Recognition of DNA Termini by the C-Terminal Region of the Ku80 and the DNA-Dependent Protein Kinase Catalytic Subunit

DNA double strand breaks (DSBs) can be generated by endogenous cellular processes or exogenous agents in mammalian cells. These breaks are highly variable with respect to DNA sequence and structure and all are recognized in some context by the DNA-dependent protein kinase (DNA-PK). DNA-PK is a criti...

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Bibliographic Details
Published in:	PloS one Vol. 10; no. 5; p. e0127321
Main Authors:	Woods, Derek S, Sears, Catherine R, Turchi, John J
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 15-05-2015 Public Library of Science (PLoS)
Subjects:	Activation Animals Antigens, Nuclear - genetics Antigens, Nuclear - metabolism Biochemistry Catalysis Catalytic Domain - genetics Cell Line Cells (Biology) Deoxyribonucleic acid DNA DNA - genetics DNA Breaks, Double-Stranded DNA damage DNA repair DNA Repair - genetics DNA structure DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism DNA-dependent protein kinase Double-strand break repair Homology Kinases Ku Autoantigen Mammalian cells Medicine Molecular biology Non-homologous end joining Nucleotide sequence Physiological aspects Protein kinase C Protein kinases Protein Kinases - genetics Protein Kinases - metabolism Proteins Recognition Repair Substrates Variation United States
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