bib245 article-title: The many ways of Wnt in cancer publication-title: Curr Opin Genet Dev contributor: fullname: Polakis – volume: 22 start-page: 839 year: 2009 end-page: 847 ident: bib169 article-title: Aberrant activation of hedgehog signaling pathway contributes to endometrial carcinogenesis through beta-catenin publication-title: Mod Pathol contributor: fullname: Au – volume: 26 start-page: 2284 year: 2007 end-page: 2294 ident: bib52 article-title: CBP/p300 are bimodal regulators of Wnt signaling publication-title: EMBO J contributor: fullname: Parker – volume: 106 start-page: 18598 year: 2009 end-page: 18603 ident: bib36 article-title: Reciprocal regulation of Wnt and Gpr177/mouse Wntless is required for embryonic axis formation publication-title: Proc Natl Acad Sci USA contributor: fullname: Mirando – volume: 275 start-page: 1784 year: 1997 end-page: 1787 ident: bib237 article-title: Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma publication-title: Science contributor: fullname: Morin – volume: 106 start-page: 6309 year: 2009 end-page: 6314 ident: bib157 article-title: Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine publication-title: Proc Natl Acad Sci USA contributor: fullname: Huyghe – volume: 103 start-page: 3799 year: 2006 end-page: 3804 ident: bib161 article-title: Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism publication-title: Proc Natl Acad Sci USA contributor: fullname: Ciarloni – volume: 87 start-page: 159 year: 1996 end-page: 170 ident: bib239 article-title: Lessons from hereditary colorectal cancer publication-title: Cell contributor: fullname: Vogelstein – volume: 2 start-page: 572 year: 2015 end-page: 575 ident: bib273 article-title: Targeting CD44 as a novel therapeutic approach for treating pancreatic cancer recurrence publication-title: Oncoscience contributor: fullname: Moutardier – volume: 5 start-page: 23 year: 2006 end-page: 26 ident: bib75 article-title: R-Spondin proteins: a novel link to beta-catenin activation publication-title: Cell Cycle contributor: fullname: Andarmani – volume: 32 start-page: 707 year: 2015 end-page: 718 ident: bib64 article-title: FOXKs promote Wnt/beta-catenin signaling by translocating DVL into the nucleus publication-title: Dev Cell contributor: fullname: Lee – volume: 102 start-page: 12171 year: 2005 end-page: 12176 ident: bib65 article-title: Specific inhibition of CBP/beta-catenin interaction rescues defects in neuronal differentiation caused by a presenilin-1 mutation publication-title: Proc Natl Acad Sci USA contributor: fullname: Nguyen – volume: 26 start-page: 951 year: 2014 end-page: 958 ident: bib72 article-title: Canonical Wnt signaling skews TGF-beta signaling in chondrocytes towards signaling via ALK1 and Smad 1/5/8 publication-title: Cell Signal contributor: fullname: van Lent – volume: 10 start-page: 16 year: 2011 ident: bib290 article-title: Soluble Frizzled-7 receptor inhibits Wnt signaling and sensitizes hepatocellular carcinoma cells towards doxorubicin publication-title: Mol Cancer contributor: fullname: Grepper – volume: 121 start-page: 1587 year: 2008 end-page: 1592 ident: bib30 article-title: role of lipid adducts on Wingless publication-title: J Cell Sci contributor: fullname: Griffith – volume: 137 start-page: 422 year: 2009 end-page: 424 ident: bib172 article-title: New insights into the role of Hedgehog signaling in gastrointestinal development and cancer publication-title: Gastroenterology contributor: fullname: Choi – volume: 134 start-page: 43 year: 2014 end-page: 54 ident: bib320 article-title: Cancer cells acquire a drug resistant, highly tumorigenic, cancer stem-like phenotype through modulation of the PI3K/Akt/beta-catenin/CBP pathway publication-title: Int J Cancer contributor: fullname: Xu – volume: 105 start-page: 533 year: 2001 end-page: 545 ident: bib230 article-title: beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin publication-title: Cell contributor: fullname: Erdmann – volume: 20 start-page: 781 year: 2004 end-page: 810 ident: bib17 article-title: The Wnt signaling pathway in development and disease publication-title: Annu Rev Cell Dev Biol contributor: fullname: Nusse – volume: 20 start-page: 645 year: 2001 end-page: 653 ident: bib323 article-title: The nonsteroidal anti-inflammatory drugs aspirin and indomethacin attenuate beta-catenin/TCF-4 signaling publication-title: Oncogene contributor: fullname: von Knebel Doeberitz – volume: 280 start-page: 3576 year: 2013 end-page: 3593 ident: bib300 article-title: Tankyrases as drug targets publication-title: FEBS J contributor: fullname: Krauss – volume: 136 start-page: 903 year: 2009 end-page: 912 ident: bib214 article-title: Transcription factor achaete scute-like 2 controls intestinal stem cell fate publication-title: Cell contributor: fullname: Hatzis – volume: 110 start-page: 20224 year: 2013 end-page: 20229 ident: bib301 article-title: Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974 publication-title: Proc Natl Acad Sci USA contributor: fullname: Hsieh – volume: 25 start-page: 111 year: 2000 end-page: 112 ident: bib32 article-title: A superfamily of membrane-bound O-acyltransferases with implications for wnt signaling publication-title: Trends Biochem Sci contributor: fullname: Hofmann – volume: 2 start-page: 133 year: 2015 end-page: 143 ident: bib247 article-title: Pancreatic cancer stromal biology and therapy publication-title: Genes Dis contributor: fullname: Xie – volume: 2 start-page: 60 year: 2008 end-page: 71 ident: bib217 article-title: Wnt, activin, and BMP signaling regulate distinct stages in the developmental pathway from embryonic stem cells to blood publication-title: Cell Stem Cell contributor: fullname: Keller – volume: 239 start-page: 16 year: 2010 end-page: 33 ident: bib143 article-title: Cross-talk between Wnt and bone morphogenic protein signaling: a turbulent relationship publication-title: Dev Dyn contributor: fullname: Hoppler – volume: 22 start-page: 1184 year: 2002 end-page: 1193 ident: bib58 article-title: Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors publication-title: Mol Cell Biol contributor: fullname: Sachs – volume: 71 start-page: 119 year: 1998 end-page: 129 ident: bib128 article-title: BMP-2/-4 and Wnt-8 cooperatively pattern the Xenopus mesoderm publication-title: Mech Dev contributor: fullname: Moon – volume: 110 start-page: 1351 year: 2013 end-page: 1356 ident: bib234 article-title: Competitive balance of intrabulge BMP/Wnt signaling reveals a robust gene network ruling stem cell homeostasis and cyclic activation publication-title: Proc Natl Acad Sci USA contributor: fullname: Chen – volume: 36 start-page: 664 year: 2000 end-page: 674 ident: bib322 article-title: The effect of non-steroidal anti-inflammatory drugs on human colorectal cancer cells: evidence of different mechanisms of action publication-title: Eur J Cancer contributor: fullname: Hull – volume: 113 start-page: 546 year: 2009 end-page: 554 ident: bib218 article-title: Wnt3a deficiency irreversibly impairs hematopoietic stem cell self-renewal and leads to defects in progenitor cell differentiation publication-title: Blood contributor: fullname: Naber – volume: 337 start-page: 59 year: 2012 end-page: 64 ident: bib29 article-title: Structural basis of Wnt recognition by Frizzled publication-title: Science contributor: fullname: Levin – volume: 73 start-page: 3132 year: 2013 end-page: 3144 ident: bib299 article-title: A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth publication-title: Cancer Res contributor: fullname: Callow – volume: 96 start-page: 5522 year: 1999 end-page: 5527 ident: bib56 article-title: The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway publication-title: Proc Natl Acad Sci USA contributor: fullname: Simcha – volume: 367 start-page: 76 year: 1994 end-page: 80 ident: bib8 article-title: Components of wingless signalling in Drosophila publication-title: Nature contributor: fullname: Perrimon – volume: 213 start-page: 152 year: 2007 end-page: 160 ident: bib274 article-title: CD44-positive colorectal adenoma cells express the potential stem cell markers musashi antigen (msi1) and ephrin B2 receptor (EphB2) publication-title: J Pathol contributor: fullname: Herbacek – volume: 32 start-page: 886 year: 2014 end-page: 901 ident: bib235 article-title: Wnt7b is an important intrinsic regulator of hair follicle stem cell homeostasis and hair follicle cycling publication-title: Stem Cells contributor: fullname: Kobielak – volume: 3 start-page: 1011 year: 2004 end-page: 1022 ident: bib123 article-title: Development of TGF-beta signalling inhibitors for cancer therapy publication-title: Nat Rev Drug Discov contributor: fullname: Sawyer – volume: 327 start-page: 542 year: 2010 end-page: 545 ident: bib212 article-title: Coexistence of quiescent and active adult stem cells in mammals publication-title: Science contributor: fullname: Clevers – volume: 7 start-page: 525 year: 2004 end-page: 534 ident: bib77 article-title: R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis publication-title: Dev Cell contributor: fullname: del Barco Barrantes – volume: 116 start-page: 2627 year: 2003 end-page: 2634 ident: bib86 article-title: Secreted antagonists of the Wnt signalling pathway publication-title: J Cell Sci contributor: fullname: Kypta – volume: 149 start-page: 261 year: 2008 end-page: 267 ident: bib109 article-title: Insulin receptor substrate-1 deficiency promotes apoptosis in the putative intestinal crypt stem cell region, limits Apcmin/+ tumors, and regulates Sox9 publication-title: Endocrinology contributor: fullname: Magness – volume: 194 start-page: 157 year: 1993 end-page: 165 ident: bib114 article-title: Activation of both Wnt-1 and Fgf-3 by insertion of mouse mammary tumor virus downstream in the reverse orientation: a reappraisal of the enhancer insertion model publication-title: Virology contributor: fullname: Moore – volume: 285 start-page: 1928 year: 2010 end-page: 1938 ident: bib106 article-title: IRS1 regulation by Wnt/beta-catenin signaling and varied contribution of IRS1 to the neoplastic phenotype publication-title: J Biol Chem contributor: fullname: Iura – volume: 65 start-page: 10423 year: 2005 end-page: 10430 ident: bib288 article-title: Identification of SFRP1 as a candidate mediator of stromal-to-epithelial signaling in prostate cancer publication-title: Cancer Res contributor: fullname: Elenbaas – volume: 50 start-page: 649 year: 1987 end-page: 657 ident: bib4 article-title: The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless publication-title: Cell contributor: fullname: Wagenaar – volume: 476 start-page: 293 year: 2011 end-page: 297 ident: bib81 article-title: Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling publication-title: Nature contributor: fullname: Low – volume: 485 start-page: 195 year: 2012 end-page: 200 ident: bib82 article-title: ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner publication-title: Nature contributor: fullname: Zhang – volume: 47 start-page: 471 year: 2005 end-page: 482 ident: bib135 article-title: Regulation of Slug transcription in embryonic ectoderm by beta-catenin-Lef/Tcf and BMP-Smad signaling publication-title: Dev Growth Differ contributor: fullname: Endo – volume: 287 start-page: 795 year: 1980 end-page: 801 ident: bib3 article-title: Mutations affecting segment number and polarity in Drosophila publication-title: Nature contributor: fullname: Wieschaus – volume: 35 start-page: 2357 year: 2014 end-page: 2364 ident: bib257 article-title: Wntless (GPR177) expression correlates with poor prognosis in B-cell precursor acute lymphoblastic leukemia via Wnt signaling publication-title: Carcinogenesis contributor: fullname: Huang – volume: 2 start-page: e1155 year: 2007 ident: bib174 article-title: Common activation of canonical Wnt signaling in pancreatic adenocarcinoma publication-title: PLoS One contributor: fullname: Heiser – volume: 22 start-page: 339 year: 2012 end-page: 346 ident: bib182 article-title: The Hippo signaling pathway and stem cell biology publication-title: Trends Cell Biol contributor: fullname: Camargo – volume: 32 start-page: 1977 year: 2013 end-page: 1989 ident: bib318 article-title: Wnt/beta-catenin signalling induces MLL to create epigenetic changes in salivary gland tumours publication-title: EMBO J contributor: fullname: Zhu – volume: 275 start-page: 1787 year: 1997 end-page: 1790 ident: bib238 article-title: Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC publication-title: Science contributor: fullname: Korinek – volume: 4 start-page: 2610 year: 2013 ident: bib255 article-title: Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells publication-title: Nat Commun contributor: fullname: Dubash – volume: 31 start-page: 99 year: 1982 end-page: 109 ident: bib1 article-title: Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome publication-title: Cell contributor: fullname: Varmus – volume: 407 start-page: 527 year: 2000 end-page: 530 ident: bib12 article-title: Arrow encodes an LDL-receptor-related protein essential for Wingless signalling publication-title: Nature contributor: fullname: Caldwell – volume: 471 start-page: 235 year: 2011 end-page: 239 ident: bib259 article-title: CREBBP mutations in relapsed acute lymphoblastic leukaemia publication-title: Nature contributor: fullname: Kasper – volume: 61 start-page: 7318 year: 2001 end-page: 7324 ident: bib110 article-title: Insulin-like growth factor-1 induces survival and growth of biologically early melanoma cells through both the mitogen-activated protein kinase and beta-catenin pathways publication-title: Cancer Res contributor: fullname: Vaidya – volume: 138 start-page: 51 year: 2009 end-page: 62 ident: bib268 article-title: WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis publication-title: Cell contributor: fullname: Zhang – volume: 131 start-page: 3751 year: 2004 end-page: 3760 ident: bib131 article-title: Combinatorial gene regulation by Bmp and Wnt in zebrafish posterior mesoderm formation publication-title: Development contributor: fullname: Kimelman – volume: 67 start-page: 573 year: 2007 end-page: 579 ident: bib294 article-title: An antagonist of dishevelled protein-protein interaction suppresses beta-catenin-dependent tumor cell growth publication-title: Cancer Res contributor: fullname: Xu – volume: 115 start-page: 4689 year: 2010 end-page: 4698 ident: bib226 article-title: Canonical BMP signaling is dispensable for hematopoietic stem cell function in both adult and fetal liver hematopoiesis, but essential to preserve colon architecture publication-title: Blood contributor: fullname: Ehinger – volume: 11 start-page: 1265 year: 2010 end-page: 1271 ident: bib37 article-title: Wnt trafficking: new insights into Wnt maturation, secretion and spreading publication-title: Traffic contributor: fullname: Basler – volume: 8 start-page: 387 year: 2008 end-page: 398 ident: bib19 article-title: Wnt signalling and its impact on development and cancer publication-title: Nat Rev Cancer contributor: fullname: Birchmeier – volume: 5 start-page: 53 year: 2005 ident: bib283 article-title: Efficacy of Wnt-1 monoclonal antibody in sarcoma cells publication-title: BMC Cancer contributor: fullname: He – volume: 44 start-page: 992 year: 2006 end-page: 1002 ident: bib99 article-title: Activation of Wnt/beta-catenin pathway during hepatocyte growth factor-induced hepatomegaly in mice publication-title: Hepatology contributor: fullname: Muller – volume: 4 start-page: 513 year: 2009 end-page: 524 ident: bib189 article-title: Metastable pluripotent states in NOD-mouse-derived ESCs publication-title: Cell Stem Cell contributor: fullname: Mitalipova – volume: 71 start-page: 1167 year: 1992 end-page: 1179 ident: bib7 article-title: wingless signaling acts through zeste-white 3, the Drosophila homolog of glycogen synthase kinase-3, to regulate engrailed and establish cell fate publication-title: Cell contributor: fullname: Perrimon – volume: 109 start-page: E2197 year: 2012 end-page: E2204 ident: bib41 article-title: Wntless functions in mature osteoblasts to regulate bone mass publication-title: Proc Natl Acad Sci USA contributor: fullname: Schumacher – volume: 7 start-page: re8 year: 2014 ident: bib267 article-title: Signaling mechanisms of the epithelial-mesenchymal transition publication-title: Sci Signal contributor: fullname: Medici – volume: 19 start-page: 4980 year: 2009 end-page: 4983 ident: bib306 article-title: 2,4-Diamino-quinazolines as inhibitors of beta-catenin/Tcf-4 pathway: Potential treatment for colorectal cancer publication-title: Bioorg Med Chem Lett contributor: fullname: Dehnhardt – volume: 70 start-page: 266 year: 2010 end-page: 276 ident: bib326 article-title: Small-molecule inhibitors of phosphatidylinositol 3-kinase/Akt signaling inhibit Wnt/beta-catenin pathway cross-talk and suppress medulloblastoma growth publication-title: Cancer Res contributor: fullname: Eksborg – volume: 271 start-page: 1826 year: 1996 end-page: 1832 ident: bib153 article-title: Interaction between Wingless and Notch signaling pathways mediated by dishevelled publication-title: Science contributor: fullname: Artavanis-Tsakonas – volume: 54 start-page: 288 year: 2011 end-page: 299 ident: bib291 article-title: Pharmacological inhibition of Frizzled-7 displays anti-tumor properties in hepatocellular carcinoma publication-title: J Hepatol contributor: fullname: Sainsily – volume: 2 start-page: 1 year: 2013 end-page: 21 ident: bib126 article-title: BMP9 signaling in stem cell differentiation and osteogenesis publication-title: Am J Stem Cells contributor: fullname: Nan – volume: 18 start-page: 2718 year: 2004 end-page: 2723 ident: bib148 article-title: LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesis publication-title: Genes Dev contributor: fullname: Hsu – volume: 34 start-page: 110 year: 2012 end-page: 118 ident: bib151 article-title: Wnt-Notch signalling: an integrated mechanism regulating transitions between cell states publication-title: Bioessays contributor: fullname: Arias – volume: 9 start-page: e115835 year: 2014 ident: bib256 article-title: Focal chromosomal copy number aberrations identify CMTM8 and GPR177 as new candidate driver genes in osteosarcoma publication-title: PLoS One contributor: fullname: Bras – volume: 79 start-page: 211 year: 2011 end-page: 219 ident: bib333 article-title: Tetrandrine inhibits Wnt/beta-catenin signaling and suppresses tumor growth of human colorectal cancer publication-title: Mol Pharmacol contributor: fullname: Zhang – volume: 346 start-page: 1248012 year: 2014 ident: bib27 article-title: Stem cell signaling. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control publication-title: Science contributor: fullname: Nusse – volume: 6 start-page: e29290 year: 2011 ident: bib338 article-title: Niclosamide suppresses cancer cell growth by inducing Wnt co-receptor LRP6 degradation and inhibiting the Wnt/beta-catenin pathway publication-title: PLoS One contributor: fullname: Roberts – volume: 6 start-page: 7 year: 2004 end-page: 14 ident: bib282 article-title: A monoclonal antibody against Wnt-1 induces apoptosis in human cancer cells publication-title: Neoplasia contributor: fullname: Uematsu – volume: 32 start-page: 82 year: 2015 end-page: 96 ident: CR112 article-title: The endothelial transcription factor ERG promotes vascular stability and growth through Wnt/beta-catenin signaling publication-title: Dev Cell contributor: fullname: Dufton – volume: 40 start-page: 1533 year: 2012 end-page: 1542 ident: CR292 article-title: Change in gene expression profiles of secreted frizzled-related proteins (SFRPs) by sodium butyrate in gastric cancers: induction of promoter demethylation and histone modification causing inhibition of Wnt signaling publication-title: Int J Oncol contributor: fullname: Lee – volume: 16 start-page: 179 year: 2014 end-page: 190 ident: CR232 article-title: transcriptional governance of hair follicle stem cells by canonical Wnt regulators publication-title: Nat Cell Biol contributor: fullname: Lin – volume: 32 start-page: 886 year: 2014 end-page: 901 ident: CR235 article-title: Wnt7b is an important intrinsic regulator of hair follicle stem cell homeostasis and hair follicle cycling publication-title: Stem Cells contributor: fullname: Kobielak – volume: 283 start-page: 21427 year: 2008 end-page: 21432 ident: CR92 article-title: DKK1 antagonizes Wnt signaling without promotion of LRP6 internalization and degradation publication-title: J Biol Chem contributor: fullname: He – volume: 33 start-page: 2169 year: 2014 end-page: 2178 ident: CR319 article-title: Small-molecule inhibition of CBP/catenin interactions eliminates drug-resistant clones in acute lymphoblastic leukemia publication-title: Oncogene contributor: fullname: Pham – volume: 317 start-page: 745 year: 2011 end-page: 756 ident: CR203 article-title: Wnt signalling mediates the cross-talk between bone marrow derived pre-adipocytic and pre-osteoblastic cell populations publication-title: Exp Cell Res contributor: fullname: AlDahmash – volume: 10 start-page: 615 year: 2004 end-page: 625 ident: CR287 article-title: Membranous expression of secreted frizzled-related protein 4 predicts for good prognosis in localized prostate cancer and inhibits PC3 cellular proliferation publication-title: Clin Cancer Res contributor: fullname: Kench – volume: 126 start-page: 2426 year: 2010 end-page: 2436 ident: CR304 article-title: Small molecule antagonists of Tcf4/beta-catenin complex inhibit the growth of HCC cells and publication-title: Int J Cancer contributor: fullname: Grepper – volume: 106 start-page: 6309 year: 2009 end-page: 6314 ident: CR157 article-title: Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine publication-title: Proc Natl Acad Sci USA contributor: fullname: Huyghe – volume: 239 start-page: 16 year: 2010 end-page: 33 ident: CR143 article-title: Cross-talk between Wnt and bone morphogenic protein signaling: a turbulent relationship publication-title: Dev Dyn contributor: fullname: Hoppler – volume: 327 start-page: 542 year: 2010 end-page: 545 ident: CR212 article-title: Coexistence of quiescent and active adult stem cells in mammals publication-title: Science contributor: fullname: Clevers – volume: 2001 start-page: pe31 year: 2001 ident: CR164 article-title: Fat hedgehogs, slower or richer? publication-title: Sci STKE contributor: fullname: van Den Heuvel – volume: 118 start-page: 681 year: 1992 end-page: 691 ident: CR6 article-title: The vertebrate adhesive junction proteins beta-catenin and plakoglobin and the Drosophila segment polarity gene armadillo form a multigene family with similar properties publication-title: J Cell Biol contributor: fullname: Green – volume: 149 start-page: 1192 year: 2012 end-page: 1205 ident: CR23 article-title: Wnt/beta-catenin signaling and disease publication-title: Cell contributor: fullname: Nusse – volume: 5 start-page: 23 year: 2006 end-page: 26 ident: CR75 article-title: R-Spondin proteins: a novel link to beta-catenin activation publication-title: Cell Cycle contributor: fullname: Andarmani – volume: 27 start-page: 7118 year: 2008 end-page: 7130 ident: CR138 article-title: Prostate tumor progression is mediated by a paracrine TGF-beta/Wnt3a signaling axis publication-title: Oncogene contributor: fullname: Iturregui – volume: 98 start-page: 479 year: 2006 end-page: 490 ident: CR156 article-title: Growth suppression induced by Notch1 activation involves Wnt-beta-catenin down-regulation in human tongue carcinoma cells publication-title: Biol Cell contributor: fullname: Wu – volume: 133 start-page: 4427 year: 2006 end-page: 4438 ident: CR162 article-title: Jagged 1 is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis publication-title: Development contributor: fullname: Lo Celso – volume: 20 start-page: 3198 year: 2014 end-page: 3210 ident: CR342 article-title: Niclosamide inhibits androgen receptor variants expression and overcomes enzalutamide resistance in castration-resistant prostate cancer publication-title: Clin Cancer Res contributor: fullname: Zhu – volume: 445 start-page: 834 year: 2007 end-page: 842 ident: CR227 article-title: Scratching the surface of skin development publication-title: Nature contributor: fullname: Fuchs – volume: 129 start-page: 3045 year: 2002 end-page: 3054 ident: CR134 article-title: Wnt and Bmp signalling cooperatively regulate graded Emx2 expression in the dorsal telencephalon publication-title: Development contributor: fullname: Koch – volume: 58 start-page: 2524 year: 1998 end-page: 2527 ident: CR243 article-title: Activation of the beta-catenin gene in primary hepatocellular carcinomas by somatic alterations involving exon 3 publication-title: Cancer Res contributor: fullname: Nagasawa – volume: 201 start-page: 204 year: 2003 end-page: 212 ident: CR251 article-title: WIF1, a component of the Wnt pathway, is down-regulated in prostate, breast, lung, and bladder cancer publication-title: J Pathol contributor: fullname: Kaiser – volume: 7 start-page: 525 year: 2004 end-page: 534 ident: CR77 article-title: R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis publication-title: Dev Cell contributor: fullname: del Barco Barrantes – volume: 253 start-page: 661 year: 1991 end-page: 665 ident: CR13 article-title: Identification of FAP locus genes from chromosome 5q21 publication-title: Science contributor: fullname: Su – volume: 476 start-page: 293 year: 2011 end-page: 297 ident: CR81 article-title: Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling publication-title: Nature contributor: fullname: Low – volume: 119 start-page: 837 year: 2009 end-page: 851 ident: CR252 article-title: Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice publication-title: J Clin Invest contributor: fullname: Kodjabachian – volume: 403 start-page: 781 year: 2000 end-page: 785 ident: CR130 article-title: Interaction between Wnt and TGF-beta signalling pathways during formation of Spemann's organizer publication-title: Nature contributor: fullname: Ogata – volume: 1 start-page: 467 year: 2005 end-page: 472 ident: CR314 article-title: ICG-001, a novel small molecule regulator of TCF/beta-catenin transcription publication-title: Med Chem contributor: fullname: Lee – volume: 337 start-page: 59 year: 2012 end-page: 64 ident: CR29 article-title: Structural basis of Wnt recognition by Frizzled publication-title: Science contributor: fullname: Levin – volume: 109 start-page: 466 year: 2012 end-page: 471 ident: CR209 article-title: The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations publication-title: Proc Natl Acad Sci USA contributor: fullname: Li – volume: 127 start-page: 73 year: 2010 end-page: 81 ident: CR171 article-title: Hedgehog pathway activity is required for the lethality and intestinal phenotypes of mice with hyperactive Wnt signaling publication-title: Mech Dev contributor: fullname: Ruiz i Altaba – volume: 2014 start-page: 162024 year: 2014 ident: CR204 article-title: A cocktail method for promoting cardiomyocyte differentiation from bone marrow-derived mesenchymal stem cells publication-title: Stem Cells Int contributor: fullname: Jiang – volume: 382 start-page: 638 year: 1996 end-page: 642 ident: CR9 article-title: Functional interaction of beta-catenin with the transcription factor LEF-1 publication-title: Nature contributor: fullname: Kuhl – volume: 14 start-page: 1087 year: 2015 end-page: 1094 ident: CR279 article-title: Targeting Wnts at the source—new mechanisms, new biomarkers, new drugs publication-title: Mol Cancer Ther contributor: fullname: Virshup – volume: 2 start-page: 26 year: 2015 end-page: 34 ident: CR264 article-title: Targeting matrix metalloproteinases in cancer: bringing new life to old ideas publication-title: Genes Dis contributor: fullname: Cao – volume: 10 start-page: 393 year: 2004 end-page: 401 ident: CR206 article-title: Effects of Wnt signaling on proliferation and differentiation of human mesenchymal stem cells publication-title: Tissue Eng contributor: fullname: Van Blitterswijk – volume: 21 start-page: 8414 year: 2002 end-page: 8427 ident: CR328 article-title: Beta-catenin-mediated transactivation and cell-cell adhesion pathways are important in curcumin (diferuylmethane)-induced growth arrest and apoptosis in colon cancer cells publication-title: Oncogene contributor: fullname: Gupta – volume: 291 start-page: 21 year: 2011 end-page: 71 ident: CR61 article-title: New insights into the mechanism of Wnt signaling pathway activation publication-title: Int Rev Cell Mol Biol contributor: fullname: Sato – volume: 218 start-page: 183 year: 2000 end-page: 198 ident: CR87 article-title: Cloning and expression of the Wnt antagonists Sfrp-2 and Frzb during chick development publication-title: Dev Biol contributor: fullname: Allen – volume: 1 start-page: 127 year: 2014 end-page: 128 ident: CR181 article-title: Wnt Hippo: A balanced act or dynamic duo? publication-title: Genes Dis contributor: fullname: Deng – volume: 391 start-page: 357 year: 1998 end-page: 362 ident: CR89 article-title: Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction publication-title: Nature contributor: fullname: Delius – volume: 24 start-page: 3404 year: 2004 end-page: 3414 ident: CR68 article-title: Acetylation of beta-catenin by p300 regulates beta-catenin-Tcf4 interaction publication-title: Mol Cell Biol contributor: fullname: Labalette – volume: 285 start-page: 1928 year: 2010 end-page: 1938 ident: CR106 article-title: IRS1 regulation by Wnt/beta-catenin signaling and varied contribution of IRS1 to the neoplastic phenotype publication-title: J Biol Chem contributor: fullname: Iura – volume: 54 start-page: 288 year: 2011 end-page: 299 ident: CR291 article-title: Pharmacological inhibition of Frizzled-7 displays anti-tumor properties in hepatocellular carcinoma publication-title: J Hepatol contributor: fullname: Sainsily – volume: 87 start-page: 159 year: 1996 end-page: 170 ident: CR239 article-title: Lessons from hereditary colorectal cancer publication-title: Cell contributor: fullname: Vogelstein – volume: 31 start-page: 2737 year: 2012 end-page: 2746 ident: CR276 article-title: Drugging Wnt signalling in cancer publication-title: Embo J contributor: fullname: Polakis – volume: 9 start-page: 105 year: 2007 ident: CR160 article-title: Cooperation between Wnt and Notch signalling in human breast cancer publication-title: Breast Cancer Res contributor: fullname: Brennan – volume: 69 start-page: 8572 year: 2009 end-page: 8578 ident: CR170 article-title: Wnt signaling stimulates transcriptional outcome of the Hedgehog pathway by stabilizing GLI1 mRNA publication-title: Cancer Res contributor: fullname: Sanek – volume: 27 start-page: 20 year: 2014 end-page: 29 ident: CR277 article-title: Targeting the beta-catenin nuclear transport pathway in cancer publication-title: Semin Cancer Biol contributor: fullname: Henderson – volume: 42 start-page: 705 year: 2007 end-page: 710 ident: CR149 article-title: Cross-talk between Wnt and Notch signaling in intestinal epithelial cell fate decision publication-title: J Gastroenterol contributor: fullname: Watanabe – volume: 280 start-page: 1036 year: 1998 end-page: 1037 ident: CR240 article-title: Landscaping the cancer terrain publication-title: Science contributor: fullname: Vogelstein – volume: 289 start-page: 195 year: 2010 end-page: 207 ident: CR155 article-title: MSX1 induces the Wnt pathway antagonist genes DKK1, DKK2, DKK3, and SFRP1 in neuroblastoma cells, but does not block Wnt3 and Wnt5A signalling to DVL3 publication-title: Cancer Lett contributor: fullname: Koster – volume: 411 start-page: 349 year: 2001 end-page: 354 ident: CR165 article-title: The Hedgehog and Wnt signalling pathways in cancer publication-title: Nature contributor: fullname: Beachy – volume: 423 start-page: 409 year: 2003 end-page: 414 ident: CR221 article-title: A role for Wnt signalling in self-renewal of haematopoietic stem cells publication-title: Nature contributor: fullname: Ailles – volume: 94 start-page: 1287 year: 2014 end-page: 1312 ident: CR180 article-title: The biology of YAP/TAZ: hippo signaling and beyond publication-title: Physiol Rev contributor: fullname: Cordenonsi – volume: 73 start-page: 4909 year: 2013 end-page: 4922 ident: CR246 article-title: Canonical wnt signaling is required for pancreatic carcinogenesis publication-title: Cancer Res contributor: fullname: Yan – volume: 262 start-page: 1731 year: 1993 end-page: 1734 ident: CR15 article-title: Association of the APC gene product with beta-catenin publication-title: Science contributor: fullname: Albert – volume: 28 start-page: 4875 year: 2008 end-page: 4882 ident: CR91 article-title: Targeted disruption of the Wnt regulator Kremen induces limb defects and high bone density publication-title: Mol Cell Biol contributor: fullname: Clement-Lacroix – volume: 149 start-page: 261 year: 2008 end-page: 267 ident: CR109 article-title: Insulin receptor substrate-1 deficiency promotes apoptosis in the putative intestinal crypt stem cell region, limits Apcmin/+ tumors, and regulates Sox9 publication-title: Endocrinology contributor: fullname: Magness – volume: 15 start-page: 726 year: 2015 end-page: 738 ident: CR344 article-title: The anthelmintic drug niclosamide inhibits the proliferative activity of human osteosarcoma cells by targeting multiple signal pathways publication-title: Curr Cancer Drug Targets contributor: fullname: Yan – volume: 11 start-page: 33 year: 2015 end-page: 42 ident: CR216 article-title: Opposing activities of Notch and Wnt signaling regulate intestinal stem cells and gut homeostasis publication-title: Cell Rep contributor: fullname: Chiu – volume: 111 start-page: 10215 year: 2014 end-page: 10220 ident: CR233 article-title: Pygo2 regulates beta-catenin-induced activation of hair follicle stem/progenitor cells and skin hyperplasia publication-title: Proc Natl Acad Sci USA contributor: fullname: Fallahi – volume: 36 start-page: 277 year: 2004 end-page: 282 ident: CR175 article-title: Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation publication-title: Nat Genet contributor: fullname: Hardwick – volume: 287 start-page: 795 year: 1980 end-page: 801 ident: CR3 article-title: Mutations affecting segment number and polarity in Drosophila publication-title: Nature contributor: fullname: Wieschaus – volume: 5 start-page: 100 year: 2009 end-page: 107 ident: CR297 article-title: Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer publication-title: Nat Chem Biol contributor: fullname: Tang – volume: 20 start-page: 427 year: 2011 end-page: 442 ident: CR74 article-title: FoxM1 promotes beta-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis publication-title: Cancer Cell contributor: fullname: Gong – volume: 280 start-page: 19883 year: 2005 end-page: 19887 ident: CR95 article-title: Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling publication-title: J Biol Chem contributor: fullname: Kang – volume: 346 start-page: 1248012 year: 2014 ident: CR27 article-title: Stem cell signaling. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control publication-title: Science contributor: fullname: Nusse – volume: 105 start-page: 18366 year: 2008 end-page: 18371 ident: CR205 article-title: The Wnt modulator sFRP2 enhances mesenchymal stem cell engraftment, granulation tissue formation and myocardial repair publication-title: Proc Natl Acad Sci USA contributor: fullname: Vincent – volume: 109 start-page: E2197 year: 2012 end-page: E2204 ident: CR41 article-title: Wntless functions in mature osteoblasts to regulate bone mass publication-title: Proc Natl Acad Sci USA contributor: fullname: Schumacher – volume: 135 start-page: 367 year: 2008 end-page: 375 ident: CR49 article-title: Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions publication-title: Development contributor: fullname: Tamai – volume: 98 start-page: 2091 year: 2001 end-page: 2100 ident: CR222 article-title: Regulation of the inhibitor-of-apoptosis family member survivin in normal cord blood and bone marrow CD34(+) cells by hematopoietic growth factors: implication of survivin expression in normal hematopoiesis publication-title: Blood contributor: fullname: Pelus – volume: 277 start-page: 25562 year: 2002 end-page: 25567 ident: CR67 article-title: Acetylation of beta-catenin by CREB-binding protein (CBP) publication-title: J Biol Chem contributor: fullname: Miska – volume: 282 start-page: 15903 year: 2007 end-page: 15911 ident: CR79 article-title: R-spondin1 is a high affinity ligand for LRP6 and induces LRP6 phosphorylation and beta-catenin signaling publication-title: J Biol Chem contributor: fullname: Semenov – volume: 16 start-page: 639 year: 2015 end-page: 652 ident: CR73 article-title: Beta-catenin regulates primitive streak induction through collaborative interactions with SMAD2/SMAD3 and OCT4 publication-title: Cell Stem Cell contributor: fullname: Lerdrup – volume: 256 start-page: 668 year: 1992 end-page: 670 ident: CR242 article-title: Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene publication-title: Science contributor: fullname: Vogelstein – volume: 44 start-page: 15495 year: 2005 end-page: 15503 ident: CR293 article-title: Identification of a specific inhibitor of the dishevelled PDZ domain publication-title: Biochemistry contributor: fullname: Wang – volume: 2 start-page: 133 year: 2015 end-page: 143 ident: CR247 article-title: Pancreatic cancer stromal biology and therapy publication-title: Genes Dis contributor: fullname: Xie – volume: 111 start-page: 7337 year: 2014 end-page: 7342 ident: CR142 article-title: Smad1 transcription factor integrates BMP2 and Wnt3a signals in migrating cardiac progenitor cells publication-title: Proc Natl Acad Sci USA contributor: fullname: Camp – volume: 110 start-page: 1351 year: 2013 end-page: 1356 ident: CR234 article-title: Competitive balance of intrabulge BMP/Wnt signaling reveals a robust gene network ruling stem cell homeostasis and cyclic activation publication-title: Proc Natl Acad Sci USA contributor: fullname: Chen – volume: 28 start-page: 2613 year: 2008 end-page: 2623 ident: CR327 article-title: Vitamin D and Wnt/beta-catenin pathway in colon cancer: role and regulation of DICKKOPF genes publication-title: Anticancer Res contributor: fullname: Pereira – volume: 132 start-page: 1819 year: 2005 end-page: 1830 ident: CR152 article-title: Notch modulates Wnt signalling by associating with Armadillo/beta-catenin and regulating its transcriptional activity publication-title: Development contributor: fullname: Sanders – volume: 13 start-page: 800 year: 2014 end-page: 811 ident: CR343 article-title: Effect of niclosamide on basal-like breast cancers publication-title: Mol Cancer Ther contributor: fullname: Aristizabal – volume: 9 start-page: e115835 year: 2014 ident: CR256 article-title: Focal chromosomal copy number aberrations identify CMTM8 and GPR177 as new candidate driver genes in osteosarcoma publication-title: PLoS One contributor: fullname: Bras – volume: 137 start-page: 422 year: 2009 end-page: 424 ident: CR172 article-title: New insights into the role of Hedgehog signaling in gastrointestinal development and cancer publication-title: Gastroenterology contributor: fullname: Choi – volume: 118 start-page: 2420 year: 2011 end-page: 2429 ident: CR220 article-title: Wnt-inhibitory factor 1 dysregulation of the bone marrow niche exhausts hematopoietic stem cells publication-title: Blood contributor: fullname: Qiu – volume: 154 start-page: 274 year: 2013 end-page: 284 ident: CR207 article-title: The intestinal crypt, a prototype stem cell compartment publication-title: Cell contributor: fullname: Clevers – volume: 71 start-page: 4172 year: 2011 end-page: 4182 ident: CR339 article-title: Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations publication-title: Cancer Res contributor: fullname: Yang – volume: 283 start-page: 12686 year: 2008 end-page: 12690 ident: CR120 article-title: HDAC6 is required for epidermal growth factor-induced beta-catenin nuclear localization publication-title: J Biol Chem contributor: fullname: Polakiewicz – volume: 22 start-page: 839 year: 2009 end-page: 847 ident: CR169 article-title: Aberrant activation of hedgehog signaling pathway contributes to endometrial carcinogenesis through beta-catenin publication-title: Mod Pathol contributor: fullname: Au – volume: 398 start-page: 431 year: 1999 end-page: 436 ident: CR88 article-title: A new secreted protein that binds to Wnt proteins and inhibits their activities publication-title: Nature contributor: fullname: Rebbert – volume: 19 start-page: 1749 year: 2004 end-page: 1757 ident: CR97 article-title: LRP5 and Wnt signaling: a union made for bone publication-title: J Bone Miner Res contributor: fullname: Nusse – volume: 67 start-page: 573 year: 2007 end-page: 579 ident: CR294 article-title: An antagonist of dishevelled protein-protein interaction suppresses beta-catenin-dependent tumor cell growth publication-title: Cancer Res contributor: fullname: Xu – volume: 99 start-page: 335 year: 1999 end-page: 345 ident: CR53 article-title: PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs publication-title: Cell contributor: fullname: Vogelstein – volume: 10 start-page: 55 year: 2004 end-page: 63 ident: CR191 article-title: Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor publication-title: Nat Med contributor: fullname: Skaltsounis – volume: 105 start-page: 1087 year: 2014 end-page: 1092 ident: CR321 article-title: Safely targeting cancer stem cells via selective catenin coactivator antagonism publication-title: Cancer Sci contributor: fullname: Kahn – volume: 402 start-page: 515 year: 2007 end-page: 523 ident: CR31 article-title: Post-translational palmitoylation and glycosylation of Wnt-5a are necessary for its signalling publication-title: Biochem J contributor: fullname: Izumi – volume: 9 start-page: 159 year: 2009 ident: CR47 article-title: Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression publication-title: BMC Cancer contributor: fullname: Waterman – volume: 102 start-page: 338 year: 2002 end-page: 342 ident: CR249 article-title: Cytoplasmic and/or nuclear accumulation of the beta-catenin protein is a frequent event in human osteosarcoma publication-title: Int J Cancer contributor: fullname: Ishikawa – volume: 26 start-page: 1078 year: 2007 end-page: 1087 ident: CR102 article-title: A positive feedback loop between hepatocyte growth factor receptor and beta-catenin sustains colorectal cancer cell invasive growth publication-title: Oncogene contributor: fullname: De Bacco – volume: 39 start-page: 145 year: 2015 end-page: 154 ident: CR201 article-title: Canonical Wnt signaling acts synergistically on BMP9-induced osteo/odontoblastic differentiation of stem cells of dental apical papilla (SCAPs) publication-title: Biomaterials contributor: fullname: Deng – volume: 20 start-page: 252 year: 2001 end-page: 259 ident: CR107 article-title: Insulin and IGF-1 stimulate the beta-catenin pathway through two signalling cascades involving GSK-3beta inhibition and Ras activation publication-title: Oncogene contributor: fullname: Blivet-Van Eggelpoel – volume: 134 start-page: 112 year: 2014 end-page: 120 ident: CR340 article-title: Inhibition of Wnt/beta-catenin pathway by niclosamide: a therapeutic target for ovarian cancer publication-title: Gynecol Oncol contributor: fullname: Samant – volume: 62 start-page: 2064 year: 2002 end-page: 2071 ident: CR100 article-title: Hepatocyte growth factor induces Wnt-independent nuclear translocation of beta-catenin after Met-beta-catenin dissociation in hepatocytes publication-title: Cancer Res contributor: fullname: Pediaditakis – volume: 278 start-page: 48805 year: 2003 end-page: 48814 ident: CR132 article-title: Smad4 and beta-catenin co-activators functionally interact with lymphoid-enhancing factor to regulate graded expression of Msx2 publication-title: J Biol Chem contributor: fullname: Sirard – volume: 116 start-page: 2627 issue: Pt 13 year: 2003 end-page: 2634 ident: CR86 article-title: Secreted antagonists of the Wnt signalling pathway publication-title: J Cell Sci contributor: fullname: Kypta – volume: 316 start-page: 1619 year: 2007 end-page: 1622 ident: CR48 article-title: Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation publication-title: Science contributor: fullname: Davidson – volume: 24 start-page: 2291 year: 2012 end-page: 2296 ident: CR334 article-title: Silibinin inhibits Wnt/beta-catenin signaling by suppressing Wnt co-receptor LRP6 expression in human prostate and breast cancer cells publication-title: Cell Signal contributor: fullname: King – volume: 280 start-page: 26770 year: 2005 end-page: 26775 ident: CR96 article-title: SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor publication-title: J Biol Chem contributor: fullname: He – volume: 49 start-page: 1935 year: 2009 end-page: 1943 ident: CR108 article-title: Overexpression of insulin receptor substrate-1 and hepatitis Bx genes causes premalignant alterations in the liver publication-title: Hepatology contributor: fullname: Kuzushita – volume: 28 start-page: 428 year: 2015 end-page: 436 ident: CR258 article-title: Analysis of wntless (WLS) expression in gastric, ovarian, and breast cancers reveals a strong association with HER2 overexpression publication-title: Mod Pathol contributor: fullname: McCluggage – volume: 111 start-page: 251 year: 2002 end-page: 263 ident: CR215 article-title: Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB publication-title: Cell contributor: fullname: Beghtel – volume: 79 start-page: 211 year: 2011 end-page: 219 ident: CR333 article-title: Tetrandrine inhibits Wnt/beta-catenin signaling and suppresses tumor growth of human colorectal cancer publication-title: Mol Pharmacol contributor: fullname: Zhang – volume: 125 start-page: 509 year: 2006 end-page: 522 ident: CR35 article-title: Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells publication-title: Cell contributor: fullname: Schutt – volume: 16 start-page: 633 year: 2009 end-page: 647 ident: CR145 article-title: Notch signaling: the core pathway and its posttranslational regulation publication-title: Dev Cell contributor: fullname: Fortini – volume: 101 start-page: 12682 year: 2004 end-page: 12687 ident: CR313 article-title: A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected] publication-title: Proc Natl Acad Sci USA contributor: fullname: Ma – volume: 1 start-page: 18 year: 2012 end-page: 28 ident: CR316 article-title: Wnt signaling orchestration with a small molecule DYRK inhibitor provides long-term xeno-free human pluripotent cell expansion publication-title: Stem Cells Transl Med contributor: fullname: Teo – volume: 243 start-page: 1095 year: 2014 end-page: 1105 ident: CR44 article-title: Concentration-dependent effects of WNTLESS on WNT1/3A signaling publication-title: Dev Dyn contributor: fullname: Li – volume: 488 start-page: 665 year: 2012 end-page: 669 ident: CR83 article-title: Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors publication-title: Nature contributor: fullname: Jordens – volume: 51 start-page: 724 year: 2012 end-page: 731 ident: CR309 article-title: Structure-based discovery of a novel inhibitor targeting the beta-catenin/Tcf4 interaction publication-title: Biochemistry contributor: fullname: Yan – volume: 11 start-page: 301 year: 2006 end-page: 312 ident: CR139 article-title: Smad7-induced beta-catenin degradation alters epidermal appendage development publication-title: Dev Cell contributor: fullname: Liang – volume: 50 start-page: 649 year: 1987 end-page: 657 ident: CR4 article-title: The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless publication-title: Cell contributor: fullname: Wagenaar – volume: 8 start-page: e75010 year: 2013 ident: CR66 article-title: The small molecule Wnt signaling modulator ICG-001 improves contractile function in chronically infarcted rat myocardium publication-title: PLoS One contributor: fullname: Nguyen – volume: 11 start-page: 229 year: 2011 end-page: 240 ident: CR125 article-title: BMP-9 induced osteogenic differentiation of mesenchymal stem cells: molecular mechanism and therapeutic potential publication-title: Curr Gene Ther contributor: fullname: Zhu – volume: 240 start-page: 365 year: 2011 end-page: 371 ident: CR43 article-title: Gpr177/mouse Wntless is essential for Wnt-mediated craniofacial and brain development publication-title: Dev Dyn contributor: fullname: Maruyama – volume: 158 start-page: 157 year: 2014 end-page: 170 ident: CR185 article-title: YAP/TAZ incorporation in the beta-catenin destruction complex orchestrates the Wnt response publication-title: Cell contributor: fullname: Soligo – volume: 109 start-page: 17942 year: 2012 end-page: 17947 ident: CR312 article-title: Inhibition of oncogenic Wnt signaling through direct targeting of beta-catenin publication-title: Proc Natl Acad Sci USA contributor: fullname: Bowman – volume: 62 start-page: 2744 year: 2002 end-page: 2748 ident: CR127 article-title: Oncogenic beta-catenin is required for bone morphogenetic protein 4 expression in human cancer cells publication-title: Cancer Res contributor: fullname: Dracheva – volume: 8 start-page: 387 year: 2008 end-page: 398 ident: CR19 article-title: Wnt signalling and its impact on development and cancer publication-title: Nat Rev Cancer contributor: fullname: Birchmeier – volume: 283 start-page: 23956 year: 2008 end-page: 23963 ident: CR141 article-title: Smad7 stabilizes beta-catenin binding to E-cadherin complex and promotes cell-cell adhesion publication-title: J Biol Chem contributor: fullname: Zhao – volume: 281 start-page: 10865 year: 2006 end-page: 10875 ident: CR329 article-title: Suppression of Wnt signaling by the green tea compound (-)-epigallocatechin 3-gallate (EGCG) in invasive breast cancer cells. Requirement of the transcriptional repressor HBP1 publication-title: J Biol Chem contributor: fullname: Rieger-Christ – volume: 71 start-page: 1167 year: 1992 end-page: 1179 ident: CR7 article-title: wingless signaling acts through zeste-white 3, the Drosophila homolog of glycogen synthase kinase-3, to regulate engrailed and establish cell fate publication-title: Cell contributor: fullname: Perrimon – volume: 90 start-page: 740 year: 1993 end-page: 744 ident: CR119 article-title: Mouse mammary tumor virus infection accelerates mammary carcinogenesis in Wnt-1 transgenic mice by insertional activation of int-2/Fgf-3 and hst/Fgf-4 publication-title: Proc Natl Acad Sci USA contributor: fullname: Kwan – volume: 2 start-page: 67 year: 2010 end-page: 80 ident: CR195 article-title: Mesenchymal stem cells: Molecular characteristics and clinical applications. World J publication-title: Stem Cells contributor: fullname: Huang – volume: 8 start-page: 76 year: 2009 ident: CR284 article-title: Blockade of Wnt-1 signaling leads to anti-tumor effects in hepatocellular carcinoma cells publication-title: Mol Cancer contributor: fullname: Grepper – volume: 2 start-page: 1 year: 2013 end-page: 21 ident: CR126 article-title: BMP9 signaling in stem cell differentiation and osteogenesis publication-title: Am J Stem Cells contributor: fullname: Nan – volume: 25 start-page: 499 year: 2015 end-page: 513 ident: CR179 article-title: YAP and TAZ: a nexus for Hippo signaling and beyond publication-title: Trends Cell Biol contributor: fullname: Guan – volume: 4 start-page: 38 year: 2012 end-page: 51 ident: CR253 article-title: The Wnt secretion protein Evi/Gpr177 promotes glioma tumourigenesis publication-title: EMBO Mol Med contributor: fullname: Bongers – volume: 13 start-page: 767 year: 2012 end-page: 779 ident: CR25 article-title: The complex world of WNT receptor signalling publication-title: Nat Rev Mol Cell Biol contributor: fullname: Niehrs – volume: 213 start-page: 152 year: 2007 end-page: 160 ident: CR274 article-title: CD44-positive colorectal adenoma cells express the potential stem cell markers musashi antigen (msi1) and ephrin B2 receptor (EphB2) publication-title: J Pathol contributor: fullname: Herbacek – volume: 30 start-page: 423 year: 2011 end-page: 433 ident: CR285 article-title: Blocking Wnt signaling by SFRP-like molecules inhibits cell proliferation and tumor growth in cells carrying active beta-catenin publication-title: Oncogene contributor: fullname: Coulouarn – volume: 106 start-page: 18598 year: 2009 end-page: 18603 ident: CR36 article-title: Reciprocal regulation of Wnt and Gpr177/mouse Wntless is required for embryonic axis formation publication-title: Proc Natl Acad Sci USA contributor: fullname: Mirando – volume: 1 start-page: 87 year: 2014 end-page: 105 ident: CR124 article-title: Bone morphogenetic protein (BMP) signaling in development and human diseases publication-title: Genes Dis contributor: fullname: Wang – volume: 49 start-page: 474 year: 2013 end-page: 486 ident: CR69 article-title: Glucose-induced beta-catenin acetylation enhances Wnt signaling in cancer publication-title: Mol Cell contributor: fullname: Ardila-Gonzalez – volume: 130 start-page: 1120 year: 2007 end-page: 1133 ident: CR177 article-title: Elucidation of a universal size-control mechanism in Drosophila and mammals publication-title: Cell contributor: fullname: Huang – volume: 1 start-page: e43 year: 2011 ident: CR310 article-title: AV-65, a novel Wnt/beta-catenin signal inhibitor, successfully suppresses progression of multiple myeloma in a mouse model publication-title: Blood Cancer J contributor: fullname: Strovel – volume: 6 start-page: 829 year: 2010 end-page: 836 ident: CR336 article-title: Small-molecule inhibition of Wnt signaling through activation of casein kinase 1alpha publication-title: Nat Chem Biol contributor: fullname: Schneider – volume: 22 start-page: 233 year: 2004 end-page: 241 ident: CR121 article-title: Bone morphogenetic proteins publication-title: Growth Factors contributor: fullname: Mundy – volume: 423 start-page: 448 year: 2003 end-page: 452 ident: CR28 article-title: Wnt proteins are lipid-modified and can act as stem cell growth factors publication-title: Nature doi: 10.1038/nature01611 contributor: fullname: Danenberg – volume: 281 start-page: 1509 year: 1998 end-page: 1512 ident: CR54 article-title: Identification of c-MYC as a target of the APC pathway publication-title: Science contributor: fullname: Rago – volume: 332 start-page: 458 year: 2011 end-page: 461 ident: CR184 article-title: Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size publication-title: Science contributor: fullname: Wang – volume: 29 start-page: 1493 year: 2015 end-page: 1506 ident: CR186 article-title: beta-Catenin destruction complex-independent regulation of Hippo-YAP signaling by APC in intestinal tumorigenesis publication-title: Genes Dev contributor: fullname: Anders – volume: 38 start-page: 437 year: 2011 end-page: 445 ident: CR332 article-title: Ginsenoside Rg3 inhibits colorectal tumor growth through the down-regulation of Wnt/ss-catenin signaling publication-title: Int J Oncol contributor: fullname: Luo – volume: 136 start-page: 903 year: 2009 end-page: 912 ident: CR214 article-title: Transcription factor achaete scute-like 2 controls intestinal stem cell fate publication-title: Cell contributor: fullname: Hatzis – volume: 2 start-page: e1155 year: 2007 ident: CR174 article-title: Common activation of canonical Wnt signaling in pancreatic adenocarcinoma publication-title: PLoS One contributor: fullname: Heiser – volume: 104 start-page: 5668 year: 2007 end-page: 5673 ident: CR315 article-title: Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency publication-title: Proc Natl Acad Sci USA contributor: fullname: Yamamoto – volume: 31 start-page: 2670 year: 2012 end-page: 2684 ident: CR2 article-title: Three decades of Wnts: a personal perspective on how a scientific field developed publication-title: Embo J contributor: fullname: Varmus – volume: 7 start-page: re8 year: 2014 ident: CR267 article-title: Signaling mechanisms of the epithelial-mesenchymal transition publication-title: Sci Signal contributor: fullname: Medici – volume: 25 start-page: 1475 year: 2005 end-page: 1488 ident: CR140 article-title: Interaction between Smad7 and beta-catenin: importance for transforming growth factor beta-induced apoptosis publication-title: Mol Cell Biol contributor: fullname: Grimsby – volume: 17 start-page: 45 year: 2007 end-page: 51 ident: CR245 article-title: The many ways of Wnt in cancer publication-title: Curr Opin Genet Dev contributor: fullname: Polakis – volume: 2 start-page: a002915 year: 2010 ident: CR263 article-title: Interplay of cadherin-mediated cell adhesion and canonical Wnt signaling publication-title: Cold Spring Harb Perspect Biol contributor: fullname: Birchmeier – volume: 93 start-page: 7950 year: 1996 end-page: 7954 ident: CR280 article-title: Apoptosis and APC in colorectal tumorigenesis publication-title: Proc Natl Acad Sci USA contributor: fullname: Kinzler – volume: 152 start-page: 87 year: 2001 end-page: 96 ident: CR281 article-title: Wnt-1 signaling inhibits apoptosis by activating beta-catenin/T cell factor-mediated transcription publication-title: J Cell Biol contributor: fullname: You – volume: 401 start-page: 969 year: 2010 end-page: 984 ident: CR71 article-title: Allosteric remodelling of the histone H3 binding pocket in the Pygo2 PHD finger triggered by its binding to the B9L/BCL9 co-factor publication-title: J Mol Biol contributor: fullname: Johnson – volume: 160 start-page: 2295 year: 2002 end-page: 2307 ident: CR117 article-title: A mouse model of hepatocellular carcinoma: ectopic expression of fibroblast growth factor 19 in skeletal muscle of transgenic mice publication-title: Am J Pathol contributor: fullname: Tomlinson – volume: 36 start-page: 313 year: 2000 end-page: 325 ident: CR101 article-title: c-met tyrosine kinase receptor expression is associated with abnormal beta-catenin expression and favourable prognostic factors in invasive breast carcinoma publication-title: Histopathology contributor: fullname: Keramopoulos – volume: 13 start-page: 812 year: 2014 end-page: 822 ident: CR346 article-title: Monensin inhibits canonical Wnt signaling in human colorectal cancer cells and suppresses tumor growth in multiple intestinal neoplasia mice publication-title: Mol Cancer Ther contributor: fullname: Vojtechova – volume: 108 start-page: 5954 year: 2011 end-page: 5963 ident: CR307 article-title: An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway publication-title: Proc Natl Acad Sci USA contributor: fullname: Carson – volume: 123 start-page: 1588 issue: Pt 9 year: 2010 end-page: 1599 ident: CR50 article-title: Stability elements in the LRP6 cytoplasmic tail confer efficient signalling upon DIX-dependent polymerization publication-title: J Cell Sci contributor: fullname: Mieszczanek – volume: 132 start-page: 215 year: 2005 end-page: 225 ident: CR136 article-title: Smad1, beta-catenin and Tcf4 associate in a molecular complex with the Myc promoter in dysplastic renal tissue and cooperate to control Myc transcription publication-title: Development contributor: fullname: Rosenblum – volume: 92 start-page: 2268 year: 1995 end-page: 2272 ident: CR116 article-title: Insertional mutagenesis identifies a member of the Wnt gene family as a candidate oncogene in the mammary epithelium of int-2/Fgf-3 transgenic mice publication-title: Proc Natl Acad Sci USA contributor: fullname: Kuo – volume: 395 start-page: 608 year: 1998 end-page: 612 ident: CR46 article-title: The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors publication-title: Nature contributor: fullname: Peterson – volume: 336 start-page: 1549 year: 2012 end-page: 1554 ident: CR250 article-title: Wnt/beta-catenin signaling regulates telomerase in stem cells and cancer cells publication-title: Science contributor: fullname: Rudloff – volume: 15 start-page: 3059 year: 2001 end-page: 3087 ident: CR163 article-title: Hedgehog signaling in animal development: paradigms and principles publication-title: Genes Dev contributor: fullname: McMahon – volume: 126 start-page: 2931 issue: Pt 13 year: 2013 end-page: 2943 ident: CR40 article-title: The apical and basolateral secretion of Wnt11 and Wnt3a in polarized epithelial cells is regulated by different mechanisms publication-title: J Cell Sci contributor: fullname: Hanaki – volume: 487 start-page: 510 year: 2012 end-page: 513 ident: CR248 article-title: RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis publication-title: Nature contributor: fullname: Stott – volume: 116 start-page: 739 year: 2001 end-page: 742 ident: CR167 article-title: Activation of expression of hedgehog target genes in basal cell carcinomas publication-title: J Invest Dermatol contributor: fullname: Chuang – volume: 72 start-page: 2822 year: 2012 end-page: 2832 ident: CR298 article-title: A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice publication-title: Cancer Res contributor: fullname: Tumova – volume: 6 start-page: 7 year: 2004 end-page: 14 ident: CR282 article-title: A monoclonal antibody against Wnt-1 induces apoptosis in human cancer cells publication-title: Neoplasia contributor: fullname: Uematsu – volume: 4 start-page: e4310 year: 2009 ident: CR63 article-title: Modulation of the beta-catenin signaling pathway by the dishevelled-associated protein Hipk1 publication-title: PLoS One contributor: fullname: Conrad – volume: 178 start-page: 635 year: 2007 end-page: 648 ident: CR213 article-title: Sox9 regulates cell proliferation and is required for Paneth cell differentiation in the intestinal epithelium publication-title: J Cell Biol contributor: fullname: Pannequin – volume: 40 start-page: 1130 year: 2008 end-page: 1135 ident: CR168 article-title: Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/beta3-catenin signaling publication-title: Nat Genet contributor: fullname: Grachtchouk – volume: 140 start-page: 3589 year: 2013 end-page: 3594 ident: CR39 article-title: Gpr177 regulates pulmonary vasculature development publication-title: Development contributor: fullname: Fu – volume: 3 start-page: 531 year: 2003 end-page: 536 ident: CR122 article-title: Targeting the TGF beta signaling network in human neoplasia publication-title: Cancer Cell contributor: fullname: Arteaga – volume: 82 start-page: 165 year: 2009 end-page: 175 ident: CR305 article-title: Small molecule inhibitors of WNT signaling effectively induce apoptosis in acute myeloid leukemia cells publication-title: Eur J Haematol contributor: fullname: Puetter – volume: 28 start-page: 2701 year: 2008 end-page: 2704 ident: CR271 article-title: Promotion of the self-renewal capacity of human acute leukemia cells by Wnt3A publication-title: Anticancer Res contributor: fullname: Nara – volume: 5 start-page: eg2 year: 2012 ident: CR24 article-title: Focus issue: Wnt and beta-catenin signaling in development and disease publication-title: Sci Signal contributor: fullname: Gough – volume: 493 start-page: 106 year: 2013 end-page: 110 ident: CR183 article-title: Restriction of intestinal stem cell expansion and the regenerative response by YAP publication-title: Nature contributor: fullname: Butler – volume: 14 start-page: 1849 year: 2008 end-page: 1858 ident: CR331 article-title: Resveratrol exerts antiproliferative activity and induces apoptosis in Waldenstrom's macroglobulinemia publication-title: Clin Cancer Res contributor: fullname: Sacco – volume: 121 start-page: 1587 issue: Pt 10 year: 2008 end-page: 1592 ident: CR30 article-title: role of lipid adducts on Wingless publication-title: J Cell Sci contributor: fullname: Griffith – volume: 137 start-page: 216 year: 2009 end-page: 233 ident: CR146 article-title: The canonical Notch signaling pathway: unfolding the activation mechanism publication-title: Cell contributor: fullname: Ilagan – volume: 20 start-page: 781 year: 2004 end-page: 810 ident: CR17 article-title: The Wnt signaling pathway in development and disease publication-title: Annu Rev Cell Dev Biol contributor: fullname: Nusse – volume: 205 start-page: 73 year: 1994 end-page: 78 ident: CR104 article-title: c-erbB-2 gene product associates with catenins in human cancer cells publication-title: Biochem Biophys Res Commun contributor: fullname: Kanai – volume: 138 start-page: 51 year: 2009 end-page: 62 ident: CR268 article-title: WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis publication-title: Cell contributor: fullname: Zhang – volume: 5 start-page: 53 year: 2005 ident: CR283 article-title: Efficacy of Wnt-1 monoclonal antibody in sarcoma cells publication-title: BMC Cancer contributor: fullname: He – volume: 19 start-page: 4980 year: 2009 end-page: 4983 ident: CR306 article-title: 2,4-Diamino-quinazolines as inhibitors of beta-catenin/Tcf-4 pathway: Potential treatment for colorectal cancer publication-title: Bioorg Med Chem Lett contributor: fullname: Dehnhardt – volume: 103 start-page: 3799 year: 2006 end-page: 3804 ident: CR161 article-title: Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism publication-title: Proc Natl Acad Sci USA contributor: fullname: Ciarloni – volume: 222 start-page: 1 year: 2010 end-page: 15 ident: CR262 article-title: Current and emerging concepts in tumour metastasis publication-title: J Pathol contributor: fullname: Murray – volume: 8 start-page: e56644 year: 2013 ident: CR254 article-title: Gpr177 deficiency impairs mammary development and prohibits Wnt-induced tumorigenesis publication-title: PLoS One contributor: fullname: Jiang – volume: 108 start-page: 13253 year: 2011 end-page: 13257 ident: CR345 article-title: Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells publication-title: Proc Natl Acad Sci USA contributor: fullname: Yu – volume: 417 start-page: 664 year: 2002 end-page: 667 ident: CR90 article-title: Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling publication-title: Nature contributor: fullname: Davidson – volume: 382 start-page: 225 year: 1996 end-page: 230 ident: CR11 article-title: A new member of the frizzled family from Drosophila functions as a Wingless receptor publication-title: Nature contributor: fullname: Samos – volume: 26 start-page: 951 year: 2014 end-page: 958 ident: CR72 article-title: Canonical Wnt signaling skews TGF-beta signaling in chondrocytes towards signaling via ALK1 and Smad 1/5/8 publication-title: Cell Signal contributor: fullname: van Lent – volume: 5 start-page: 13 year: 2013 end-page: 31 ident: CR98 article-title: Wnt signaling in bone formation and its therapeutic potential for bone diseases publication-title: Ther Adv Musculoskelet Dis contributor: fullname: Wang – volume: 40 start-page: 783 year: 2009 end-page: 794 ident: CR158 article-title: Histologic subtypes of hepatoblastoma are characterized by differential canonical Wnt and Notch pathway activation in DLK+ precursors publication-title: Hum Pathol contributor: fullname: Adesina – volume: 471 start-page: 235 year: 2011 end-page: 239 ident: CR259 article-title: CREBBP mutations in relapsed acute lymphoblastic leukaemia publication-title: Nature contributor: fullname: Kasper – volume: 4 start-page: 148ra117 year: 2012 ident: CR311 article-title: Targeted disruption of the BCL9/beta-catenin complex inhibits oncogenic Wnt signaling publication-title: Sci Transl Med contributor: fullname: Bird – volume: 96 start-page: 5522 year: 1999 end-page: 5527 ident: CR56 article-title: The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway publication-title: Proc Natl Acad Sci USA contributor: fullname: Simcha – volume: 4 start-page: a007971 year: 2012 ident: CR190 article-title: Wnt pathway regulation of embryonic stem cell self-renewal publication-title: Cold Spring Harb Perspect Biol contributor: fullname: Merrill – volume: 275 start-page: 1787 year: 1997 end-page: 1790 ident: CR238 article-title: Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC publication-title: Science contributor: fullname: Korinek – volume: 284 start-page: 16256 year: 2009 end-page: 16263 ident: CR295 article-title: Discovery and characterization of a small molecule inhibitor of the PDZ domain of dishevelled publication-title: J Biol Chem contributor: fullname: Zhang – volume: 23 start-page: 1405 year: 2014 end-page: 1416 ident: CR200 article-title: Bone morphogenetic protein-9 effectively induces osteo/odontoblastic differentiation of the reversibly immortalized stem cells of dental apical papilla publication-title: Stem Cells Dev contributor: fullname: Zhang – volume: 19 start-page: 683 year: 2009 end-page: 697 ident: CR272 article-title: WNT signaling regulates self-renewal and differentiation of prostate cancer cells with stem cell characteristics publication-title: Cell Res contributor: fullname: Prowse – volume: 32 start-page: 707 year: 2015 end-page: 718 ident: CR64 article-title: FOXKs promote Wnt/beta-catenin signaling by translocating DVL into the nucleus publication-title: Dev Cell contributor: fullname: Lee – volume: 13 start-page: 242 year: 2012 ident: CR84 article-title: The R-spondin protein family publication-title: Genome Biol contributor: fullname: Clevers – volume: 75 start-page: 1341 year: 2015 end-page: 1353 ident: CR341 article-title: Niclosamide suppresses cell migration and invasion in enzalutamide resistant prostate cancer cells via Stat3-AR axis inhibition publication-title: Prostate contributor: fullname: Armstrong – volume: 398 start-page: 422 year: 1999 end-page: 426 ident: CR55 article-title: Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells publication-title: Nature contributor: fullname: McCormick – volume: 87 start-page: 97 year: 2007 end-page: 103 ident: CR21 article-title: Wnt signaling and human diseases: what are the therapeutic implications? publication-title: Lab Invest contributor: fullname: Deng – volume: 25 start-page: 111 year: 2000 end-page: 112 ident: CR32 article-title: A superfamily of membrane-bound O-acyltransferases with implications for wnt signaling publication-title: Trends Biochem Sci contributor: fullname: Hofmann – volume: 162 start-page: 780 year: 2015 end-page: 794 ident: CR187 article-title: Alternative Wnt signaling activates YAP/TAZ publication-title: Cell contributor: fullname: Yu – volume: 26 start-page: 1303 year: 2014 end-page: 1309 ident: CR335 article-title: Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/beta-catenin and mTORC1 signaling in prostate and breast cancer cells publication-title: Cell Signal contributor: fullname: Li – volume: 34 start-page: 110 year: 2012 end-page: 118 ident: CR151 article-title: Wnt-Notch signalling: an integrated mechanism regulating transitions between cell states publication-title: Bioessays contributor: fullname: Arias – volume: 10 start-page: 3116 year: 1996 end-page: 3128 ident: CR33 article-title: The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing publication-title: Genes Dev contributor: fullname: Klingensmith – volume: 65 start-page: 10423 year: 2005 end-page: 10430 ident: CR288 article-title: Identification of SFRP1 as a candidate mediator of stromal-to-epithelial signaling in prostate cancer publication-title: Cancer Res contributor: fullname: Elenbaas – volume: 10 start-page: 16 year: 2011 ident: CR290 article-title: Soluble Frizzled-7 receptor inhibits Wnt signaling and sensitizes hepatocellular carcinoma cells towards doxorubicin publication-title: Mol Cancer contributor: fullname: Grepper – volume: 407 start-page: 527 year: 2000 end-page: 530 ident: CR12 article-title: Arrow encodes an LDL-receptor-related protein essential for Wingless signalling publication-title: Nature contributor: fullname: Caldwell – volume: 63 start-page: 7345 year: 2003 end-page: 7355 ident: CR325 article-title: A selective small molecule inhibitor of c-Met kinase inhibits c-Met-dependent phenotypes and exhibits cytoreductive antitumor activity publication-title: Cancer Res contributor: fullname: Burrows – volume: 6 start-page: 449 year: 2006 end-page: 458 ident: CR261 article-title: Metastasis: a question of life or death publication-title: Nat Rev Cancer contributor: fullname: Puisieux – volume: 2 start-page: 8 year: 2002 ident: CR60 article-title: A transcriptional response to Wnt protein in human embryonic carcinoma cells. BMC publication-title: Dev Biol contributor: fullname: Pollack – volume: 367 start-page: 80 year: 1994 end-page: 83 ident: CR5 article-title: Dishevelled and armadillo act in the wingless signalling pathway in Drosophila publication-title: Nature contributor: fullname: Perrimon – volume: 12 start-page: 468 year: 2010 end-page: 476 ident: CR265 article-title: Wnt activity defines colon cancer stem cells and is regulated by the microenvironment publication-title: Nat Cell Biol contributor: fullname: van der Heijden – volume: 280 start-page: 3576 year: 2013 end-page: 3593 ident: CR300 article-title: Tankyrases as drug targets publication-title: FEBS J contributor: fullname: Krauss – volume: 3 start-page: 493 year: 2008 end-page: 507 ident: CR193 article-title: Periodic activation of Wnt/beta-catenin signaling enhances somatic cell reprogramming mediated by cell fusion publication-title: Cell Stem Cell contributor: fullname: Pepe – volume: 6 start-page: e29290 year: 2011 ident: CR338 article-title: Niclosamide suppresses cancer cell growth by inducing Wnt co-receptor LRP6 degradation and inhibiting the Wnt/beta-catenin pathway publication-title: PLoS One contributor: fullname: Roberts – volume: 289 start-page: 9221 year: 2014 end-page: 9232 ident: CR194 