Selection for spiral waves in the social amoebae Dictyostelium
Starving Dictyostelium amoebae emit pulses of the chemoattractant cAMP that are relayed from cell to cell as circular and spiral waves. We have recently modeled spiral wave formation in Dictyostelium. Our model suggests that a secreted protein inhibitor of an extracellular cAMP phosphodiesterase sel...
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| Published in: | Proceedings of the National Academy of Sciences - PNAS Vol. 94; no. 25; pp. 13719 - 13723 |
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| Language: | English |
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National Academy of Sciences of the United States of America
09-12-1997
National Acad Sciences National Academy of Sciences The National Academy of Sciences of the USA |
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| Abstract | Starving Dictyostelium amoebae emit pulses of the chemoattractant cAMP that are relayed from cell to cell as circular and spiral waves. We have recently modeled spiral wave formation in Dictyostelium. Our model suggests that a secreted protein inhibitor of an extracellular cAMP phosphodiesterase selects for spirals. Herein we test the essential features of this prediction by comparing wave propagation in wild type and inhibitor mutants. We find that mutants rarely form spirals. The territory size of mutant strains is approximately 50 times smaller than wild type, and the mature fruiting bodies are smaller but otherwise normal. These results identify a mechanism for selecting one wave symmetry over another in an excitable system and suggest that the phosphodiesterase inhibitor may be under selection because it helps regulate territory size |
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| AbstractList | Starving Dictyostelium amoebae emit pulses of the chemoattractant cAMP that are relayed from cell to cell as circular and spiral waves. We have recently modeled spiral wave formation in Dictyostelium . Our model suggests that a secreted protein inhibitor of an extracellular cAMP phosphodiesterase selects for spirals. Herein we test the essential features of this prediction by comparing wave propagation in wild type and inhibitor mutants. We find that mutants rarely form spirals. The territory size of mutant strains is approximately 50 times smaller than wild type, and the mature fruiting bodies are smaller but otherwise normal. These results identify a mechanism for selecting one wave symmetry over another in an excitable system and suggest that the phosphodiesterase inhibitor may be under selection because it helps regulate territory size. Starving Dictyostelium amoebae emit pulses of the chemoattractant cAMP that are relayed from cell to cell as circular and spiral waves. We have recently modeled spiral wave formation in Dictyostelium. Our model suggests that a secreted protein inhibitor of an extracellular cAMP phosphodiesterase selects for spirals. Herein we test the essential features of this prediction by comparing wave propagation in wild type and inhibitor mutants. We find that mutants rarely form spirals. The territory size of mutant strains is approximately 50 times smaller than wild type, and the mature fruiting bodies are smaller but otherwise normal. These results identify a mechanism for selecting one wave symmetry over another in an excitable system and suggest that the phosphodiesterase inhibitor may be under selection because it helps regulate territory size Starving Dictyostelium amoebae emit pulses of the chemoattractant cAMP that are relayed from cell to cell as circular and spiral waves. A model of spiral wave formation in Dictyostelium suggests that a secreted protein inhibitor of an extracellular cAMP phosphodiesterase selects for spirals. Starving Dictyostelium amoebae emit pulses of the chemoattractant cAMP that are relayed from cell to cell as circular and spiral waves. We have recently modeled spiral wave formation in Dictyostelium . Our model suggests that a secreted protein inhibitor of an extracellular cAMP phosphodiesterase selects for spirals. Herein we test the essential features of this prediction by comparing wave propagation in wild type and inhibitor mutants. We find that mutants rarely form spirals. The territory size of mutant strains is approximately 50 times smaller than wild type, and the mature fruiting bodies are smaller but otherwise normal. These results identify a mechanism for selecting one wave symmetry over another in an excitable system and suggest that the phosphodiesterase inhibitor may be under selection because it helps regulate territory size. |
