Transcriptome profiling of human FoxP3+ regulatory T cells

Abstract The major goal of this study was to perform an in depth characterization of the “gene signature” of human FoxP3+ T regulatory cells (Tregs). Highly purified Tregs and T conventional cells (Tconvs) from multiple healthy donors (HD), either freshly explanted or activated in vitro , were analy...

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Bibliographic Details
Published in:	Human immunology Vol. 77; no. 2; pp. 201 - 213
Main Authors:	Bhairavabhotla, Ravikiran, Kim, Yong C, Glass, Deborah D, Escobar, Thelma M, Patel, Mira C, Zahr, Rami, Nguyen, Cuong K, Kilaru, Gokhul K, Muljo, Stefan A, Shevach, Ethan M
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-02-2016
Subjects:	Allergy and Immunology Cells, Cultured Differentially expressed Forkhead Transcription Factors - metabolism FoxP3 Gene Regulatory Networks Gene signature Humans Immune Tolerance - genetics Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism LAYN Lectins, C-Type - genetics Lectins, C-Type - metabolism MicroRNAs - genetics MiR-146a MiR-146b MiR-21 MiRNA nCounter analysis PNA RNA sequencing RNA, Small Interfering - genetics RTKN2 Suppressive cells T-Lymphocyte Subsets - immunology T-Lymphocytes, Regulatory - immunology Transcriptome fluorescence activated cell sorter DE MiR-146b PNA MiR-146a MiR-21 RTKN2 Suppressive cells FACS peripheral blood T conventional cells differentially expressed rIL-2 RNA-seq micro RNA Tconvs recombinant Interleukin-2 miRNA umbilical cord blood Rhotekin-2 FoxP3 Gene Ontology CB peptide nucleic acid RNA sequencing Gene signature Tregs GO LAYN Log2 Fold Change nCounter analysis poly A + RNA sequencing healthy donor PB T regulatory cells Layilin Log2FC HD dendritic cell DC Differentially expressed MiRNA
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