article-title: Regulation of induced pluripotent stem (iPS) cell induction by Wnt/beta-catenin signaling publication-title: J Biol Chem contributor: fullname: Fong – volume: 98 start-page: 14973 year: 2001 end-page: 14978 ident: CR57 article-title: Elevated expression of axin2 and hnkd mRNA provides evidence that Wnt/beta -catenin signaling is activated in human colon tumors publication-title: Proc Natl Acad Sci USA contributor: fullname: Rohan – volume: 262 start-page: 1734 year: 1993 end-page: 1737 ident: CR16 article-title: Association of the APC tumor suppressor protein with catenins publication-title: Science contributor: fullname: Kinzler – volume: 47 start-page: 471 year: 2005 end-page: 482 ident: CR135 article-title: Regulation of Slug transcription in embryonic ectoderm by beta-catenin-Lef/Tcf and BMP-Smad signaling publication-title: Dev Growth Differ contributor: fullname: Endo – volume: 15 start-page: 178 year: 2014 end-page: 196 ident: CR266 article-title: Molecular mechanisms of epithelial-mesenchymal transition publication-title: Nat Rev Mol Cell Biol contributor: fullname: Derynck – volume: 97 start-page: 8358 year: 2000 end-page: 8363 ident: CR129 article-title: Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways publication-title: Proc Natl Acad Sci USA contributor: fullname: Attisano – volume: 19 start-page: 2588 year: 2008 end-page: 2596 ident: CR78 article-title: R-Spondin family members regulate the Wnt pathway by a common mechanism publication-title: Mol Biol Cell contributor: fullname: Tran – volume: 395 start-page: 604 year: 1998 end-page: 608 ident: CR45 article-title: Drosophila Tcf and Groucho interact to repress Wingless signalling activity publication-title: Nature contributor: fullname: Moline – volume: 5 start-page: pii: a008029 year: 2013 ident: CR228 article-title: Wnt signaling in skin development, homeostasis, and disease publication-title: Cold Spring Harb Perspect Biol contributor: fullname: Nusse – volume: 4 start-page: 2610 year: 2013 ident: CR255 article-title: Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells publication-title: Nat Commun contributor: fullname: Dubash – volume: 279 start-page: 45020 year: 2004 end-page: 45027 ident: CR202 article-title: Regulating the balance between peroxisome proliferator-activated receptor gamma and beta-catenin signaling during adipogenesis. A glycogen synthase kinase 3beta phosphorylation-defective mutant of beta-catenin inhibits expression of a subset of adipogenic genes publication-title: J Biol Chem contributor: fullname: Farmer – volume: 253 start-page: 665 year: 1991 end-page: 669 ident: CR14 article-title: Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients publication-title: Science contributor: fullname: Miyoshi – volume: 102 start-page: 11480 year: 2005 end-page: 11485 ident: CR223 article-title: Differential requirements for survivin in hematopoietic cell development publication-title: Proc Natl Acad Sci USA contributor: fullname: Keerthivasan – volume: 5 start-page: 1059 year: 2006 end-page: 1064 ident: CR115 article-title: Cross-talk of WNT and FGF signaling pathways at GSK3beta to regulate beta-catenin and SNAIL signaling cascades publication-title: Cancer Biol Ther contributor: fullname: Katoh – volume: 33 start-page: 2913 year: 2015 end-page: 2924 ident: CR270 article-title: LGR5 promotes breast cancer progression and maintains stem-like cells through activation of Wnt/beta-catenin signaling publication-title: Stem Cells contributor: fullname: Kong – volume: 5 start-page: 91 year: 2004 end-page: 102 ident: CR303 article-title: Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex publication-title: Cancer Cell contributor: fullname: France – volume: 194 start-page: 157 year: 1993 end-page: 165 ident: CR114 article-title: Activation of both Wnt-1 and Fgf-3 by insertion of mouse mammary tumor virus downstream in the reverse orientation: a reappraisal of the enhancer insertion model publication-title: Virology contributor: fullname: Moore – volume: 71 start-page: 119 year: 1998 end-page: 129 ident: CR128 article-title: BMP-2/-4 and Wnt-8 cooperatively pattern the Xenopus mesoderm publication-title: Mech Dev contributor: fullname: Moon – volume: 307 start-page: 131 year: 1984 end-page: 136 ident: CR236 article-title: Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15 publication-title: Nature contributor: fullname: Cox – volume: 71 start-page: 3553 year: 2014 end-page: 3567 ident: CR150 article-title: Wnt-Notch signalling cross-talk in development and disease publication-title: Cell Mol Life Sci contributor: fullname: Brennan – volume: 113 start-page: 546 year: 2009 end-page: 554 ident: CR218 article-title: Wnt3a deficiency irreversibly impairs hematopoietic stem cell self-renewal and leads to defects in progenitor cell differentiation publication-title: Blood contributor: fullname: Naber – volume: 134 start-page: 43 year: 2014 end-page: 54 ident: CR320 article-title: Cancer cells acquire a drug resistant, highly tumorigenic, cancer stem-like phenotype through modulation of the PI3K/Akt/beta-catenin/CBP pathway publication-title: Int J Cancer contributor: fullname: Xu – volume: 365 start-page: 328 year: 2012 end-page: 338 ident: CR42 article-title: Wls-mediated Wnts differentially regulate distal limb patterning and tissue morphogenesis publication-title: Dev Biol contributor: fullname: Zhang – volume: 434 start-page: 843 year: 2005 end-page: 850 ident: CR18 article-title: Wnt signalling in stem cells and cancer publication-title: Nature doi: 10.1038/nature03319 contributor: fullname: Clevers – volume: 19 start-page: 391 year: 2005 end-page: 398 ident: CR111 article-title: Beta-catenin is involved in insulin-like growth factor 1-mediated transactivation of the androgen receptor publication-title: Mol Endocrinol contributor: fullname: Sun – volume: 15 start-page: 7529 year: 2009 end-page: 7537 ident: CR113 article-title: Vascular endothelial growth factor receptor-1 is synthetic lethal to aberrant {beta}-catenin activation in colon cancer publication-title: Clin Cancer Res contributor: fullname: Marasa – volume: 18 start-page: 2718 year: 2004 end-page: 2723 ident: CR148 article-title: LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesis publication-title: Genes Dev contributor: fullname: Hsu – volume: 279 start-page: 55958 year: 2004 end-page: 55968 ident: CR197 article-title: Connective tissue growth factor (CTGF) is regulated by Wnt and bone morphogenetic proteins signaling in osteoblast differentiation of mesenchymal stem cells publication-title: J Biol Chem contributor: fullname: Si – volume: 108 start-page: 11452 year: 2011 end-page: 11457 ident: CR80 article-title: R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling publication-title: Proc Natl Acad Sci USA contributor: fullname: Lin – volume: 13 start-page: 2448 year: 2009 end-page: 2464 ident: CR199 article-title: BMP-9-induced osteogenic differentiation of mesenchymal progenitors requires functional canonical Wnt/beta-catenin signalling publication-title: J Cell Mol Med contributor: fullname: Luo – volume: 9 start-page: 731 year: 2010 end-page: 741 ident: CR286 article-title: Wnt inhibitory factor 1 decreases tumorigenesis and metastasis in osteosarcoma publication-title: Mol Cancer Ther contributor: fullname: Tu – volume: 480 start-page: 118 year: 2011 end-page: 122 ident: CR105 article-title: Nuclear PKM2 regulates beta-catenin transactivation upon EGFR activation publication-title: Nature contributor: fullname: Ji – volume: 22 start-page: 339 year: 2012 end-page: 346 ident: CR182 article-title: The Hippo signaling pathway and stem cell biology publication-title: Trends Cell Biol contributor: fullname: Camargo – volume: 48 start-page: 10267 year: 2009 end-page: 10274 ident: CR337 article-title: The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling publication-title: Biochemistry contributor: fullname: Lu – volume: 131 start-page: 3751 year: 2004 end-page: 3760 ident: CR131 article-title: Combinatorial gene regulation by Bmp and Wnt in zebrafish posterior mesoderm formation publication-title: Development contributor: fullname: Kimelman – volume: 6 start-page: 306 year: 2005 end-page: 317 ident: CR166 article-title: Communicating with Hedgehogs publication-title: Nat Rev Mol Cell Biol contributor: fullname: Scott – volume: 4 start-page: 14 year: 2011 end-page: 25 ident: CR22 article-title: The therapeutic potential of the Wnt signaling pathway in bone disorders publication-title: Curr Mol Pharmacol contributor: fullname: Zhang – volume: 44 start-page: 992 year: 2006 end-page: 1002 ident: CR99 article-title: Activation of Wnt/beta-catenin pathway during hepatocyte growth factor-induced hepatomegaly in mice publication-title: Hepatology contributor: fullname: Muller – volume: 94 start-page: 6770 year: 1997 end-page: 6775 ident: CR85 article-title: Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action publication-title: Proc Natl Acad Sci USA contributor: fullname: Kelley – volume: 130 start-page: 4295 year: 2003 end-page: 4305 ident: CR94 article-title: Wise, a context-dependent activator and inhibitor of Wnt signalling publication-title: Development contributor: fullname: Mercurio – volume: 36 start-page: 664 year: 2000 end-page: 674 ident: CR322 article-title: The effect of non-steroidal anti-inflammatory drugs on human colorectal cancer cells: evidence of different mechanisms of action publication-title: Eur J Cancer contributor: fullname: Hull – volume: 3 start-page: 132 year: 2008 end-page: 135 ident: CR317 article-title: Wnt signaling promotes reprogramming of somatic cells to pluripotency publication-title: Cell Stem Cell contributor: fullname: Chevalier – volume: 11 start-page: 1265 year: 2010 end-page: 1271 ident: CR37 article-title: Wnt trafficking: new insights into Wnt maturation, secretion and spreading publication-title: Traffic contributor: fullname: Basler – volume: 461 start-page: 614 year: 2009 end-page: 620 ident: CR296 article-title: Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling publication-title: Nature contributor: fullname: Liu – volume: 109 start-page: 47 year: 2002 end-page: 60 ident: CR51 article-title: Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex publication-title: Cell contributor: fullname: Brunner – volume: 105 start-page: 533 year: 2001 end-page: 545 ident: CR230 article-title: beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin publication-title: Cell contributor: fullname: Erdmann – volume: 26 start-page: 2955 year: 2006 end-page: 2964 ident: CR198 article-title: CCN1/Cyr61 is regulated by the canonical Wnt signal and plays an important role in Wnt3A-induced osteoblast differentiation of mesenchymal stem cells publication-title: Mol Cell Biol contributor: fullname: Luu – volume: 31 start-page: 344 year: 2015 end-page: 351 ident: CR210 article-title: Repairing organs: lessons from intestine and liver publication-title: Trends Genet contributor: fullname: Clevers – volume: 129 start-page: 626 year: 2005 end-page: 638 ident: CR211 article-title: Expression pattern of Wnt signaling components in the adult intestine publication-title: Gastroenterology contributor: fullname: Begthel – volume: 86 start-page: 391 year: 1996 end-page: 399 ident: CR10 article-title: XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos publication-title: Cell contributor: fullname: Oosterwegel – volume: 67 start-page: 5371 year: 2007 end-page: 5379 ident: CR289 article-title: The soluble wnt receptor Frizzled8CRD-hFc inhibits the growth of teratocarcinomas publication-title: Cancer Res contributor: fullname: Ernst – volume: 3 start-page: 1011 year: 2004 end-page: 1022 ident: CR123 article-title: Development of TGF-beta signalling inhibitors for cancer therapy publication-title: Nat Rev Drug Discov contributor: fullname: Sawyer – volume: 24 start-page: 245 year: 2000 end-page: 250 ident: CR244 article-title: AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1 publication-title: Nat Genet contributor: fullname: Furukawa – volume: 73 start-page: 3132 year: 2013 end-page: 3144 ident: CR299 article-title: A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth publication-title: Cancer Res contributor: fullname: Callow – volume: 303 start-page: 848 year: 2004 end-page: 851 ident: CR137 article-title: TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia publication-title: Science contributor: fullname: Plieth – volume: 29 start-page: 277 year: 2014 end-page: 291 ident: CR38 article-title: WLS retrograde transport to the endoplasmic reticulum during Wnt secretion publication-title: Dev Cell contributor: fullname: Canning – volume: 25 start-page: 254 year: 2013 end-page: 264 ident: CR188 article-title: Wnt signaling in stem and cancer stem cells publication-title: Curr Opin Cell Biol contributor: fullname: Garratt – volume: 474 start-page: 220 year: 2011 end-page: 224 ident: CR224 article-title: A somitic Wnt16/Notch pathway specifies haematopoietic stem cells publication-title: Nature contributor: fullname: Ong – volume: 41 start-page: 1068 year: 2009 end-page: 1075 ident: CR231 article-title: Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia publication-title: Nat Genet contributor: fullname: Polak – volume: 180 start-page: 1087 year: 2008 end-page: 1100 ident: CR62 article-title: Nuclear Dvl, c-Jun, beta-catenin, and TCF form a complex leading to stabilization of beta-catenin-TCF interaction publication-title: J Cell Biol contributor: fullname: Xi – volume: 2 start-page: 572 year: 2015 end-page: 575 ident: CR273 article-title: Targeting CD44 as a novel therapeutic approach for treating pancreatic cancer recurrence publication-title: Oncoscience contributor: fullname: Moutardier – volume: 126 start-page: 752 year: 2009 end-page: 759 ident: CR70 article-title: The PHD domain is required to link Drosophila Pygopus to Legless/beta-catenin and not to histone H3 publication-title: Mech Dev contributor: fullname: Basler – volume: 13 start-page: 513 year: 2014 end-page: 532 ident: CR278 article-title: Can we safely target the WNT pathway? publication-title: Nat Rev Drug Discov contributor: fullname: Kahn – volume: 263 start-page: 145 year: 2008 end-page: 156 ident: CR176 article-title: Cross-talk of hedgehog and Wnt pathways in gastric cancer publication-title: Cancer Lett contributor: fullname: Akiyoshi – volume: 283 start-page: 23371 year: 2008 end-page: 23375 ident: CR93 article-title: Characterization of the Kremen-binding site on Dkk1 and elucidation of the role of Kremen in Dkk-mediated Wnt antagonism publication-title: J Biol Chem contributor: fullname: Li – volume: 151 start-page: 1457 year: 2012 end-page: 1473 ident: CR260 article-title: beta-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis publication-title: Cell contributor: fullname: Cox – volume: 61 start-page: 7318 year: 2001 end-page: 7324 ident: CR110 article-title: Insulin-like growth factor-1 induces survival and growth of biologically early melanoma cells through both the mitogen-activated protein kinase and beta-catenin pathways publication-title: Cancer Res contributor: fullname: Vaidya – volume: 29 start-page: 3236 year: 2010 end-page: 3248 ident: CR192 article-title: Oct-3/4 regulates stem cell identity and cell fate decisions by modulating Wnt/beta-catenin signalling publication-title: EMBO J contributor: fullname: Farago – volume: 2 start-page: 60 year: 2008 end-page: 71 ident: CR217 article-title: Wnt, activin, and BMP signaling regulate distinct stages in the developmental pathway from embryonic stem cells to blood publication-title: Cell Stem Cell contributor: fullname: Keller – volume: 126 start-page: 4557 year: 1999 end-page: 4568 ident: CR229 article-title: Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation publication-title: Development contributor: fullname: Fuchs – volume: 70 start-page: 266 year: 2010 end-page: 276 ident: CR326 article-title: Small-molecule inhibitors of phosphatidylinositol 3-kinase/Akt signaling inhibit Wnt/beta-catenin pathway cross-talk and suppress medulloblastoma growth publication-title: Cancer Res contributor: fullname: Eksborg – volume: 328 start-page: 227 year: 2005 end-page: 234 ident: CR330 article-title: Quercetin, a potent inhibitor against beta-catenin/Tcf signaling in SW480 colon cancer cells publication-title: Biochem Biophys Res Commun contributor: fullname: Hahm – volume: 16 start-page: 35 year: 2011 end-page: 41 ident: CR275 article-title: New avenues to target Wnt/beta-catenin signaling publication-title: Drug Discov Today contributor: fullname: Zaman – volume: 275 start-page: 1784 year: 1997 end-page: 1787 ident: CR237 article-title: Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma publication-title: Science contributor: fullname: Morin – volume: 64 start-page: 60 year: 2006 end-page: 67 ident: CR308 article-title: Inhibition of protein-protein interactions: the discovery of druglike beta-catenin inhibitors by combining virtual and biophysical screening publication-title: Proteins contributor: fullname: Knapp – volume: 11 start-page: 791 year: 2006 end-page: 801 ident: CR34 article-title: Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion publication-title: Dev Cell contributor: fullname: Kurata – volume: 8 start-page: 739 year: 2005 end-page: 750 ident: CR196 article-title: Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis publication-title: Dev Cell contributor: fullname: Garrett-Beal – volume: 12 start-page: 528 year: 2007 end-page: 541 ident: CR219 article-title: Loss of beta-catenin impairs the renewal of normal and CML stem cells publication-title: Cancer Cell contributor: fullname: Chen – volume: 31 start-page: 99 year: 1982 end-page: 109 ident: CR1 article-title: Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome publication-title: Cell contributor: fullname: Varmus – volume: 115 start-page: 4689 year: 2010 end-page: 4698 ident: CR226 article-title: Canonical BMP signaling is dispensable for hematopoietic stem cell function in both adult and fetal liver hematopoiesis, but essential to preserve colon architecture publication-title: Blood contributor: fullname: Ehinger – volume: 22 start-page: 1172 year: 2002 end-page: 1183 ident: CR59 article-title: Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway publication-title: Mol Cell Biol contributor: fullname: Domon – volume: 141 start-page: 1614 year: 2014 end-page: 1626 ident: CR178 article-title: The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease publication-title: Development contributor: fullname: Varelas – volume: 26 start-page: 2284 year: 2007 end-page: 2294 ident: CR52 article-title: CBP/p300 are bimodal regulators of Wnt signaling publication-title: EMBO J contributor: fullname: Parker – volume: 13 start-page: 11 year: 2013 end-page: 26 ident: CR26 article-title: WNT signalling pathways as therapeutic targets in cancer publication-title: Nat Rev Cancer contributor: fullname: Moon – volume: 9 start-page: 2 year: 2011 end-page: 4 ident: CR225 article-title: Wnt to notch relay signaling induces definitive hematopoiesis publication-title: Cell Stem Cell contributor: fullname: Schroeder – volume: 46 start-page: 1679 year: 2010 end-page: 1691 ident: CR269 article-title: Interaction between human-breast cancer metastasis and bone microenvironment through activated hepatocyte growth factor/Met and beta-catenin/Wnt pathways publication-title: Eur J Cancer contributor: fullname: Matteucci – volume: 22 start-page: 1184 year: 2002 end-page: 1193 ident: CR58 article-title: Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors publication-title: Mol Cell Biol contributor: fullname: Sachs – volume: 367 start-page: 76 year: 1994 end-page: 80 ident: CR8 article-title: Components of wingless signalling in Drosophila publication-title: Nature contributor: fullname: Perrimon – volume: 4 start-page: 513 year: 2009 end-page: 524 ident: CR189 article-title: Metastable pluripotent states in NOD-mouse-derived ESCs publication-title: Cell Stem Cell contributor: fullname: Mitalipova – volume: 102 start-page: 12171 year: 2005 end-page: 12176 ident: CR65 article-title: Specific inhibition of CBP/beta-catenin interaction rescues defects in neuronal differentiation caused by a presenilin-1 mutation publication-title: Proc Natl Acad Sci USA contributor: fullname: Nguyen – volume: 3 start-page: 113 year: 2003 end-page: 120 ident: CR241 article-title: Adenomatous polyposis coli/beta-catenin interaction and downstream targets: altered gene expression in gastrointestinal tumors publication-title: Clin Colorectal Cancer contributor: fullname: Groden – volume: 33 start-page: 416 year: 2003 end-page: 421 ident: CR154 article-title: Notch1 functions as a tumor suppressor in mouse skin publication-title: Nat Genet contributor: fullname: Raj – volume: 485 start-page: 195 year: 2012 end-page: 200 ident: CR82 article-title: ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner publication-title: Nature contributor: fullname: Zhang – volume: 36 start-page: 547 year: 2009 end-page: 559 ident: CR103 article-title: EGF-induced ERK activation promotes CK2-mediated disassociation of alpha-Catenin from beta-Catenin and transactivation of beta-Catenin publication-title: Mol Cell contributor: fullname: Nika – volume: 141 start-page: 2206 year: 2014 end-page: 2215 ident: CR302 article-title: Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts publication-title: Development contributor: fullname: Madan – volume: 193 start-page: 161 year: 2003 end-page: 170 ident: CR324 article-title: Tyrosine kinase inhibitor STI-571/Gleevec down-regulates the beta-catenin signaling activity publication-title: Cancer Lett contributor: fullname: Haydon – volume: 281 start-page: 13247 year: 2006 end-page: 13257 ident: CR76 article-title: Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression publication-title: J Biol Chem contributor: fullname: Smith – volume: 271 start-page: 1826 year: 1996 end-page: 1832 ident: CR153 article-title: Interaction between Wingless and Notch signaling pathways mediated by dishevelled publication-title: Science contributor: fullname: Artavanis-Tsakonas – volume: 17 start-page: 9 year: 2009 end-page: 26 ident: CR20 article-title: Wnt/beta-catenin signaling: components, mechanisms, and diseases publication-title: Dev Cell contributor: fullname: He – volume: 83-A Suppl 1 start-page: S31 issue: Pt 1 year: 2001 end-page: S39 ident: CR133 article-title: Transcriptional regulation by Smads: cross-talk between the TGF-beta and Wnt pathways publication-title: J Bone Joint Surg Am contributor: fullname: Attisano – volume: 68 start-page: 5086 year: 2008 end-page: 5095 ident: CR118 article-title: Inhibition of fibroblast growth factor 19 reduces tumor growth by modulating beta-catenin signaling publication-title: Cancer Res contributor: fullname: Qing – volume: 478 start-page: 255 year: 2011 end-page: 259 ident: CR208 article-title: A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable publication-title: Nature contributor: fullname: Warming – volume: 110 start-page: 20224 year: 2013 end-page: 20229 ident: CR301 article-title: Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974 publication-title: Proc Natl Acad Sci USA contributor: fullname: Hsieh – volume: 284 start-page: 770 year: 1999 end-page: 776 ident: CR144 article-title: Notch signaling: cell fate control and signal integration in development publication-title: Science contributor: fullname: Lake – volume: 6 start-page: 314 year: 2005 end-page: 322 ident: CR147 article-title: Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance publication-title: Nat Immunol contributor: fullname: DiMascio – volume: 35 start-page: 2357 year: 2014 end-page: 2364 ident: CR257 article-title: Wntless (GPR177) expression correlates with poor prognosis in B-cell precursor acute lymphoblastic leukemia via Wnt signaling publication-title: Carcinogenesis contributor: fullname: Huang – volume: 32 start-page: 1977 year: 2013 end-page: 1989 ident: CR318 article-title: Wnt/beta-catenin signalling induces MLL to create epigenetic changes in salivary gland tumours publication-title: EMBO J contributor: fullname: Zhu – volume: 176 start-page: 518 year: 2010 end-page: 527 ident: CR159 article-title: The Sex-determining region Y-box 4 and homeobox C6 transcriptional networks in prostate cancer progression: cros-stalk with the Wnt, Notch, and PI3K pathways publication-title: Am J Pathol contributor: fullname: Moreno – volume: 137 start-page: 629 year: 2009 end-page: 638 ident: CR173 article-title: Reduced level of smoothened suppresses intestinal tumorigenesis by down-regulation of Wnt signaling publication-title: Gastroenterology contributor: fullname: Kitamura – volume: 20 start-page: 645 year: 2001 end-page: 653 ident: CR323 article-title: The nonsteroidal anti-inflammatory drugs aspirin and indomethacin attenuate beta-catenin/TCF-4 signaling publication-title: Oncogene contributor: fullname: von Knebel Doeberitz – volume: 137 start-page: 422 year: 2009 ident: 10.1038/labinvest.2015.144_bib172 article-title: New insights into the role of Hedgehog signaling in gastrointestinal development and cancer publication-title: Gastroenterology doi: 10.1053/j.gastro.2009.06.021 contributor: fullname: Kim – volume: 222 start-page: 1 year: 2010 ident: 10.1038/labinvest.2015.144_bib262 article-title: Current and emerging concepts in tumour metastasis publication-title: J Pathol doi: 10.1002/path.2727 contributor: fullname: Coghlin – volume: 25 start-page: 499 year: 2015 ident: 10.1038/labinvest.2015.144_bib179 article-title: YAP and TAZ: a nexus for Hippo signaling and beyond publication-title: Trends Cell Biol doi: 10.1016/j.tcb.2015.05.002 contributor: fullname: Hansen – volume: 19 start-page: 2588 year: 2008 ident: 10.1038/labinvest.2015.144_bib78 article-title: R-Spondin family members regulate the Wnt pathway by a common mechanism publication-title: Mol Biol Cell doi: 10.1091/mbc.e08-02-0187 contributor: fullname: Kim – volume: 129 start-page: 626 year: 2005 ident: 10.1038/labinvest.2015.144_bib211 article-title: Expression pattern of Wnt signaling components in the adult intestine publication-title: Gastroenterology doi: 10.1016/j.gastro.2005.06.007 contributor: fullname: Gregorieff – volume: 25 start-page: 111 year: 2000 ident: 10.1038/labinvest.2015.144_bib32 article-title: A superfamily of membrane-bound O-acyltransferases with implications for wnt signaling publication-title: Trends Biochem Sci doi: 10.1016/S0968-0004(99)01539-X contributor: fullname: Hofmann – volume: 101 start-page: 12682 year: 2004 ident: 10.1038/labinvest.2015.144_bib313 article-title: A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected] publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0404875101 contributor: fullname: Emami – volume: 20 start-page: 781 year: 2004 ident: 10.1038/labinvest.2015.144_bib17 article-title: The Wnt signaling pathway in development and disease publication-title: Annu Rev Cell Dev Biol doi: 10.1146/annurev.cellbio.20.010403.113126 contributor: fullname: Logan – volume: 109 start-page: E2197 year: 2012 ident: 10.1038/labinvest.2015.144_bib41 article-title: Wntless functions in mature osteoblasts to regulate bone mass publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1120407109 contributor: fullname: Zhong – volume: 8 start-page: 76 year: 2009 ident: 10.1038/labinvest.2015.144_bib284 article-title: Blockade of Wnt-1 signaling leads to anti-tumor effects in hepatocellular carcinoma cells publication-title: Mol Cancer doi: 10.1186/1476-4598-8-76 contributor: fullname: Wei – volume: 19 start-page: 1749 year: 2004 ident: 10.1038/labinvest.2015.144_bib97 article-title: LRP5 and Wnt signaling: a union made for bone publication-title: J Bone Miner Res doi: 10.1359/JBMR.040816 contributor: fullname: Johnson – volume: 253 start-page: 665 year: 1991 ident: 10.1038/labinvest.2015.144_bib14 article-title: Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients publication-title: Science doi: 10.1126/science.1651563 contributor: fullname: Nishisho – volume: 5 start-page: 91 year: 2004 ident: 10.1038/labinvest.2015.144_bib303 article-title: Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex publication-title: Cancer Cell doi: 10.1016/S1535-6108(03)00334-9 contributor: fullname: Lepourcelet – volume: 6 start-page: 829 year: 2010 ident: 10.1038/labinvest.2015.144_bib336 article-title: Small-molecule inhibition of Wnt signaling through activation of casein kinase 1alpha publication-title: Nat Chem Biol doi: 10.1038/nchembio.453 contributor: fullname: Thorne – volume: 402 start-page: 515 year: 2007 ident: 10.1038/labinvest.2015.144_bib31 article-title: Post-translational palmitoylation and glycosylation of Wnt-5a are necessary for its signalling publication-title: Biochem J doi: 10.1042/BJ20061476 contributor: fullname: Kurayoshi – volume: 178 start-page: 635 year: 2007 ident: 10.1038/labinvest.2015.144_bib213 article-title: Sox9 regulates cell proliferation and is required for Paneth cell differentiation in the intestinal epithelium publication-title: J Cell Biol doi: 10.1083/jcb.200704152 contributor: fullname: Bastide – volume: 94 start-page: 1287 year: 2014 ident: 10.1038/labinvest.2015.144_bib180 article-title: The biology of YAP/TAZ: hippo signaling and beyond publication-title: Physiol Rev doi: 10.1152/physrev.00005.2014 contributor: fullname: Piccolo – volume: 119 start-page: 837 year: 2009 ident: 10.1038/labinvest.2015.144_bib252 article-title: Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice publication-title: J Clin Invest doi: 10.1172/JCI37175 contributor: fullname: Kansara – volume: 109 start-page: 47 year: 2002 ident: 10.1038/labinvest.2015.144_bib51 article-title: Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex publication-title: Cell doi: 10.1016/S0092-8674(02)00679-7 contributor: fullname: Kramps – volume: 285 start-page: 1928 year: 2010 ident: 10.1038/labinvest.2015.144_bib106 article-title: IRS1 regulation by Wnt/beta-catenin signaling and varied contribution of IRS1 to the neoplastic phenotype publication-title: J Biol Chem doi: 10.1074/jbc.M109.060319 contributor: fullname: Bommer – volume: 26 start-page: 2284 year: 2007 ident: 10.1038/labinvest.2015.144_bib52 article-title: CBP/p300 are bimodal regulators of Wnt signaling publication-title: EMBO J doi: 10.1038/sj.emboj.7601667 contributor: fullname: Li – volume: 280 start-page: 3576 year: 2013 ident: 10.1038/labinvest.2015.144_bib300 article-title: Tankyrases as drug targets publication-title: FEBS J doi: 10.1111/febs.12320 contributor: fullname: Lehtio – volume: 2 start-page: 8 year: 2002 ident: 10.1038/labinvest.2015.144_bib60 article-title: A transcriptional response to Wnt protein in human embryonic carcinoma cells. BMC publication-title: Dev Biol contributor: fullname: Willert – volume: 47 start-page: 471 year: 2005 ident: 10.1038/labinvest.2015.144_bib135 article-title: Regulation of Slug transcription in embryonic ectoderm by beta-catenin-Lef/Tcf and BMP-Smad signaling publication-title: Dev Growth Differ doi: 10.1111/j.1440-169X.2005.00821.x contributor: fullname: Sakai – volume: 50 start-page: 649 year: 1987 ident: 10.1038/labinvest.2015.144_bib4 article-title: The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless publication-title: Cell doi: 10.1016/0092-8674(87)90038-9 contributor: fullname: Rijsewijk – volume: 11 start-page: 33 year: 2015 ident: 10.1038/labinvest.2015.144_bib216 article-title: Opposing activities of Notch and Wnt signaling regulate intestinal stem cells and gut homeostasis publication-title: Cell Rep doi: 10.1016/j.celrep.2015.03.007 contributor: fullname: Tian – volume: 39 start-page: 145 year: 2015 ident: 10.1038/labinvest.2015.144_bib201 article-title: Canonical Wnt signaling acts synergistically on BMP9-induced osteo/odontoblastic differentiation of stem cells of dental apical papilla (SCAPs) publication-title: Biomaterials doi: 10.1016/j.biomaterials.2014.11.007 contributor: fullname: Zhang – volume: 72 start-page: 2822 year: 2012 ident: 10.1038/labinvest.2015.144_bib298 article-title: A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-11-3336 contributor: fullname: Waaler – volume: 31 start-page: 99 year: 1982 ident: 10.1038/labinvest.2015.144_bib1 article-title: Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome publication-title: Cell doi: 10.1016/0092-8674(82)90409-3 contributor: fullname: Nusse – volume: 86 start-page: 391 year: 1996 ident: 10.1038/labinvest.2015.144_bib10 article-title: XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos publication-title: Cell doi: 10.1016/S0092-8674(00)80112-9 contributor: fullname: Molenaar – volume: 106 start-page: 6309 year: 2009 ident: 10.1038/labinvest.2015.144_bib157 article-title: Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0900427106 contributor: fullname: Fre – volume: 21 start-page: 8414 year: 2002 ident: 10.1038/labinvest.2015.144_bib328 article-title: Beta-catenin-mediated transactivation and cell-cell adhesion pathways are important in curcumin (diferuylmethane)-induced growth arrest and apoptosis in colon cancer cells publication-title: Oncogene doi: 10.1038/sj.onc.1205947 contributor: fullname: Jaiswal – volume: 8 start-page: 387 year: 2008 ident: 10.1038/labinvest.2015.144_bib19 article-title: Wnt signalling and its impact on development and cancer publication-title: Nat Rev Cancer doi: 10.1038/nrc2389 contributor: fullname: Klaus – volume: 134 start-page: 112 year: 2014 ident: 10.1038/labinvest.2015.144_bib340 article-title: Inhibition of Wnt/beta-catenin pathway by niclosamide: a therapeutic target for ovarian cancer publication-title: Gynecol Oncol doi: 10.1016/j.ygyno.2014.04.005 contributor: fullname: Arend – volume: 162 start-page: 780 year: 2015 ident: 10.1038/labinvest.2015.144_bib187 article-title: Alternative Wnt signaling activates YAP/TAZ publication-title: Cell doi: 10.1016/j.cell.2015.07.013 contributor: fullname: Park – volume: 17 start-page: 9 year: 2009 ident: 10.1038/labinvest.2015.144_bib20 article-title: Wnt/beta-catenin signaling: components, mechanisms, and diseases publication-title: Dev Cell doi: 10.1016/j.devcel.2009.06.016 contributor: fullname: MacDonald – volume: 2 start-page: 133 year: 2015 ident: 10.1038/labinvest.2015.144_bib247 article-title: Pancreatic cancer stromal biology and therapy publication-title: Genes Dis doi: 10.1016/j.gendis.2015.01.002 contributor: fullname: Xie – volume: 31 start-page: 2737 year: 2012 ident: 10.1038/labinvest.2015.144_bib276 article-title: Drugging Wnt signalling in cancer publication-title: Embo J doi: 10.1038/emboj.2012.126 contributor: fullname: Polakis – volume: 480 start-page: 118 year: 2011 ident: 10.1038/labinvest.2015.144_bib105 article-title: Nuclear PKM2 regulates beta-catenin transactivation upon EGFR activation publication-title: Nature doi: 10.1038/nature10598 contributor: fullname: Yang – volume: 126 start-page: 2931 issue: Pt 13 year: 2013 ident: 10.1038/labinvest.2015.144_bib40 article-title: The apical and basolateral secretion of Wnt11 and Wnt3a in polarized epithelial cells is regulated by different mechanisms publication-title: J Cell Sci contributor: fullname: Yamamoto – volume: 279 start-page: 55958 year: 2004 ident: 10.1038/labinvest.2015.144_bib197 article-title: Connective tissue growth factor (CTGF) is regulated by Wnt and bone morphogenetic proteins signaling in osteoblast differentiation of mesenchymal stem cells publication-title: J Biol Chem doi: 10.1074/jbc.M407810200 contributor: fullname: Luo – volume: 11 start-page: 1265 year: 2010 ident: 10.1038/labinvest.2015.144_bib37 article-title: Wnt trafficking: new insights into Wnt maturation, secretion and spreading publication-title: Traffic doi: 10.1111/j.1600-0854.2010.01076.x contributor: fullname: Port – volume: 65 start-page: 10423 year: 2005 ident: 10.1038/labinvest.2015.144_bib288 article-title: Identification of SFRP1 as a candidate mediator of stromal-to-epithelial signaling in prostate cancer publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-05-0824 contributor: fullname: Joesting – volume: 13 start-page: 513 year: 2014 ident: 10.1038/labinvest.2015.144_bib278 article-title: Can we safely target the WNT pathway? publication-title: Nat Rev Drug Discov doi: 10.1038/nrd4233 contributor: fullname: Kahn – volume: 253 start-page: 661 year: 1991 ident: 10.1038/labinvest.2015.144_bib13 article-title: Identification of FAP locus genes from chromosome 5q21 publication-title: Science doi: 10.1126/science.1651562 contributor: fullname: Kinzler – volume: 13 start-page: 11 year: 2013 ident: 10.1038/labinvest.2015.144_bib26 article-title: WNT signalling pathways as therapeutic targets in cancer publication-title: Nat Rev Cancer doi: 10.1038/nrc3419 contributor: fullname: Anastas – volume: 97 start-page: 8358 year: 2000 ident: 10.1038/labinvest.2015.144_bib129 article-title: Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.150152697 contributor: fullname: Labbe – volume: 9 start-page: 731 year: 2010 ident: 10.1038/labinvest.2015.144_bib286 article-title: Wnt inhibitory factor 1 decreases tumorigenesis and metastasis in osteosarcoma publication-title: Mol Cancer Ther doi: 10.1158/1535-7163.MCT-09-0147 contributor: fullname: Rubin – volume: 6 start-page: 7 year: 2004 ident: 10.1038/labinvest.2015.144_bib282 article-title: A monoclonal antibody against Wnt-1 induces apoptosis in human cancer cells publication-title: Neoplasia doi: 10.1016/S1476-5586(04)80048-4 contributor: fullname: He – volume: 365 start-page: 328 year: 2012 ident: 10.1038/labinvest.2015.144_bib42 article-title: Wls-mediated Wnts differentially regulate distal limb patterning and tissue morphogenesis publication-title: Dev Biol doi: 10.1016/j.ydbio.2012.02.019 contributor: fullname: Zhu – volume: 130 start-page: 1120 year: 2007 ident: 10.1038/labinvest.2015.144_bib177 article-title: Elucidation of a universal size-control mechanism in Drosophila and mammals publication-title: Cell doi: 10.1016/j.cell.2007.07.019 contributor: fullname: Dong – volume: 109 start-page: 466 year: 2012 ident: 10.1038/labinvest.2015.144_bib209 article-title: The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1118857109 contributor: fullname: Yan – volume: 243 start-page: 1095 year: 2014 ident: 10.1038/labinvest.2015.144_bib44 article-title: Concentration-dependent effects of WNTLESS on WNT1/3A signaling publication-title: Dev Dyn doi: 10.1002/dvdy.24149 contributor: fullname: Galli – volume: 7 start-page: re8 year: 2014 ident: 10.1038/labinvest.2015.144_bib267 article-title: Signaling mechanisms of the epithelial-mesenchymal transition publication-title: Sci Signal doi: 10.1126/scisignal.2005189 contributor: fullname: Gonzalez – volume: 281 start-page: 13247 year: 2006 ident: 10.1038/labinvest.2015.144_bib76 article-title: Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression publication-title: J Biol Chem doi: 10.1074/jbc.M508324200 contributor: fullname: Nam – volume: 127 start-page: 73 year: 2010 ident: 10.1038/labinvest.2015.144_bib171 article-title: Hedgehog pathway activity is required for the lethality and intestinal phenotypes of mice with hyperactive Wnt signaling publication-title: Mech Dev doi: 10.1016/j.mod.2009.10.005 contributor: fullname: Varnat – volume: 36 start-page: 664 year: 2000 ident: 10.1038/labinvest.2015.144_bib322 article-title: The effect of non-steroidal anti-inflammatory drugs on human colorectal cancer cells: evidence of different mechanisms of action publication-title: Eur J Cancer doi: 10.1016/S0959-8049(99)00333-0 contributor: fullname: Smith – volume: 111 start-page: 251 year: 2002 ident: 10.1038/labinvest.2015.144_bib215 article-title: Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB publication-title: Cell doi: 10.1016/S0092-8674(02)01015-2 contributor: fullname: Batlle – volume: 19 start-page: 683 year: 2009 ident: 10.1038/labinvest.2015.144_bib272 article-title: WNT signaling regulates self-renewal and differentiation of prostate cancer cells with stem cell characteristics publication-title: Cell Res doi: 10.1038/cr.2009.43 contributor: fullname: Bisson – volume: 5 start-page: 53 year: 2005 ident: 10.1038/labinvest.2015.144_bib283 article-title: Efficacy of Wnt-1 monoclonal antibody in sarcoma cells publication-title: BMC Cancer doi: 10.1186/1471-2407-5-53 contributor: fullname: Mikami – volume: 316 start-page: 1619 year: 2007 ident: 10.1038/labinvest.2015.144_bib48 article-title: Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation publication-title: Science doi: 10.1126/science.1137065 contributor: fullname: Bilic – volume: 154 start-page: 274 year: 2013 ident: 10.1038/labinvest.2015.144_bib207 article-title: The intestinal crypt, a prototype stem cell compartment publication-title: Cell doi: 10.1016/j.cell.2013.07.004 contributor: fullname: Clevers – volume: 29 start-page: 3236 year: 2010 ident: 10.1038/labinvest.2015.144_bib192 article-title: Oct-3/4 regulates stem cell identity and cell fate decisions by modulating Wnt/beta-catenin signalling publication-title: EMBO J doi: 10.1038/emboj.2010.200 contributor: fullname: Abu-Remaileh – volume: 87 start-page: 97 year: 2007 ident: 10.1038/labinvest.2015.144_bib21 article-title: Wnt signaling and human diseases: what are the therapeutic implications? publication-title: Lab Invest doi: 10.1038/labinvest.3700509 contributor: fullname: Luo – volume: 10 start-page: 16 year: 2011 ident: 10.1038/labinvest.2015.144_bib290 article-title: Soluble Frizzled-7 receptor inhibits Wnt signaling and sensitizes hepatocellular carcinoma cells towards doxorubicin publication-title: Mol Cancer doi: 10.1186/1476-4598-10-16 contributor: fullname: Wei – volume: 98 start-page: 479 year: 2006 ident: 10.1038/labinvest.2015.144_bib156 article-title: Growth suppression induced by Notch1 activation involves Wnt-beta-catenin down-regulation in human tongue carcinoma cells publication-title: Biol Cell doi: 10.1042/BC20060020 contributor: fullname: Duan – volume: 283 start-page: 23371 year: 2008 ident: 10.1038/labinvest.2015.144_bib93 article-title: Characterization of the Kremen-binding site on Dkk1 and elucidation of the role of Kremen in Dkk-mediated Wnt antagonism publication-title: J Biol Chem doi: 10.1074/jbc.M802376200 contributor: fullname: Wang – volume: 284 start-page: 770 year: 1999 ident: 10.1038/labinvest.2015.144_bib144 article-title: Notch signaling: cell fate control and signal integration in development publication-title: Science doi: 10.1126/science.284.5415.770 contributor: fullname: Artavanis-Tsakonas – volume: 2 start-page: 67 year: 2010 ident: 10.1038/labinvest.2015.144_bib195 article-title: Mesenchymal stem cells: Molecular characteristics and clinical applications. World J publication-title: Stem Cells contributor: fullname: Rastegar – volume: 6 start-page: 314 year: 2005 ident: 10.1038/labinvest.2015.144_bib147 article-title: Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance publication-title: Nat Immunol doi: 10.1038/ni1164 contributor: fullname: Duncan – volume: 64 start-page: 60 year: 2006 ident: 10.1038/labinvest.2015.144_bib308 article-title: Inhibition of protein-protein interactions: the discovery of druglike beta-catenin inhibitors by combining virtual and biophysical screening publication-title: Proteins doi: 10.1002/prot.20955 contributor: fullname: Trosset – volume: 317 start-page: 745 year: 2011 ident: 10.1038/labinvest.2015.144_bib203 article-title: Wnt signalling mediates the cross-talk between bone marrow derived pre-adipocytic and pre-osteoblastic cell populations publication-title: Exp Cell Res doi: 10.1016/j.yexcr.2010.12.015 contributor: fullname: Taipaleenmaki – volume: 29 start-page: 1493 year: 2015 ident: 10.1038/labinvest.2015.144_bib186 article-title: beta-Catenin destruction complex-independent regulation of Hippo-YAP signaling by APC in intestinal tumorigenesis publication-title: Genes Dev doi: 10.1101/gad.264515.115 contributor: fullname: Cai – volume: 194 start-page: 157 year: 1993 ident: 10.1038/labinvest.2015.144_bib114 article-title: Activation of both Wnt-1 and Fgf-3 by insertion of mouse mammary tumor virus downstream in the reverse orientation: a reappraisal of the enhancer insertion model publication-title: Virology doi: 10.1006/viro.1993.1245 contributor: fullname: Clausse – volume: 6 start-page: 449 year: 2006 ident: 10.1038/labinvest.2015.144_bib261 article-title: Metastasis: a question of life or death publication-title: Nat Rev Cancer doi: 10.1038/nrc1886 contributor: fullname: Mehlen – volume: 116 start-page: 739 year: 2001 ident: 10.1038/labinvest.2015.144_bib167 article-title: Activation of expression of hedgehog target genes in basal cell carcinomas publication-title: J Invest Dermatol doi: 10.1046/j.1523-1747.2001.01315.x contributor: fullname: Bonifas – volume: 126 start-page: 4557 year: 1999 ident: 10.1038/labinvest.2015.144_bib229 article-title: Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation publication-title: Development doi: 10.1242/dev.126.20.4557 contributor: fullname: DasGupta – volume: 280 start-page: 19883 year: 2005 ident: 10.1038/labinvest.2015.144_bib95 article-title: Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling publication-title: J Biol Chem doi: 10.1074/jbc.M413274200 contributor: fullname: Li – volume: 63 start-page: 7345 year: 2003 ident: 10.1038/labinvest.2015.144_bib325 article-title: A selective small molecule inhibitor of c-Met kinase inhibits c-Met-dependent phenotypes in vitro and exhibits cytoreductive antitumor activity in vivo publication-title: Cancer Res contributor: fullname: Christensen – volume: 34 start-page: 110 year: 2012 ident: 10.1038/labinvest.2015.144_bib151 article-title: Wnt-Notch signalling: an integrated mechanism regulating transitions between cell states publication-title: Bioessays doi: 10.1002/bies.201100102 contributor: fullname: Munoz-Descalzo – volume: 476 start-page: 293 year: 2011 ident: 10.1038/labinvest.2015.144_bib81 article-title: Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling publication-title: Nature doi: 10.1038/nature10337 contributor: fullname: de Lau – volume: 69 start-page: 8572 year: 2009 ident: 10.1038/labinvest.2015.144_bib170 article-title: Wnt signaling stimulates transcriptional outcome of the Hedgehog pathway by stabilizing GLI1 mRNA publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-09-1500 contributor: fullname: Noubissi – volume: 20 start-page: 645 year: 2001 ident: 10.1038/labinvest.2015.144_bib323 article-title: The nonsteroidal anti-inflammatory drugs aspirin and indomethacin attenuate beta-catenin/TCF-4 signaling publication-title: Oncogene doi: 10.1038/sj.onc.1204123 contributor: fullname: Dihlmann – volume: 136 start-page: 903 year: 2009 ident: 10.1038/labinvest.2015.144_bib214 article-title: Transcription factor achaete scute-like 2 controls intestinal stem cell fate publication-title: Cell doi: 10.1016/j.cell.2009.01.031 contributor: fullname: van der Flier – volume: 2001 start-page: pe31 year: 2001 ident: 10.1038/labinvest.2015.144_bib164 article-title: Fat hedgehogs, slower or richer? publication-title: Sci STKE doi: 10.1126/stke.2001.100.pe31 contributor: fullname: van Den Heuvel – volume: 20 start-page: 3198 year: 2014 ident: 10.1038/labinvest.2015.144_bib342 article-title: Niclosamide inhibits androgen receptor variants expression and overcomes enzalutamide resistance in castration-resistant prostate cancer publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-13-3296 contributor: fullname: Liu – volume: 3 start-page: 113 year: 2003 ident: 10.1038/labinvest.2015.144_bib241 article-title: Adenomatous polyposis coli/beta-catenin interaction and downstream targets: altered gene expression in gastrointestinal tumors publication-title: Clin Colorectal Cancer doi: 10.3816/CCC.2003.n.018 contributor: fullname: Clements – volume: 279 start-page: 45020 year: 2004 ident: 10.1038/labinvest.2015.144_bib202 publication-title: J Biol Chem doi: 10.1074/jbc.M407050200 contributor: fullname: Liu – volume: 391 start-page: 357 year: 1998 ident: 10.1038/labinvest.2015.144_bib89 article-title: Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction publication-title: Nature doi: 10.1038/34848 contributor: fullname: Glinka – volume: 151 start-page: 1457 year: 2012 ident: 10.1038/labinvest.2015.144_bib260 article-title: beta-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis publication-title: Cell doi: 10.1016/j.cell.2012.11.026 contributor: fullname: Rosenbluh – volume: 70 start-page: 266 year: 2010 ident: 10.1038/labinvest.2015.144_bib326 article-title: Small-molecule inhibitors of phosphatidylinositol 3-kinase/Akt signaling inhibit Wnt/beta-catenin pathway cross-talk and suppress medulloblastoma growth publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-09-0578 contributor: fullname: Baryawno – volume: 105 start-page: 1087 year: 2014 ident: 10.1038/labinvest.2015.144_bib321 article-title: Safely targeting cancer stem cells