| Author | Cox, E.C Franke, J Lee, K.J Goldstein, R.E Palsson, E Kessin, R.H |
| AuthorAffiliation | Department of Molecular Biology and ‡ Department of Physics, Princeton University, Princeton, NJ 08544; and ‖ Department of Anatomy and Cell Biology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032 |
| AuthorAffiliation_xml | – name: Department of Molecular Biology and ‡ Department of Physics, Princeton University, Princeton, NJ 08544; and ‖ Department of Anatomy and Cell Biology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032 |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/9391092$$D View this record in MEDLINE/PubMed |
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| Copyright | Copyright 1993-1997 National Academy of Sciences Copyright National Academy of Sciences Dec 9, 1997 Copyright © 1997, The National Academy of Sciences of the USA 1997 |
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| Notes | F60 1997067899 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 To whom reprint requests should be addressed. e-mail: ecox@pucc.princeton.edu. Current address: Department of Mathematics, University of Utah, Salt Lake City, UT 84102. Communicated by J. T. Bonner, Princeton University, Princeton, NJ Current address: Department of Physics, Korea University, Sungbuk-Gu, Anam-Dong 5-1, Seoul, 136-701, Korea. Current address: Department of Physics, University of Arizona, Tucson, AZ 85121. |
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| References | Waddell D R (e_1_3_3_17_2) 1982; 70 e_1_3_3_6_2 e_1_3_3_8_2 e_1_3_3_7_2 e_1_3_3_9_2 e_1_3_3_16_2 e_1_3_3_19_2 e_1_3_3_18_2 e_1_3_3_13_2 e_1_3_3_24_2 e_1_3_3_12_2 e_1_3_3_23_2 e_1_3_3_15_2 e_1_3_3_14_2 e_1_3_3_2_2 e_1_3_3_20_2 e_1_3_3_1_2 e_1_3_3_4_2 Pálsson E (e_1_3_3_5_2) 1997 e_1_3_3_11_2 e_1_3_3_22_2 e_1_3_3_3_2 e_1_3_3_10_2 e_1_3_3_21_2 |
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| Snippet | Starving Dictyostelium amoebae emit pulses of the chemoattractant cAMP that are relayed from cell to cell as circular and spiral waves. We have recently... Starving Dictyostelium amoebae emit pulses of the chemoattractant cAMP that are relayed from cell to cell as circular and spiral waves. We have recently... Starving Dictyostelium amoebae emit pulses of the chemoattractant cAMP that are relayed from cell to cell as circular and spiral waves. A model of spiral wave... |
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| SubjectTerms | 3',5'-Cyclic-AMP Phosphodiesterases - antagonists & inhibitors 3',5'-Cyclic-AMP Phosphodiesterases - physiology Aggregation AMP Animals BIOCHEMISTRY BIOCHIMIE Biological Sciences Biology BIOQUIMICA C-AMP CAMP PHOSPHODIESTERASE Circles Computer Simulation Cyclic AMP - physiology CYTOCHEMISTRY Developmental biology DICTYOSTELIUM Dictyostelium - cytology Dictyostelium - genetics Dictyostelium - physiology DICTYOSTELIUM DISCOIDEUM DIMENSION DIMENSIONS DISTRIBUCION ESPACIAL DISTRIBUTION SPATIALE ENZYME INHIBITORS Enzyme Inhibitors - metabolism ESTERASAS ESTERASE ESTERASES Fruiting bodies INHIBIDORES DE ENZIMAS INHIBITEUR D'ENZYME Models, Biological Movement MUTANT MUTANTES MUTANTS Mutation Oscillators PATTERNS Phase plane PHOSPHORIC DIESTER HYDROLASES PROTEINAS PROTEINE PROTEINS Protozoa SECRECION SECRETION Signal Transduction - physiology SIZE SPATIAL DISTRIBUTION Starvation Wave propagation Waves |
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| Title | Selection for spiral waves in the social amoebae Dictyostelium |
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