Transformation Foci in IDH1-mutated Gliomas Show STAT3 Phosphorylation and Downregulate the Metabolic Enzyme ETNPPL, a Negative Regulator of Glioma Growth

IDH1-mutated gliomas are slow-growing brain tumours which progress into high-grade gliomas. The early molecular events causing this progression are ill-defined. Previous studies revealed that 20% of these tumours already have transformation foci. These foci offer opportunities to better understand m...

Full description

Saved in:

Bibliographic Details
Published in:	Scientific reports Vol. 10; no. 1; p. 5504
Main Authors:	Leventoux, N., Augustus, M., Azar, S., Riquier, S., Villemin, J. P., Guelfi, S., Falha, L., Bauchet, L., Gozé, C., Ritchie, W., Commes, T., Duffau, H., Rigau, V. , Hugnot, J. P.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 26-03-2020 Nature Publishing Group
Subjects:	13/106 13/109 13/51 13/89 14/19 38/61 631/67 631/67/1922 Astrocytes Biochemistry, Molecular Biology Brain cancer Brain Neoplasms - genetics Brain Neoplasms - metabolism Brain Neoplasms - pathology Brain tumors Cancer Carbon-Oxygen Lyases - genetics Cell interactions Cell Line, Tumor Cell Proliferation Cell signaling Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology Connexin 43 Cytoskeleton Disease Progression Down-Regulation Enzymes Epidermal growth factor receptors Ethanolamine Ethanolamine-phosphate phospho-lyase Gap junctions Gene Expression Profiling Genetic transformation Glioma Glioma - genetics Glioma - metabolism Glioma - pathology Glioma cells Humanities and Social Sciences Humans Immunohistochemistry Isocitrate Dehydrogenase - genetics Life Sciences Lipid Metabolism Localization Metabolism multidisciplinary Mutation Neural coding Neurobiology Neurons and Cognition Phosphorylation Protein biosynthesis Ribonucleic acid RNA Science Science (multidisciplinary) Signal Transduction Stat3 protein STAT3 Transcription Factor - metabolism Stem cells Tumors Wnt protein
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	IDH1-mutated gliomas are slow-growing brain tumours which progress into high-grade gliomas. The early molecular events causing this progression are ill-defined. Previous studies revealed that 20% of these tumours already have transformation foci. These foci offer opportunities to better understand malignant progression. We used immunohistochemistry and high throughput RNA profiling to characterize foci cells. These have higher pSTAT3 staining revealing activation of JAK/STAT signaling. They downregulate RNAs involved in Wnt signaling ( DAAM2, SFRP2 ), EGFR signaling ( MLC1 ), cytoskeleton and cell-cell communication ( EZR, GJA1 ). In addition, foci cells show reduced levels of RNA coding for Ethanolamine-Phosphate Phospho-Lyase ( ETNPPL/AGXT2L1 ), a lipid metabolism enzyme. ETNPPL is involved in the catabolism of phosphoethanolamine implicated in membrane synthesis. We detected ETNPPL protein in glioma cells as well as in astrocytes in the human brain. Its nuclear localization suggests additional roles for this enzyme. ETNPPL expression is inversely correlated to glioma grade and we found no ETNPPL protein in glioblastomas. Overexpression of ETNPPL reduces the growth of glioma stem cells indicating that this enzyme opposes gliomagenesis. Collectively, these results suggest that a combined alteration in membrane lipid metabolism and STAT3 pathway promotes IDH1-mutated glioma malignant progression.
AbstractList	IDH1-mutated gliomas are slow-growing brain tumours which progress into high-grade gliomas. The early molecular events causing this progression are ill-defined. Previous studies revealed that 20% of these tumours already have transformation foci. These foci offer opportunities to better understand malignant progression. We used immunohistochemistry and high throughput RNA profiling to characterize foci cells. These have higher pSTAT3 staining revealing activation of JAK/STAT signaling. They downregulate RNAs involved in Wnt signaling (DAAM2, SFRP2), EGFR signaling (MLC1), cytoskeleton and cell-cell communication (EZR, GJA1). In addition, foci cells show reduced levels of RNA coding for Ethanolamine-Phosphate Phospho-Lyase (ETNPPL/AGXT2L1), a lipid metabolism enzyme. ETNPPL is involved in the catabolism of phosphoethanolamine implicated in membrane synthesis. We detected ETNPPL protein in glioma cells as well as in astrocytes in the human brain. Its nuclear localization suggests additional roles for this enzyme. ETNPPL expression is inversely correlated to glioma grade and we found no ETNPPL protein in glioblastomas. Overexpression of ETNPPL reduces the growth of glioma stem cells indicating that this enzyme opposes gliomagenesis. Collectively, these results suggest that a combined alteration in membrane lipid metabolism and STAT3 pathway promotes IDH1-mutated glioma malignant progression. IDH1-mutated gliomas are slow-growing brain tumours which progress into high-grade gliomas. The early molecular events causing this progression are ill-defined. Previous studies revealed that 20% of these tumours already have transformation foci. These foci offer opportunities to better understand malignant progression. We used immunohistochemistry and high throughput RNA profiling to characterize foci cells. These have higher pSTAT3 staining revealing activation of JAK/STAT signaling. They downregulate RNAs involved in Wnt signaling ( DAAM2, SFRP2 ), EGFR signaling ( MLC1 ), cytoskeleton and cell-cell communication ( EZR, GJA1 ). In addition, foci cells show reduced levels of RNA coding for Ethanolamine-Phosphate Phospho-Lyase ( ETNPPL/AGXT2L1 ), a lipid metabolism enzyme. ETNPPL is involved in the catabolism of phosphoethanolamine implicated in membrane synthesis. We detected ETNPPL protein in glioma cells as well as in astrocytes in the human brain. Its nuclear localization suggests additional roles for this enzyme. ETNPPL expression is inversely correlated to glioma grade and we found no ETNPPL protein in glioblastomas. Overexpression of ETNPPL reduces the growth of glioma stem cells indicating that this enzyme opposes gliomagenesis. Collectively, these results suggest that a combined alteration in membrane lipid metabolism and STAT3 pathway promotes IDH1-mutated glioma malignant progression.
ArticleNumber	5504
Author	Guelfi, S. Leventoux, N. Rigau, V. Commes, T. Augustus, M. Gozé, C. Riquier, S. Villemin, J. P. Hugnot, J. P. Falha, L. Duffau, H. Ritchie, W. Azar, S. Bauchet, L.
