Biomarkers and Their Possible Functions in the Intestinal Microenvironment of Chagasic Megacolon: An Overview of the (Neuro)inflammatory Process

The association between inflammatory processes and intestinal neuronal destruction during the progression of Chagasic megacolon is well established. However, many other components play essential roles, both in the long-term progression and control of the clinical status of patients infected with Try...

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Published in:	Journal of immunology research Vol. 2021; pp. 6668739 - 17
Main Authors:	do Carmo Neto, José Rodrigues, Braga, Yarlla Loyane Lira, da Costa, Arthur Wilson Florêncio, Lucio, Fernanda Hélia, do Nascimento, Thais Cardoso, dos Reis, Marlene Antônia, Celes, Mara Rubia Nunes, de Oliveira, Flávia Aparecida, Machado, Juliana Reis, da Silva, Marcos Vinícius
Format:	Journal Article
Language:	English
Published:	Egypt Hindawi 2021 Hindawi Limited
Subjects:	Biomarkers Disease Dysphagia Enteric nervous system Glial cells Homeostasis Immunology Infections Inflammation Intestine Lymphocytes Mast cells Microenvironments Nervous system Neuronal-glial interactions Neurons Parasites Pathophysiology Proteins Review Serotonin Brazil
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Abstract	The association between inflammatory processes and intestinal neuronal destruction during the progression of Chagasic megacolon is well established. However, many other components play essential roles, both in the long-term progression and control of the clinical status of patients infected with Trypanosoma cruzi. Components such as neuronal subpopulations, enteric glial cells, mast cells and their proteases, and homeostasis-related proteins from several organic systems (serotonin and galectins) are differentially involved in the progression of Chagasic megacolon. This review is aimed at revealing the characteristics of the intestinal microenvironment found in Chagasic megacolon by using different types of already used biomarkers. Information regarding these components may provide new therapeutic alternatives and improve the understanding of the association between T. cruzi infection and immune, endocrine, and neurological system changes.
AbstractList	The association between inflammatory processes and intestinal neuronal destruction during the progression of Chagasic megacolon is well established. However, many other components play essential roles, both in the long-term progression and control of the clinical status of patients infected with Trypanosoma cruzi. Components such as neuronal subpopulations, enteric glial cells, mast cells and their proteases, and homeostasis-related proteins from several organic systems (serotonin and galectins) are differentially involved in the progression of Chagasic megacolon. This review is aimed at revealing the characteristics of the intestinal microenvironment found in Chagasic megacolon by using different types of already used biomarkers. Information regarding these components may provide new therapeutic alternatives and improve the understanding of the association between T. cruzi infection and immune, endocrine, and neurological system changes. The association between inflammatory processes and intestinal neuronal destruction during the progression of Chagasic megacolon is well established. However, many other components play essential roles, both in the long-term progression and control of the clinical status of patients infected with Trypanosoma cruzi . Components such as neuronal subpopulations, enteric glial cells, mast cells and their proteases, and homeostasis-related proteins from several organic systems (serotonin and galectins) are differentially involved in the progression of Chagasic megacolon. This review is aimed at revealing the characteristics of the intestinal microenvironment found in Chagasic megacolon by using different types of already used biomarkers. Information regarding these components may provide new therapeutic alternatives and improve the understanding of the association between T. cruzi infection and immune, endocrine, and neurological system changes. The association between inflammatory processes and intestinal neuronal destruction during the progression of Chagasic megacolon is well established. However, many other components play essential roles, both in the long-term progression and control of the clinical status of patients infected with . Components such as neuronal subpopulations, enteric glial cells, mast cells and their proteases, and homeostasis-related proteins from several organic systems (serotonin and galectins) are differentially involved in the progression of Chagasic megacolon. This review is aimed at revealing the characteristics of the intestinal microenvironment found in Chagasic megacolon by using different types of already used biomarkers. Information regarding these components may provide new therapeutic alternatives and improve the understanding of the association between infection and immune, endocrine, and neurological system changes.
Author	do Nascimento, Thais Cardoso de Oliveira, Flávia Aparecida dos Reis, Marlene Antônia da Costa, Arthur Wilson Florêncio Celes, Mara Rubia Nunes Machado, Juliana Reis Braga, Yarlla Loyane Lira da Silva, Marcos Vinícius do Carmo Neto, José Rodrigues Lucio, Fernanda Hélia
AuthorAffiliation	1 Department of Bioscience and Technology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, GO, Brazil 3 Department of Microbiology, Immunology and Parasitology, Institute of Biological and Natural Sciences, Federal University of Triângulo Mineiro, Uberaba, Minas Gerais, Brazil 2 Department of General Pathology, Federal University of Triângulo Mineiro, Uberaba, Minas Gerais, Brazil
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ContentType	Journal Article
Copyright	Copyright © 2021 José Rodrigues do Carmo Neto et al. Copyright © 2021 José Rodrigues do Carmo Neto et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0 Copyright © 2021 José Rodrigues do Carmo Neto et al. 2021
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Snippet	The association between inflammatory processes and intestinal neuronal destruction during the progression of Chagasic megacolon is well established. However,...
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SubjectTerms	Biomarkers Disease Dysphagia Enteric nervous system Glial cells Homeostasis Immunology Infections Inflammation Intestine Lymphocytes Mast cells Microenvironments Nervous system Neuronal-glial interactions Neurons Parasites Pathophysiology Proteins Review Serotonin
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Title	Biomarkers and Their Possible Functions in the Intestinal Microenvironment of Chagasic Megacolon: An Overview of the (Neuro)inflammatory Process
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