Baicalein upregulates DDIT4 expression which mediates mTOR inhibition and growth inhibition in cancer cells

Highlights • Baicalein, a natural compound, causes tumor suppression of cancer cells both in vitro and in vivo. • Baicalein upregulates DDIT4 which inhibits mTOR and mediates growth inhibition. • Baicalein is effective in chemotherapy resistant cancer cells.

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Bibliographic Details
Published in:	Cancer letters Vol. 358; no. 2; pp. 170 - 179
Main Authors:	Wang, Yujun, Han, Ernest, Xing, Quanhua, Yan, Jin, Arrington, Amanda, Wang, Charles, Tully, Dylan, Kowolik, Claudia M, Lu, David M, Frankel, Paul H, Zhai, Jing, Wen, Wei, Horne, David, Yip, M.L. Richard, Yim, John H
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier B.V 28-03-2015 Elsevier Limited
Subjects:	Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacology Baicalein Breast cancer Cell growth Cell Line, Tumor Cell Proliferation - drug effects Cellular stress Charitable foundations Chemotherapy Clinical trials DDIT4 Deoxyribonucleic acid Disease Models, Animal DNA Female Flavanones - administration & dosage Flavanones - pharmacology Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic - drug effects Growth inhibition Hematology, Oncology and Palliative Medicine Humans Inhibition Interferon IRF1 Kinases Mice mTOR Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology p53 Protein Phosphorylation Platinum Polymerase chain reaction Protein Kinase Inhibitors - administration & dosage Protein Kinase Inhibitors - pharmacology Proteins RNA-mediated interference Rodents Time Factors TOR protein TOR Serine-Threonine Kinases - antagonists & inhibitors TOR Serine-Threonine Kinases - metabolism Transcription Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic Tumor cell lines Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumors Up-Regulation Baicalein mTOR Cellular stress IRF1 DDIT4
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Summary:	Highlights • Baicalein, a natural compound, causes tumor suppression of cancer cells both in vitro and in vivo. • Baicalein upregulates DDIT4 which inhibits mTOR and mediates growth inhibition. • Baicalein is effective in chemotherapy resistant cancer cells.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Current address: University of Hawaii Cancer Center, 701 Ilalo St, Honolulu, HI 96813
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2014.12.033