Author_xml	– sequence: 1 givenname: N. orcidid: 0000-0001-7023-9859 surname: Leventoux fullname: Leventoux, N. organization: Institute for Neurosciences of Montpellier, Institut National de la Santé et de la Recherche Médicale (INSERM). U1051 - Hôpital Saint-Éloi, 80 Avenue Augustin Fliche - 34091 Montpellier cedex 5, Keio University School of Medicine, Physiology Department. 35 Shinanomachi, Shinjuku-ku – sequence: 2 givenname: M. surname: Augustus fullname: Augustus, M. organization: Institute for Neurosciences of Montpellier, Institut National de la Santé et de la Recherche Médicale (INSERM). U1051 - Hôpital Saint-Éloi, 80 Avenue Augustin Fliche - 34091 Montpellier cedex 5 – sequence: 3 givenname: S. surname: Azar fullname: Azar, S. organization: Institute for Neurosciences of Montpellier, Institut National de la Santé et de la Recherche Médicale (INSERM). U1051 - Hôpital Saint-Éloi, 80 Avenue Augustin Fliche - 34091 Montpellier cedex 5 – sequence: 4 givenname: S. surname: Riquier fullname: Riquier, S. organization: Institute for Regenerative Medicine & Biotherapy, Hôpital Saint-Éloi, 80 Avenue Augustin Fliche - 34091 Montpellier cedex 5 – sequence: 5 givenname: J. P. surname: Villemin fullname: Villemin, J. P. organization: Institute of Human Genetics, Centre National de la Recherche Scientifique (CNRS). UMR9002, 141 rue de la Cardonille – sequence: 6 givenname: S. surname: Guelfi fullname: Guelfi, S. organization: Institute for Neurosciences of Montpellier, Institut National de la Santé et de la Recherche Médicale (INSERM). U1051 - Hôpital Saint-Éloi, 80 Avenue Augustin Fliche - 34091 Montpellier cedex 5 – sequence: 7 givenname: L. surname: Falha fullname: Falha, L. organization: Institute for Neurosciences of Montpellier, Institut National de la Santé et de la Recherche Médicale (INSERM). U1051 - Hôpital Saint-Éloi, 80 Avenue Augustin Fliche - 34091 Montpellier cedex 5 – sequence: 8 givenname: L. surname: Bauchet fullname: Bauchet, L. organization: Institute for Neurosciences of Montpellier, Institut National de la Santé et de la Recherche Médicale (INSERM). U1051 - Hôpital Saint-Éloi, 80 Avenue Augustin Fliche - 34091 Montpellier cedex 5, Neurosurgery Department. Hôpital Gui de Chauliac, 80 Avenue Augustin Fliche – sequence: 9 givenname: C. surname: Gozé fullname: Gozé, C. organization: Institute for Neurosciences of Montpellier, Institut National de la Santé et de la Recherche Médicale (INSERM). U1051 - Hôpital Saint-Éloi, 80 Avenue Augustin Fliche - 34091 Montpellier cedex 5, Laboratory of Solid Tumors Biology. Hôpital Lapeyronie, 371 Avenue du Doyen Giraud – sequence: 10 givenname: W. orcidid: 0000-0001-8162-1439 surname: Ritchie fullname: Ritchie, W. organization: Institute of Human Genetics, Centre National de la Recherche Scientifique (CNRS). UMR9002, 141 rue de la Cardonille – sequence: 11 givenname: T. surname: Commes fullname: Commes, T. organization: Institute for Regenerative Medicine & Biotherapy, Hôpital Saint-Éloi, 80 Avenue Augustin Fliche - 34091 Montpellier cedex 5 – sequence: 12 givenname: H. orcidid: 0000-0002-6558-2342 surname: Duffau fullname: Duffau, H. organization: Institute for Neurosciences of Montpellier, Institut National de la Santé et de la Recherche Médicale (INSERM). U1051 - Hôpital Saint-Éloi, 80 Avenue Augustin Fliche - 34091 Montpellier cedex 5, Neurosurgery Department. Hôpital Gui de Chauliac, 80 Avenue Augustin Fliche – sequence: 13 givenname: V. orcidid: 0000-0002-8017-5489 surname: Rigau fullname: Rigau, V. organization: Institute for Neurosciences of Montpellier, Institut National de la Santé et de la Recherche Médicale (INSERM). U1051 - Hôpital Saint-Éloi, 80 Avenue Augustin Fliche - 34091 Montpellier cedex 5, Department of Pathology and Oncobiology. Hôpital Gui de Chauliac, 80 Avenue Augustin Fliche – sequence: 14 givenname: J. P. surname: Hugnot fullname: Hugnot, J. P. email: jean-philippe.hugnot@umontpellier.fr organization: Institute for Neurosciences of Montpellier, Institut National de la Santé et de la Recherche Médicale (INSERM). U1051 - Hôpital Saint-Éloi, 80 Avenue Augustin Fliche - 34091 Montpellier cedex 5, University of Montpellier, Place Eugène Bataillon
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/32218467$$D View this record in MEDLINE/PubMed https://inserm.hal.science/inserm-02540074$$DView record in HAL
BookMark	eNp9kl1v0zAUhiM0xMbYH-ACWeJ2Gf7Kh2-Qqq1rJ5VRsXBtOfFJk6mxOztpVX4KvxZvKWNwgW9snfO-z6sjn7fRkbEGoug9wRcEs_yT5yQReYwpjlNKeBKTV9EJxeFBGaVHL97H0Zn39zichApOxJvoOFRJztPsJPpZOGV8bV2n-tYadG2rFrUG3VzNSdwNvepBo9m6tZ3y6K6xO3RXTAqGlo31m8a6_Xr0KaPRld0ZB6shlAD1DaAv0KvSrtsKTc2PfQdoWtwul4tzpNAtrIJxC-jbaLAO2foQhGbO7vrmXfS6VmsPZ4f7NPp-PS0u5_Hi6-zmcrKIq5TwPmYqw6nmKavyVBNRYSFYzYDoTNM8g6QsOal0gkUCTAgiEp0RDVCVACzIODuNPo_czVB2oCswvVNruXFtp9xeWtXKvzumbeTKbmUWonBGA-B8BDT_2OaThWyNB9dJTBOOcca3JMg_HvKcfRjA9_LeDs6EESVlOeNZnjIRVHRUVc5676B-JhMsHzdAjhsQyFg-bYB8RH94Ocqz5fd_BwEbBT60zArcn-z_YH8BJme-tQ
