Bradykinin stimulates tumor necrosis factor and interleukin-1 release from macrophages

• Published in: FEBS letters Vol. 247; no. 2; pp. 189 - 192
• Main Authors: Tiffany, Carol W., Burch, Ronald M.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 24-04-1989; Elsevier
• Subjects: Analytical, structural and metabolic biochemistry; Animals; Biological and medical sciences; Bradykinin; Bradykinin - analogs & derivatives; Bradykinin - pharmacology; Bradykinin antagonist; Cell Line; Cytokine; Fundamental and applied biological sciences. Psychology; Interleukin-1; Interleukin-1 - metabolism; Lipoprotein Lipase - antagonists & inhibitors; Macrophage; Macrophages - metabolism; Mice; Prostaglandins E - biosynthesis; Protein hormones. Growth factors. Cytokines; Proteins; Receptors, Bradykinin; Receptors, Neurotransmitter - physiology; Tumor necrosis factor; Tumor Necrosis Factor-alpha - metabolism; Interleukin-1; Bradykinin antagonist; Tumor necrosis factor; Bradykinin; Cytokine; Macrophage; Cell culture; Radiolabelling; Interleukin; Peptide hormone; Stimulation
• ISSN: 0014-5793; 1873-3468
• DOI: 10.1016/0014-5793(89)81331-6

Bradykinin and related kinins have been implicated in the initiation and maintenance of inflammation. Cytokines appear to be the primary mediators of many inflammatory diseases. The potential ability of bradykinin to stimulate release of tumor necrosis factor and interleukin-1 from macrophages was examined. Bradykinin stimulated release of both cytokines from P388-D1 and RAW264.7 murine macrophages. Studies with selective agonists and antagonists suggest that cytokine release is mediated by a B
1 kinin receptor.