Structure and Biosynthetic Assembly of Gulmirecins, Macrolide Antibiotics from the Predatory Bacterium Pyxidicoccus fallax

Structure and Biosynthetic Assembly of Gulmirecins, Macrolide Antibiotics from the Predatory Bacterium Pyxidicoccus fallax

The gulmirecins constitute a new class of glycosylated macrolides that were isolated from the predatory bacterium Pyxidicoccus fallax HKI 727. Their structures were solved by a combination of NMR spectroscopic experiments and chemical derivatization. Analysis of the annotated gulmirecin gene cluster...

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Published in:Chemistry : a European journal Vol. 20; no. 48; pp. 15933 - 15940
Main Authors: Schieferdecker, Sebastian, König, Stefanie, Weigel, Christiane, Dahse, Hans-Martin, Werz, Oliver, Nett, Markus
Format: Journal Article
Language:English
Published: Weinheim WILEY-VCH Verlag 24-11-2014
WILEY‐VCH Verlag
Wiley Subscription Services, Inc
Subjects:
Anti-Bacterial Agents - biosynthesis
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antibiotics
Assembly
Bacteria
Bacteriocins - biosynthesis
Bacteriocins - chemistry
Bacteriocins - pharmacology
Bacteriology
Biological Products - chemistry
Biomedical materials
Chemistry
Genes
Human
Humans
Hunting
Macrolides - chemistry
Macrolides - metabolism
Macrolides - pharmacology
Magnetic Resonance Spectroscopy
Methicillin-Resistant Staphylococcus aureus - drug effects
Microbial Sensitivity Tests
Molecular Sequence Data
Molecular Structure
MRSA
Multigene Family
natural products
NMR spectroscopy
polyketides
Polyketides - chemistry
Staphylococcus aureus
Staphylococcus infections
structure elucidation
natural products
structure elucidation
NMR spectroscopy
polyketides
antibiotics
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Abstract The gulmirecins constitute a new class of glycosylated macrolides that were isolated from the predatory bacterium Pyxidicoccus fallax HKI 727. Their structures were solved by a combination of NMR spectroscopic experiments and chemical derivatization. Analysis of the annotated gulmirecin gene cluster complemented the configurational assignment and provided insights into the stereochemical course of the biosynthetic assembly. The gulmirecins exhibit strong activity against staphylococci, including methicillin‐resistant Staphylococcus aureus, but no cytotoxic effects on human cells. Molecules for hunting: Bioactivity‐guided screening of the predatory bacterium Pyxidicoccus fallax HKI 727 led to the discovery of two new macrolide antibiotics (see figure). Both compounds inhibit the growth of Gram‐positive bacteria, including methicillin‐resistant Staphylococcus aureus (MRSA), and show no cytotoxicity against human cells.
AbstractList The gulmirecins constitute a new class of glycosylated macrolides that were isolated from the predatory bacterium Pyxidicoccus fallax HKI 727. Their structures were solved by a combination of NMR spectroscopic experiments and chemical derivatization. Analysis of the annotated gulmirecin gene cluster complemented the configurational assignment and provided insights into the stereochemical course of the biosynthetic assembly. The gulmirecins exhibit strong activity against staphylococci, including methicillin-resistant Staphylococcus aureus, but no cytotoxic effects on human cells.
The gulmirecins constitute a new class of glycosylated macrolides that were isolated from the predatory bacterium Pyxidicoccus fallax HKI 727. Their structures were solved by a combination of NMR spectroscopic experiments and chemical derivatization. Analysis of the annotated gulmirecin gene cluster complemented the configurational assignment and provided insights into the stereochemical course of the biosynthetic assembly. The gulmirecins exhibit strong activity against staphylococci, including methicillin-resistant Staphylococcus aureus, but no cytotoxic effects on human cells. Molecules for hunting: Bioactivity-guided screening of the predatory bacterium Pyxidicoccus fallax HKI 727 led to the discovery of two new macrolide antibiotics (see figure). Both compounds inhibit the growth of Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), and show no cytotoxicity against human cells.
The gulmirecins constitute a new class of glycosylated macrolides that were isolated from the predatory bacterium Pyxidicoccus fallax HKI 727. Their structures were solved by a combination of NMR spectroscopic experiments and chemical derivatization. Analysis of the annotated gulmirecin gene cluster complemented the configurational assignment and provided insights into the stereochemical course of the biosynthetic assembly. The gulmirecins exhibit strong activity against staphylococci, including methicillin‐resistant Staphylococcus aureus, but no cytotoxic effects on human cells. Molecules for hunting: Bioactivity‐guided screening of the predatory bacterium Pyxidicoccus fallax HKI 727 led to the discovery of two new macrolide antibiotics (see figure). Both compounds inhibit the growth of Gram‐positive bacteria, including methicillin‐resistant Staphylococcus aureus (MRSA), and show no cytotoxicity against human cells.
