Selection for spiral waves in the social amoebae Dictyostelium

Starving Dictyostelium amoebae emit pulses of the chemoattractant cAMP that are relayed from cell to cell as circular and spiral waves. We have recently modeled spiral wave formation in Dictyostelium. Our model suggests that a secreted protein inhibitor of an extracellular cAMP phosphodiesterase sel...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 94; no. 25; pp. 13719 - 13723
Main Authors:	Palsson, E, Lee, K.J, Goldstein, R.E, Franke, J, Kessin, R.H, Cox, E.C
Format:	Journal Article
Language:	English
Published:	United States National Academy of Sciences of the United States of America 09-12-1997 National Acad Sciences National Academy of Sciences The National Academy of Sciences of the USA
Subjects:	3',5'-Cyclic-AMP Phosphodiesterases - antagonists & inhibitors 3',5'-Cyclic-AMP Phosphodiesterases - physiology Aggregation AMP Animals BIOCHEMISTRY BIOCHIMIE Biological Sciences Biology BIOQUIMICA C-AMP CAMP PHOSPHODIESTERASE Circles Computer Simulation Cyclic AMP - physiology CYTOCHEMISTRY Developmental biology DICTYOSTELIUM Dictyostelium - cytology Dictyostelium - genetics Dictyostelium - physiology DICTYOSTELIUM DISCOIDEUM DIMENSION DIMENSIONS DISTRIBUCION ESPACIAL DISTRIBUTION SPATIALE ENZYME INHIBITORS Enzyme Inhibitors - metabolism ESTERASAS ESTERASE ESTERASES Fruiting bodies INHIBIDORES DE ENZIMAS INHIBITEUR D'ENZYME Models, Biological Movement MUTANT MUTANTES MUTANTS Mutation Oscillators PATTERNS Phase plane PHOSPHORIC DIESTER HYDROLASES PROTEINAS PROTEINE PROTEINS Protozoa SECRECION SECRETION Signal Transduction - physiology SIZE SPATIAL DISTRIBUTION Starvation Wave propagation Waves
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Summary:	Starving Dictyostelium amoebae emit pulses of the chemoattractant cAMP that are relayed from cell to cell as circular and spiral waves. We have recently modeled spiral wave formation in Dictyostelium. Our model suggests that a secreted protein inhibitor of an extracellular cAMP phosphodiesterase selects for spirals. Herein we test the essential features of this prediction by comparing wave propagation in wild type and inhibitor mutants. We find that mutants rarely form spirals. The territory size of mutant strains is approximately 50 times smaller than wild type, and the mature fruiting bodies are smaller but otherwise normal. These results identify a mechanism for selecting one wave symmetry over another in an excitable system and suggest that the phosphodiesterase inhibitor may be under selection because it helps regulate territory size
Bibliography:	F60 1997067899 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 To whom reprint requests should be addressed. e-mail: ecox@pucc.princeton.edu. Current address: Department of Mathematics, University of Utah, Salt Lake City, UT 84102. Communicated by J. T. Bonner, Princeton University, Princeton, NJ Current address: Department of Physics, Korea University, Sungbuk-Gu, Anam-Dong 5-1, Seoul, 136-701, Korea. Current address: Department of Physics, University of Arizona, Tucson, AZ 85121.
ISSN:	0027-8424 1091-6490
DOI:	10.1073/pnas.94.25.13719