CitedBy_id	crossref_primary_10_1007_s12031_022_02054_2 crossref_primary_10_1523_JNEUROSCI_1401_23_2023 crossref_primary_10_7717_peerj_15834 crossref_primary_10_3390_cancers13092107 crossref_primary_10_1016_j_nbd_2023_106388 crossref_primary_10_2139_ssrn_4387831 crossref_primary_10_1016_j_animal_2022_100679 crossref_primary_10_25259_JNRP_155_2023 crossref_primary_10_1109_JBHI_2021_3091506 crossref_primary_10_3390_cancers13030437 crossref_primary_10_3233_THC_230738 crossref_primary_10_1016_j_jbc_2021_100830 crossref_primary_10_1038_s41467_020_16168_x crossref_primary_10_1038_s41388_020_01503_9 crossref_primary_10_1002_jcp_30993 crossref_primary_10_1002_cam4_5681 crossref_primary_10_1093_noajnl_vdab026 crossref_primary_10_3390_medicina58101319 crossref_primary_10_3390_nu14010066 crossref_primary_10_3389_fcvm_2022_853468 crossref_primary_10_1007_s10555_020_09941_3 crossref_primary_10_3389_fncel_2023_1097512 crossref_primary_10_1042_BSR20211476 crossref_primary_10_1016_j_freeradbiomed_2023_02_017 crossref_primary_10_1186_s43046_022_00133_4 crossref_primary_10_1007_s12094_023_03111_x crossref_primary_10_1016_j_jprot_2021_104258
Cites_doi	10.1002/stem.185 10.1002/ijc.25416 10.1620/tjem.221.11 10.1158/0008-5472.CAN-09-3769 10.4137/TOG.S1903 10.1038/ng.3457 10.1002/glia.23240 10.1038/nature20123 10.1101/gr.165126.113 10.1038/sj.onc.1205949 10.1111/nan.12432 10.1002/iub.1178 10.1002/glia.22429 10.1158/0008-5472.CAN-14-0008 10.1007/s00428-014-1712-5 10.1007/s11060-012-0831-6 10.1002/jcb.10012 10.1126/science.aai8478 10.1016/j.ccr.2006.03.003 10.1093/neuonc/nov136 10.1016/j.canlet.2017.05.002 10.1093/hmg/ddw032 10.1200/JCO.2017.72.6737 10.1074/jbc.M606754200 10.1016/j.pharep.2017.01.001 10.1093/neuonc/nos139 10.1002/stem.1685 10.1038/nature08712 10.1016/j.ccr.2009.12.020 10.1038/ncomms3612 10.1093/nar/gku1055 10.1038/nrc3818 10.1038/labinvest.2015.140 10.1016/j.tibs.2016.05.013 10.1136/jclinpath-2015-203042 10.1158/1541-7786.MCR-08-0435 10.1158/1078-0432.CCR-07-4923 10.1186/s12859-016-0917-9 10.1016/j.devcel.2011.10.025 10.1016/j.neuron.2015.11.013 10.1016/0014-4827(81)90045-8 10.1126/science.1260419 10.1097/CCO.0000000000000483
ContentType	Journal Article
Copyright	The Author(s) 2020 This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Distributed under a Creative Commons Attribution 4.0 International License
Copyright_xml	– notice: The Author(s) 2020 – notice: This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: Distributed under a Creative Commons Attribution 4.0 International License
DBID	C6C CGR CUY CVF ECM EIF NPM AAYXX CITATION 3V. 7X7 7XB 88A 88E 88I 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ HCIFZ K9. LK8 M0S M1P M2P M7P PIMPY PQEST PQQKQ PQUKI Q9U 1XC VOOES 5PM
DOI	10.1038/s41598-020-62145-1
DatabaseName	SpringerOpen Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef ProQuest Central (Corporate) ProQuest Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) Science Database (Alumni Edition) ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection AUTh Library subscriptions: ProQuest Central ProQuest Natural Science Collection ProQuest One Community College ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection (Proquest) (PQ_SDU_P3) ProQuest Health & Medical Complete (Alumni) Biological Sciences Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) ProQuest Science Journals Biological Science Database Publicly Available Content Database (Proquest) (PQ_SDU_P3) ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central Basic Hyper Article en Ligne (HAL) Hyper Article en Ligne (HAL) (Open Access) PubMed Central (Full Participant titles)
DatabaseTitle	MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Publicly Available Content Database ProQuest Central Student ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest Natural Science Collection ProQuest Biology Journals (Alumni Edition) ProQuest Central Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Biological Science Collection ProQuest Medical Library (Alumni) ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest Central Basic ProQuest Science Journals ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest Central (Alumni)
DatabaseTitleList	CrossRef MEDLINE Publicly Available Content Database
Database_xml	– sequence: 1 dbid: ECM name: MEDLINE url: https://search.ebscohost.com/login.aspx?direct=true&db=cmedm&site=ehost-live sourceTypes: Index Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Biology
EISSN	2045-2322
ExternalDocumentID	oai_HAL_inserm_02540074v1 10_1038_s41598_020_62145_1 32218467
Genre	Research Support, Non-U.S. Gov't Journal Article
GroupedDBID	0R~ 3V. 4.4 53G 5VS 7X7 88A 88E 88I 8FE 8FH 8FI 8FJ AAFWJ AAJSJ AAKDD ABDBF ABUWG ACGFS ACSMW ADBBV ADRAZ AENEX AFKRA AJTQC ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS AZQEC BAWUL BBNVY BCNDV BENPR BHPHI BPHCQ BVXVI C6C CCPQU DIK DWQXO EBD EBLON EBS ESX FYUFA GNUQQ GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE KQ8 LK8 M0L M1P M2P M48 M7P M~E NAO OK1 PIMPY PQQKQ PROAC PSQYO RIG RNT RNTTT RPM SNYQT UKHRP CGR CUY CVF ECM EIF NPM AAYXX CITATION 7XB 8FK K9. PQEST PQUKI Q9U 1XC VOOES 5PM AFPKN
ID	FETCH-LOGICAL-c614t-3a706d463c86d19c0993f3e1d7d287e5bb41cd5095e399195d71deecbee33e143
IEDL.DBID	RPM
ISSN	2045-2322
IngestDate	Tue Sep 17 21:27:32 EDT 2024 Tue Oct 15 16:07:32 EDT 2024 Sat Nov 09 11:23:08 EST 2024 Thu Nov 21 21:08:17 EST 2024 Wed Oct 16 00:39:56 EDT 2024 Fri Oct 11 20:50:03 EDT 2024
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	1
Language	English
License	Distributed under a Creative Commons Attribution 4.0 International License: http://creativecommons.org/licenses/by/4.0 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c614t-3a706d463c86d19c0993f3e1d7d287e5bb41cd5095e399195d71deecbee33e143
Notes	PMCID: PMC7099072
ORCID	0000-0001-7023-9859 0000-0002-6558-2342 0000-0002-8017-5489 0000-0001-8162-1439 0000-0002-3215-048X 0000-0003-1077-2496 0000-0002-7918-0176
OpenAccessLink	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7099072/