The gulmirecins constitute a new class of glycosylated macrolides that were isolated from the predatory bacterium Pyxidicoccus fallax HKI 727. Their structures were solved by a combination of NMR spectroscopic experiments and chemical derivatization. Analysis of the annotated gulmirecin gene cluster complemented the configurational assignment and provided insights into the stereochemical course of the biosynthetic assembly. The gulmirecins exhibit strong activity against staphylococci, including methicillin‐resistant Staphylococcus aureus , but no cytotoxic effects on human cells.
Author Dahse, Hans-Martin
Werz, Oliver
König, Stefanie
Schieferdecker, Sebastian
Weigel, Christiane
Nett, Markus
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  givenname: Hans-Martin
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  givenname: Oliver
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  organization: Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University, Philosophenweg 14, 07743 Jena (Germany)
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  email: Markus.Nett@hki-jena.de
  organization: Junior Research Group, "Secondary Metabolism of Predatory Bacteria", Leibniz Institute for Natural Product Research and Infection Biology, Hans-Knöll-Institute, Adolf-Reichwein-Str. 23, 07745 Jena (Germany), Fax: (+49) 3641-5320811
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Cites_doi 10.1002/cbic.200400459
10.1093/nar/gkr931
10.1016/0031-9422(92)83678-R
10.1002/anie.201106435
10.1177/089686080402400214
10.1080/07328308408058819
10.1021/ol500779s
10.1007/978-3-319-04900-7_4
10.1039/c4np00011k
10.1002/ejoc.200300539
10.1021/np0401664
10.1021/jo0707075
10.1021/ja3119674
10.1007/s10495-007-0150-0
10.1039/b707989n
10.1002/anie.200704897
10.1016/S1570-0232(03)00362-3
10.1002/(SICI)1099-0690(200003)2000:6<913::AID-EJOC913>3.0.CO;2-L
10.1111/j.1574-6968.1999.tb13576.x
10.1002/anie.200806121
10.1002/cbic.201300268
10.1038/ja.2014.31
10.1002/cbic.200300581
10.1039/b817073h
10.1021/ja804194c
10.1073/pnas.0700962104
10.1248/cpb.55.899
10.1039/b612668p
10.1073/pnas.0607335103
10.1021/ja309685n
10.1002/anie.200605198
10.1007/s10295-006-0082-7
10.1002/chem.201301379
10.1038/sj.jp.7211773
10.1093/nar/gkg847
10.1093/nar/gkg095
10.1002/ange.200806121
10.1021/ol402967y
10.1016/j.bmc.2010.01.053
10.1128/JB.05052-11
10.4056/sigs.2194987
10.1093/nar/28.1.33
10.1039/c2md20120h
10.1016/j.bmc.2008.11.025
10.1016/j.chembiol.2010.01.016
10.1021/cr2003344
10.1021/ja00722a087
10.1002/ange.200605198
10.1093/nar/gkh063
10.1021/bi0268706
10.1002/ange.201106435
10.1021/bi015864r
10.1016/j.jbiotec.2005.10.011
10.1093/nar/29.1.41
10.1016/0014-5793(95)01119-Y
10.1016/j.ympev.2010.08.028
10.1093/nar/30.1.276
10.1021/bi00006a006
10.1002/ange.200704897
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polyketides
antibiotics
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References R. L. Tatusov, M. Y. Galperin, D. A. Natale, E. V. Koonin, Nucleic Acids Res. 2000, 28, 33-36.
L. Etzbach, A. Plaza, R. Garcia, S. Baumann, R. Müller, Org. Lett. 2014, 16, 2414-2417.
D. Menche, F. Arikan, O. Perlova, N. Hortsmann, W. Ahlbrecht, S. C. Wenzel, R. Jansen, H. Irschik, R. Müller, J. Am. Chem. Soc. 2008, 130, 14234-14243
S. Schieferdecker, T. E. Exner, H. Gross, M. Roth, M. Nett, J. Antibiot. 2014, 67, 519-525.
S. Q. Lew, J. Saez, R. Whyte, Y. Stephenson, Perit. Dial. Int. 2004, 24, 195-196
J. B. McAlpine, B. O. Bachmann, M. Piraee, S. Tremblay, A.-M. Alarco, E. Zazopoulos, C. M. Farnet, J. Nat. Prod. 2005, 68, 493-496
R. Jansen, B. Kunze, H. Reichenbach, G. Höfle, Eur. J. Org. Chem. 2000, 913-919.
C. Hertweck, Angew. Chem. Int. Ed. 2009, 48, 4688-4716
B. Boeckmann, A. Bairoch, R. Apweiler, M.-C. Blatter, A. Estreicher, E. Gasteiger, M. J. Martin, K. Michoud, C. O'Donovan, I. Phan, S. Pilbout, M. Schneider, Nucleic Acids Res. 2003, 31, 365-370.
