Detecting cancer by monitoring circulating tumor DNA

DNA that is shed by dead tumor cells into the blood, termed circulating tumor DNA (ctDNA), is a rich resource that could potentially be used for cancer diagnostics and monitoring. A new study describes a sequencing-based method that improves upon the sensitivity and specificity achieved by past tech...

Full description

Saved in:

Bibliographic Details
Published in:	Nature medicine Vol. 20; no. 5; pp. 474 - 475
Main Authors:	Spellman, Paul T, Gray, Joe W
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01-05-2014 Nature Publishing Group
Subjects:	45/23 49/23 49/98 631/1647/514/1948 631/67/2322 Analysis Biomarkers, Tumor - blood Biomedicine Cancer Cancer Research Carcinoma, Non-Small-Cell Lung - diagnosis Deoxyribonucleic acid DNA DNA, Neoplasm - isolation & purification Genetic aspects Humans Identification and classification Infectious Diseases Medical screening Metabolic Diseases Molecular Medicine Neoplasms - diagnosis Neurosciences news-and-views Reagents Tumorigenesis
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	DNA that is shed by dead tumor cells into the blood, termed circulating tumor DNA (ctDNA), is a rich resource that could potentially be used for cancer diagnostics and monitoring. A new study describes a sequencing-based method that improves upon the sensitivity and specificity achieved by past techniques for detecting ctDNA and that can be used for monitoring of disease burden in patients with non–small-cell lung cancer ( pages 548–554 ).
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Commentary-1
ISSN:	1078-8956 1546-170X
DOI:	10.1038/nm.3564