CEF is superior to CMF for tumours with TOP2A aberrations: a Subpopulation Treatment Effect Pattern Plot (STEPP) analysis on Danish Breast Cancer Cooperative Group Study 89D

The aim of this study was to examine TOP2A gene copy number changes as a means to identify groups of breast cancer patients with superior benefit from treatment with anthracyclines. Tumour tissue was retrospectively collected and successfully analysed for TOP2A in 773 of 980 Danish patients randomly...

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Bibliographic Details
Published in:	Breast cancer research and treatment Vol. 123; no. 1; pp. 163 - 169
Main Authors:	Gunnarsdóttir, Katrín Á, Jensen, Maj-Britt, Zahrieh, David, Gelber, Richard D, Knoop, Ann, Bonetti, Marco, Mouridsen, Henning, Ejlertsen, Bent
Format:	Journal Article
Language:	English
Published:	Boston Boston : Springer US 01-08-2010 Springer US Springer Springer Nature B.V
Subjects:	Analysis Anthracycline Anthracyclines Antigens, Neoplasm - genetics Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Breast cancer breast neoplasms Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - mortality Cancer Cancer research Cancer therapies Care and treatment Chemotherapy Cisplatin Clinical Trial Clinical trials Cyclophosphamide Cyclophosphamide - administration & dosage Data Interpretation, Statistical Disease-Free Survival DNA Topoisomerases, Type II - genetics DNA-Binding Proteins - genetics Drug Resistance, Neoplasm - genetics Epirubicin - administration & dosage Female Fluorouracil - administration & dosage Gene Dosage Genes Gynecology. Andrology. Obstetrics Humans In Situ Hybridization, Fluorescence Mammary gland diseases Medical sciences Medicine Medicine & Public Health Methotrexate Methotrexate - administration & dosage Oncology Oncology, Experimental Poly-ADP-Ribose Binding Proteins Randomized Controlled Trials as Topic STEPP TOP2A Treatment Treatment Outcome Tumors Denmark Europe Breast cancer Treatment Anthracycline STEPP Chromosomal aberration TOP2A Breast disease Malignant tumor Cell subpopulation Mammary gland diseases Anthracyclins Pattern analysis Cancer
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