Knockdown of proteins involved in iron metabolism limits tick reproduction and development

Ticks are among the most important vectors of a wide range of human and animal diseases. During blood feeding, ticks are exposed to an enormous amount of free iron that must be appropriately used and detoxified. However, the mechanism of iron metabolism in ticks is poorly understood. Here, we show t...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 106; no. 4; pp. 1033 - 1038
Main Authors:	Hajdusek, Ondrej, Sojka, Daniel, Kopacek, Petr, Buresova, Veronika, Franta, Zdenek, Sauman, Ivo, Winzerling, Joy, Grubhoffer, Libor
Format:	Journal Article
Language:	English
Published:	United States National Academy of Sciences 27-01-2009 National Acad Sciences
Subjects:	animal development animal proteins Animal reproduction Animals Biological Sciences Blood Blotting, Western Cloning, Molecular Eggs Feeding Behavior Female females ferritin Ferritins Ferritins - genetics Gene Expression Profiling Gene Expression Regulation Gene Silencing genes Genes, Insect Guinea Pigs hematophagy Hemolymph Insect Proteins - genetics Insect Proteins - metabolism Insects Intracellular Space - metabolism Iron Iron - metabolism iron regulatory proteins Ixodes ricinus Ixodidae Male Messenger RNA Metabolism Mineral metabolism Models, Biological Ovaries Parasites Phylogeny Protein Biosynthesis Protein metabolism Proteins Reproduction RNA interference RNA, Messenger - genetics RNA, Messenger - metabolism Salivary glands sexual reproduction Survival Analysis Ticks Ticks - genetics Ticks - growth & development Ticks - physiology translation (genetics)
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