Influence of Long-term Enteral Nutrition on Pharmacokinetics of Digoxin in Rats

This study was designed to clarify the influence of long-term enteral nutrition (EN) on the pharmacokinetics of digoxin. Rats were fed EN diets (semi-digested, digested, and elemental) for 4 weeks, then digoxin (0.05mg/kg) was administered orally. The AUC0-∞and ka of digoxin were significantly reduc...

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Bibliographic Details
Published in:	DRUG METABOLISM AND PHARMACOKINETICS Vol. 28; no. 1; pp. 44 - 52
Main Authors:	Higashi, Keiichiro, Tanaka, Chihiro, Imanishi, Kaori, Sawamoto, Kazuki, Horikawa, Takumi, Ohkawa, Hiroko, Matsushita, Ryo, Sai, Yoshimichi, Miyamoto, Ken-ichi
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 2013 Japanese Society for the Study of Xenobiotics
Subjects:	absorption Animals ATP Binding Cassette Transporter, Sub-Family B - genetics ATP-Binding Cassette, Sub-Family B, Member 1 - genetics Body Weight Cardiotonic Agents - pharmacokinetics Cyp3a2 Cytochrome P-450 CYP3A - genetics digoxin Digoxin - pharmacokinetics Enteral Nutrition Male Membrane Proteins - genetics metabolism Oatp Organ Size P-gp pharmacokinetics Rats Rats, Sprague-Dawley enteral nutrition P-gp absorption pharmacokinetics metabolism Cyp3a2 digoxin Oatp
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