PARTICLE - a triplex-forming long ncRNA regulates locus specific methylation in response to low dose irradiation

Exposure to low dose irradiation causes transiently elevated expression of a long ncRNA PARTICLE (Gene PARTICL- 'Promoter of MAT2A-Antisense RadiaTion Induced Circulating LncRNA). PARTICLE affords both a cytosolic scaffold for th e tumor suppressor methionine adenosyltransferase (MAT2A) and a n...

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Published in:	Cell reports (Cambridge) Vol. 11; no. 3; pp. 474 - 485
Main Authors:	O'Leary, Valerie Bríd, Ovsepian, Saak Victor, Carrascosa, Laura Garcia, Buske, Fabian Andreas, Radulovic, Vanja, Niyazi, Maximilian, Moertl, Simone, Trau, Matt, Atkinson, MichaelJohn, Anastasov, Nataša
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 21-04-2015 Elsevier
Subjects:	Carcinoma, Squamous Cell - radiotherapy Cell Line Chromatin Immunoprecipitation DNA Methylation - genetics DNA Methylation - radiation effects Electrophoretic Mobility Shift Assay Gene Expression Regulation - radiation effects Head and Neck Neoplasms - radiotherapy Humans Immunoblotting In Situ Hybridization Methionine Adenosyltransferase - biosynthesis Methionine Adenosyltransferase - genetics Oligonucleotide Array Sequence Analysis Radiation, Ionizing RNA, Long Noncoding - biosynthesis RNA, Long Noncoding - genetics Squamous Cell Carcinoma of Head and Neck Surface Plasmon Resonance
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Abstract	Exposure to low dose irradiation causes transiently elevated expression of a long ncRNA PARTICLE (Gene PARTICL- 'Promoter of MAT2A-Antisense RadiaTion Induced Circulating LncRNA). PARTICLE affords both a cytosolic scaffold for th e tumor suppressor methionine adenosyltransferase (MAT2A) and a nuclear genetic platform for transcriptional repression. In situ hybridisation discloses that PARTICLE-MAT2A associate together following irradiation. Bromouridine tracing and presence in exosomes indicate intercellular transport, and this is supported by ex-vivo data from radiotherapy-treated patients. Surface plasmon resonance indicates that PARTICLE forms a DNA-lncRNA triplex upstream of a MAT2A promoter CpG island. We show that PARTICLE represses MAT2A via methylation and demonstrate that the radiation-induced PARTICLE lncRNA interacts with the transcription repressive complex proteins G9a and SUZ12 (subunit of PRC2). The interplay of PARTICLE with MAT2A, implicates this lncRNA in intercellular communication as well as a recruitment platform for gene silencing machineries through triplex formation in response to irradiation. [Display omitted]
AbstractList	Exposure to low-dose irradiation causes transiently elevated expression of the long ncRNA PARTICLE (gene PARTICLE, promoter of MAT2A-antisense radiation-induced circulating lncRNA). PARTICLE affords both a cytosolic scaffold for the tumor suppressor methionine adenosyltransferase (MAT2A) and a nuclear genetic platform for transcriptional repression. In situ hybridization discloses that PARTICLE and MAT2A associate together following irradiation. Bromouridine tracing and presence in exosomes indicate intercellular transport, and this is supported by ex vivo data from radiotherapy-treated patients. Surface plasmon resonance indicates that PARTICLE forms a DNA-lncRNA triplex upstream of a MAT2A promoter CpG island. We show that PARTICLE represses MAT2A via methylation and demonstrate that the radiation-induced PARTICLE interacts with the transcription-repressive complex proteins G9a and SUZ12 (subunit of PRC2). The interplay of PARTICLE with MAT2A implicates this lncRNA in intercellular communication and as a recruitment platform for gene-silencing machineries through triplex formation in response to irradiation. Exposure to low dose irradiation causes transiently elevated expression of a long ncRNA PARTICLE (Gene PARTICL- 'Promoter of MAT2A-Antisense RadiaTion Induced Circulating LncRNA). PARTICLE affords both a cytosolic scaffold for th e tumor suppressor methionine adenosyltransferase (MAT2A) and a nuclear genetic platform for transcriptional repression. In situ hybridisation discloses that PARTICLE-MAT2A associate together following irradiation. Bromouridine tracing and presence in exosomes indicate intercellular transport, and this is supported by ex-vivo data from radiotherapy-treated patients. Surface plasmon resonance indicates that PARTICLE forms a DNA-lncRNA triplex upstream of a MAT2A promoter CpG island. We show that PARTICLE represses MAT2A via methylation and demonstrate that the radiation-induced PARTICLE lncRNA interacts with the transcription repressive complex proteins G9a and SUZ12 (subunit of PRC2). The interplay of PARTICLE with MAT2A, implicates this lncRNA in intercellular communication as well as a recruitment platform for gene silencing machineries through triplex formation in response to irradiation. [Display omitted] Exposure to low-dose irradiation causes transiently elevated expression of the long ncRNA PARTICLE (gene PARTICLE, promoter of MAT2A-antisense radiation-induced circulating lncRNA). PARTICLE affords both a cytosolic scaffold for the tumor suppressor methionine adenosyltransferase (MAT2A) and a nuclear genetic platform for transcriptional repression. In situ hybridization discloses that PARTICLE and MAT2A associate together following irradiation. Bromouridine tracing and presence in exosomes indicate intercellular transport, and this is supported by ex vivo data from radiotherapy-treated patients. Surface plasmon resonance indicates that PARTICLE forms a DNA-lncRNA triplex upstream of a MAT2A promoter CpG island. We show that PARTICLE represses MAT2A via methylation and demonstrate that the radiation-induced PARTICLE interacts with the transcription-repressive complex proteins G9a and SUZ12 (subunit of PRC2). The interplay of PARTICLE with MAT2A implicates this lncRNA in intercellular communication and as a recruitment platform for gene-silencing machineries through triplex formation in response to irradiation.
