RNA polymerase subunit RPB5 plays a role in transcriptional activation

A mutation in RPBS (rpb5-9), an essential RNA polymerase subunit assembled into RNA polymerases I, II, and III, revealed a role for this subunit in transcriptional activation. Activation by GAL4-VP16 was impaired upon in vitro transcription with mutant whole-cell extracts. In vivo experiments using...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 95; no. 26; pp. 15281 - 15286
Main Authors:	Miyao, TG, Woychik, N.A
Format:	Journal Article
Language:	English
Published:	United States National Academy of Sciences of the United States of America 22-12-1998 National Acad Sciences National Academy of Sciences The National Academy of Sciences
Subjects:	Amino acids Biochemistry Biological Sciences Cell growth Chimeras Conserved Sequence DNA-directed RNA polymerase enzyme activity Fungal Proteins - metabolism Genes Genetic mutation Genotype Humans Hybridity initiation Kinetics Macromolecular Substances messenger RNA mutagenesis Mutagenesis, Site-Directed mutants Plasmids Polymerase Chain Reaction promoter regions Promoter Regions, Genetic Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - metabolism recombinant proteins Ribonucleic acid RNA RNA Polymerase I - chemistry RNA Polymerase I - metabolism RNA Polymerase II - chemistry RNA Polymerase II - metabolism RNA Polymerase III - chemistry RNA Polymerase III - metabolism Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Social interaction Trans-Activators - metabolism transcription (genetics) Transcription, Genetic Transcriptional Activation Yeasts
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