Bicarbonate buffered peritoneal dialysis fluid upregulates angiopoietin-1 and promotes vessel maturation

Ultrafiltration decline is a progressive issue for patients on chronic peritoneal dialysis (PD) and can be caused by peritoneal angiogenesis induced by PD fluids. A recent pediatric trial suggests better preservation of ultrafiltration with bicarbonate versus lactate buffered fluid; underlying molec...

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Bibliographic Details
Published in:	PloS one Vol. 12; no. 12; p. e0189903
Main Authors:	Eich, Gwendolyn, Bartosova, Maria, Tischer, Christian, Wlodkowski, Tanja Tamara, Schaefer, Betti, Pichl, Sebastian, Kraewer, Nicole, Ranchin, Bruno, Vondrak, Karel, Liebau, Max Christoph, Hackert, Thilo, Schmitt, Claus Peter
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 18-12-2017 Public Library of Science (PLoS)
Subjects:	Abundance Angiogenesis Angiopoietin Bicarbonates Biology and Life Sciences Blood vessels Buffers Carbonates Children Comparative analysis Degradation Dialysis Endothelial cells Endothelium Fluids Glucose Histomorphometry Immunohistochemistry Incubation Lactic acid Maturation Medicine Medicine and Health Sciences Microscopy Molecular modelling mRNA Network analysis Pediatrics Peritoneal dialysis Peritoneum Peritonitis pH effects Physical Sciences Preservation Promoters (Genetics) Protein folding Protein-tyrosine kinase receptors Research and Analysis Methods Translocation Tyrosine Ultrafiltration Umbilical vein Vascular endothelial growth factor Germany
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