S. Felder, S. Kehraus, E. Neu, G. Bierbaum, T. F. Schäberle, G. M. König, ChemBioChem 2013, 14, 1363-1371.
D. Menche, Nat. Prod. Rep. 2008, 25, 905-918.
S. Felder, S. Dreisigacker, S. Kehraus, E. Neu, G. Bierbaum, P. R. Wright, D. Menche, T. F. Schäberle, G. M. König, Chem. Eur. J. 2013, 19, 9319-9324.
Angew. Chem. 2007, 119, 4985-4988
C. D. Reeves, S. Murli, G. W. Ashley, M. Piagentini, C. R. Hutchinson, R. McDaniel, Biochemistry 2001, 40, 15464-15470.
R. H. Lambalot, D. E. Cane, J. J. Aparicio, L. Katz, Biochemistry 1995, 34, 1858-1866.
A. Bateman, E. Birney, L. Cerruti, R. Durbin, L. Etwiller, S. R. Eddy, S. Griffiths-Jones, K. L. Howe, M. Marshall, E. L. L. Sonnhammer, Nucleic Acids Res. 2002, 30, 276-280.
H. Kiss, M. Nett, N. Domin, K. Martin, J. A. Maresca, A. Copeland, A. Lapidus, S. Lucas, K. W. Berry, T. G. Del Rio, E. Dalin, H. Tice, S. Pitluck, P. Richardson, D. Bruce, L. Goodwin, C. Han, J. C. Detter, J. Schmutz, T. Brettin, M. Land, L. Hauser, N. C. Kyrpides, N. Ivanova, M. Göker, T. Woyke, H.-P. Klenk, D. A. Bryant, Stand. Genomic Sci. 2011, 5, 356-370.
Angew. Chem. 2009, 121, 4782-4811.
H. B. Bode, R. Müller, J. Ind. Microbiol. Biotechnol. 2006, 33, 577-588
R. Garcia, K. Gerth, M. Stadler, I. J. Dogma, R. Müller, Mol. Phylogenet. Evol. 2010, 57, 878-887.
B. Li, X. Xie, X. Zhang, Z. Cai, H. Zhu, Wei Sheng Wu Xue Bao 2013, 53, 379-389.
R. Reid, M. Piagentini, E. Rodriguez, G. Ashley, N. Viswanathan, J. Carney, D. V. Santi, C. R. Hutchinson, R. McDaniel, Biochemistry 2003, 42, 72-79
F. N. Lamari, R. Kuhn, N. K. Karamanos, J. Chromatogr. B 2003, 793, 15-36.
D. J. Hoffman, G. D. Brown, F. A. Lombardo, J. Perinatol. 2007, 27, 519-520.
Angew. Chem. 2008, 120, 2341-2344
P. K. Agrawal, Phytochemistry 1992, 31, 3307-3330.
T. Tanaka, T. Nakashima, T. Ueda, K. Tomii, I. Kouno, Chem. Pharm. Bull. 2007, 55, 899-901.
M. Nett, G. M. König, Nat. Prod. Rep. 2007, 24, 1245-1261.
M. O. Martin, J. Mol. Microbiol. Biotechnol. 2002, 4, 467-477.
K. J. Weissman, R. Müller, Bioorg. Med. Chem. 2009, 17, 2121-2136.
B. T. Gregg, K. C. Golden, J. F. Quinn, J. Org. Chem. 2007, 72, 5890-5893.
Angew. Chem. 2012, 124, 1282-1286
T. F. Schäberle, F. Lohr, A. Schmitz, G. M. König, Nat. Prod. Rep. 2014, 31, 953-972.
S. C. Wenzel, R. Müller, Nat. Prod. Rep. 2009, 26, 1385-1407
C. Claudel-Renard, C. Chevalet, T. Faraut, D. Kahn, Nucleic Acids Res. 2003, 31, 6633-6639.
R. C. Beier, B. P. Mundy, J. Carbohydr. Chem. 1984, 3, 253-266
D. H. Haft, B. J. Loftus, D. L. Richardson, F. Yang, J. A. Eisen, I. T. Paulsen, O. White, Nucleic Acids Res. 2001, 29, 41-43.