PMID	32218467
PQID	2383478639
PQPubID	2041939
ParticipantIDs	pubmedcentral_primary_oai_pubmedcentral_nih_gov_7099072 hal_primary_oai_HAL_inserm_02540074v1 proquest_journals_2383478639 crossref_primary_10_1038_s41598_020_62145_1 pubmed_primary_32218467 springer_journals_10_1038_s41598_020_62145_1
PublicationCentury	2000
PublicationDate	2020-03-26
PublicationDateYYYYMMDD	2020-03-26
PublicationDate_xml	– month: 03 year: 2020 text: 2020-03-26 day: 26
PublicationDecade	2020
PublicationPlace	London
PublicationPlace_xml	– name: London – name: England
PublicationTitle	Scientific reports
PublicationTitleAbbrev	Sci Rep
PublicationTitleAlternate	Sci Rep
PublicationYear	2020
Publisher	Nature Publishing Group UK Nature Publishing Group
Publisher_xml	– name: Nature Publishing Group UK – name: Nature Publishing Group
References	Bao (CR7) 2014; 24 Sherry, Reeves, Wu, Cochran (CR26) 2009; 27 Guichet (CR11) 2013; 61 Brown (CR17) 2015; 43 Boukouris, Zervopoulos, Michelakis (CR40) 2016; 41 Ajioka, Akaike, Watanabe (CR43) 2002; 84 Yu, Lee, Herrmann, Buettner, Jove (CR21) 2014; 14 CR39 Liu (CR32) 2017; 69 Doucette (CR24) 2012; 14 Azar (CR12) 2018; 66 Liu, Luo, Halim, Song (CR15) 2017; 401 Sun (CR19) 2006; 9 Duffau (CR6) 2018; 30 Lee, Deneen (CR31) 2012; 22 Kano-Sueoka, Errick (CR42) 1981; 136 van den Bent, Smits, Kros, Chang (CR1) 2017; 35 Yoshihara (CR13) 2013; 4 Villalva (CR27) 2011; 128 Esteve, Bovolenta (CR33) 2010; 221 Madhavan (CR20) 2009; 7 Alvarez (CR25) 2007; 2 Schiroli, Cirrincione, Donini, Peracchi (CR16) 2013; 65 Warrington (CR29) 2010; 70 Pedeutour-Braccini (CR9) 2015; 466 Venteicher, Tirosh, Hebert, Yizhak, Neftel, Filbin, Hovestadt, Escalante, Shaw, Rodman, Gillespie, Dionne, Luo, Ravichandran, Mylvaganam, Mount, Onozato, Nahed, Wakimoto, Curry, Iafrate, Rivera, Frosch, Golub, Brastianos, Getz, Patel, Monje, Cahill, Rozenblatt-Rosen, Louis, Bernstein, Regev, Suvà (CR4) 2017; 355 Su (CR23) 2007; 282 Waitkus, Diplas, Yan (CR5) 2016; 18 Carro (CR28) 2010; 463 Verhaak (CR41) 2010; 17 Lanciotti (CR34) 2016; 25 Lee, Lee, Ahn, Lee, Nam (CR30) 2016; 96 Wesseling, Capper (CR2) 2018; 44 Tirosh (CR3) 2016; 539 Giaume, Venance (CR35) 1995; 2 Yu (CR37) 2012; 30 Gozé (CR10) 2012; 108 Bai (CR8) 2016; 48 Konduri (CR36) 2002; 21 Deng, Brägelmann, Schultze, Perner (CR14) 2016; 17 Zhang (CR18) 2016; 89 Ding (CR38) 2016; 69 Esmaeili (CR44) 2014; 74 Lo, Cao, Zhu, Ali-Osman (CR22) 2008; 14 C Giaume (62145_CR35) 1995; 2 RGW Verhaak (62145_CR41) 2010; 17 D Schiroli (62145_CR16) 2013; 65 H Bai (62145_CR8) 2016; 48 L Sun (62145_CR19) 2006; 9 AE Boukouris (62145_CR40) 2016; 41 M Esmaeili (62145_CR44) 2014; 74 Q Ding (62145_CR38) 2016; 69 Andrew S. Venteicher (62145_CR4) 2017; 355 MJ van den Bent (62145_CR1) 2017; 35 C Villalva (62145_CR27) 2011; 128 Z Pedeutour-Braccini (62145_CR9) 2015; 466 NM Warrington (62145_CR29) 2010; 70 A Lanciotti (62145_CR34) 2016; 25 P Esteve (62145_CR33) 2010; 221 MM Sherry (62145_CR26) 2009; 27 Y Lee (62145_CR30) 2016; 96 P Wesseling (62145_CR2) 2018; 44 H-W Su (62145_CR23) 2007; 282 MS Carro (62145_CR28) 2010; 463 SD Konduri (62145_CR36) 2002; 21 HK Lee (62145_CR31) 2012; 22 Z-S Bao (62145_CR7) 2014; 24 K Yoshihara (62145_CR13) 2013; 4 S Azar (62145_CR12) 2018; 66 M Deng (62145_CR14) 2016; 17 Y Zhang (62145_CR18) 2016; 89 Q Liu (62145_CR15) 2017; 401 I Tirosh (62145_CR3) 2016; 539 C Gozé (62145_CR10) 2012; 108 H Yu (62145_CR21) 2014; 14 Y Liu (62145_CR32) 2017; 69 I Ajioka (62145_CR43) 2002; 84 MS Waitkus (62145_CR5) 2016; 18 TA Doucette (62145_CR24) 2012; 14 H Duffau (62145_CR6) 2018; 30 JV Alvarez (62145_CR25) 2007; 2 P-O Guichet (62145_CR11) 2013; 61 S Madhavan (62145_CR20) 2009; 7 H-W Lo (62145_CR22) 2008; 14 62145_CR39 S-C Yu (62145_CR37) 2012; 30 GR Brown (62145_CR17) 2015; 43 T Kano-Sueoka (62145_CR42) 1981; 136
References_xml	– volume: 27 start-page: 2383 year: 2009 end-page: 2392 ident: CR26 article-title: STAT3 is required for proliferation and maintenance of multipotency in glioblastoma stem cells publication-title: Stem Cells. doi: 10.1002/stem.185 contributor: fullname: Cochran – volume: 128 start-page: 826 year: 2011 end-page: 838 ident: CR27 article-title: STAT3 is essential for the maintenance of neurosphere-initiating tumor cells in patients with glioblastomas: a potential for targeted therapy? publication-title: Int. J. Cancer. doi: 10.1002/ijc.25416 contributor: fullname: Villalva – volume: 221 start-page: 11 year: 2010 end-page: 17 ident: CR33 article-title: The advantages and disadvantages of sfrp1 and sfrp2 expression in pathological events publication-title: Tohoku J. Exp. Med. doi: 10.1620/tjem.221.11 contributor: fullname: Bovolenta – volume: 70 start-page: 5717 year: 2010 end-page: 5727 ident: CR29 article-title: Cyclic AMP suppression is sufficient to induce gliomagenesis in a mouse model of neurofibromatosis-1 publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-09-3769 contributor: fullname: Warrington – volume: 2 start-page: 99 year: 2007 end-page: 105 ident: CR25 article-title: A STAT3 Gene Expression Signature in Gliomas is Associated with a Poor Prognosis publication-title: Transl. Oncogenomics. doi: 10.4137/TOG.S1903 contributor: fullname: Alvarez – volume: 48 start-page: 59 year: 2016 end-page: 66 ident: CR8 article-title: Integrated genomic characterization of IDH1-mutant glioma malignant progression publication-title: Nat. Genet. doi: 10.1038/ng.3457 contributor: fullname: Bai – volume: 66 start-page: 239 year: 2018 end-page: 