Author	Trau, Matt Buske, Fabian Andreas Atkinson, MichaelJohn Carrascosa, Laura Garcia Anastasov, Nataša Radulovic, Vanja Ovsepian, Saak Victor Moertl, Simone Niyazi, Maximilian O'Leary, Valerie Bríd
Author_xml	– sequence: 1 givenname: Valerie Bríd surname: O'Leary fullname: O'Leary, Valerie Bríd email: valerie.oleary@helmholtz-muenchen.de organization: Institute of Radiation Biology, Helmholtz Zentrum Munich - German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany – sequence: 2 givenname: Saak Victor surname: Ovsepian fullname: Ovsepian, Saak Victor organization: DZNE, Ludwig-Maximilian-Universität Munich, Zentrum für Neuropathologie, 81377 Munich, Germany – sequence: 3 givenname: Laura Garcia surname: Carrascosa fullname: Carrascosa, Laura Garcia organization: Centre for Personalized Nanomedicine, Australian Institute for Bio-engineering and Nanotechnology, The University of Queensland, Corner College and Cooper Roads, Brisbane, 4072 Queensland, Australia – sequence: 4 givenname: Fabian Andreas surname: Buske fullname: Buske, Fabian Andreas organization: Kinghorn Cancer Centre, Garvan Institute of Medical Research, 384 Victoria St., Darlinghurst, Syndey, NSW 2010, Australia – sequence: 5 givenname: Vanja surname: Radulovic fullname: Radulovic, Vanja organization: Institute of Radiation Biology, Helmholtz Zentrum Munich - German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany – sequence: 6 givenname: Maximilian surname: Niyazi fullname: Niyazi, Maximilian organization: Department of Radiation Oncology, Ludwig-Maximilian-Universität Munich, Marchianinistrasse 15, 81377 Munich, Germany – sequence: 7 givenname: Simone surname: Moertl fullname: Moertl, Simone organization: Institute of Radiation Biology, Helmholtz Zentrum Munich - German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany – sequence: 8 givenname: Matt surname: Trau fullname: Trau, Matt organization: Centre for Personalized Nanomedicine, Australian Institute for Bio-engineering and Nanotechnology, The University of Queensland, Corner College and Cooper Roads, Brisbane, 4072 Queensland, Australia – sequence: 9 givenname: MichaelJohn surname: Atkinson fullname: Atkinson, MichaelJohn organization: Institute of Radiation Biology, Helmholtz Zentrum Munich - German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany – sequence: 10 givenname: Nataša surname: Anastasov fullname: Anastasov, Nataša organization: Institute of Radiation Biology, Helmholtz Zentrum Munich - German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany
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Cites_doi	10.1186/gb-2014-15-1-r6 10.1038/nature08975 10.1002/0471143030.cb0322s30 10.1186/1479-5876-9-9 10.1016/j.canlet.2013.09.009 10.1016/j.mrfmmm.2004.03.011 10.1093/hmg/ddq353 10.1126/science.1147182 10.1016/j.cell.2007.03.036 10.1016/j.mrrev.2012.12.001 10.1101/gad.380906 10.1042/bj2930481 10.1038/ng.848 10.1038/nsmb0207-103 10.1371/journal.pone.0050329 10.1007/s10238-012-0181-x 10.1126/science.1192002 10.1186/1748-717X-7-206 10.1074/jbc.M101914200 10.1016/j.cell.2007.05.022 10.1016/j.cellsig.2013.02.006 10.1096/fj.01-0040com 10.1016/j.molcel.2013.12.005 10.1186/1748-717X-8-296 10.1038/ncb1685 10.1021/ac502214z 10.1101/gr.130237.111 10.1016/S0168-9525(97)01013-5 10.1016/j.molcel.2011.08.018 10.4161/cc.25795 10.4161/epi.4.5.9282 10.1002/wrna.1194 10.1016/j.stem.2010.08.004 10.1039/C3CC49607D 10.1038/nrc2677 10.1093/nar/gkq1138 10.1038/nature09784 10.1007/s00411-010-0342-9 10.1126/science.1103388 10.1016/S0163-7258(96)00197-0 10.1038/nature06992
