Progressive Chromatin Condensation and H3K9 Methylation Regulate the Differentiation of Embryonic and Hematopoietic Stem Cells

Epigenetic regulation serves as the basis for stem cell differentiation into distinct cell types, but it is unclear how global epigenetic changes are regulated during this process. Here, we tested the hypothesis that global chromatin organization affects the lineage potential of stem cells and that...

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Bibliographic Details
Published in:	Stem cell reports Vol. 5; no. 5; pp. 728 - 740
Main Authors:	Ugarte, Fernando, Sousae, Rebekah, Cinquin, Bertrand, Martin, Eric W., Krietsch, Jana, Sanchez, Gabriela, Inman, Margaux, Tsang, Herman, Warr, Matthew, Passegué, Emmanuelle, Larabell, Carolyn A., Forsberg, E. Camilla
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 10-11-2015 Elsevier
Subjects:	60 APPLIED LIFE SCIENCES Animals Cell Differentiation Chromatin Assembly and Disassembly Embryonic Stem Cells - cytology Embryonic Stem Cells - metabolism Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Heterochromatin - genetics Heterochromatin - metabolism Histone-Lysine N-Methyltransferase - antagonists & inhibitors Histone-Lysine N-Methyltransferase - metabolism Histones - metabolism Methylation Mice Mice, Inbred C57BL
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