A. C. Ross, Y. Xu, L. Lu, R. D. Kersten, Z. Shao, A. M. Al-Suwailem, P. C. Dorrestein, P.-Y. Qian, B. S. Moore, J. Am. Chem. Soc. 2013, 135, 1155-1162
S. C. Wenzel, R. Müller, Curr. Opin. Drug Discovery Dev. 2009, 12, 220-230
D. Janssen, D. Albert, R. Jansen, R. Müller, M. Kalesse, Angew. Chem. Int. Ed. 2007, 46, 4898-4901
B. S. Goldman, W. C. Nierman, D. Kaiser, S. C. Slater, A. S. Durkin, J. A. Eisen, C. M. Ronning, W. B. Barbazuk, M. Blanchard, C. Field, C. Halling, G. Hinkle, O. Iartchuk, H. S. Kim, C. Mackenzie, R. Madupu, N. Miller, A. Shvartsbeyn, S. A. Sullivan, M. Vaudin, R. Wiegand, H. B. Kaplan, Proc. Natl. Acad. Sci. USA 2006, 103, 15200-15205
J. Niggemann, M. Herrmann, K. Gerth, H. Irschik, H. Reichenbach, G. Höfle, Eur. J. Org. Chem. 2004, 487-492
P. Caffrey, ChemBioChem 2003, 4, 654-657
F. Krauth, H.-M. Dahse, H.-H. Rüttinger, P. Frohberg, Bioorg. Med. Chem. 2010, 18, 1816-1821.
J. Ishikawa, K. Hotta, FEMS Microbiol. Lett. 1999, 174, 251-253.
J. M. Seco, E. Quiñoá, R. Riguera, Chem. Rev. 2012, 112, 4603-4641.
J. D. Mee, D. W. Heseltine, E. C. Taylor, J. Am. Chem. Soc. 1970, 92, 5816-5817.
M. Bock, K. Buntin, R. Müller, A. Kirschning, Angew. Chem. Int. Ed. 2008, 47, 2308-2311
S. F. Haydock, J. F. Aparicio, I. Molnár, T. Schwecke, L. E. Khaw, A. König, A. F. A. Marsden, I. S. Galloway, J. Staunton, P. F. Leadlay, FEBS Lett. 1995, 374, 246-248
A. Plaza, K. Viehrig, R. Garcia, R. Müller, Org. Lett. 2013, 15, 5882-5885.
C. Johnston, A. Ibrahim, N. Magarvey, Med. Chem. Commun. 2012, 3, 932-937
S. Essig, S. Bretzke, R. Müller, D. Menche, J. Am. Chem. Soc. 2012, 134, 19362-19365.
I. Letunic, T. Doerks, P. Bork, Nucleic Acids Res. 2012, 40, D302-D305.
Y. Chai, D. Pistorius, A. Ullrich, K. J. Weissman, U. Kazmaier, R. Müller, Chem. Biol. 2010, 17, 296-309
Y. Xiao, X. Wei, R. Ebright, D. Wall, J. Bacteriol. 2011, 193, 4626-4633.
M. Kopp, H. Irschik, S. Pradella, R. Müller, ChemBioChem 2005, 6, 1277-1286.
J. Barbier, R. Jansen, H. Irschik, S. Benson, K. Gerth, B. Böhlendorf, G. Höfle, H. Reichenbach, J. Wegner, C. Zeilinger, A. Kirschning, R. Müller, Angew. Chem. Int. Ed. 2012, 51, 1256-1260
O. Perlova, K. Gerth, O. Kaiser, A. Hans, R. Müller, J. Biotechnol. 2006, 121, 174-191
I. Tretiakova, D. Blaesius, L. Maxia, S. Wesselbrog, K. Schulze-Osthoff, J. Cinatl Jr., M. Michaelis, O. Werz, Apoptosis 2008, 13, 119-131.
D. W. Udwary, L. Zeigler, R. N. Asolkar, V. Singan, A. Lapidus, W. Fenical, P. R. Jensen, B. S. Moore, Proc. Natl. Acad. Sci. USA 2007, 104, 10376-10381.
