PprA contributes to Deinococcus radiodurans resistance to nalidixic acid, genome maintenance after DNA damage and interacts with deinococcal topoisomerases

PprA is known to contribute to Deinococcus radiodurans' remarkable capacity to survive a variety of genotoxic assaults. The molecular bases for PprA's role(s) in the maintenance of the damaged D. radiodurans genome are incompletely understood, but PprA is thought to promote D. radiodurans&...

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Bibliographic Details
Published in:	PloS one Vol. 9; no. 1; p. e85288
Main Authors:	Kota, Swathi, Charaka, Vijaya K, Ringgaard, Simon, Waldor, Matthew K, Misra, Hari S
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 15-01-2014 Public Library of Science (PLoS)
Subjects:	Acid resistance Acids Anti-Bacterial Agents - pharmacology Bacterial Proteins - genetics Bacterial Proteins - physiology Base Sequence Biology Cell division Damage Deinococcus - drug effects Deinococcus - genetics Deinococcus - physiology Deinococcus radiodurans Deoxyribonucleic acid DNA DNA Damage DNA Primers DNA repair DNA topoisomerase (ATP-hydrolysing) DNA Topoisomerases, Type I - metabolism Double-strand break repair Drug Resistance, Bacterial - genetics E coli Enzymes Escherichia coli Gene expression Genome, Bacterial Genomes Genomics Genotoxicity Infectious diseases Ionizing radiation Kinases Laboratories Ligases Medical schools Molecular biology Nalidixic acid Nalidixic Acid - pharmacology Plasmids Proteins Repair Reverse Transcriptase Polymerase Chain Reaction Signal transduction Womens health Mumbai India United States > US Massachusetts India
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