255 ident: CR12 article-title: Cellular and molecular characterization of IDH1-mutated diffuse low-grade gliomas reveals tumor heterogeneity and absence of EGFR/PDGFRα activation publication-title: Glia doi: 10.1002/glia.23240 contributor: fullname: Azar – volume: 539 start-page: 309 year: 2016 end-page: 313 ident: CR3 article-title: Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma publication-title: Nature. doi: 10.1038/nature20123 contributor: fullname: Tirosh – ident: CR39 – volume: 24 start-page: 1765 year: 2014 end-page: 1773 ident: CR7 article-title: RNA-seq of 272 gliomas revealed a novel, recurrent PTPRZ1-MET fusion transcript in secondary glioblastomas publication-title: Genome Res. doi: 10.1101/gr.165126.113 contributor: fullname: Bao – volume: 21 start-page: 8705 year: 2002 end-page: 8712 ident: CR36 article-title: Modulation of cystatin C expression impairs the invasive and tumorigenic potential of human glioblastoma cells publication-title: Oncogene. doi: 10.1038/sj.onc.1205949 contributor: fullname: Konduri – volume: 44 start-page: 139 year: 2018 end-page: 150 ident: CR2 article-title: WHO 2016 Classification of gliomas publication-title: Neuropathol. Appl. Neurobiol. doi: 10.1111/nan.12432 contributor: fullname: Capper – volume: 65 start-page: 645 year: 2013 end-page: 650 ident: CR16 article-title: Strict reaction and substrate specificity of AGXT2L1, the human O-phosphoethanolamine phospho-lyase publication-title: IUBMB Life. doi: 10.1002/iub.1178 contributor: fullname: Peracchi – volume: 61 start-page: 225 year: 2013 end-page: 239 ident: CR11 article-title: Cell death and neuronal differentiation of glioblastoma stem-like cells induced by neurogenic transcription factors publication-title: Glia. doi: 10.1002/glia.22429 contributor: fullname: Guichet – volume: 74 start-page: 4898 year: 2014 end-page: 4907 ident: CR44 article-title: IDH1 R132H mutation generates a distinct phospholipid metabolite profile in glioma publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-14-0008 contributor: fullname: Esmaeili – volume: 466 start-page: 433 year: 2015 end-page: 444 ident: CR9 article-title: Microfoci of malignant progression in diffuse low-grade gliomas: towards the creation of an intermediate grade in glioma classification? publication-title: Virchows Arch. doi: 10.1007/s00428-014-1712-5 contributor: fullname: Pedeutour-Braccini – volume: 108 start-page: 69 year: 2012 end-page: 75 ident: CR10 article-title: 1P19Q loss but not IDH1 mutations influences WHO grade II gliomas spontaneous growth publication-title: J. Neurooncol. doi: 10.1007/s11060-012-0831-6 contributor: fullname: Gozé – volume: 84 start-page: 249 year: 2002 end-page: 263 ident: CR43 article-title: Ethanolamine is a co-mitogenic factor for proliferation of primary hepatocytes publication-title: J. Cell Biochem. doi: 10.1002/jcb.10012 contributor: fullname: Watanabe – volume: 355 start-page: eaai8478 issue: 6332 year: 2017 ident: CR4 article-title: Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq publication-title: Science doi: 10.1126/science.aai8478 contributor: fullname: Suvà – volume: 9 start-page: 287 year: 2006 end-page: 300 ident: CR19 article-title: Neuronal and glioma-derived stem cell factor induces angiogenesis within the brain publication-title: Cancer Cell. doi: 10.1016/j.ccr.2006.03.003 contributor: fullname: Sun – volume: 18 start-page: 16 year: 2016 end-page: 26 ident: CR5 article-title: Isocitrate dehydrogenase mutations in gliomas publication-title: Neuro-oncology. doi: 10.1093/neuonc/nov136 contributor: fullname: Yan – volume: 401 start-page: 39 year: 2017 end-page: 45 ident: CR15 article-title: Targeting lipid metabolism of cancer cells: A promising therapeutic strategy for cancer publication-title: Cancer Lett. doi: 10.1016/j.canlet.2017.05.002 contributor: fullname: Song – volume: 25 start-page: 1543 year: 2016 end-page: 1558 ident: CR34 article-title: Megalencephalic leukoencephalopathy with subcortical cysts protein-1 regulates epidermal growth factor receptor signaling in astrocytes publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddw032 contributor: fullname: Lanciotti – volume: 35 start-page: 2394 year: 2017 end-page: 2401 ident: CR1 article-title: Diffuse Infiltrating Oligodendroglioma and Astrocytoma publication-title: J. Clin. Oncol. doi: 10.1200/JCO.2017.72.6737 contributor: fullname: Chang – volume: 282 start-page: 9883 year: 2007 end-page: 9894 ident: CR23 article-title: Cell confluence-induced activation of signal transducer and activator of transcription-3 (Stat3) triggers epithelial dome formation via augmentation of sodium hydrogen exchanger-3 (NHE3) expression publication-title: J. Biol. Chem. doi: 10.1074/jbc.M606754200 contributor: fullname: Su – volume: 69 start-page: 403 year: 2017 end-page: 408 ident: CR32 article-title: Secreted frizzled-related protein 2- mediated cancer events: Friend or foe? publication-title: Pharmacol. Rep. doi: 10.1016/j.pharep.2017.01.001 contributor: fullname: Liu – volume: 14 start-page: 1136 year: 2012 end-page: 1145 ident: CR24 article-title: Signal transducer and activator of transcription 3 promotes angiogenesis and drives malignant progression in glioma publication-title: Neuro-oncology. doi: 10.1093/neuonc/nos139 contributor: fullname: Doucette – volume: 2 start-page: 335 year: 1995 end-page: 345 ident: CR35 article-title: Gap junctions in brain glial cells and development publication-title: Perspect. Dev. Neurobiol. contributor: fullname: Venance – volume: 30 start-page: 108 year: 2012 end-page: 120 ident: CR37 article-title: Connexin 43 reverses malignant phenotypes of glioma stem cells by modulating E-cadherin publication-title: Stem Cells. doi: 10.1002/stem.1685 contributor: fullname: Yu – volume: 463 start-page: 318 year: 2010 end-page: 325 ident: CR28 article-title: The transcriptional network for mesenchymal transformation of brain tumours publication-title: Nature. doi: 10.1038/nature08712 contributor: fullname: Carro – volume: 17 start-page: 98 year: 2010 end-page: 110 ident: CR41 article-title: & Cancer Genome Atlas Research Network. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1 publication-title: Cancer Cell. doi: 10.1016/j.ccr.2009.12.020 contributor: fullname: Verhaak – volume: 4 year: 2013 ident: CR13 article-title: Inferring tumour purity and stromal and immune cell admixture from expression data publication-title: Nat. Commun. doi: 10.1038/ncomms3612 contributor: fullname: Yoshihara – volume: 30 start-page: 383 year: 2018 end-page: 389 ident: CR6 article-title: Diffuse low-grade glioma, oncological outcome and quality of life: a surgical perspective publication-title: Curr. Opin. Oncol. contributor: fullname: Duffau – volume: 43 start-page: 36 year: 2015 end-page: 42 ident: CR17 article-title: Gene: a gene-centered information resource at NCBI publication-title: Nucleic Acids Res. doi: 10.1093/nar/gku1055 contributor: fullname: Brown – volume: 14 start-page: 736 year: 2014 end-page: 746 ident: CR21 article-title: Revisiting STAT3 signalling in cancer: new and unexpected biological functions publication-title: Nat. Rev. Cancer. doi: 10.1038/nrc3818 contributor: fullname: Jove – volume: 96 start-page: 137 year: 2016 end-page: 150 ident: CR30 article-title: WNT signaling in glioblastoma and therapeutic opportunities publication-title: Lab. Invest. doi: 10.1038/labinvest.2015.140 contributor: fullname: Nam – volume: 41 start-page: 712 year: 2016 end-page: 730 ident: CR40 article-title: Metabolic Enzymes Moonlighting in the Nucleus: Metabolic Regulation of Gene Transcription publication-title: Trends Biochem. Sci. doi: 10.1016/j.tibs.2016.05.013 contributor: fullname: Michelakis – volume: 69 start-page: 215 year: 2016 end-page: 220 ident: CR38 article-title: AGXT2L1 is down-regulated in heptocellular carcinoma and associated with abnormal lipogenesis publication-title: J. Clin. Pathol. doi: 10.1136/jclinpath-2015-203042 contributor: fullname: Ding – volume: 7 start-page: 157 year: 2009 end-page: 167 ident: CR20 article-title: Rembrandt: helping personalized medicine become a reality through integrative translational research publication-title: Mol. Cancer Res. doi: 10.1158/1541-7786.MCR-08-0435 contributor: fullname: Madhavan – volume: 14 start-page: 6042 year: 2008 end-page: 6054 ident: CR22 article-title: Constitutively activated STAT3 frequently coexpresses with epidermal growth factor receptor in high-grade gliomas and targeting STAT3 sensitizes them to Iressa and alkylators publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-07-4923 contributor: fullname: Ali-Osman – volume: 17 year: 2016 ident: CR14 article-title: Web-TCGA: an online platform for integrated analysis of molecular cancer data sets publication-title: BMC Bioinformatics. doi: 10.1186/s12859-016-0917-9 contributor: fullname: Perner – volume: 22 start-page: 183 year: 2012 end-page: 196 ident: CR31 article-title: Daam2 is required for dorsal patterning via modulation of canonical Wnt signaling in the developing spinal cord publication-title: Dev. Cell. doi: 10.1016/j.devcel.2011.10.025 contributor: fullname: Deneen – volume: 89 start-page: 37 year: 2016 end-page: 53 ident: CR18 article-title: Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse publication-title: Neuron. doi: 10.1016/j.neuron.2015.11.013 contributor: fullname: Zhang – volume: 136 start-page: 137 year: 1981 end-page: 145 ident: CR42 article-title: Effects of phosphoethanolamine and ethanolamine on growth of mammary carcinoma cells in culture publication-title: Exp. Cell Res. doi: 10.1016/0014-4827(81)90045-8 contributor: fullname: Errick – volume: 35 start-page: 2394 year: 2017 ident: 62145_CR1 publication-title: J. Clin. Oncol. doi: 10.1200/JCO.2017.72.6737 contributor: fullname: MJ van den Bent – volume: 70 start-page: 5717 year: 2010 ident: 62145_CR29 publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-09-3769 contributor: fullname: NM Warrington – volume: 17 start-page: 98 year: 2010 ident: 62145_CR41 publication-title: Cancer Cell. doi: 10.1016/j.ccr.2009.12.020 contributor: fullname: RGW Verhaak – volume: 25 start-page: 1543 year: 2016 ident: 62145_CR34 publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddw032 contributor: fullname: A Lanciotti – volume: 282 start-page: 9883 year: 2007 ident: 62145_CR23 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M606754200 contributor: fullname: H-W Su – ident: 62145_CR39 doi: 10.1126/science.1260419 – volume: 463 start-page: 318 year: 2010 ident: 62145_CR28 publication-title: Nature. doi: 10.1038/nature08712 contributor: fullname: MS Carro – volume: 2 start-page: 335 year: 1995 ident: 62145_CR35 publication-title: Perspect. Dev. Neurobiol. contributor: fullname: C Giaume – volume: 355 start-page: eaai8478 issue: 6332 year: 2017 ident: 62145_CR4 publication-title: Science doi: 10.1126/science.aai8478 contributor: fullname: Andrew S. Venteicher – volume: 