M. Kanehisa, S. Goto, S. Kawashima, Y. Okuno, M. Hattori, Nucleic Acids Res. 2004, 32, 277D-280D.
2007; 104
2010; 57
2009 2009; 48 121
2010; 18
2006; 33
2010; 17
1995; 34
2004; 24
2007; 72
2008 2008; 47 120
1995; 374
2011; 193
2014; 67
2001; 40
2003; 793
2005; 68
2009; 12
2013; 19
2004; 32
2013; 15
2013; 14
2012; 134
2000
2012 2012; 51 124
2013; 53
2014; 16
2008; 25
2003; 4
2006; 121
1999; 174
2007; 24
2003; 42
2007; 27
2009; 17
2000; 28
2002; 30
2002; 4
2008; 13
2004
2001; 29
1992; 31
2007; 55
2011; 5
2003; 31
2009; 26
2012; 3
2012; 112
1970; 92
1984; 3
2007 2007; 46 119
2013; 135
2005; 6
2008; 130
2006; 103
2014; 31
2012; 40
e_1_2_6_51_2
e_1_2_6_72_2
e_1_2_6_53_2
e_1_2_6_74_2
e_1_2_6_30_2
e_1_2_6_70_2
e_1_2_6_13_2
e_1_2_6_34_2
e_1_2_6_59_2
e_1_2_6_11_2
e_1_2_6_32_2
e_1_2_6_17_2
e_1_2_6_38_2
e_1_2_6_55_2
Wenzel S. C. (e_1_2_6_2_2) 2009; 12
e_1_2_6_15_2
e_1_2_6_36_2
e_1_2_6_57_2
e_1_2_6_62_2
e_1_2_6_64_2
e_1_2_6_20_2
e_1_2_6_41_2
e_1_2_6_60_2
Lew S. Q. (e_1_2_6_52_2) 2004; 24
Li B. (e_1_2_6_19_2) 2013; 53
e_1_2_6_7_2
e_1_2_6_9_2
e_1_2_6_3_2
e_1_2_6_5_2
e_1_2_6_24_2
e_1_2_6_47_2
e_1_2_6_22_2
e_1_2_6_49_2
e_1_2_6_1_2
e_1_2_6_28_2
e_1_2_6_43_2
e_1_2_6_26_3
e_1_2_6_66_2
e_1_2_6_26_2
e_1_2_6_45_2
e_1_2_6_68_2
e_1_2_6_50_2
e_1_2_6_73_2
e_1_2_6_31_2
e_1_2_6_71_2
e_1_2_6_18_2
e_1_2_6_12_2
e_1_2_6_35_2
e_1_2_6_58_2
e_1_2_6_10_2
e_1_2_6_33_2
e_1_2_6_31_3
e_1_2_6_16_2
e_1_2_6_39_2
e_1_2_6_54_2
e_1_2_6_14_2
e_1_2_6_37_2
e_1_2_6_56_2
e_1_2_6_56_3
e_1_2_6_61_2
e_1_2_6_63_2
e_1_2_6_42_2
e_1_2_6_40_2
e_1_2_6_8_2
e_1_2_6_29_2
Martin M. O. (e_1_2_6_4_2) 2002; 4
e_1_2_6_6_2
e_1_2_6_23_2
e_1_2_6_48_2
e_1_2_6_69_2
e_1_2_6_21_2
e_1_2_6_65_2
e_1_2_6_27_2
e_1_2_6_44_2
e_1_2_6_25_3
e_1_2_6_67_2
e_1_2_6_25_2
e_1_2_6_46_2
References_xml – volume: 55
  start-page: 899
  year: 2007
  end-page: 901
  publication-title: Chem. Pharm. Bull.
– volume: 112
  start-page: 4603
  year: 2012
  end-page: 4641
  publication-title: Chem. Rev.
– volume: 34
  start-page: 1858
  year: 1995
  end-page: 1866
  publication-title: Biochemistry
– volume: 30
  start-page: 276
  year: 2002
  end-page: 280
  publication-title: Nucleic Acids Res.
– volume: 92
  start-page: 5816
  year: 1970
  end-page: 5817
  publication-title: J. Am. Chem. Soc.
– start-page: 913
  year: 2000
  end-page: 919
  publication-title: Eur. J. Org. Chem.
– volume: 24
  start-page: 1245
  year: 2007
  end-page: 1261
  publication-title: Nat. Prod. Rep.
– volume: 3
  start-page: 253
  year: 1984
  end-page: 266
  publication-title: J. Carbohydr. Chem.
– volume: 28
  start-page: 33
  year: 2000
  end-page: 36
  publication-title: Nucleic Acids Res.
– volume: 47 120
  start-page: 2308 2341
  year: 2008 2008
  end-page: 2311 2344
  publication-title: Angew. Chem. Int. Ed. Angew. Chem.
– volume: 31
  start-page: 953
  year: 2014
  end-page: 972
  publication-title: Nat. Prod. Rep.
– volume: 24
  start-page: 195
  year: 2004
  end-page: 196
  publication-title: Perit. Dial. Int.
