Association and Activation of Jak-Tyk Kinases by CNTF-LIF-OSM-IL-6 β Receptor Components

• Published in: Science (American Association for the Advancement of Science) Vol. 263; no. 5143; pp. 92 - 95
• Main Authors: Stahl, Neil, Boulton, Teri G., Farruggella, Thomas, Ip, Nancy Y., Davis, Sam, Witthuhn, Bruce A., Quelle, Frederick W., Silvennoinen, Olli, Barbieri, Giovanna, Pellegrini, Sandra, Ihle, James N., Yancopoulos, George D.
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for the Advancement of Science 07-01-1994; American Association for the Advancement of Science
• Subjects: Animals; Antibodies; Antigens, CD; Antiserum; Biological and medical sciences; Cell Line; Cell lines; Cell physiology; Ciliary Neurotrophic Factor; Cytokine Receptor gp130; Cytokine receptors; Cytokines; Cytokines - metabolism; Cytokines - pharmacology; Detergents; Dimerization; Enzyme Activation; Fundamental and applied biological sciences. Psychology; Growth Inhibitors; Interleukin-6; Janus Kinase 1; Janus Kinase 2; Leukemia Inhibitory Factor; Ligands; Lymphokines; Membrane Glycoproteins - metabolism; Molecular and cellular biology; Nerve Tissue Proteins - metabolism; Nerve Tissue Proteins - pharmacology; Oncostatin M; Peptides - metabolism; Peptides - pharmacology; Phosphorylation; Protein tyrosine kinase; Protein-Tyrosine Kinases - metabolism; Proteins - metabolism; Proto-Oncogene Proteins; Receptor, Ciliary Neurotrophic Factor; Receptors; Receptors, Cytokine - metabolism; Receptors, Growth Factor - metabolism; Receptors, Interleukin - metabolism; Receptors, Interleukin-6; Receptors, Oncostatin M; Receptors, OSM-LIF; Responses to growth factors, tumor promotors, other factors; Tyrosine - metabolism; Human; Interleukin 6; Signal transduction; Cell line; Enzyme; Transferases; Animal; Cytokine; Activation; Ciliary neurotrophic factor; Protein-tyrosine kinase; Biological receptor
• ISSN: 0036-8075; 1095-9203
• DOI: 10.1126/science.8272873

A recently defined family of cytokines, consisting of ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M (OSM), and interleukin-6 (IL-6), utilize the Jak-Tyk family of cytoplasmic tyrosine kinases. The β receptor components for this cytokine family, gp 130 and LIF receptor β, constitutively associate with Jak-Tyk kinases. Activation of these kinases occurs as a result of ligand-induced dimerization of the receptor β components. Unlike other cytokine receptors studied to date, the receptors for the CNTF cytokine family utilize all known members of the Jak-Tyk family, but induce distinct patterns of Jak-Tyk phosphorylation in different cell lines.