Role of Spleen-Derived Monocytes/Macrophages in Acute Ischemic Brain Injury

Monocytes/macrophages (MMs), mononuclear phagocytes, have been implicated in stroke-induced inflammation and injury. However, the presence of pro-inflammatory Ly-6Chigh and antiinflammatory Ly-6Clow monocyte subsets raises uncertainty regarding their role in stroke pathologic assessment. With recent...

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Bibliographic Details
Published in:	Journal of cerebral blood flow and metabolism Vol. 34; no. 8; pp. 1411 - 1419
Main Authors:	Kim, Eunhee, Yang, Jiwon, Beltran, Cesar D, Cho, Sunghee
Format:	Journal Article
Language:	English
Published:	London, England SAGE Publications 01-08-2014 Sage Publications Ltd Nature Publishing Group
Subjects:	Acute Disease Animals Antigens, Ly - immunology Brain - immunology Brain - pathology Brain Ischemia - immunology Brain Ischemia - pathology Cell Count Chemotaxis - immunology Disease Models, Animal Flow Cytometry Macrophages - immunology Male Mice Mice, Inbred C57BL Monocytes - immunology Original Spleen - cytology Spleen - immunology Spleen - surgery Splenectomy Stroke - immunology Stroke - pathology Ly-6Chigh Ly-6Clow monocytes/macrophages spleen ischemic stroke splenectomy
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