via selective catenin coactivator antagonism publication-title: Cancer Sci doi: 10.1111/cas.12471 contributor: fullname: Lenz – volume: 16 start-page: 633 year: 2009 ident: 10.1038/labinvest.2015.144_bib145 article-title: Notch signaling: the core pathway and its posttranslational regulation publication-title: Dev Cell doi: 10.1016/j.devcel.2009.03.010 contributor: fullname: Fortini – volume: 24 start-page: 2291 year: 2012 ident: 10.1038/labinvest.2015.144_bib334 article-title: Silibinin inhibits Wnt/beta-catenin signaling by suppressing Wnt co-receptor LRP6 expression in human prostate and breast cancer cells publication-title: Cell Signal doi: 10.1016/j.cellsig.2012.07.009 contributor: fullname: Lu – volume: 291 start-page: 21 year: 2011 ident: 10.1038/labinvest.2015.144_bib61 article-title: New insights into the mechanism of Wnt signaling pathway activation publication-title: Int Rev Cell Mol Biol doi: 10.1016/B978-0-12-386035-4.00002-1 contributor: fullname: Kikuchi – volume: 240 start-page: 365 year: 2011 ident: 10.1038/labinvest.2015.144_bib43 article-title: Gpr177/mouse Wntless is essential for Wnt-mediated craniofacial and brain development publication-title: Dev Dyn doi: 10.1002/dvdy.22541 contributor: fullname: Fu – volume: 108 start-page: 11452 year: 2011 ident: 10.1038/labinvest.2015.144_bib80 article-title: R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1106083108 contributor: fullname: Carmon – volume: 471 start-page: 235 year: 2011 ident: 10.1038/labinvest.2015.144_bib259 article-title: CREBBP mutations in relapsed acute lymphoblastic leukaemia publication-title: Nature doi: 10.1038/nature09727 contributor: fullname: Mullighan – volume: 239 start-page: 16 year: 2010 ident: 10.1038/labinvest.2015.144_bib143 article-title: Cross-talk between Wnt and bone morphogenic protein signaling: a turbulent relationship publication-title: Dev Dyn contributor: fullname: Itasaki – volume: 109 start-page: 17942 year: 2012 ident: 10.1038/labinvest.2015.144_bib312 article-title: Inhibition of oncogenic Wnt signaling through direct targeting of beta-catenin publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1208396109 contributor: fullname: Grossmann – volume: 106 start-page: 18598 year: 2009 ident: 10.1038/labinvest.2015.144_bib36 article-title: Reciprocal regulation of Wnt and Gpr177/mouse Wntless is required for embryonic axis formation publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0904894106 contributor: fullname: Fu – volume: 79 start-page: 211 year: 2011 ident: 10.1038/labinvest.2015.144_bib333 article-title: Tetrandrine inhibits Wnt/beta-catenin signaling and suppresses tumor growth of human colorectal cancer publication-title: Mol Pharmacol doi: 10.1124/mol.110.068668 contributor: fullname: He – volume: 28 start-page: 4875 year: 2008 ident: 10.1038/labinvest.2015.144_bib91 article-title: Targeted disruption of the Wnt regulator Kremen induces limb defects and high bone density publication-title: Mol Cell Biol doi: 10.1128/MCB.00222-08 contributor: fullname: Ellwanger – volume: 445 start-page: 834 year: 2007 ident: 10.1038/labinvest.2015.144_bib227 article-title: Scratching the surface of skin development publication-title: Nature doi: 10.1038/nature05659 contributor: fullname: Fuchs – volume: 13 start-page: 767 year: 2012 ident: 10.1038/labinvest.2015.144_bib25 article-title: The complex world of WNT receptor signalling publication-title: Nat Rev Mol Cell Biol doi: 10.1038/nrm3470 contributor: fullname: Niehrs – volume: 3 start-page: 1011 year: 2004 ident: 10.1038/labinvest.2015.144_bib123 article-title: Development of TGF-beta signalling inhibitors for cancer therapy publication-title: Nat Rev Drug Discov doi: 10.1038/nrd1580 contributor: fullname: Yingling – volume: 201 start-page: 204 year: 2003 ident: 10.1038/labinvest.2015.144_bib251 article-title: WIF1, a component of the Wnt pathway, is down-regulated in prostate, breast, lung, and bladder cancer publication-title: J Pathol doi: 10.1002/path.1449 contributor: fullname: Wissmann – volume: 129 start-page: 3045 year: 2002 ident: 10.1038/labinvest.2015.144_bib134 article-title: Wnt and Bmp signalling cooperatively regulate graded Emx2 expression in the dorsal telencephalon publication-title: Development doi: 10.1242/dev.129.13.3045 contributor: fullname: Theil – volume: 398 start-page: 422 year: 1999 ident: 10.1038/labinvest.2015.144_bib55 article-title: Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells publication-title: Nature doi: 10.1038/18884 contributor: fullname: Tetsu – volume: 62 start-page: 2744 year: 2002 ident: 10.1038/labinvest.2015.144_bib127 article-title: Oncogenic beta-catenin is required for bone morphogenetic protein 4 expression in human cancer cells publication-title: Cancer Res contributor: fullname: Kim – volume: 71 start-page: 1167 year: 1992 ident: 10.1038/labinvest.2015.144_bib7 article-title: wingless signaling acts through zeste-white 3, the Drosophila homolog of glycogen synthase kinase-3, to regulate engrailed and establish cell fate publication-title: Cell doi: 10.1016/S0092-8674(05)80065-0 contributor: fullname: Siegfried – volume: 126 start-page: 2426 year: 2010 ident: 10.1038/labinvest.2015.144_bib304 article-title: Small molecule antagonists of Tcf4/beta-catenin complex inhibit the growth of HCC cells in vitroin vivo publication-title: Int J Cancer contributor: fullname: Wei – volume: 22 start-page: 1172 year: 2002 ident: 10.1038/labinvest.2015.144_bib59 article-title: Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway publication-title: Mol Cell Biol doi: 10.1128/MCB.22.4.1172-1183.2002 contributor: fullname: Jho – volume: 2 start-page: 572 year: 2015 ident: 10.1038/labinvest.2015.144_bib273 article-title: Targeting CD44 as a novel therapeutic approach for treating pancreatic cancer recurrence publication-title: Oncoscience doi: 10.18632/oncoscience.172 contributor: fullname: Molejon – volume: 262 start-page: 1734 year: 1993 ident: 10.1038/labinvest.2015.144_bib16 article-title: Association of the APC tumor suppressor protein with catenins publication-title: Science doi: 10.1126/science.8259519 contributor: fullname: Su – volume: 110 start-page: 20224 year: 2013 ident: 10.1038/labinvest.2015.144_bib301 article-title: Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1314239110 contributor: fullname: Liu – volume: 118 start-page: 2420 year: 2011 ident: 10.1038/labinvest.2015.144_bib220 article-title: Wnt-inhibitory factor 1 dysregulation of the bone marrow niche exhausts hematopoietic stem cells publication-title: Blood doi: 10.1182/blood-2010-09-305664 contributor: fullname: Schaniel – volume: 149 start-page: 261 year: 2008 ident: 10.1038/labinvest.2015.144_bib109 article-title: Insulin receptor substrate-1 deficiency promotes apoptosis in the putative intestinal crypt stem cell region, limits Apcmin/+ tumors, and regulates Sox9 publication-title: Endocrinology doi: 10.1210/en.2007-0869 contributor: fullname: Ramocki – volume: 111 start-page: 10215 year: 2014 ident: 10.1038/labinvest.2015.144_bib233 article-title: Pygo2 regulates beta-catenin-induced activation of hair follicle stem/progenitor cells and skin hyperplasia publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1311395111 contributor: fullname: Sun – volume: 92 start-page: 2268 year: 1995 ident: 10.1038/labinvest.2015.144_bib116 article-title: Insertional mutagenesis identifies a member of the Wnt gene family as a candidate oncogene in the mammary epithelium of int-2/Fgf-3 transgenic mice publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.92.6.2268 contributor: fullname: Lee – volume: 275 start-page: 1787 year: 1997 ident: 10.1038/labinvest.2015.144_bib238 article-title: Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC publication-title: Science doi: 10.1126/science.275.5307.1787 contributor: fullname: Morin – volume: 1 start-page: 467 year: 2005 ident: 10.1038/labinvest.2015.144_bib314 article-title: ICG-001, a novel small molecule regulator of TCF/beta-catenin transcription publication-title: Med Chem doi: 10.2174/1573406054864098 contributor: fullname: Eguchi – volume: 67 start-page: 573 year: 2007 ident: 10.1038/labinvest.2015.144_bib294 article-title: An antagonist of dishevelled protein-protein interaction suppresses beta-catenin-dependent tumor cell growth publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-06-2726 contributor: fullname: Fujii – volume: 115 start-page: 4689 year: 2010 ident: 10.1038/labinvest.2015.144_bib226 article-title: Canonical BMP signaling is dispensable for hematopoietic stem cell function in both adult and fetal liver hematopoiesis, but essential to preserve colon architecture publication-title: Blood doi: 10.1182/blood-2009-05-220988 contributor: fullname: Singbrant – volume: 102 start-page: 338 year: 2002 ident: 10.1038/labinvest.2015.144_bib249 article-title: Cytoplasmic and/or nuclear accumulation of the beta-catenin protein is a frequent event in human osteosarcoma publication-title: Int J Cancer doi: 10.1002/ijc.10719 contributor: fullname: Haydon – volume: 51 start-page: 724 year: 2012 ident: 10.1038/labinvest.2015.144_bib309 article-title: Structure-based discovery of a novel inhibitor targeting the beta-catenin/Tcf4 interaction publication-title: Biochemistry doi: 10.1021/bi201428h contributor: fullname: Tian – volume: 62 start-page: 2064 year: 2002 ident: 10.1038/labinvest.2015.144_bib100 article-title: Hepatocyte growth factor induces Wnt-independent nuclear translocation of beta-catenin after Met-beta-catenin dissociation in hepatocytes publication-title: Cancer Res contributor: fullname: Monga – volume: 48 start-page: 10267 year: 2009 ident: 10.1038/labinvest.2015.144_bib337 article-title: The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling publication-title: Biochemistry doi: 10.1021/bi9009677 contributor: fullname: Chen – volume: 23 start-page: 1405 year: 2014 ident: 10.1038/labinvest.2015.144_bib200 article-title: Bone morphogenetic protein-9 effectively induces osteo/odontoblastic differentiation of the reversibly immortalized stem cells of dental apical papilla publication-title: Stem Cells Dev doi: 10.1089/scd.2013.0580 contributor: fullname: Wang – volume: 116 start-page: 2627 issue: Pt 13 year: 2003 ident: 10.1038/labinvest.2015.144_bib86 article-title: Secreted antagonists of the Wnt signalling pathway publication-title: J Cell Sci doi: 10.1242/jcs.00623 contributor: fullname: Kawano – volume: 2 start-page: e1155 year: 2007 ident: 10.1038/labinvest.2015.144_bib174 article-title: Common activation of canonical Wnt signaling in pancreatic adenocarcinoma publication-title: PLoS One doi: 10.1371/journal.pone.0001155 contributor: fullname: Pasca di Magliano – volume: 6 start-page: e29290 year: 2011 ident: 10.1038/labinvest.2015.144_bib338 article-title: Niclosamide suppresses cancer cell growth by inducing Wnt co-receptor LRP6 degradation and inhibiting the Wnt/beta-catenin pathway publication-title: PLoS One doi: 10.1371/journal.pone.0029290 contributor: fullname: Lu – volume: 5 start-page: 13 year: 2013 ident: 10.1038/labinvest.2015.144_bib98 article-title: Wnt signaling in bone formation and its therapeutic potential for bone diseases publication-title: Ther Adv Musculoskelet Dis doi: 10.1177/1759720X12466608 contributor: fullname: Kim – volume: 336 start-page: 1549 year: 2012 ident: 10.1038/labinvest.2015.144_bib250 article-title: Wnt/beta-catenin signaling regulates telomerase in stem cells and cancer cells publication-title: Science doi: 10.1126/science.1218370 contributor: fullname: Hoffmeyer – volume: 19 start-page: 391 year: 2005 ident: 10.1038/labinvest.2015.144_bib111 article-title: Beta-catenin is involved in insulin-like growth factor 1-mediated transactivation of the androgen receptor publication-title: Mol Endocrinol doi: 10.1210/me.2004-0208 contributor: fullname: Verras – volume: 71 start-page: 119 year: 1998 ident: 10.1038/labinvest.2015.144_bib128 article-title: BMP-2/-4 and Wnt-8 cooperatively pattern the Xenopus mesoderm publication-title: Mech Dev doi: 10.1016/S0925-4773(98)00004-5 contributor: fullname: Hoppler – volume: 474 start-page: 220 year: 2011 ident: 10.1038/labinvest.2015.144_bib224 article-title: A somitic Wnt16/Notch pathway specifies haematopoietic stem cells publication-title: Nature doi: 10.1038/nature10107 contributor: fullname: Clements – volume: 90 start-page: 740 year: 1993 ident: 10.1038/labinvest.2015.144_bib119 article-title: Mouse mammary tumor virus infection accelerates mammary carcinogenesis in Wnt-1 transgenic mice by insertional activation of int-2/Fgf-3 and hst/Fgf-4 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.90.2.740 contributor: fullname: Shackleford – volume: 4 start-page: 148ra117 year: 2012 ident: 10.1038/labinvest.2015.144_bib311 article-title: Targeted disruption of the BCL9/beta-catenin complex inhibits oncogenic Wnt signaling publication-title: Sci Transl Med doi: 10.1126/scitranslmed.3003808 contributor: fullname: Takada – volume: 135 start-page: 367 year: 2008 ident: 10.1038/labinvest.2015.144_bib49 article-title: Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions publication-title: Development doi: 10.1242/dev.013540 contributor: fullname: Zeng – volume: 71 start-page: 4172 year: 2011 ident: 10.1038/labinvest.2015.144_bib339 article-title: Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-10-3978 contributor: fullname: Osada – volume: 9 start-page: 159 year: 2009 ident: 10.1038/labinvest.2015.144_bib47 article-title: Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression publication-title: BMC Cancer doi: 10.1186/1471-2407-9-159 contributor: fullname: Arce – volume: 367 start-page: 80 year: 1994 ident: 10.1038/labinvest.2015.144_bib5 article-title: Dishevelled and armadillo act in the wingless signalling pathway in Drosophila publication-title: Nature doi: 10.1038/367080a0 contributor: fullname: Noordermeer – volume: 67 start-page: 5371 year: 2007 ident: 10.1038/labinvest.2015.144_bib289 article-title: The soluble wnt receptor Frizzled8CRD-hFc inhibits the growth of teratocarcinomas in vivo publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-07-0266 contributor: fullname: DeAlmeida – volume: 11 start-page: 301 year: 2006 ident: 10.1038/labinvest.2015.144_bib139 article-title: Smad7-induced beta-catenin degradation alters epidermal appendage development publication-title: Dev Cell doi: 10.1016/j.devcel.2006.06.014 contributor: fullname: Han – volume: 346 start-page: 1248012 year: 2014 ident: 10.1038/labinvest.2015.144_bib27 article-title: Stem cell signaling. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control publication-title: Science doi: 10.1126/science.1248012 contributor: fullname: Clevers – volume: 152 start-page: 87 year: 2001 ident: 10.1038/labinvest.2015.144_bib281 article-title: Wnt-1 signaling inhibits apoptosis by activating beta-catenin/T cell factor-mediated transcription publication-title: J Cell Biol doi: 10.1083/jcb.152.1.87 contributor: fullname: Chen – volume: 283 start-page: 23956 year: 2008 ident: 10.1038/labinvest.2015.144_bib141 article-title: Smad7 stabilizes beta-catenin binding to E-cadherin complex and promotes cell-cell adhesion publication-title: J Biol Chem doi: 10.1074/jbc.M800351200 contributor: fullname: Tang – volume: 126 start-page: 752 year: 2009 ident: 10.1038/labinvest.2015.144_bib70 article-title: The PHD domain is required to link Drosophila Pygopus to Legless/beta-catenin and not to histone H3 publication-title: Mech Dev doi: 10.1016/j.mod.2009.04.003 contributor: fullname: Kessler – volume: 132 start-page: 1819 year: 2005 ident: 10.1038/labinvest.2015.144_bib152 article-title: Notch modulates Wnt signalling by associating with Armadillo/beta-catenin and regulating its transcriptional activity publication-title: Development doi: 10.1242/dev.01724 contributor: fullname: Hayward – volume: 87 start-page: 159 year: 1996 ident: 10.1038/labinvest.2015.144_bib239 article-title: Lessons from hereditary colorectal cancer publication-title: Cell doi: 10.1016/S0092-8674(00)81333-1 contributor: fullname: Kinzler – volume: 2 start-page: a002915 year: 2010 ident: 10.1038/labinvest.2015.144_bib263 article-title: Interplay of cadherin-mediated cell adhesion and canonical Wnt signaling publication-title: Cold Spring Harb Perspect Biol doi: 10.1101/cshperspect.a002915 contributor: fullname: Heuberger – volume: 33 start-page: 2169 year: 2014 ident: 10.1038/labinvest.2015.144_bib319 article-title: Small-molecule inhibition of CBP/catenin interactions eliminates drug-resistant clones in acute lymphoblastic leukemia publication-title: Oncogene doi: 10.1038/onc.2013.169 contributor: fullname: Gang – volume: 68 start-page: 5086 year: 2008 ident: 10.1038/labinvest.2015.144_bib118 article-title: Inhibition of fibroblast growth factor 19 reduces tumor growth by modulating beta-catenin signaling publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-07-2325 contributor: fullname: Pai – volume: 332 start-page: 458 year: 2011 ident: 10.1038/labinvest.2015.144_bib184 article-title: Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size publication-title: Science doi: 10.1126/science.1199010 contributor: fullname: Heallen – volume: 20 start-page: 252 year: 2001 ident: 10.1038/labinvest.2015.144_bib107 article-title: Insulin and IGF-1 stimulate the beta-catenin pathway through two signalling cascades involving GSK-3beta inhibition and Ras activation publication-title: Oncogene doi: 10.1038/sj.onc.1204064 contributor: fullname: Desbois-Mouthon – volume: 398 start-page: 431 year: 1999 ident: 10.1038/labinvest.2015.144_bib88 article-title: A new secreted protein that binds to Wnt proteins and inhibits their activities publication-title: Nature doi: 10.1038/18899 contributor: fullname: Hsieh – volume: 32 start-page: 707 year: 2015 ident: 10.1038/labinvest.2015.144_bib64 article-title: FOXKs promote Wnt/beta-catenin signaling by translocating DVL into the nucleus publication-title: Dev Cell doi: 10.1016/j.devcel.2015.01.031 contributor: fullname: Wang – volume: 487 start-page: 510 year: 2012 ident: 10.1038/labinvest.2015.144_bib248 article-title: RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis publication-title: Nature doi: 10.1038/nature11217 contributor: fullname: Yu – volume: 98 start-page: 14973 year: 2001 ident: 10.1038/labinvest.2015.144_bib57 article-title: Elevated expression of axin2 and hnkd mRNA provides evidence that Wnt/beta -catenin signaling is activated in human colon tumors publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.261574498 contributor: fullname: Yan – volume: 22 start-page: 339 year: 2012 ident: 10.1038/labinvest.2015.144_bib182 article-title: The Hippo signaling pathway and stem cell biology publication-title: Trends Cell Biol doi: 10.1016/j.tcb.2012.04.006 contributor: fullname: Ramos – volume: 99 start-page: 335 year: 1999 ident: 10.1038/labinvest.2015.144_bib53 article-title: PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs publication-title: Cell doi: 10.1016/S0092-8674(00)81664-5 contributor: fullname: He – volume: 49 start-page: 474 year: 2013 ident: 10.1038/labinvest.2015.144_bib69 article-title: Glucose-induced beta-catenin acetylation enhances Wnt signaling in cancer publication-title: Mol Cell doi: 10.1016/j.molcel.2012.11.022 contributor: fullname: Chocarro-Calvo – volume: 71 start-page: 3553 year: 2014 ident: 10.1038/labinvest.2015.144_bib150 article-title: Wnt-Notch signalling cross-talk in development and disease publication-title: Cell Mol Life Sci doi: 10.1007/s00018-014-1644-x contributor: fullname: Collu – volume: 417 start-page: 664 year: 2002 ident: 10.1038/labinvest.2015.144_bib90 article-title: Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling publication-title: Nature doi: 10.1038/nature756 contributor: fullname: Mao – volume: 280 start-page: 1036 year: 1998 ident: 10.1038/labinvest.2015.144_bib240 article-title: Landscaping the cancer terrain publication-title: Science doi: 10.1126/science.280.5366.1036 contributor: fullname: Kinzler – volume: 17 start-page: 45 year: 2007 ident: 10.1038/labinvest.2015.144_bib245 article-title: The many ways of Wnt in cancer publication-title: Curr Opin Genet Dev doi: 10.1016/j.gde.2006.12.007 contributor: fullname: Polakis – volume: 125 start-page: 509 year: 2006 ident: 10.1038/labinvest.2015.144_bib35 article-title: Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells publication-title: Cell doi: 10.1016/j.cell.2006.02.049 contributor: fullname: Banziger – volume: 5 start-page: 23 year: 2006 ident: 10.1038/labinvest.2015.144_bib75 article-title: R-Spondin proteins: a novel link to beta-catenin activation publication-title: Cell Cycle doi: 10.4161/cc.5.1.2305 contributor: fullname: Kim – volume: 281 start-page: 1509 year: 1998 ident: 10.1038/labinvest.2015.144_bib54 article-title: Identification of c-MYC as a target of the APC pathway publication-title: Science doi: 10.1126/science.281.5382.1509 contributor: fullname: He – volume: 401 start-page: 969 year: 2010 ident: 10.1038/labinvest.2015.144_bib71 article-title: Allosteric remodelling of the histone H3 binding pocket in the Pygo2 PHD finger triggered by its binding to the B9L/BCL9 co-factor publication-title: J Mol Biol doi: 10.1016/j.jmb.2010.07.007 contributor: fullname: Miller – volume: 13 start-page: 800 year: 2014 ident: 10.1038/labinvest.2015.144_bib343 article-title: Effect of niclosamide on basal-like breast cancers publication-title: Mol Cancer Ther doi: 10.1158/1535-7163.MCT-13-0555 contributor: fullname: Londono-Joshi – volume: 287 start-page: 795 year: 1980 ident: 10.1038/labinvest.2015.144_bib3 article-title: Mutations affecting segment number and polarity in Drosophila publication-title: Nature doi: 10.1038/287795a0 contributor: fullname: Nusslein-Volhard – volume: 5 start-page: 1059 year: 2006 ident: 10.1038/labinvest.2015.144_bib115 article-title: Cross-talk of WNT and FGF signaling pathways at GSK3beta to regulate beta-catenin and SNAIL signaling cascades publication-title: Cancer Biol Ther doi: 10.4161/cbt.5.9.3151 contributor: fullname: Katoh – volume: 40 start-page: 1533 year: 2012 ident: 10.1038/labinvest.2015.144_bib292 article-title: Change in gene expression profiles of secreted frizzled-related proteins (SFRPs) by sodium butyrate in gastric cancers: induction of promoter demethylation and histone modification causing inhibition of Wnt signaling publication-title: Int J Oncol contributor: fullname: Shin – volume: 3 start-page: 132 year: 2008 ident: 10.1038/labinvest.2015.144_bib317 article-title: Wnt signaling promotes reprogramming of somatic cells to pluripotency publication-title: Cell Stem Cell doi: 10.1016/j.stem.2008.06.019 contributor: fullname: Marson – volume: 149 start-page: 1192 year: 2012 ident: 10.1038/labinvest.2015.144_bib23 article-title: Wnt/beta-catenin signaling and disease publication-title: Cell doi: 10.1016/j.cell.2012.05.012 contributor: fullname: Clevers – volume: 1 start-page: 18 year: 2012 ident: 10.1038/labinvest.2015.144_bib316 article-title: Wnt signaling orchestration with a small molecule DYRK inhibitor provides long-term xeno-free human pluripotent cell expansion publication-title: Stem Cells Transl Med doi: 10.5966/sctm.2011-0033 contributor: fullname: Hasegawa – volume: 104 start-page: 5668 year: 2007 ident: 10.1038/labinvest.2015.144_bib315 article-title: Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0701331104 contributor: fullname: Miyabayashi – volume: 176 start-page: 518 year: 2010 ident: 10.1038/labinvest.2015.144_bib159 article-title: The Sex-determining region Y-box 4 and homeobox C6 transcriptional networks in prostate cancer progression: cros-stalk with the Wnt, Notch, and PI3K pathways publication-title: Am J Pathol doi: 10.2353/ajpath.2010.090657 contributor: fullname: Moreno – volume: 411 start-page: 349 year: 2001 ident: 10.1038/labinvest.2015.144_bib165 article-title: The Hedgehog and Wnt signalling pathways in cancer publication-title: Nature doi: 10.1038/35077219 contributor: fullname: Taipale – volume: 328 start-page: 227 year: 2005 ident: 10.1038/labinvest.2015.144_bib330 article-title: Quercetin, a potent inhibitor against beta-catenin/Tcf signaling in SW480 colon cancer cells publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2004.12.151 contributor: fullname: Park – volume: 4 start-page: 14 year: 2011 ident: 10.1038/labinvest.2015.144_bib22 article-title: The therapeutic potential of the Wnt signaling pathway in bone disorders