– volume: 31
  start-page: 6633
  year: 2003
  end-page: 6639
  publication-title: Nucleic Acids Res.
– volume: 67
  start-page: 519
  year: 2014
  end-page: 525
  publication-title: J. Antibiot.
– volume: 57
  start-page: 878
  year: 2010
  end-page: 887
  publication-title: Mol. Phylogenet. Evol.
– volume: 33
  start-page: 577
  year: 2006
  end-page: 588
  publication-title: J. Ind. Microbiol. Biotechnol.
– volume: 4
  start-page: 467
  year: 2002
  end-page: 477
  publication-title: J. Mol. Microbiol. Biotechnol.
– volume: 53
  start-page: 379
  year: 2013
  end-page: 389
  publication-title: Wei Sheng Wu Xue Bao
– volume: 31
  start-page: 3307
  year: 1992
  end-page: 3330
  publication-title: Phytochemistry
– volume: 130
  start-page: 14234
  year: 2008
  end-page: 14243
  publication-title: J. Am. Chem. Soc.
– volume: 4
  start-page: 654
  year: 2003
  end-page: 657
  publication-title: ChemBioChem
– volume: 174
  start-page: 251
  year: 1999
  end-page: 253
  publication-title: FEMS Microbiol. Lett.
– volume: 13
  start-page: 119
  year: 2008
  end-page: 131
  publication-title: Apoptosis
– volume: 18
  start-page: 1816
  year: 2010
  end-page: 1821
  publication-title: Bioorg. Med. Chem.
– volume: 12
  start-page: 220
  year: 2009
  end-page: 230
  publication-title: Curr. Opin. Drug Discovery Dev.
– volume: 16
  start-page: 2414
  year: 2014
  end-page: 2417
  publication-title: Org. Lett.
– volume: 42
  start-page: 72
  year: 2003
  end-page: 79
  publication-title: Biochemistry
– volume: 3
  start-page: 932
  year: 2012
  end-page: 937
  publication-title: Med. Chem. Commun.
– volume: 104
  start-page: 10376
  year: 2007
  end-page: 10381
  publication-title: Proc. Natl. Acad. Sci. USA
– volume: 17
  start-page: 296
  year: 2010
  end-page: 309
  publication-title: Chem. Biol.
– volume: 72
  start-page: 5890
  year: 2007
  end-page: 5893
  publication-title: J. Org. Chem.
– volume: 26
  start-page: 1385
  year: 2009
  end-page: 1407
  publication-title: Nat. Prod. Rep.
– volume: 793
  start-page: 15
  year: 2003
  end-page: 36
  publication-title: J. Chromatogr. B
– volume: 46 119
  start-page: 4898 4985
  year: 2007 2007
  end-page: 4901 4988
  publication-title: Angew. Chem. Int. Ed. Angew. Chem.
– volume: 5
  start-page: 356
  year: 2011
  end-page: 370
  publication-title: Stand. Genomic Sci.
– volume: 134
  start-page: 19362
  year: 2012
  end-page: 19365
  publication-title: J. Am. Chem. Soc.
– volume: 193
  start-page: 4626
  year: 2011
  end-page: 4633
  publication-title: J. Bacteriol.
– start-page: 487
  year: 2004
  end-page: 492
  publication-title: Eur. J. Org. Chem.
– volume: 374
  start-page: 246
  year: 1995
  end-page: 248
  publication-title: FEBS Lett.
– volume: 17
  start-page: 2121
  year: 2009
  end-page: 2136
  publication-title: Bioorg. Med. Chem.
– volume: 40
  start-page: 302
  year: 2012
  end-page: 305
  publication-title: Nucleic Acids Res.
– volume: 40
  start-page: 15464
  year: 2001
  end-page: 15470
  publication-title: Biochemistry
– volume: 68
  start-page: 493
  year: 2005
  end-page: 496
  publication-title: J. Nat. Prod.
– volume: 103
  start-page: 15200
  year: 2006
  end-page: 15205
  publication-title: Proc. Natl. Acad. Sci. USA
– volume: 29
  start-page: 41
  year: 2001
  end-page: 43
  publication-title: Nucleic Acids Res.
– volume: 19
  start-page: 9319
  year: 2013
  end-page: 9324
  publication-title: Chem. Eur. J.
– volume: 135
  start-page: 1155
  year: 2013
  end-page: 1162
  publication-title: J. Am. Chem. Soc.
– volume: 6
  start-page: 1277
  year: 2005
  end-page: 1286
  publication-title: ChemBioChem
– volume: 32
  start-page: 277D
  year: 2004
  end-page: 280D
  publication-title: Nucleic Acids Res.
