2,3,7,8-Tetrachlorodibenzo-p-dioxin activates the aryl hydrocarbon receptor and alters sex steroid hormone secretion without affecting growth of mouse antral follicles in vitro

The persistent environmental contaminant, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is an ovarian toxicant. These studies were designed to characterize the actions of TCDD on steroidogenesis and growth of intact mouse antral follicles in vitro. Specifically, these studies tested the hypothesis that...

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Bibliographic Details
Published in:	Toxicology and applied pharmacology Vol. 261; no. 1; pp. 88 - 96
Main Authors:	Karman, Bethany N., Basavarajappa, Mallikarjuna S., Craig, Zelieann R., Flaws, Jodi A.
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier Inc 15-05-2012 Elsevier
Subjects:	60 APPLIED LIFE SCIENCES AMINO ACIDS ANDROSTENEDIONE ANIMAL TISSUES Animals Antral follicle Aryl Hydrocarbon Hydroxylases - drug effects Aryl Hydrocarbon Hydroxylases - metabolism Aryl hydrocarbon receptor Aryl hydrocarbon receptors Biological and medical sciences Cell culture Contaminants Cytochrome P-450 CYP1B1 Data processing DIOXIN Dioxins - administration & dosage Dioxins - toxicity Dose-Response Relationship, Drug ESTRADIOL Female Follicles Gonadal Steroid Hormones - secretion Growth hormone Hormones HYDROCARBONS HYDROXYPREGNENONE IN VITRO In Vitro Techniques Medical sciences MICE Ovarian Follicle - drug effects Ovarian Follicle - growth & development OVARIES Ovary Pregnenolone Pregnenolone - pharmacology PROGESTERONE Proliferation RECEPTORS Receptors, Aryl Hydrocarbon - drug effects Receptors, Aryl Hydrocarbon - metabolism SECRETION SEX Sex hormones Steroidogenesis STH TCDD TESTOSTERONE Time Factors Tissue culture TISSUE CULTURES Toxicants Toxicology Transcription TCDD Ovary Aryl hydrocarbon receptor Steroidogenesis Proliferation Antral follicle Cell proliferation Dioxin derivatives Hydrocarbon Growth Secretion Toxicity Rodentia In vitro Ah receptor Vertebrata Mammalia Mouse Animal Female genital system Sex steroid hormone
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