Subtelomeric factors antagonize telomere anchoring and Tel1-independent telomere length regulation
Yeast telomeres are anchored at the nuclear envelope (NE) through redundant pathways that require the telomere‐binding factors yKu and Sir4. Significant variation is observed in the efficiency with which different telomeres are anchored, however, suggesting that other forces influence this interacti...
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| Published in: | The EMBO journal Vol. 25; no. 4; pp. 857 - 867 |
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| Format: | Journal Article |
| Language: | English |
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Chichester, UK
John Wiley & Sons, Ltd
22-02-2006
Blackwell Publishing Ltd EMBO Press |
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| Abstract | Yeast telomeres are anchored at the nuclear envelope (NE) through redundant pathways that require the telomere‐binding factors yKu and Sir4. Significant variation is observed in the efficiency with which different telomeres are anchored, however, suggesting that other forces influence this interaction. Here, we show that subtelomeric elements and the insulator factors that bind them antagonize the association of telomeres with the NE. This is detectable when the redundancy in anchoring pathways is compromised. Remarkably, these same conditions lead to a reduction in steady‐state telomere length in the absence of the ATM‐kinase homologue Tel1. Both the delocalization of telomeres and reduction in telomere length can be induced by targeting of Tbf1 or Reb1, or the viral transactivator VP16, to a site 23 kb away from the TG repeat. This correlation suggests that telomere anchoring and a Tel1‐independent pathway of telomere length regulation are linked, lending a functional significance to the association of yeast telomeres with the NE. |
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| AbstractList | Yeast telomeres are anchored at the nuclear envelope (NE) through redundant pathways that require the telomere‐binding factors yKu and Sir4. Significant variation is observed in the efficiency with which different telomeres are anchored, however, suggesting that other forces influence this interaction. Here, we show that subtelomeric elements and the insulator factors that bind them antagonize the association of telomeres with the NE. This is detectable when the redundancy in anchoring pathways is compromised. Remarkably, these same conditions lead to a reduction in steady‐state telomere length in the absence of the ATM‐kinase homologue Tel1. Both the delocalization of telomeres and reduction in telomere length can be induced by targeting of Tbf1 or Reb1, or the viral transactivator VP16, to a site 23 kb away from the TG repeat. This correlation suggests that telomere anchoring and a Tel1‐independent pathway of telomere length regulation are linked, lending a functional significance to the association of yeast telomeres with the NE. |
| Author | Gasser, Susan M Hediger, Florence van Houwe, Griet Berthiau, Anne-Sophie Gilson, Eric |
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| DOI | 10.1038/sj.emboj.7600976 |
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| Keywords | TELOMERE yKu TELOMERASE GENOMIQUE NUCLEAR ORGANIZATION SIR4 |
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| Snippet | Yeast telomeres are anchored at the nuclear envelope (NE) through redundant pathways that require the telomere‐binding factors yKu and Sir4. Significant... Yeast telomeres are anchored at the nuclear envelope (NE) through redundant pathways that require the telomere-binding factors yKu and Sir4. Significant... |
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| SubjectTerms | Cellular Biology Chromosomes, Fungal - genetics Chromosomes, Fungal - metabolism Dinucleotide Repeats - physiology DNA-binding proteins DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Fungal Proteins - genetics Fungal Proteins - metabolism Herpes Simplex Virus Protein Vmw65 - genetics Herpes Simplex Virus Protein Vmw65 - metabolism Intracellular Signaling Peptides and Proteins Life Sciences Nuclear Envelope - genetics Nuclear Envelope - metabolism nuclear membrane nuclear organization nucleoproteins Protein-Serine-Threonine Kinases Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Silent Information Regulator Proteins, Saccharomyces cerevisiae - genetics Silent Information Regulator Proteins, Saccharomyces cerevisiae - metabolism Sir4 subtelomeric factors subtelomeric proteins telomerase Telomere - genetics Telomere - metabolism telomere anchoring telomere length regulation telomeres Yeasts yKu |
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| Title | Subtelomeric factors antagonize telomere anchoring and Tel1-independent telomere length regulation |
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