– volume: 14
  start-page: 1363
  year: 2013
  end-page: 1371
  publication-title: ChemBioChem
– volume: 27
  start-page: 519
  year: 2007
  end-page: 520
  publication-title: J. Perinatol.
– volume: 31
  start-page: 365
  year: 2003
  end-page: 370
  publication-title: Nucleic Acids Res.
– volume: 51 124
  start-page: 1256 1282
  year: 2012 2012
  end-page: 1260 1286
  publication-title: Angew. Chem. Int. Ed. Angew. Chem.
– volume: 15
  start-page: 5882
  year: 2013
  end-page: 5885
  publication-title: Org. Lett.
– volume: 48 121
  start-page: 4688 4782
  year: 2009 2009
  end-page: 4716 4811
  publication-title: Angew. Chem. Int. Ed. Angew. Chem.
– volume: 25
  start-page: 905
  year: 2008
  end-page: 918
  publication-title: Nat. Prod. Rep.
– volume: 121
  start-page: 174
  year: 2006
  end-page: 191
  publication-title: J. Biotechnol.
– ident: e_1_2_6_64_2
  doi: 10.1002/cbic.200400459
– ident: e_1_2_6_71_2
  doi: 10.1093/nar/gkr931
– ident: e_1_2_6_50_2
  doi: 10.1016/0031-9422(92)83678-R
– ident: e_1_2_6_58_2
– ident: e_1_2_6_56_2
  doi: 10.1002/anie.201106435
– volume: 24
  start-page: 195
  year: 2004
  ident: e_1_2_6_52_2
  publication-title: Perit. Dial. Int.
  doi: 10.1177/089686080402400214
  contributor:
    fullname: Lew S. Q.
– ident: e_1_2_6_49_2
  doi: 10.1080/07328308408058819
– ident: e_1_2_6_13_2
  doi: 10.1021/ol500779s
– ident: e_1_2_6_36_2
  doi: 10.1007/978-3-319-04900-7_4
– ident: e_1_2_6_61_2
– ident: e_1_2_6_12_2
  doi: 10.1039/c4np00011k
– ident: e_1_2_6_21_2
  doi: 10.1002/ejoc.200300539
– ident: e_1_2_6_34_2
  doi: 10.1021/np0401664
– ident: e_1_2_6_45_2
  doi: 10.1021/jo0707075
– ident: e_1_2_6_59_2
  doi: 10.1021/ja3119674
– ident: e_1_2_6_54_2
  doi: 10.1007/s10495-007-0150-0
– volume: 53
  start-page: 379
  year: 2013
  ident: e_1_2_6_19_2
  publication-title: Wei Sheng Wu Xue Bao
  contributor:
    fullname: Li B.
– ident: e_1_2_6_43_2
  doi: 10.1039/b707989n
– ident: e_1_2_6_9_2
– ident: e_1_2_6_26_2
  doi: 10.1002/anie.200704897
– ident: e_1_2_6_65_2
– ident: e_1_2_6_46_2
  doi: 10.1016/S1570-0232(03)00362-3
– ident: e_1_2_6_22_2
  doi: 10.1002/(SICI)1099-0690(200003)2000:6<913::AID-EJOC913>3.0.CO;2-L
– ident: e_1_2_6_67_2
  doi: 10.1111/j.1574-6968.1999.tb13576.x
– ident: e_1_2_6_31_2
  doi: 10.1002/anie.200806121
– ident: e_1_2_6_15_2
  doi: 10.1002/cbic.201300268
– ident: e_1_2_6_17_2
  doi: 10.1038/ja.2014.31
– ident: e_1_2_6_41_2
  doi: 10.1002/cbic.200300581
– ident: e_1_2_6_10_2
  doi: 10.1039/b817073h
– ident: e_1_2_6_27_2
  doi: 10.1021/ja804194c
– ident: e_1_2_6_35_2
  doi: 10.1073/pnas.0700962104
– ident: e_1_2_6_47_2
  doi: 10.1248/cpb.55.899
– ident: e_1_2_6_3_2
  doi: 10.1039/b612668p
– ident: e_1_2_6_7_2
  doi: 10.1073/pnas.0607335103
– ident: e_1_2_6_28_2
  doi: 10.1021/ja309685n
– ident: e_1_2_6_25_2
  doi: 10.1002/anie.200605198
– ident: e_1_2_6_11_2
  doi: 10.1007/s10295-006-0082-7
– ident: e_1_2_6_16_2
  doi: 10.1002/chem.201301379
– ident: e_1_2_6_30_2
– ident: e_1_2_6_53_2
  doi: 10.1038/sj.jp.7211773
– ident: e_1_2_6_69_2
  doi: 10.1093/nar/gkg847
– ident: e_1_2_6_73_2
  doi: 10.1093/nar/gkg095
– ident: e_1_2_6_31_3
  doi: 10.1002/ange.200806121
– ident: e_1_2_6_14_2
  doi: 10.1021/ol402967y
– ident: e_1_2_6_55_2
– ident: e_1_2_6_66_2
