Melanoma‐targeted chemo‐thermo‐immuno (CTI)‐therapy using N‐propionyl‐4‐S‐cysteaminylphenol‐magnetite nanoparticles elicits CTL response via heat shock protein‐peptide complex release

Melanogenesis substrate, N‐propionyl‐4‐S‐cysteaminylphenol (NPrCAP) is specifically taken up by melanoma cells and inhibits their growth by producing cytotxic free radicals. By taking advantage of this unique chemical agent, we have established melanoma‐targeting intracellular hyperthermia by conjug...

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Bibliographic Details
Published in:	Cancer science Vol. 101; no. 9; pp. 1939 - 1946
Main Authors:	Sato, Akiko, Tamura, Yasuaki, Sato, Noriyuki, Yamashita, Toshiharu, Takada, Tomoaki, Sato, Makito, Osai, Yasue, Okura, Masae, Ono, Ichiro, Ito, Akira, Honda, Hiroyuki, Wakamatsu, Kazumasa, Ito, Shosuke, Jimbow, Kowichi
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01-09-2010 Blackwell
Subjects:	Animals Biological and medical sciences Cell Line, Tumor Cross-Priming - immunology Cystamine - analogs & derivatives Cystamine - chemistry Cytotoxicity, Immunologic - immunology Dendritic Cells - immunology Dendritic Cells - metabolism Dermatology Electromagnetic Fields Female Heat-Shock Proteins - immunology Heat-Shock Proteins - metabolism Hot Temperature HSP72 Heat-Shock Proteins - immunology HSP72 Heat-Shock Proteins - metabolism Hyperthermia, Induced Magnetite Nanoparticles - administration & dosage Magnetite Nanoparticles - chemistry Magnetite Nanoparticles - therapeutic use Medical sciences Melanoma, Experimental - immunology Melanoma, Experimental - pathology Melanoma, Experimental - therapy Mice Mice, Inbred C57BL Original Peptides - immunology Peptides - metabolism Phenols - chemistry Protein Binding T-Lymphocytes - immunology T-Lymphocytes - metabolism T-Lymphocytes, Cytotoxic - immunology Tumors Tumors of the skin and soft tissue. Premalignant lesions Cancerology Magnetite Treatment Peptides Nanoparticle Targeted therapy Malignant melanoma Heat shock protein Malignant tumor Cytotoxic T lymphocyte Cancer
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