Enabling plant synthetic biology through genome engineering

Highlights • Rewriting genomes will play an important role in plant synthetic biology. • Sequence-specific nucleases enable almost any DNA sequence change in plant cells. • The advantages and limitations of current sequence-specific nucleases are discussed. • A comprehensive list of recent plant gen...

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Published in:	Trends in biotechnology (Regular ed.) Vol. 33; no. 2; pp. 120 - 131
Main Authors:	Baltes, Nicholas J, Voytas, Daniel F
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-02-2015 Elsevier Limited
Subjects:	Agrobacterium - genetics Climate change CRISPR/Cas Deoxyribonucleic acid Design DNA DNA End-Joining Repair Endonucleases - genetics Gene expression Gene Expression Regulation, Plant Gene Targeting - methods Genetic engineering Genetic Engineering - methods genome engineering Genome, Plant Genomes Genomics Homologous Recombination Internal Medicine Metabolites Methods Mutagenesis, Site-Directed - methods Nitrogen Fixation - genetics Organisms Plants - genetics sequence-specific nuclease Signal transduction Synthetic biology Synthetic Biology - methods TALEN Tobacco Zinc Fingers - genetics zinc-finger nuclease synthetic biology sequence-specific nuclease zinc-finger nuclease CRISPR/Cas TALEN genome engineering
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Abstract	Highlights • Rewriting genomes will play an important role in plant synthetic biology. • Sequence-specific nucleases enable almost any DNA sequence change in plant cells. • The advantages and limitations of current sequence-specific nucleases are discussed. • A comprehensive list of recent plant genome engineering achievements is provided. • Achievements in genome engineering are related to plant synthetic biology projects.
AbstractList	Synthetic biology seeks to create new biological systems, including user-designed plants and plant cells. These systems can be employed for a variety of purposes, ranging from producing compounds of industrial or therapeutic value, to reducing crop losses by altering cellular responses to pathogens or climate change. To realize the full potential of plant synthetic biology, techniques are required that provide control over the genetic code - enabling targeted modifications to DNA sequences within living plant cells. Such control is now within reach owing to recent advances in the use of sequence-specific nucleases to precisely engineer genomes. We discuss here the enormous potential provided by genome engineering for plant synthetic biology. •Rewriting genomes will play an important role in plant synthetic biology.•Sequence-specific nucleases enable almost any DNA sequence change in plant cells.•The advantages and limitations of current sequence-specific nucleases are discussed.•A comprehensive list of recent plant genome engineering achievements is provided.•Achievements in genome engineering are related to plant synthetic biology projects. Synthetic biology seeks to create new biological systems, including user-designed plants and plant cells. These systems can be employed for a variety of purposes, ranging from producing compounds of industrial or therapeutic value, to reducing crop losses by altering cellular responses to pathogens or climate change. To realize the full potential of plant synthetic biology, techniques are required that provide control over the genetic code – enabling targeted modifications to DNA sequences within living plant cells. Such control is now within reach owing to recent advances in the use of sequence-specific nucleases to precisely engineer genomes. We discuss here the enormous potential provided by genome engineering for plant synthetic biology. Highlights • Rewriting genomes will play an important role in plant synthetic biology. • Sequence-specific nucleases enable almost any DNA sequence change in plant cells. • The advantages and limitations of current sequence-specific nucleases are discussed. • A comprehensive list of recent plant genome engineering achievements is provided. • Achievements in genome engineering are related to plant synthetic biology projects.
Author	Baltes, Nicholas J Voytas, Daniel F
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BackLink	https://www.ncbi.nlm.nih.gov/pubmed/25496918$$D View this record in MEDLINE/PubMed
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Copyright	Elsevier Ltd 2014 Elsevier Ltd Copyright © 2014 Elsevier Ltd. All rights reserved. Copyright Elsevier Limited Feb 2015
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Snippet	Highlights • Rewriting genomes will play an important role in plant synthetic biology. • Sequence-specific nucleases enable almost any DNA sequence change in... •Rewriting genomes will play an important role in plant synthetic biology.•Sequence-specific nucleases enable almost any DNA sequence change in plant... Synthetic biology seeks to create new biological systems, including user-designed plants and plant cells. These systems can be employed for a variety of...
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SubjectTerms	Agrobacterium - genetics Climate change CRISPR/Cas Deoxyribonucleic acid Design DNA DNA End-Joining Repair Endonucleases - genetics Gene expression Gene Expression Regulation, Plant Gene Targeting - methods Genetic engineering Genetic Engineering - methods genome engineering Genome, Plant Genomes Genomics Homologous Recombination Internal Medicine Metabolites Methods Mutagenesis, Site-Directed - methods Nitrogen Fixation - genetics Organisms Plants - genetics sequence-specific nuclease Signal transduction Synthetic biology Synthetic Biology - methods TALEN Tobacco Zinc Fingers - genetics zinc-finger nuclease
Title	Enabling plant synthetic biology through genome engineering
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