  doi: 10.1016/j.bmc.2010.01.053
– ident: e_1_2_6_24_2
– ident: e_1_2_6_5_2
  doi: 10.1128/JB.05052-11
– ident: e_1_2_6_8_2
  doi: 10.4056/sigs.2194987
– ident: e_1_2_6_72_2
  doi: 10.1093/nar/28.1.33
– ident: e_1_2_6_32_2
– ident: e_1_2_6_33_2
  doi: 10.1039/c2md20120h
– ident: e_1_2_6_60_2
  doi: 10.1016/j.bmc.2008.11.025
– ident: e_1_2_6_62_2
  doi: 10.1016/j.chembiol.2010.01.016
– ident: e_1_2_6_6_2
– ident: e_1_2_6_23_2
  doi: 10.1021/cr2003344
– ident: e_1_2_6_57_2
  doi: 10.1021/ja00722a087
– ident: e_1_2_6_25_3
  doi: 10.1002/ange.200605198
– ident: e_1_2_6_74_2
  doi: 10.1093/nar/gkh063
– ident: e_1_2_6_42_2
  doi: 10.1021/bi0268706
– ident: e_1_2_6_20_2
– ident: e_1_2_6_56_3
  doi: 10.1002/ange.201106435
– ident: e_1_2_6_39_2
  doi: 10.1021/bi015864r
– ident: e_1_2_6_63_2
  doi: 10.1016/j.jbiotec.2005.10.011
– ident: e_1_2_6_68_2
  doi: 10.1093/nar/29.1.41
– ident: e_1_2_6_38_2
  doi: 10.1016/0014-5793(95)01119-Y
– ident: e_1_2_6_51_2
– ident: e_1_2_6_48_2
– ident: e_1_2_6_40_2
– volume: 4
  start-page: 467
  year: 2002
  ident: e_1_2_6_4_2
  publication-title: J. Mol. Microbiol. Biotechnol.
  contributor:
    fullname: Martin M. O.
– ident: e_1_2_6_18_2
  doi: 10.1016/j.ympev.2010.08.028
– ident: e_1_2_6_29_2
– ident: e_1_2_6_37_2
– ident: e_1_2_6_70_2
  doi: 10.1093/nar/30.1.276
– ident: e_1_2_6_44_2
  doi: 10.1021/bi00006a006
– volume: 12
  start-page: 220
  year: 2009
  ident: e_1_2_6_2_2
  publication-title: Curr. Opin. Drug Discovery Dev.
  contributor:
    fullname: Wenzel S. C.
– ident: e_1_2_6_1_2
– ident: e_1_2_6_26_3
  doi: 10.1002/ange.200704897
SSID ssj0009633
Score 2.358809
Snippet The gulmirecins constitute a new class of glycosylated macrolides that were isolated from the predatory bacterium Pyxidicoccus fallax HKI 727. Their structures...
The gulmirecins constitute a new class of glycosylated macrolides that were isolated from the predatory bacterium Pyxidicoccus fallax HKI 727. Their structures...
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SubjectTerms Anti-Bacterial Agents - biosynthesis
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antibiotics
Assembly
Bacteria
Bacteriocins - biosynthesis
Bacteriocins - chemistry
Bacteriocins - pharmacology
Bacteriology
Biological Products - chemistry
Biomedical materials
Chemistry
Genes
Human
Humans
Hunting
Macrolides - chemistry
Macrolides - metabolism
Macrolides - pharmacology
Magnetic Resonance Spectroscopy
Methicillin-Resistant Staphylococcus aureus - drug effects
Microbial Sensitivity Tests
Molecular Sequence Data
Molecular Structure
MRSA
Multigene Family
natural products
NMR spectroscopy
polyketides
Polyketides - chemistry
Staphylococcus aureus
Staphylococcus infections
structure elucidation
Title Structure and Biosynthetic Assembly of Gulmirecins, Macrolide Antibiotics from the Predatory Bacterium Pyxidicoccus fallax
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https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fchem.201404291
https://www.ncbi.nlm.nih.gov/pubmed/25287056
https://www.proquest.com/docview/1624891622
https://search.proquest.com/docview/1625347558
https://search.proquest.com/docview/1694973164
https://search.proquest.com/docview/1786189520
Volume 20
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