4 year: 2013 ident: 62145_CR13 publication-title: Nat. Commun. doi: 10.1038/ncomms3612 contributor: fullname: K Yoshihara – volume: 21 start-page: 8705 year: 2002 ident: 62145_CR36 publication-title: Oncogene. doi: 10.1038/sj.onc.1205949 contributor: fullname: SD Konduri – volume: 18 start-page: 16 year: 2016 ident: 62145_CR5 publication-title: Neuro-oncology. doi: 10.1093/neuonc/nov136 contributor: fullname: MS Waitkus – volume: 43 start-page: 36 year: 2015 ident: 62145_CR17 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gku1055 contributor: fullname: GR Brown – volume: 539 start-page: 309 year: 2016 ident: 62145_CR3 publication-title: Nature. doi: 10.1038/nature20123 contributor: fullname: I Tirosh – volume: 30 start-page: 383 year: 2018 ident: 62145_CR6 publication-title: Curr. Opin. Oncol. doi: 10.1097/CCO.0000000000000483 contributor: fullname: H Duffau – volume: 27 start-page: 2383 year: 2009 ident: 62145_CR26 publication-title: Stem Cells. doi: 10.1002/stem.185 contributor: fullname: MM Sherry – volume: 128 start-page: 826 year: 2011 ident: 62145_CR27 publication-title: Int. J. Cancer. doi: 10.1002/ijc.25416 contributor: fullname: C Villalva – volume: 136 start-page: 137 year: 1981 ident: 62145_CR42 publication-title: Exp. Cell Res. doi: 10.1016/0014-4827(81)90045-8 contributor: fullname: T Kano-Sueoka – volume: 17 year: 2016 ident: 62145_CR14 publication-title: BMC Bioinformatics. doi: 10.1186/s12859-016-0917-9 contributor: fullname: M Deng – volume: 69 start-page: 215 year: 2016 ident: 62145_CR38 publication-title: J. Clin. Pathol. doi: 10.1136/jclinpath-2015-203042 contributor: fullname: Q Ding – volume: 89 start-page: 37 year: 2016 ident: 62145_CR18 publication-title: Neuron. doi: 10.1016/j.neuron.2015.11.013 contributor: fullname: Y Zhang – volume: 14 start-page: 6042 year: 2008 ident: 62145_CR22 publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-07-4923 contributor: fullname: H-W Lo – volume: 2 start-page: 99 year: 2007 ident: 62145_CR25 publication-title: Transl. Oncogenomics. doi: 10.4137/TOG.S1903 contributor: fullname: JV Alvarez – volume: 22 start-page: 183 year: 2012 ident: 62145_CR31 publication-title: Dev. Cell. doi: 10.1016/j.devcel.2011.10.025 contributor: fullname: HK Lee – volume: 65 start-page: 645 year: 2013 ident: 62145_CR16 publication-title: IUBMB Life. doi: 10.1002/iub.1178 contributor: fullname: D Schiroli – volume: 44 start-page: 139 year: 2018 ident: 62145_CR2 publication-title: Neuropathol. Appl. Neurobiol. doi: 10.1111/nan.12432 contributor: fullname: P Wesseling – volume: 401 start-page: 39 year: 2017 ident: 62145_CR15 publication-title: Cancer Lett. doi: 10.1016/j.canlet.2017.05.002 contributor: fullname: Q Liu – volume: 66 start-page: 239 year: 2018 ident: 62145_CR12 publication-title: Glia doi: 10.1002/glia.23240 contributor: fullname: S Azar – volume: 24 start-page: 1765 year: 2014 ident: 62145_CR7 publication-title: Genome Res. doi: 10.1101/gr.165126.113 contributor: fullname: Z-S Bao – volume: 41 start-page: 712 year: 2016 ident: 62145_CR40 publication-title: Trends Biochem. Sci. doi: 10.1016/j.tibs.2016.05.013 contributor: fullname: AE Boukouris – volume: 30 start-page: 108 year: 2012 ident: 62145_CR37 publication-title: Stem Cells. doi: 10.1002/stem.1685 contributor: fullname: S-C Yu – volume: 466 start-page: 433 year: 2015 ident: 62145_CR9 publication-title: Virchows Arch. doi: 10.1007/s00428-014-1712-5 contributor: fullname: Z Pedeutour-Braccini – volume: 84 start-page: 249 year: 2002 ident: 62145_CR43 publication-title: J. Cell Biochem. doi: 10.1002/jcb.10012 contributor: fullname: I Ajioka – volume: 7 start-page: 157 year: 2009 ident: 62145_CR20 publication-title: Mol. Cancer Res. doi: 10.1158/1541-7786.MCR-08-0435 contributor: fullname: S Madhavan – volume: 48 start-page: 59 year: 2016 ident: 62145_CR8 publication-title: Nat. Genet. doi: 10.1038/ng.3457 contributor: fullname: H Bai – volume: 14 start-page: 1136 year: 2012 ident: 62145_CR24 publication-title: Neuro-oncology. doi: 10.1093/neuonc/nos139 contributor: fullname: TA Doucette – volume: 61 start-page: 225 year: 2013 ident: 62145_CR11 publication-title: Glia. doi: 10.1002/glia.22429 contributor: fullname: P-O Guichet – volume: 96 start-page: 137 year: 2016 ident: 62145_CR30 publication-title: Lab. Invest. doi: 10.1038/labinvest.2015.140 contributor: fullname: Y Lee – volume: 221 start-page: 11 year: 2010 ident: 62145_CR33 publication-title: Tohoku J. Exp. Med. doi: 10.1620/tjem.221.11 contributor: fullname: P Esteve – volume: 69 start-page: 403 year: 2017 ident: 62145_CR32 publication-title: Pharmacol. Rep. doi: 10.1016/j.pharep.2017.01.001 contributor: fullname: Y Liu – volume: 14 start-page: 736 year: 2014 ident: 62145_CR21 publication-title: Nat. Rev. Cancer. doi: 10.1038/nrc3818 contributor: fullname: H Yu – volume: 9 start-page: 287 year: 2006 ident: 62145_CR19 publication-title: Cancer Cell. doi: 10.1016/j.ccr.2006.03.003 contributor: fullname: L Sun – volume: 108 start-page: 69 year: 2012 ident: 62145_CR10 publication-title: J. Neurooncol. doi: 10.1007/s11060-012-0831-6 contributor: fullname: C Gozé – volume: 74 start-page: 4898 year: 2014 ident: 62145_CR44 publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-14-0008 contributor: fullname: M Esmaeili
SSID	ssj0000529419
Score	2.4833546
Snippet	IDH1-mutated gliomas are slow-growing brain tumours which progress into high-grade gliomas. The early molecular events causing this progression are...
