APOBEC3G hypermutates genomic DNA and inhibits Ty1 retrotransposition in yeast

Human cells harbor a variety of factors that function to block the proliferation of foreign nucleic acid. The APOBEC3G enzyme inhibits the replication of retroviruses by deaminating nascent retroviral cDNA cytosines to uracils, lesions that can result in lethal levels of hypermutation. Here, we demo...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 102; no. 28; pp. 9854 - 9859
Main Authors:	Schumacher, A.J, Nissley, D.V, Harris, R.S
Format:	Journal Article
Language:	English
Published:	United States National Academy of Sciences 12-07-2005 National Acad Sciences
Subjects:	Amino Acid Transport Systems, Basic - genetics APOBEC-3G Deaminase Biological Sciences Canavanine - metabolism Complementary DNA Cytidine Deaminase cytosine Cytosine - metabolism deamination Deoxyribonucleic acid DNA DNA Primers Enzymes Genetic mutation Genetic vectors Genomics HIV 1 Humans hypermutation Immunoblotting Lesions Mutagenesis Mutation Mutation - genetics Nucleoside Deaminases Proteins - metabolism Repressor Proteins Retroelements - genetics retrotransposition Retrotransposons Retroviridae Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae Proteins - genetics Sequence Analysis, DNA transposition (genetics) Yeast Yeasts
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