The importance of dog population contact network structures in rabies transmission

• Published in: PLoS neglected tropical diseases Vol. 12; no. 8; p. e0006680
• Main Authors: Laager, Mirjam, Mbilo, Céline, Madaye, Enos Abdelaziz, Naminou, Abakar, Léchenne, Monique, Tschopp, Aurélie, Naïssengar, Service Kemdongarti, Smieszek, Timo, Zinsstag, Jakob, Chitnis, Nakul
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01-08-2018; Public Library of Science (PLoS)
• Subjects: Algorithms; Animal Distribution; Animal populations; Animals; Biology and Life Sciences; Chad - epidemiology; Cities; Computer and Information Sciences; Computer simulation; Distribution; Dog Diseases - epidemiology; Dog Diseases - prevention & control; Dog Diseases - transmission; Dogs; Domestic animals; Empirical analysis; Epidemiology; Heterogeneity; Immunization; Importation; Influence; Mass Vaccination - veterinary; Medical research; Medicine and Health Sciences; Models, Biological; Outbreaks; Patchiness; Preventive medicine; Probability theory; Rabies; Rabies - epidemiology; Rabies - prevention & control; Rabies - veterinary; Rabies Vaccines - administration & dosage; Rabies Vaccines - immunology; Residential density; Spatial heterogeneity; Transmission; Tropical diseases; Vaccination; Vaccines; Chad; Cities; United Kingdom > UK; Australia; Switzerland
• ISSN: 1935-2735; 1935-2727; 1935-2735
• DOI: 10.1371/journal.pntd.0006680

Canine rabies transmission was interrupted in N'Djaména, Chad, following two mass vaccination campaigns. However, after nine months cases resurged with re-establishment of endemic rabies transmission to pre-intervention levels. Previous analyses investigated district level spatial heterogeneity of vaccination coverage, and dog density; and importation, identifying the latter as the primary factor for rabies resurgence. Here we assess the impact of individual level heterogeneity on outbreak probability, effectiveness of vaccination campaigns and likely time to resurgence after a campaign. Geo-located contact sensors recorded the location and contacts of 237 domestic dogs in N'Djaména over a period of 3.5 days. The contact network data showed that urban dogs are socially related to larger communities and constrained by the urban architecture. We developed a network generation algorithm that extrapolates this empirical contact network to networks of large dog populations and applied it to simulate rabies transmission in N'Djaména. The model predictions aligned well with the rabies incidence data. Using the model we demonstrated, that major outbreaks are prevented when at least 70% of dogs are vaccinated. The probability of a minor outbreak also decreased with increasing vaccination coverage, but reached zero only when coverage was near total. Our results suggest that endemic rabies in N'Djaména may be explained by a series of importations with subsequent minor outbreaks. We show that highly connected dogs hold a critical role in transmission and that targeted vaccination of such dogs would lead to more efficient vaccination campaigns.