The Intricate Relationship between Type 2 Diabetes Mellitus (T2DM), Insulin Resistance (IR), and Nonalcoholic Fatty Liver Disease (NAFLD)

• Published in: Journal of diabetes research Vol. 2020; no. 2020; pp. 1 - 16
• Main Authors: Floria, Mariana, Maranduca, Minela Aida, Lacatusu, Cristina Mihaela, Ciocoiu, Manuela, Costea, Claudia Florida, Gosav, Evelina Maria, Tanase, Daniela-Maria, Ouatu, Anca
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 2020; Hindawi; Hindawi Limited
• Subjects: Apoptosis; Diabetes; Fatty acids; Gene expression; Glucose; Glycerol; Homeostasis; Inflammation; Insulin resistance; Kinases; Lipid peroxidation; Lipids; Liver diseases; Metabolic disorders; Metabolic syndrome; Obesity; Oxidation; Oxidative stress; Proteins; Review; Tumor necrosis factor-TNF
• ISSN: 2314-6745; 2314-6753
• DOI: 10.1155/2020/3920196

Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) remain as one of the most global problematic metabolic diseases with rapidly increasing prevalence and incidence. Epidemiological studies noted that T2DM patients have by two-fold increase to develop NAFLD, and vice versa. This complex and intricate association is supported and mediated by insulin resistance (IR). In this review, we discuss the NAFLD immunopathogenesis, connection with IR and T2DM, the role of screening and noninvasive tools, and mostly the impact of the current antidiabetic drugs on steatosis liver and new potential therapeutic targets.