SourceID	pubmedcentral hal proquest crossref pubmed springer
SourceType	Open Access Repository Aggregation Database Index Database Publisher
StartPage	5504
SubjectTerms	13/106 13/109 13/51 13/89 14/19 38/61 631/67 631/67/1922 Astrocytes Biochemistry, Molecular Biology Brain cancer Brain Neoplasms - genetics Brain Neoplasms - metabolism Brain Neoplasms - pathology Brain tumors Cancer Carbon-Oxygen Lyases - genetics Cell interactions Cell Line, Tumor Cell Proliferation Cell signaling Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology Connexin 43 Cytoskeleton Disease Progression Down-Regulation Enzymes Epidermal growth factor receptors Ethanolamine Ethanolamine-phosphate phospho-lyase Gap junctions Gene Expression Profiling Genetic transformation Glioma Glioma - genetics Glioma - metabolism Glioma - pathology Glioma cells Humanities and Social Sciences Humans Immunohistochemistry Isocitrate Dehydrogenase - genetics Life Sciences Lipid Metabolism Localization Metabolism multidisciplinary Mutation Neural coding Neurobiology Neurons and Cognition Phosphorylation Protein biosynthesis Ribonucleic acid RNA Science Science (multidisciplinary) Signal Transduction Stat3 protein STAT3 Transcription Factor - metabolism Stem cells Tumors Wnt protein
Title	Transformation Foci in IDH1-mutated Gliomas Show STAT3 Phosphorylation and Downregulate the Metabolic Enzyme ETNPPL, a Negative Regulator of Glioma Growth
URI	https://link.springer.com/article/10.1038/s41598-020-62145-1 https://www.ncbi.nlm.nih.gov/pubmed/32218467 https://www.proquest.com/docview/2383478639 https://inserm.hal.science/inserm-02540074 https://pubmed.ncbi.nlm.nih.gov/PMC7099072
Volume	10
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
link	http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9NAEF6RSkhcEG8CpZoDnKibrNfPY9QkDVIbRcRI3FZe76a2FK-jPKjSn8KvZdZrtw0VFy6-eO2x_c1ovvHOg5DPss-UUos-mjgevCBKnShCu0pDz_eFq1Lqm0LhyTyc_oyGI9Mmx29rYeqk_UwUZ3pZnukir3MrV2XWa_PEerOr89Ds5oRur0M6yA0fhOi2obcbezRuCmT6LOpt0EmZQjITKJnG3I4ZD4OKTCM7Xv7eH3Vykw35mGo-zpj8a9u09kbjF-R5QyNhYB_3JXmi9Cvy1A6W3L8mv5MHfLTSMEYIoNDwbTihTrkzBFPCxbIwyUEwz6sbmCeDhMEsrzarvFrvbYYcpFrCEOP0tZ1YrwDpIlypLWrOsshgpG_3pYJRMp3NLk8hham6rhuJw3d7QbWGatEIgguM-Lf5G_JjPErOJ04zhcHJ0HVvHZaG_UB6AcuiQNI4w2_PFkxRGUqMtpQvhEczibzDV0h2aOzLkEqlMqEUw2Uee0uOdKXVewICHaaS6Cs9DON84QkZxLHwozTAKExI2iVfWyz4yjbb4PUmOYu4BZEjiLwGkePqLwjX3ULTJ3syuOSFRtstuanyN_zoF647bgHljYFuODIV5oUR8rMueWexvbtTqxpdEh6gfiDq8Axqat2au9HMLjlt9eNe5L_f5MN_C_pInrlGr_vMcYNjcrRd79Qn0tnI3Un9d-Gkto0_LQoQig
link.rule.ids	230,315,729,782,786,866,887,27933,27934,53800,53802
linkProvider	National Library of Medicine
linkToHtml	http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lj9MwELboIgQX3o_CAj7Aic02jvNwjtW23a5oq4oGiZsVxy6J1DhV2rIqP4VfyziP3S0rLnvJJZOMrPlG8408D4Q-SZsqpZY2uDg8XJ_FFmPgV3Hgep5wVEw80yg8XgSzH2wwNGNyvLYXpiraT0R2qlf5qc7SqrZynSe9tk6sN5-eBeY2J3B6HXQf_NW2byTp9UhvJ3RJ2LTI2JT1NhCmTCuZSZXMaG7LLIgBKBNWL5i_jkid1NRD3iabt2sm_7k4reLR6MkdT_IUPW4IKO7Xr5-he0o_Rw_qlZT7F-hPdIPJFhqPwHg40_hiMCZWvjPUVOLzVWbKivAiLS7xIupHFM_TYrNOi3Jf19bhWEs8gAy_rHfdKwxEE0_VFjC3yhI81L_3ucLDaDafT05wjGfqZzWCHH-rPyhKXCwbRfi8LC636Uv0fTSMzsZWs7_BSiDoby0aB7YvXZ8mzJckTOCsdEkVkYGEPE15QrgkkcBYPAU0iYSeDIhUKhFKURBz6St0pAut3iAsINQqCVHWhQTQE66QfhgKj8U-5G9Cki760tqQr-sxHby6XqeM18bnYHxeGZ-D9Gcw85WgmbA97k94psHrc27mAxhm9Qvkjlsg8Ma1Nxw4DnUDBsyui17XmLj6UwupLgoO0HKg6vANIKMa6t0goYtOWlxdq_z_Sd7eWdFH9HAcTSd8cjH7-g49coxv2NRy_GN0tC136j3qbOTuQ-VZfwHkrCUf
linkToPdf	http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lj9MwELboIhAX3o_CAj7Aic3m4TyP1bbdruhWEQ0SNyuOXRKpcaq0ZVV-Cr-WcZx0t6y4wCWXTDKy_I3mG3n8DUIfuEWEEAsLQhwerh-mRhhCXKWB63nMEantqYvCk3kw-xYOR0omZz_qq2naz1hxKpflqSzyprdyVWZm1ydmxpdngTrNCRxzxRdmD92FmLWcG4W6lvV2IteO2msyFgnNNaQqdZ1MlUtKnttQQ2IAznaoh8xfZ6VernoibxPO232TfxyeNjlp_Og_VvMYPWyJKB5okyfojpBP0T09mnL3DP1KbjDaSuIxbCIuJL4YTmyj3CqKyvH5slDtRXieV1d4ngwSguO8Wq_yqt7pHjucSo6HUOnXeua9wEA48aXYAPaWRYZH8ueuFHiUzOJ4eoJTPBPfGyly_EV_UNW4WrSO8HldXW3y5-jreJScTYx2joORQfLfGCQNLJ-7PslCn9tRBuslCyJsHnCo14THmGtnHJiLJ4Au2ZHHA5sLkTEhCJi55AU6kpUUrxBmkHIFh2zrQiHoMZdxP4qYF6Y-1HGM2330qdtHutJyHbQ5Zich1QCgAADaAICC9UfY6r2hUtqeDKa0kBD9JVU6AYph_QC74w4MtA3xNQWuQ9wgBIbXRy81LvZ_6mDVR8EBYg5cHb4BdDTi3i0a-uikw9a1y7-v5PU_O3qP7sfDMZ1ezD6_QQ8cFR4WMRz_GB1t6q14i3prvn3XBNdvJpAnnw
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Transformation+Foci+in+IDH1-mutated+Gliomas+Show+STAT3+Phosphorylation+and+Downregulate+the+Metabolic+Enzyme+ETNPPL%2C+a+Negative+Regulator+of+Glioma+Growth&rft.jtitle=Scientific+reports&rft.au=Leventoux%2C+N.&rft.au=Augustus%2C+M.&rft.au=Azar%2C+S.&rft.au=Riquier%2C+S.&rft.date=2020-03-26&rft.pub=Nature+Publishing+Group+UK&rft.eissn=2045-2322&rft.volume=10&rft.issue=1&rft_id=info:doi/10.1038%2Fs41598-020-62145-1&rft.externalDocID=10_1038_s41598_020_62145_1
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2045-2322&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2045-2322&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2045-2322&client=summon