Test for Constant Fatality Rate of an Emerging Epidemic: With Applications to Severe Acute Respiratory Syndrome in Hong Kong and Beijing

• Published in: Biometrics Vol. 64; no. 3; pp. 869 - 876
• Main Authors: Lam, K.F, Deshpande, J.V, Lau, E.H.Y, Naik-Nimbalkar, U.V, Yip, P.S.F, Xu, Ying
• Format: Journal Article
• Language: English
• Published: Malden, USA Blackwell Publishing Inc 01-09-2008; Blackwell Publishing; Blackwell Publishing Ltd
• Subjects: Biometric Methodology; Biometrics; Biometry - methods; Brownian motion; China - epidemiology; Death; Disease Outbreaks - statistics & numerical data; Environmental Monitoring - statistics & numerical data; Epidemics; Epidemiological Monitoring; Epidemiology; Estimators; Hong Kong - epidemiology; Humans; Infectious disease; infectious diseases; Maximum likelihood estimation; Medical research; Models, Statistical; Mortality; Null hypothesis; Probabilities; Real-time fatality rate; Severe acute respiratory syndrome; Severe Acute Respiratory Syndrome - mortality; Simulation; Zero-mean martingale; Hong Kong; China
• ISSN: 0006-341X; 1541-0420
• DOI: 10.1111/j.1541-0420.2007.00935.x

The etiology, pathogenesis, and prognosis for a newly emerging disease are generally unknown to clinicians. Effective interventions and treatments at the earliest possible times are warranted to suppress the fatality of the disease to a minimum, and inappropriate treatments should be abolished. In this situation, the ability to extract most information out of the data available is critical so that important decisions can be made. Ineffectiveness of the treatment can be reflected by a constant fatality over time while effective treatment normally leads to a decreasing fatality rate. A statistical test for constant fatality over time is proposed in this article. The proposed statistic is shown to converge to a Brownian motion asymptotically under the null hypothesis. With the special features of the Brownian motion, we are able to analyze the first passage time distribution based on a sequential tests approach. This allows the null hypothesis of constant fatality rate to be rejected at the earliest possible time when adequate statistical evidence accumulates. Simulation studies show that the performance of the proposed test is good and it is extremely sensitive in picking up decreasing fatality rate. The proposed test is applied to the severe acute respiratory syndrome data in Hong Kong and Beijing.