帕金森病痴呆相关临床研究进展

帕金森病是临床常见的神经变性病,以运动症状和非运动症状为主要临床特征。帕金森病痴呆是其中常见的非运动症状,发生率和病残率较高,治疗效果不理想。近年国际上关于帕金森病痴呆的基础与临床研究取得新进展。本文拟从临床视角对帕金森病痴呆的流行病学特征、神经心理学特征、预测因素、诊断及药物治疗进展进行综述,以期有助于推动国内帕金森病痴呆的研究。...

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Published in:中国现代神经疾病杂志 Vol. 17; no. 2; pp. 95 - 100
Main Author: 杨仕林 吴云成
Format: Journal Article
Language:Chinese
Published: 200080,上海交通大学附属第一人民医院神经内科 2017
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Summary:帕金森病是临床常见的神经变性病,以运动症状和非运动症状为主要临床特征。帕金森病痴呆是其中常见的非运动症状,发生率和病残率较高,治疗效果不理想。近年国际上关于帕金森病痴呆的基础与临床研究取得新进展。本文拟从临床视角对帕金森病痴呆的流行病学特征、神经心理学特征、预测因素、诊断及药物治疗进展进行综述,以期有助于推动国内帕金森病痴呆的研究。
Bibliography:Parkinson's disease(PD) is a common neurodegenerative disease,characterized bytypical motor symptoms and various non-motor symptoms(NMS).Parkinson's disease dementia(PDD) isone common NMS,with high prevalence,disability rate,and poor response to treatment.Recently therehave been increasingly new findings in clinical and experimental studies on PDD.This review focuses onits epidemiology,neuropsychological characteristics,predictive factors,diagnosis and pharmacotherapy fromclinical perspective so as to promote its research in China.
YANG Shi-lin, WU Yun-cheng (Department of Neurology, Shanghai General Hospital, Shanghai 200080, China)
Parkinson disease; Dementia; Review
12-1363/R
ISSN:1672-6731
DOI:10.3969/j.issn.1672-6731.2017.02.003