publication-title: Curr Mol Pharmacol doi: 10.2174/1874467211104010014 contributor: fullname: Wagner – volume: 282 start-page: 15903 year: 2007 ident: 10.1038/labinvest.2015.144_bib79 article-title: R-spondin1 is a high affinity ligand for LRP6 and induces LRP6 phosphorylation and beta-catenin signaling publication-title: J Biol Chem doi: 10.1074/jbc.M701927200 contributor: fullname: Wei – volume: 35 start-page: 2357 year: 2014 ident: 10.1038/labinvest.2015.144_bib257 article-title: Wntless (GPR177) expression correlates with poor prognosis in B-cell precursor acute lymphoblastic leukemia via Wnt signaling publication-title: Carcinogenesis doi: 10.1093/carcin/bgu166 contributor: fullname: Chiou – volume: 180 start-page: 1087 year: 2008 ident: 10.1038/labinvest.2015.144_bib62 article-title: Nuclear Dvl, c-Jun, beta-catenin, and TCF form a complex leading to stabilization of beta-catenin-TCF interaction publication-title: J Cell Biol doi: 10.1083/jcb.200710050 contributor: fullname: Gan – volume: 2 start-page: 1 year: 2013 ident: 10.1038/labinvest.2015.144_bib126 article-title: BMP9 signaling in stem cell differentiation and osteogenesis publication-title: Am J Stem Cells contributor: fullname: Lamplot – volume: 46 start-page: 1679 year: 2010 ident: 10.1038/labinvest.2015.144_bib269 article-title: Interaction between human-breast cancer metastasis and bone microenvironment through activated hepatocyte growth factor/Met and beta-catenin/Wnt pathways publication-title: Eur J Cancer doi: 10.1016/j.ejca.2010.02.036 contributor: fullname: Previdi – volume: 281 start-page: 10865 year: 2006 ident: 10.1038/labinvest.2015.144_bib329 article-title: Suppression of Wnt signaling by the green tea compound (-)-epigallocatechin 3-gallate (EGCG) in invasive breast cancer cells. Requirement of the transcriptional repressor HBP1 publication-title: J Biol Chem doi: 10.1074/jbc.M513378200 contributor: fullname: Kim – volume: 16 start-page: 639 year: 2015 ident: 10.1038/labinvest.2015.144_bib73 article-title: Beta-catenin regulates primitive streak induction through collaborative interactions with SMAD2/SMAD3 and OCT4 publication-title: Cell Stem Cell doi: 10.1016/j.stem.2015.03.008 contributor: fullname: Funa – volume: 8 start-page: 739 year: 2005 ident: 10.1038/labinvest.2015.144_bib196 article-title: Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis publication-title: Dev Cell doi: 10.1016/j.devcel.2005.03.016 contributor: fullname: Day – volume: 395 start-page: 604 year: 1998 ident: 10.1038/labinvest.2015.144_bib45 article-title: Drosophila Tcf and Groucho interact to repress Wingless signalling activity publication-title: Nature doi: 10.1038/26982 contributor: fullname: Cavallo – volume: 102 start-page: 12171 year: 2005 ident: 10.1038/labinvest.2015.144_bib65 article-title: Specific inhibition of CBP/beta-catenin interaction rescues defects in neuronal differentiation caused by a presenilin-1 mutation publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0504600102 contributor: fullname: Teo – volume: 289 start-page: 9221 year: 2014 ident: 10.1038/labinvest.2015.144_bib194 article-title: Regulation of induced pluripotent stem (iPS) cell induction by Wnt/beta-catenin signaling publication-title: J Biol Chem doi: 10.1074/jbc.M113.542845 contributor: fullname: Zhang – volume: 277 start-page: 25562 year: 2002 ident: 10.1038/labinvest.2015.144_bib67 article-title: Acetylation of beta-catenin by CREB-binding protein (CBP) publication-title: J Biol Chem doi: 10.1074/jbc.M201196200 contributor: fullname: Wolf – volume: 283 start-page: 21427 year: 2008 ident: 10.1038/labinvest.2015.144_bib92 article-title: DKK1 antagonizes Wnt signaling without promotion of LRP6 internalization and degradation publication-title: J Biol Chem doi: 10.1074/jbc.M800014200 contributor: fullname: Semenov – volume: 121 start-page: 1587 issue: Pt 10 year: 2008 ident: 10.1038/labinvest.2015.144_bib30 article-title: In vivo role of lipid adducts on Wingless publication-title: J Cell Sci doi: 10.1242/jcs.015958 contributor: fullname: Franch-Marro – volume: 83-A Suppl 1 start-page: S31 issue: Pt 1 year: 2001 ident: 10.1038/labinvest.2015.144_bib133 article-title: Transcriptional regulation by Smads: cross-talk between the TGF-beta and Wnt pathways publication-title: J Bone Joint Surg Am contributor: fullname: Letamendia – volume: 9 start-page: 105 year: 2007 ident: 10.1038/labinvest.2015.144_bib160 article-title: Cooperation between Wnt and Notch signalling in human breast cancer publication-title: Breast Cancer Res doi: 10.1186/bcr1671 contributor: fullname: Collu – volume: 73 start-page: 3132 year: 2013 ident: 10.1038/labinvest.2015.144_bib299 article-title: A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-12-4562 contributor: fullname: Lau – volume: 25 start-page: 254 year: 2013 ident: 10.1038/labinvest.2015.144_bib188 article-title: Wnt signaling in stem and cancer stem cells publication-title: Curr Opin Cell Biol doi: 10.1016/j.ceb.2013.01.004 contributor: fullname: Holland – volume: 131 start-page: 3751 year: 2004 ident: 10.1038/labinvest.2015.144_bib131 article-title: Combinatorial gene regulation by Bmp and Wnt in zebrafish posterior mesoderm formation publication-title: Development doi: 10.1242/dev.01236 contributor: fullname: Szeto – volume: 32 start-page: 82 year: 2015 ident: 10.1038/labinvest.2015.144_bib112 article-title: The endothelial transcription factor ERG promotes vascular stability and growth through Wnt/beta-catenin signaling publication-title: Dev Cell doi: 10.1016/j.devcel.2014.11.016 contributor: fullname: Birdsey – volume: 10 start-page: 615 year: 2004 ident: 10.1038/labinvest.2015.144_bib287 article-title: Membranous expression of secreted frizzled-related protein 4 predicts for good prognosis in localized prostate cancer and inhibits PC3 cellular proliferation in vitro publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-0707-03 contributor: fullname: Horvath – volume: 42 start-page: 705 year: 2007 ident: 10.1038/labinvest.2015.144_bib149 article-title: Cross-talk between Wnt and Notch signaling in intestinal epithelial cell fate decision publication-title: J Gastroenterol doi: 10.1007/s00535-007-2087-z contributor: fullname: Nakamura – volume: 1 start-page: 127 year: 2014 ident: 10.1038/labinvest.2015.144_bib181 article-title: Wnt Hippo: A balanced act or dynamic duo? publication-title: Genes Dis doi: 10.1016/j.gendis.2014.09.001 contributor: fullname: Wang – volume: 382 start-page: 225 year: 1996 ident: 10.1038/labinvest.2015.144_bib11 article-title: A new member of the frizzled family from Drosophila functions as a Wingless receptor publication-title: Nature doi: 10.1038/382225a0 contributor: fullname: Bhanot – volume: 271 start-page: 1826 year: 1996 ident: 10.1038/labinvest.2015.144_bib153 article-title: Interaction between Wingless and Notch signaling pathways mediated by dishevelled publication-title: Science doi: 10.1126/science.271.5257.1826 contributor: fullname: Axelrod – volume: 33 start-page: 416 year: 2003 ident: 10.1038/labinvest.2015.144_bib154 article-title: Notch1 functions as a tumor suppressor in mouse skin publication-title: Nat Genet doi: 10.1038/ng1099 contributor: fullname: Nicolas – volume: 26 start-page: 2955 year: 2006 ident: 10.1038/labinvest.2015.144_bib198 article-title: CCN1/Cyr61 is regulated by the canonical Wnt signal and plays an important role in Wnt3A-induced osteoblast differentiation of mesenchymal stem cells publication-title: Mol Cell Biol doi: 10.1128/MCB.26.8.2955-2964.2006 contributor: fullname: Si – volume: 29 start-page: 277 year: 2014 ident: 10.1038/labinvest.2015.144_bib38 article-title: WLS retrograde transport to the endoplasmic reticulum during Wnt secretion publication-title: Dev Cell doi: 10.1016/j.devcel.2014.03.016 contributor: fullname: Yu – volume: 27 start-page: 7118 year: 2008 ident: 10.1038/labinvest.2015.144_bib138 article-title: Prostate tumor progression is mediated by a paracrine TGF-beta/Wnt3a signaling axis publication-title: Oncogene doi: 10.1038/onc.2008.293 contributor: fullname: Li – volume: 205 start-page: 73 year: 1994 ident: 10.1038/labinvest.2015.144_bib104 article-title: c-erbB-2 gene product associates with catenins in human cancer cells publication-title: Biochem Biophys Res Commun doi: 10.1006/bbrc.1994.2631 contributor: fullname: Ochiai – volume: 9 start-page: 2 year: 2011 ident: 10.1038/labinvest.2015.144_bib225 article-title: Wnt to notch relay signaling induces definitive hematopoiesis publication-title: Cell Stem Cell doi: 10.1016/j.stem.2011.06.011 contributor: fullname: Loeffler – volume: 93 start-page: 7950 year: 1996 ident: 10.1038/labinvest.2015.144_bib280 article-title: Apoptosis and APC in colorectal tumorigenesis publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.93.15.7950 contributor: fullname: Morin – volume: 16 start-page: 179 year: 2014 ident: 10.1038/labinvest.2015.144_bib232 article-title: In vivo transcriptional governance of hair follicle stem cells by canonical Wnt regulators publication-title: Nat Cell Biol doi: 10.1038/ncb2903 contributor: fullname: Lien – volume: 38 start-page: 437 year: 2011 ident: 10.1038/labinvest.2015.144_bib332 article-title: Ginsenoside Rg3 inhibits colorectal tumor growth through the down-regulation of Wnt/ss-catenin signaling publication-title: Int J Oncol doi: 10.3892/ijo.2010.858 contributor: fullname: He – volume: 24 start-page: 3404 year: 2004 ident: 10.1038/labinvest.2015.144_bib68 article-title: Acetylation of beta-catenin by p300 regulates beta-catenin-Tcf4 interaction publication-title: Mol Cell Biol doi: 10.1128/MCB.24.8.3404-3414.2004 contributor: fullname: Levy – volume: 73 start-page: 4909 year: 2013 ident: 10.1038/labinvest.2015.144_bib246 article-title: Canonical wnt signaling is required for pancreatic carcinogenesis publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-12-4384 contributor: fullname: Zhang – volume: 123 start-page: 1588 issue: Pt 9 year: 2010 ident: 10.1038/labinvest.2015.144_bib50 article-title: Stability elements in the LRP6 cytoplasmic tail confer efficient signalling upon DIX-dependent polymerization publication-title: J Cell Sci doi: 10.1242/jcs.067546 contributor: fullname: Metcalfe – volume: 256 start-page: 668 year: 1992 ident: 10.1038/labinvest.2015.144_bib242 article-title: Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene publication-title: Science doi: 10.1126/science.1350108 contributor: fullname: Su – volume: 213 start-page: 152 year: 2007 ident: 10.1038/labinvest.2015.144_bib274 article-title: CD44-positive colorectal adenoma cells express the potential stem cell markers musashi antigen (msi1) and ephrin B2 receptor (EphB2) publication-title: J Pathol doi: 10.1002/path.2220 contributor: fullname: Schulenburg – volume: 32 start-page: 1977 year: 2013 ident: 10.1038/labinvest.2015.144_bib318 article-title: Wnt/beta-catenin signalling induces MLL to create epigenetic changes in salivary gland tumours publication-title: EMBO J doi: 10.1038/emboj.2013.127 contributor: fullname: Wend – volume: 10 start-page: 393 year: 2004 ident: 10.1038/labinvest.2015.144_bib206 article-title: Effects of Wnt signaling on proliferation and differentiation of human mesenchymal stem cells publication-title: Tissue Eng doi: 10.1089/107632704323061753 contributor: fullname: De Boer – volume: 22 start-page: 1184 year: 2002 ident: 10.1038/labinvest.2015.144_bib58 article-title: Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors publication-title: Mol Cell Biol doi: 10.1128/MCB.22.4.1184-1193.2002 contributor: fullname: Lustig – volume: 395 start-page: 608 year: 1998 ident: 10.1038/labinvest.2015.144_bib46 article-title: The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors publication-title: Nature doi: 10.1038/26989 contributor: fullname: Roose – volume: 289 start-page: 195 year: 2010 ident: 10.1038/labinvest.2015.144_bib155 article-title: MSX1 induces the Wnt pathway antagonist genes DKK1, DKK2, DKK3, and SFRP1 in neuroblastoma cells, but does not block Wnt3 and Wnt5A signalling to DVL3 publication-title: Cancer Lett doi: 10.1016/j.canlet.2009.08.019 contributor: fullname: Revet – volume: 75 start-page: 1341 year: 2015 ident: 10.1038/labinvest.2015.144_bib341 article-title: Niclosamide suppresses cell migration and invasion in enzalutamide resistant prostate cancer cells via Stat3-AR axis inhibition publication-title: Prostate doi: 10.1002/pros.23015 contributor: fullname: Liu – volume: 160 start-page: 2295 year: 2002 ident: 10.1038/labinvest.2015.144_bib117 article-title: A mouse model of hepatocellular carcinoma: ectopic expression of fibroblast growth factor 19 in skeletal muscle of transgenic mice publication-title: Am J Pathol doi: 10.1016/S0002-9440(10)61177-7 contributor: fullname: Nicholes – volume: 141 start-page: 2206 year: 2014 ident: 10.1038/labinvest.2015.144_bib302 article-title: Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts publication-title: Development doi: 10.1242/dev.104976 contributor: fullname: Kabiri – volume: 96 start-page: 5522 year: 1999 ident: 10.1038/labinvest.2015.144_bib56 article-title: The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.96.10.5522 contributor: fullname: Shtutman – volume: 61 start-page: 7318 year: 2001 ident: 10.1038/labinvest.2015.144_bib110 article-title: Insulin-like growth factor-1 induces survival and growth of biologically early melanoma cells through both the mitogen-activated protein kinase and beta-catenin pathways publication-title: Cancer Res contributor: fullname: Satyamoorthy – volume: 105 start-page: 18366 year: 2008 ident: 10.1038/labinvest.2015.144_bib205 article-title: The Wnt modulator sFRP2 enhances mesenchymal stem cell engraftment, granulation tissue formation and myocardial repair publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0803437105 contributor: fullname: Alfaro – volume: 12 start-page: 468 year: 2010 ident: 10.1038/labinvest.2015.144_bib265 article-title: Wnt activity defines colon cancer stem cells and is regulated by the microenvironment publication-title: Nat Cell Biol doi: 10.1038/ncb2048 contributor: fullname: Vermeulen – volume: 138 start-page: 51 year: 2009 ident: 10.1038/labinvest.2015.144_bib268 article-title: WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis publication-title: Cell doi: 10.1016/j.cell.2009.04.030 contributor: fullname: Nguyen – volume: 4 start-page: 513 year: 2009 ident: 10.1038/labinvest.2015.144_bib189 article-title: Metastable pluripotent states in NOD-mouse-derived ESCs publication-title: Cell Stem Cell doi: 10.1016/j.stem.2009.04.015 contributor: fullname: Hanna – volume: 8 start-page: e56644 year: 2013 ident: 10.1038/labinvest.2015.144_bib254 article-title: Gpr177 deficiency impairs mammary development and prohibits Wnt-induced tumorigenesis publication-title: PLoS One doi: 10.1371/journal.pone.0056644 contributor: fullname: Maruyama – volume: 478 start-page: 255 year: 2011 ident: 10.1038/labinvest.2015.144_bib208 article-title: A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable publication-title: Nature doi: 10.1038/nature10408 contributor: fullname: Tian – volume: 6 start-page: 306 year: 2005 ident: 10.1038/labinvest.2015.144_bib166 article-title: Communicating with Hedgehogs publication-title: Nat Rev Mol Cell Biol doi: 10.1038/nrm1622 contributor: fullname: Hooper – volume: 27 start-page: 20 year: 2014 ident: 10.1038/labinvest.2015.144_bib277 article-title: Targeting the beta-catenin nuclear transport pathway in cancer publication-title: Semin Cancer Biol doi: 10.1016/j.semcancer.2014.04.012 contributor: fullname: Jamieson – volume: 262 start-page: 1731 year: 1993 ident: 10.1038/labinvest.2015.144_bib15 article-title: Association of the APC gene product with beta-catenin publication-title: Science doi: 10.1126/science.8259518 contributor: fullname: Rubinfeld – volume: 4 start-page: 38 year: 2012 ident: 10.1038/labinvest.2015.144_bib253 article-title: The Wnt secretion protein Evi/Gpr177 promotes glioma tumourigenesis publication-title: EMBO Mol Med doi: 10.1002/emmm.201100186 contributor: fullname: Augustin – volume: 367 start-page: 76 year: 1994 ident: 10.1038/labinvest.2015.144_bib8 article-title: Components of wingless signalling in Drosophila publication-title: Nature doi: 10.1038/367076a0 contributor: fullname: Siegfried – volume: 44 start-page: 992 year: 2006 ident: 10.1038/labinvest.2015.144_bib99 article-title: Activation of Wnt/beta-catenin pathway during hepatocyte growth factor-induced hepatomegaly in mice publication-title: Hepatology doi: 10.1002/hep.21317 contributor: fullname: Apte – volume: 41 start-page: 1068 year: 2009 ident: 10.1038/labinvest.2015.144_bib231 article-title: Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia publication-title: Nat Genet doi: 10.1038/ng.431 contributor: fullname: Nguyen – volume: 54 start-page: 288 year: 2011 ident: 10.1038/labinvest.2015.144_bib291 article-title: Pharmacological inhibition of Frizzled-7 displays anti-tumor properties in hepatocellular carcinoma publication-title: J Hepatol doi: 10.1016/j.jhep.2010.06.033 contributor: fullname: Nambotin – volume: 133 start-page: 4427 year: 2006 ident: 10.1038/labinvest.2015.144_bib162 article-title: Jagged 1 is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis publication-title: Development doi: 10.1242/dev.02644 contributor: fullname: Estrach – volume: 16 start-page: 35 year: 2011 ident: 10.1038/labinvest.2015.144_bib275 article-title: New avenues to target Wnt/beta-catenin signaling publication-title: Drug Discov Today doi: 10.1016/j.drudis.2010.11.007 contributor: fullname: Verkaar – volume: 423 start-page: 448 year: 2003 ident: 10.1038/labinvest.2015.144_bib28 article-title: Wnt proteins are lipid-modified and can act as stem cell growth factors publication-title: Nature doi: 10.1038/nature01611 contributor: fullname: Willert – volume: 337 start-page: 59 year: 2012 ident: 10.1038/labinvest.2015.144_bib29 article-title: Structural basis of Wnt recognition by Frizzled publication-title: Science doi: 10.1126/science.1222879 contributor: fullname: Janda – volume: 130 start-page: 4295 year: 2003 ident: 10.1038/labinvest.2015.144_bib94 article-title: Wise, a context-dependent activator and inhibitor of Wnt signalling publication-title: Development doi: 10.1242/dev.00674 contributor: fullname: Itasaki – volume: 103 start-page: 3799 year: 2006 ident: 10.1038/labinvest.2015.144_bib161 article-title: Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0600065103 contributor: fullname: Ayyanan – volume: 102 start-page: 11480 year: 2005 ident: 10.1038/labinvest.2015.144_bib223 article-title: Differential requirements for survivin in hematopoietic cell development publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0500303102 contributor: fullname: Gurbuxani – volume: 82 start-page: 165 year: 2009 ident: 10.1038/labinvest.2015.144_bib305 article-title: Small molecule inhibitors of WNT signaling effectively induce apoptosis in acute myeloid leukemia cells publication-title: Eur J Haematol doi: 10.1111/j.1600-0609.2008.01188.x contributor: fullname: Minke – volume: 26 start-page: 1078 year: 2007 ident: 10.1038/labinvest.2015.144_bib102 article-title: A positive feedback loop between hepatocyte growth factor receptor and beta-catenin sustains colorectal cancer cell invasive growth publication-title: Oncogene doi: 10.1038/sj.onc.1209859 contributor: fullname: Rasola – volume: 218 start-page: 183 year: 2000 ident: 10.1038/labinvest.2015.144_bib87 article-title: Cloning and expression of the Wnt antagonists Sfrp-2 and Frzb during chick development publication-title: Dev Biol doi: 10.1006/dbio.1999.9586 contributor: fullname: Ladher – volume: 493 start-page: 106 year: 2013 ident: 10.1038/labinvest.2015.144_bib183 article-title: Restriction of intestinal stem cell expansion and the regenerative response by YAP publication-title: Nature doi: 10.1038/nature11693 contributor: fullname: Barry – volume: 58 start-page: 2524 year: 1998 ident: 10.1038/labinvest.2015.144_bib243 article-title: Activation of the beta-catenin gene in primary hepatocellular carcinomas by somatic alterations involving exon 3 publication-title: Cancer Res contributor: fullname: Miyoshi – volume: 407 start-page: 527 year: 2000 ident: 10.1038/labinvest.2015.144_bib12 article-title: Arrow encodes an LDL-receptor-related protein essential for Wingless signalling publication-title: Nature doi: 10.1038/35035110 contributor: fullname: Wehrli – volume: 4 start-page: e4310 year: 2009 ident: 10.1038/labinvest.2015.144_bib63 article-title: Modulation of the beta-catenin signaling pathway by the dishevelled-associated protein Hipk1 publication-title: PLoS One doi: 10.1371/journal.pone.0004310 contributor: fullname: Louie – volume: 137 start-page: 629 year: 2009 ident: 10.1038/labinvest.2015.144_bib173 article-title: Reduced level of smoothened suppresses intestinal tumorigenesis by down-regulation of Wnt signaling publication-title: Gastroenterology doi: 10.1053/j.gastro.2009.04.059 contributor: fullname: Arimura – volume: 30 start-page: 423 year: 2011 ident: 10.1038/labinvest.2015.144_bib285 article-title: Blocking Wnt signaling by SFRP-like molecules inhibits in vivo cell proliferation and tumor growth in cells carrying active beta-catenin publication-title: Oncogene doi: 10.1038/onc.2010.432 contributor: fullname: Lavergne – volume: 10 start-page: 3116 year: 1996 ident: 10.1038/labinvest.2015.144_bib33 article-title: The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing publication-title: Genes Dev doi: 10.1101/gad.10.24.3116 contributor: fullname: Kadowaki – volume: 31 start-page: 344 year: 2015 ident: 10.1038/labinvest.2015.144_bib210 article-title: Repairing organs: lessons from intestine and liver publication-title: Trends Genet doi: 10.1016/j.tig.2015.04.005 contributor: fullname: Gehart – volume: 36 start-page: 277 year: 2004 ident: 10.1038/labinvest.2015.144_bib175 article-title: Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation publication-title: Nat Genet doi: 10.1038/ng1304 contributor: fullname: van den Brink – volume: 94 start-page: 6770 year: 1997 ident: 10.1038/labinvest.2015.144_bib85 article-title: Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.94.13.6770 contributor: fullname: Finch – volume: 40 start-page: 783 year: 2009 ident: 10.1038/labinvest.2015.144_bib158 article-title: Histologic subtypes of hepatoblastoma are characterized by differential canonical Wnt and Notch pathway activation in DLK+ precursors publication-title: Hum Pathol doi: 10.1016/j.humpath.2008.07.022 contributor: fullname: Lopez-Terrada – volume: 44 start-page: 15495 year: 2005 ident: 10.1038/labinvest.2015.144_bib293 article-title: Identification of a specific inhibitor of the dishevelled PDZ domain publication-title: Biochemistry doi: 10.1021/bi0512602 contributor: fullname: Shan – volume: 3 start-page: 531 year: 2003 ident: 10.1038/labinvest.2015.144_bib122 article-title: Targeting the TGF beta signaling network in human neoplasia publication-title: Cancer Cell doi: 10.1016/S1535-6108(03)00135-1 contributor: fullname: Dumont – volume: 137 start-page: 216 year: 2009 ident: 10.1038/labinvest.2015.144_bib146 article-title: The canonical Notch signaling pathway: unfolding the activation mechanism publication-title: Cell doi: 10.1016/j.cell.2009.03.045 contributor: fullname: Kopan – volume: 140 start-page: 3589 year: 2013 ident: 10.1038/labinvest.2015.144_bib39 article-title: Gpr177 regulates pulmonary vasculature development publication-title: Development doi: 10.1242/dev.095471 contributor: fullname: Jiang – volume: 31 start-page: 2670 year: 2012 ident: 10.1038/labinvest.2015.144_bib2 article-title: Three decades of Wnts: a personal perspective on how a scientific field developed publication-title: Embo J doi: 10.1038/emboj.2012.146 contributor: fullname: Nusse – volume: 14 start-page: 1849 year: 2008 ident: 10.1038/labinvest.2015.144_bib331 article-title: Resveratrol exerts antiproliferative activity and induces apoptosis in Waldenstrom's macroglobulinemia publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-07-1750 contributor: fullname: Roccaro – volume: 111 start-page: 7337 year: 2014 ident: 10.1038/labinvest.2015.144_bib142 article-title: Smad1 transcription factor integrates BMP2 and Wnt3a signals in migrating cardiac progenitor cells publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1321764111 contributor: fullname: Song – volume: 461 start-page: 614 year: 2009 ident: 