Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage

Recent findings have established caspase-2 as an important apical regulator in apoptotic pathways leading from DNA damage to release of mitochondrial cytochrome c and subsequent activation of effector caspases. Yet, the molecular map connecting the embarking stimuli of genotoxic stress with caspase-...

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Bibliographic Details
Published in:	Oncogene Vol. 25; no. 41; pp. 5683 - 5692
Main Authors:	VAKIFAHMETOGLU, H, OLSSON, M, ORRENIUS, S, ZHIVOTOVSKY, B
Format:	Journal Article
Language:	English
Published:	Basingstoke Nature Publishing 14-09-2006 Nature Publishing Group
Subjects:	5-Fluorouracil Ageing, cell death Apoptosis Apoptosis - drug effects Base Sequence Biological and medical sciences Caspase 2 Caspases - metabolism Caspases - physiology Cell Line, Tumor Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cells Colonic Neoplasms - enzymology Colonic Neoplasms - genetics Colonic Neoplasms - pathology Colorectal cancer Cytochrome c Deoxyribonucleic acid DNA DNA Damage DNA Primers Enzyme Activation Enzymes Fluorescent Antibody Technique Fluorouracil - pharmacology Fundamental and applied biological sciences. Psychology Genotoxicity Humans Medicin och hälsovetenskap Mitochondria Molecular and cellular biology p53 Protein Proteins Reverse Transcriptase Polymerase Chain Reaction siRNA Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumor Suppressor Protein p53 - physiology Enzyme Caspase Carcinogenesis Essential PIDDosome complex p53 Peptidases TP53 Gene DNA Hydrolases Lesion caspase-2 Apoptosis Tumor suppressor gene 5-FU
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