10.1038/labinvest.2015.144_bib296 article-title: Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling publication-title: Nature doi: 10.1038/nature08356 contributor: fullname: Huang – volume: 2 start-page: 60 year: 2008 ident: 10.1038/labinvest.2015.144_bib217 article-title: Wnt, activin, and BMP signaling regulate distinct stages in the developmental pathway from embryonic stem cells to blood publication-title: Cell Stem Cell doi: 10.1016/j.stem.2007.10.011 contributor: fullname: Nostro – volume: 283 start-page: 12686 year: 2008 ident: 10.1038/labinvest.2015.144_bib120 article-title: HDAC6 is required for epidermal growth factor-induced beta-catenin nuclear localization publication-title: J Biol Chem doi: 10.1074/jbc.C700185200 contributor: fullname: Li – volume: 1 start-page: 87 year: 2014 ident: 10.1038/labinvest.2015.144_bib124 article-title: Bone morphogenetic protein (BMP) signaling in development and human diseases publication-title: Genes Dis doi: 10.1016/j.gendis.2014.07.005 contributor: fullname: Wang – volume: 15 start-page: 3059 year: 2001 ident: 10.1038/labinvest.2015.144_bib163 article-title: Hedgehog signaling in animal development: paradigms and principles publication-title: Genes Dev doi: 10.1101/gad.938601 contributor: fullname: Ingham – volume: 98 start-page: 2091 year: 2001 ident: 10.1038/labinvest.2015.144_bib222 article-title: Regulation of the inhibitor-of-apoptosis family member survivin in normal cord blood and bone marrow CD34(+) cells by hematopoietic growth factors: implication of survivin expression in normal hematopoiesis publication-title: Blood doi: 10.1182/blood.V98.7.2091 contributor: fullname: Fukuda – volume: 110 start-page: 1351 year: 2013 ident: 10.1038/labinvest.2015.144_bib234 article-title: Competitive balance of intrabulge BMP/Wnt signaling reveals a robust gene network ruling stem cell homeostasis and cyclic activation publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1121312110 contributor: fullname: Kandyba – volume: 108 start-page: 13253 year: 2011 ident: 10.1038/labinvest.2015.144_bib345 article-title: Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1110431108 contributor: fullname: Lu – volume: 10 start-page: 55 year: 2004 ident: 10.1038/labinvest.2015.144_bib191 article-title: Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor publication-title: Nat Med doi: 10.1038/nm979 contributor: fullname: Sato – volume: 13 start-page: 2448 year: 2009 ident: 10.1038/labinvest.2015.144_bib199 article-title: BMP-9-induced osteogenic differentiation of mesenchymal progenitors requires functional canonical Wnt/beta-catenin signalling publication-title: J Cell Mol Med doi: 10.1111/j.1582-4934.2008.00569.x contributor: fullname: Tang – volume: 327 start-page: 542 year: 2010 ident: 10.1038/labinvest.2015.144_bib212 article-title: Coexistence of quiescent and active adult stem cells in mammals publication-title: Science doi: 10.1126/science.1180794 contributor: fullname: Li – volume: 7 start-page: 525 year: 2004 ident: 10.1038/labinvest.2015.144_bib77 article-title: R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis publication-title: Dev Cell doi: 10.1016/j.devcel.2004.07.019 contributor: fullname: Kazanskaya – volume: 113 start-page: 546 year: 2009 ident: 10.1038/labinvest.2015.144_bib218 article-title: Wnt3a deficiency irreversibly impairs hematopoietic stem cell self-renewal and leads to defects in progenitor cell differentiation publication-title: Blood doi: 10.1182/blood-2008-06-163774 contributor: fullname: Luis – volume: 33 start-page: 2913 year: 2015 ident: 10.1038/labinvest.2015.144_bib270 article-title: LGR5 promotes breast cancer progression and maintains stem-like cells through activation of Wnt/beta-catenin signaling publication-title: Stem Cells doi: 10.1002/stem.2083 contributor: fullname: Yang – volume: 40 start-page: 1130 year: 2008 ident: 10.1038/labinvest.2015.144_bib168 article-title: Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/beta3-catenin signaling publication-title: Nat Genet doi: 10.1038/ng.192 contributor: fullname: Yang – volume: 108 start-page: 5954 year: 2011 ident: 10.1038/labinvest.2015.144_bib307 article-title: An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1017496108 contributor: fullname: Gonsalves – volume: 28 start-page: 428 year: 2015 ident: 10.1038/labinvest.2015.144_bib258 article-title: Analysis of wntless (WLS) expression in gastric, ovarian, and breast cancers reveals a strong association with HER2 overexpression publication-title: Mod Pathol doi: 10.1038/modpathol.2014.114 contributor: fullname: Stewart – volume: 36 start-page: 547 year: 2009 ident: 10.1038/labinvest.2015.144_bib103 article-title: EGF-induced ERK activation promotes CK2-mediated disassociation of alpha-Catenin from beta-Catenin and transactivation of beta-Catenin publication-title: Mol Cell doi: 10.1016/j.molcel.2009.09.034 contributor: fullname: Ji – volume: 22 start-page: 233 year: 2004 ident: 10.1038/labinvest.2015.144_bib121 article-title: Bone morphogenetic proteins publication-title: Growth Factors doi: 10.1080/08977190412331279890 contributor: fullname: Chen – volume: 105 start-page: 533 year: 2001 ident: 10.1038/labinvest.2015.144_bib230 article-title: beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin publication-title: Cell doi: 10.1016/S0092-8674(01)00336-1 contributor: fullname: Huelsken – volume: 11 start-page: 229 year: 2011 ident: 10.1038/labinvest.2015.144_bib125 article-title: BMP-9 induced osteogenic differentiation of mesenchymal stem cells: molecular mechanism and therapeutic potential publication-title: Curr Gene Ther doi: 10.2174/156652311795684777 contributor: fullname: Luther – volume: 118 start-page: 681 year: 1992 ident: 10.1038/labinvest.2015.144_bib6 article-title: The vertebrate adhesive junction proteins beta-catenin and plakoglobin and the Drosophila segment polarity gene armadillo form a multigene family with similar properties publication-title: J Cell Biol doi: 10.1083/jcb.118.3.681 contributor: fullname: Peifer – volume: 423 start-page: 409 year: 2003 ident: 10.1038/labinvest.2015.144_bib221 article-title: A role for Wnt signalling in self-renewal of haematopoietic stem cells publication-title: Nature doi: 10.1038/nature01593 contributor: fullname: Reya – volume: 132 start-page: 215 year: 2005 ident: 10.1038/labinvest.2015.144_bib136 article-title: Smad1, beta-catenin and Tcf4 associate in a molecular complex with the Myc promoter in dysplastic renal tissue and cooperate to control Myc transcription publication-title: Development doi: 10.1242/dev.01573 contributor: fullname: Hu – volume: 275 start-page: 1784 year: 1997 ident: 10.1038/labinvest.2015.144_bib237 article-title: Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma publication-title: Science doi: 10.1126/science.275.5307.1784 contributor: fullname: Korinek – volume: 15 start-page: 7529 year: 2009 ident: 10.1038/labinvest.2015.144_bib113 article-title: Vascular endothelial growth factor receptor-1 is synthetic lethal to aberrant {beta}-catenin activation in colon cancer publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-09-0336 contributor: fullname: Naik – volume: 5 start-page: 100 year: 2009 ident: 10.1038/labinvest.2015.144_bib297 article-title: Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer publication-title: Nat Chem Biol doi: 10.1038/nchembio.137 contributor: fullname: Chen – volume: 403 start-page: 781 year: 2000 ident: 10.1038/labinvest.2015.144_bib130 article-title: Interaction between Wnt and TGF-beta signalling pathways during formation of Spemann's organizer publication-title: Nature doi: 10.1038/35001602 contributor: fullname: Nishita – volume: 12 start-page: 528 year: 2007 ident: 10.1038/labinvest.2015.144_bib219 article-title: Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo publication-title: Cancer Cell doi: 10.1016/j.ccr.2007.11.003 contributor: fullname: Zhao – volume: 13 start-page: 812 year: 2014 ident: 10.1038/labinvest.2015.144_bib346 article-title: Monensin inhibits canonical Wnt signaling in human colorectal cancer cells and suppresses tumor growth in multiple intestinal neoplasia mice publication-title: Mol Cancer Ther doi: 10.1158/1535-7163.MCT-13-0625 contributor: fullname: Tumova – volume: 488 start-page: 665 year: 2012 ident: 10.1038/labinvest.2015.144_bib83 article-title: Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors publication-title: Nature doi: 10.1038/nature11308 contributor: fullname: Koo – volume: 22 start-page: 839 year: 2009 ident: 10.1038/labinvest.2015.144_bib169 article-title: Aberrant activation of hedgehog signaling pathway contributes to endometrial carcinogenesis through beta-catenin publication-title: Mod Pathol doi: 10.1038/modpathol.2009.45 contributor: fullname: Liao – volume: 158 start-page: 157 year: 2014 ident: 10.1038/labinvest.2015.144_bib185 article-title: YAP/TAZ incorporation in the beta-catenin destruction complex orchestrates the Wnt response publication-title: Cell doi: 10.1016/j.cell.2014.06.013 contributor: fullname: Azzolin – volume: 263 start-page: 145 year: 2008 ident: 10.1038/labinvest.2015.144_bib176 article-title: Cross-talk of hedgehog and Wnt pathways in gastric cancer publication-title: Cancer Lett doi: 10.1016/j.canlet.2007.12.030 contributor: fullname: Yanai – volume: 18 start-page: 2718 year: 2004 ident: 10.1038/labinvest.2015.144_bib148 article-title: LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesis publication-title: Genes Dev doi: 10.1101/gad.1249504 contributor: fullname: Galceran – volume: 28 start-page: 2613 year: 2008 ident: 10.1038/labinvest.2015.144_bib327 article-title: Vitamin D and Wnt/beta-catenin pathway in colon cancer: role and regulation of DICKKOPF genes publication-title: Anticancer Res contributor: fullname: Pendas-Franco – volume: 134 start-page: 43 year: 2014 ident: 10.1038/labinvest.2015.144_bib320 article-title: Cancer cells acquire a drug resistant, highly tumorigenic, cancer stem-like phenotype through modulation of the PI3K/Akt/beta-catenin/CBP pathway publication-title: Int J Cancer doi: 10.1002/ijc.28341 contributor: fullname: He – volume: 303 start-page: 848 year: 2004 ident: 10.1038/labinvest.2015.144_bib137 article-title: TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia publication-title: Science doi: 10.1126/science.1090922 contributor: fullname: Bhowmick – volume: 32 start-page: 886 year: 2014 ident: 10.1038/labinvest.2015.144_bib235 article-title: Wnt7b is an important intrinsic regulator of hair follicle stem cell homeostasis and hair follicle cycling publication-title: Stem Cells doi: 10.1002/stem.1599 contributor: fullname: Kandyba – volume: 382 start-page: 638 year: 1996 ident: 10.1038/labinvest.2015.144_bib9 article-title: Functional interaction of beta-catenin with the transcription factor LEF-1 publication-title: Nature doi: 10.1038/382638a0 contributor: fullname: Behrens – volume: 5 start-page: eg2 year: 2012 ident: 10.1038/labinvest.2015.144_bib24 article-title: Focus issue: Wnt and beta-catenin signaling in development and disease publication-title: Sci Signal contributor: fullname: Gough – volume: 19 start-page: 4980 year: 2009 ident: 10.1038/labinvest.2015.144_bib306 article-title: 2,4-Diamino-quinazolines as inhibitors of beta-catenin/Tcf-4 pathway: Potential treatment for colorectal cancer publication-title: Bioorg Med Chem Lett doi: 10.1016/j.bmcl.2009.07.070 contributor: fullname: Chen – volume: 8 start-page: e75010 year: 2013 ident: 10.1038/labinvest.2015.144_bib66 article-title: The small molecule Wnt signaling modulator ICG-001 improves contractile function in chronically infarcted rat myocardium publication-title: PLoS One doi: 10.1371/journal.pone.0075010 contributor: fullname: Sasaki – volume: 49 start-page: 1935 year: 2009 ident: 10.1038/labinvest.2015.144_bib108 article-title: Overexpression of insulin receptor substrate-1 and hepatitis Bx genes causes premalignant alterations in the liver publication-title: Hepatology doi: 10.1002/hep.22856 contributor: fullname: Longato – volume: 4 start-page: 2610 year: 2013 ident: 10.1038/labinvest.2015.144_bib255 article-title: Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells publication-title: Nat Commun doi: 10.1038/ncomms3610 contributor: fullname: Voloshanenko – volume: 280 start-page: 26770 year: 2005 ident: 10.1038/labinvest.2015.144_bib96 article-title: SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor publication-title: J Biol Chem doi: 10.1074/jbc.M504308200 contributor: fullname: Semenov – volume: 28 start-page: 2701 year: 2008 ident: 10.1038/labinvest.2015.144_bib271 article-title: Promotion of the self-renewal capacity of human acute leukemia cells by Wnt3A publication-title: Anticancer Res contributor: fullname: Kawaguchi-Ihara – volume: 15 start-page: 726 year: 2015 ident: 10.1038/labinvest.2015.144_bib344 article-title: The anthelmintic drug niclosamide inhibits the proliferative activity of human osteosarcoma cells by targeting multiple signal pathways publication-title: Curr Cancer Drug Targets doi: 10.2174/1568009615666150629132157 contributor: fullname: Liao – volume: 26 start-page: 951 year: 2014 ident: 10.1038/labinvest.2015.144_bib72 article-title: Canonical Wnt signaling skews TGF-beta signaling in chondrocytes towards signaling via ALK1 and Smad 1/5/8 publication-title: Cell Signal doi: 10.1016/j.cellsig.2014.01.021 contributor: fullname: van den Bosch – volume: 485 start-page: 195 year: 2012 ident: 10.1038/labinvest.2015.144_bib82 article-title: ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner publication-title: Nature doi: 10.1038/nature11019 contributor: fullname: Hao – volume: 5 start-page: a008029 year: 2013 ident: 10.1038/labinvest.2015.144_bib228 article-title: Wnt signaling in skin development, homeostasis, and disease publication-title: Cold Spring Harb Perspect Biol doi: 10.1101/cshperspect.a008029 contributor: fullname: Lim – volume: 193 start-page: 161 year: 2003 ident: 10.1038/labinvest.2015.144_bib324 article-title: Tyrosine kinase inhibitor STI-571/Gleevec down-regulates the beta-catenin signaling activity publication-title: Cancer Lett doi: 10.1016/S0304-3835(03)00013-2 contributor: fullname: Zhou – volume: 11 start-page: 791 year: 2006 ident: 10.1038/labinvest.2015.144_bib34 article-title: Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion publication-title: Dev Cell doi: 10.1016/j.devcel.2006.10.003 contributor: fullname: Takada – volume: 25 start-page: 1475 year: 2005 ident: 10.1038/labinvest.2015.144_bib140 article-title: Interaction between Smad7 and beta-catenin: importance for transforming growth factor beta-induced apoptosis publication-title: Mol Cell Biol doi: 10.1128/MCB.25.4.1475-1488.2005 contributor: fullname: Edlund – volume: 2014 start-page: 162024 year: 2014 ident: 10.1038/labinvest.2015.144_bib204 article-title: A cocktail method for promoting cardiomyocyte differentiation from bone marrow-derived mesenchymal stem cells publication-title: Stem Cells Int doi: 10.1155/2014/162024 contributor: fullname: Gao – volume: 15 start-page: 178 year: 2014 ident: 10.1038/labinvest.2015.144_bib266 article-title: Molecular mechanisms of epithelial-mesenchymal transition publication-title: Nat Rev Mol Cell Biol doi: 10.1038/nrm3758 contributor: fullname: Lamouille – volume: 9 start-page: e115835 year: 2014 ident: 10.1038/labinvest.2015.144_bib256 article-title: Focal chromosomal copy number aberrations identify CMTM8 and GPR177 as new candidate driver genes in osteosarcoma publication-title: PLoS One doi: 10.1371/journal.pone.0115835 contributor: fullname: Both – volume: 1 start-page: e43 year: 2011 ident: 10.1038/labinvest.2015.144_bib310 article-title: AV-65, a novel Wnt/beta-catenin signal inhibitor, successfully suppresses progression of multiple myeloma in a mouse model publication-title: Blood Cancer J doi: 10.1038/bcj.2011.41 contributor: fullname: Yao – volume: 141 start-page: 1614 year: 2014 ident: 10.1038/labinvest.2015.144_bib178 article-title: The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease publication-title: Development doi: 10.1242/dev.102376 contributor: fullname: Varelas – volume: 36 start-page: 313 year: 2000 ident: 10.1038/labinvest.2015.144_bib101 article-title: c-met tyrosine kinase receptor expression is associated with abnormal beta-catenin expression and favourable prognostic factors in invasive breast carcinoma publication-title: Histopathology doi: 10.1046/j.1365-2559.2000.00847.x contributor: fullname: Nakopoulou – volume: 24 start-page: 245 year: 2000 ident: 10.1038/labinvest.2015.144_bib244 article-title: AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1 publication-title: Nat Genet doi: 10.1038/73448 contributor: fullname: Satoh – volume: 284 start-page: 16256 year: 2009 ident: 10.1038/labinvest.2015.144_bib295 article-title: Discovery and characterization of a small molecule inhibitor of the PDZ domain of dishevelled publication-title: J Biol Chem doi: 10.1074/jbc.M109.009647 contributor: fullname: Grandy – volume: 13 start-page: 242 year: 2012 ident: 10.1038/labinvest.2015.144_bib84 article-title: The R-spondin protein family publication-title: Genome Biol doi: 10.1186/gb-2012-13-3-242 contributor: fullname: de Lau – volume: 26 start-page: 1303 year: 2014 ident: 10.1038/labinvest.2015.144_bib335 article-title: Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/beta-catenin and mTORC1 signaling in prostate and breast cancer cells publication-title: Cell Signal doi: 10.1016/j.cellsig.2014.02.018 contributor: fullname: Lu – volume: 278 start-page: 48805 year: 2003 ident: 10.1038/labinvest.2015.144_bib132 article-title: Smad4 and beta-catenin co-activators functionally interact with lymphoid-enhancing factor to regulate graded expression of Msx2 publication-title: J Biol Chem doi: 10.1074/jbc.M305472200 contributor: fullname: Hussein – volume: 2 start-page: 26 year: 2015 ident: 10.1038/labinvest.2015.144_bib264 article-title: Targeting matrix metalloproteinases in cancer: bringing new life to old ideas publication-title: Genes Dis doi: 10.1016/j.gendis.2014.12.002 contributor: fullname: Cathcart – volume: 20 start-page: 427 year: 2011 ident: 10.1038/labinvest.2015.144_bib74 article-title: FoxM1 promotes beta-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis publication-title: Cancer Cell doi: 10.1016/j.ccr.2011.08.016 contributor: fullname: Zhang – volume: 434 start-page: 843 year: 2005 ident: 10.1038/labinvest.2015.144_bib18 article-title: Wnt signalling in stem cells and cancer publication-title: Nature doi: 10.1038/nature03319 contributor: fullname: Reya – volume: 4 start-page: a007971 year: 2012 ident: 10.1038/labinvest.2015.144_bib190 article-title: Wnt pathway regulation of embryonic stem cell self-renewal publication-title: Cold Spring Harb Perspect Biol doi: 10.1101/cshperspect.a007971 contributor: fullname: Merrill – volume: 3 start-page: 493 year: 2008 ident: 10.1038/labinvest.2015.144_bib193 article-title: Periodic activation of Wnt/beta-catenin signaling enhances somatic cell reprogramming mediated by cell fusion publication-title: Cell Stem Cell doi: 10.1016/j.stem.2008.08.017 contributor: fullname: Lluis – volume: 307 start-page: 131 year: 1984 ident: 10.1038/labinvest.2015.144_bib236 article-title: Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15 publication-title: Nature doi: 10.1038/307131a0 contributor: fullname: Nusse – volume: 14 start-page: 1087 year: 2015 ident: 10.1038/labinvest.2015.144_bib279 article-title: Targeting Wnts at the source—new mechanisms, new biomarkers, new drugs publication-title: Mol Cancer Ther doi: 10.1158/1535-7163.MCT-14-1038 contributor: fullname: Madan |
| SSID | ssj0014465 |
| Score | 2.608613 |
| Snippet | The canonical WNT/β-catenin signaling pathway governs a myriad of biological processes underlying the development and maintenance of adult tissue homeostasis,... The canonical WNT/ β -catenin signaling pathway governs a myriad of biological processes underlying the development and maintenance of adult tissue... The canonical WNT/ beta -catenin signaling pathway governs a myriad of biological processes underlying the development and maintenance of adult tissue... The canonical WNT/β-catenin signaling pathway governs a myriad of biological processes underlying development and maintenance of adult tissue homeostasis,... |
| SourceID | pubmedcentral proquest crossref pubmed springer elsevier |
| SourceType | Open Access Repository Aggregation Database Index Database Publisher |
| StartPage | 116 |
| SubjectTerms | 13/95 45/100 631/67 631/67/1059 Animals Carcinogenesis Drug Discovery Humans Laboratory Medicine Medicine Medicine & Public Health Mice Neoplasms - drug therapy pathobiology-in-focus Pathology Stem Cells Wnt Proteins Wnt Signaling Pathway |
| Title | The evolving roles of canonical WNT signaling in stem cells and tumorigenesis: implications in targeted cancer therapies |
| URI | https://dx.doi.org/10.1038/labinvest.2015.144 https://link.springer.com/article/10.1038/labinvest.2015.144 https://www.ncbi.nlm.nih.gov/pubmed/26618721 https://www.proquest.com/docview/1760274244 https://search.proquest.com/docview/1872838932 https://pubmed.ncbi.nlm.nih.gov/PMC4731283 |
| Volume | 96 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwELe6ISFeEN8EBjISbyVQx0mc8IZYUdHEXlbE4CVyEodFYsm0tRJ_Pnf-StpqCJDoQ1TZbuP4fjmffb87E_ISAwPErJGg_TIexrlioQQrP4zKGoyTNOeVjkpbnIjj0-xwHs8nE3fI2lD2XyUNZSBrjJz9C2n7P4UC-A4yhytIHa5_LHcFOkdvFCB3UHM1YAB7EwH55Xg5RdKG_GGjWTCT8xT370225tX6HA_LQhXYarpcu8U5N9xxsFMrBIzmKF7KC8dF9KHVGlvowG-HTB6Dy_-r3aY-GlxDtuS09Y38Zvai776fq3a76bezHoOQpZ187d4F83Rnt6Hmgmo2OJ9oRoRpZnLBvFZOL89C1EdjxW2OwrUAjUZamLF0NKEzk2FlZ64wmeHhXTPjgDS_BH3dw8zo-YonOtE-dCnC0-ZBie2RGxFoNuSQHn488m4rzD5nOEXmCWyUFtzpze59rrOEdlc6u4TdLa-9NoaWd8htu4qh7wz87pKJ6u6Rm58sT-M--QkopA6FVKOQ9g31KKSAQupRSNuOIgqpRiEFFNINFL6lYwxia4dBajBIPQYfkM8f5sv3i9Ce8RFWsJRehbBc50kzE_UskXma1KAeMsUrdI_LOq_hkzYil1JUTAgeN0kt47LKmzRWoGKqhj8k-9B19ZhQxVgZRWUqq4zHqZIZTvS1qsukzJOsFAGZuvEuLkwql0JTMHhWeOkUKB1YD8cBSZxICmuMGiOzAPz89ncHTn6FVQtXBROp5kRg9QtfDYocx1V2ql9Dm0yAqQ_Lhyggj4y4fTfRioZqFhCxAQTfAJPEb9Z07ZlOFh8LDiYoD8grB5lRt659iif_-PRPya3hPT8g-6vLtXpG9q7q9XP9pvwCxz31oA |
| link.rule.ids | 230,315,782,786,887,27935,27936,48286,48348,48349,48360,49592,49653,49654,49665 |
| linkProvider | Flying Publisher |
| linkToHtml | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB7RrQRceJRXoC2uxA0iNms7drgh6GqrtnvpIhAXy4kdkQNZ1OxK_HxmHGfVB0WiOcZOZHvG428y30wA3lBigBrXFq2f5qkofJZaRPnppHQITvKCVyErbXam5t_050MqkyOGXJjAdh9CksFS94nh-j0uShNKTxAfS1JQcgu2BaJ1OYLt6dF38tJj9ICKgPXUDp7m6IHFZJm_v-WmA-k64LzOm7wSPA1n0vTh7WbzCB5EDMo-9krzGO74dgfunsYo-xP4jbrDPNot-tjAiH_YsWXNUAjLkEXJvs4XjIgflnLZWdMyqgbNKAbQMds6tlr_pB9ukRltug-sucBap949-9w7emPlz1mfA4Yu-1P4Mj1cfJql8Q8NaYWO0CpFZ4vLeqzcWNoilw6Fqz2vKLhpXeHwymtVWKuqTCkuaumsKKuizoVHBalq_gxGOHT_ApjPsnIyKXNbaS5ybzWZaeddKctC6lIl8HYQk_nVF-IwIYDOtdkspqHFRG9GJCAHSZoIJXqIYPCk-Odzu4PYTdzMnclUHiLa1HywacZtSOtqW79cYx-tEKgh-Jsk8LzXks0wCQNhc5aAuqQ_mw5U4vtyS9v8CKW-heIIIHgC7wYtujCsG2fx8v-6v4Z7s8XpiTk5mh-_gvt4O_LSd2G0Ol_7Pdjq3Ho_7rI_4jMsWQ |
| linkToPdf | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LT9wwEB7BIiEutJRX2m1rpN4gYrNOYocbKqwWtayQCgJxsZzYETmQRWRX4ud3JnEiHgUJNcfYifwY299kvm8C8IOEAWKQa9z9JPfDxAa-RpTvD1OD4CROeFar0sZ_xORKHh1TmpxOxV-z3duQZKNpoCxN5Wz_zuROJC73cYCKOg0FcbMiClAuwlJIeoQeLI1Orsljd5EESgjW0Dy4H6M35oQz_37La4fTS_D5kkP5LJBan0-jD__fs4-w6rApO2yMaQ0WbPkJlk9d9H0dHtCmmMX9jD5CMOIlVmyaM5ycaa2uZJeTc0aEEE0ad1aUjLJEM4oNVEyXhs3mt_QjLtpei-qAFY_Y7FS7YaVbQ2_M7D1rtGHoym_Axej4_OfYd39u8DN0kGY-OmE8ygfCDCKdxJHBSZeWZxT01CYxeMW5SLQWWSAED_PI6DDNkjwOLRpOlvNN6GHT7TYwGwTpcJjGOpM8jK2WtH0ba9IoTSKZCg922ylTd02CDlUH1rlU3WAqGkz0ckIPonZWlYMYDXRQeIK8-Vy_NQHlFnmlAhHXkW4q3umKcXnSuOrSTudYRwoEcAgKhx5sNRbTNZOwERYHHognttRVoNTfT0vK4qZOAR4KjsCCe7DXWtSjZr3ai8_vq_4dls-ORur3yeTXF1jBu46u3ofe7H5uv8JiZebf3IL7C8RJNTI |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+evolving+roles+of+canonical+WNT+signaling+in+stem+cells+and+tumorigenesis%3A+implications+in+targeted+cancer+therapies&rft.jtitle=Laboratory+investigation&rft.au=Yang%2C+Ke&rft.au=Wang%2C+Xin&rft.au=Zhang%2C+Hongmei&rft.au=Wang%2C+Zhongliang&rft.date=2016-02-01&rft.pub=Elsevier+Inc&rft.issn=0023-6837&rft.eissn=1530-0307&rft.volume=96&rft.issue=2&rft.spage=116&rft.epage=136&rft_id=info:doi/10.1038%2Flabinvest.2015.144&rft.externalDocID=S0023683722023017 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0023-6837&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0023-6837&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0023-6837&client=summon |