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References	Margueron (10.1016/j.celrep.2015.03.043_bib18) 2011; 469 Struhl (10.1016/j.celrep.2015.03.043_bib29) 2007; 14 Wan (10.1016/j.celrep.2015.03.043_bib37) 2013; 25 Morris (10.1016/j.celrep.2015.03.043_bib21) 2009; 4 Sina (10.1016/j.celrep.2015.03.043_bib28) 2014; 86 Summerer (10.1016/j.celrep.2015.03.043_bib30) 2013; 8 Morgan (10.1016/j.celrep.2015.03.043_bib20) 2015; 356 Yang (10.1016/j.celrep.2015.03.043_bib40) 2001; 15 Anastasov (10.1016/j.celrep.2015.03.043_bib3) 2012; 7 Conrad (10.1016/j.celrep.2015.03.043_bib10) 2014; 5 Tsai (10.1016/j.celrep.2015.03.043_bib34) 2010; 329 Wang (10.1016/j.celrep.2015.03.043_bib38) 2011; 43 Kadhim (10.1016/j.celrep.2015.03.043_bib15) 2013; 752 Mozzetta (10.1016/j.celrep.2015.03.043_bib22) 2014; 53 Zhang (10.1016/j.celrep.2015.03.043_bib41) 2007; 129 Amaral (10.1016/j.celrep.2015.03.043_bib2) 2011; 39 Huarte (10.1016/j.celrep.2015.03.043_bib13) 2010; 19 Mato (10.1016/j.celrep.2015.03.043_bib19) 1997; 73 van Heesch (10.1016/j.celrep.2015.03.043_bib35) 2014; 15 Waldren (10.1016/j.celrep.2015.03.043_bib36) 2004; 551 Carrascosa (10.1016/j.celrep.2015.03.043_bib8) 2014; 50 Théry (10.1016/j.celrep.2015.03.043_bib33) 2006; Chapter 3 Campbell (10.1016/j.celrep.2015.03.043_bib7) 2013; 12 Gupta (10.1016/j.celrep.2015.03.043_bib12) 2010; 464 Surface (10.1016/j.celrep.2015.03.043_bib31) 2010; 7 Pluder (10.1016/j.celrep.2015.03.043_bib25) 2011; 50 Wang (10.1016/j.celrep.2015.03.043_bib39) 2008; 454 Alvarez (10.1016/j.celrep.2015.03.043_bib1) 1993; 293 Tachibana (10.1016/j.celrep.2015.03.043_bib32) 2001; 276 Azzalin (10.1016/j.celrep.2015.03.043_bib4) 2007; 318 Schoeftner (10.1016/j.celrep.2015.03.043_bib27) 2008; 10 Lässer (10.1016/j.celrep.2015.03.043_bib17) 2011; 9 Mullenders (10.1016/j.celrep.2015.03.043_bib23) 2009; 9 Chaumeil (10.1016/j.celrep.2015.03.043_bib9) 2006; 20 González (10.1016/j.celrep.2015.03.043_bib11) 2012; 7 Özgür (10.1016/j.celrep.2015.03.043_bib24) 2013; 13 Bertone (10.1016/j.celrep.2015.03.043_bib5) 2004; 306 Kotb (10.1016/j.celrep.2015.03.043_bib16) 1997; 13 Buske (10.1016/j.celrep.2015.03.043_bib6) 2012; 22 Hung (10.1016/j.celrep.2015.03.043_bib14) 2011; 43 Rinn (10.1016/j.celrep.2015.03.043_bib26) 2007; 129
References_xml	– volume: 15 start-page: R6 year: 2014 ident: 10.1016/j.celrep.2015.03.043_bib35 article-title: Extensive localization of long noncoding RNAs to the cytosol and mono- and polyribosomal complexes publication-title: Genome Biol. doi: 10.1186/gb-2014-15-1-r6 contributor: fullname: van Heesch – volume: 464 start-page: 1071 year: 2010 ident: 10.1016/j.celrep.2015.03.043_bib12 article-title: Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis publication-title: Nature doi: 10.1038/nature08975 contributor: fullname: Gupta – volume: Chapter 3 year: 2006 ident: 10.1016/j.celrep.2015.03.043_bib33 article-title: Isolation and characterization of exosomes from cell culture supernatants and biological fluids publication-title: Curr. Protoc. Cell Biol. doi: 10.1002/0471143030.cb0322s30 contributor: fullname: Théry – volume: 9 start-page: 9 year: 2011 ident: 10.1016/j.celrep.2015.03.043_bib17 article-title: Human saliva, plasma and breast milk exosomes contain RNA: uptake by macrophages publication-title: J. Transl. Med. doi: 10.1186/1479-5876-9-9 contributor: fullname: Lässer – volume: 356 start-page: 17 year: 2015 ident: 10.1016/j.celrep.2015.03.043_bib20 article-title: Non-targeted effects induced by ionizing radiation: mechanisms and potential impact on radiation induced health effects publication-title: Cancer Lett. doi: 10.1016/j.canlet.2013.09.009 contributor: fullname: Morgan – volume: 551 start-page: 255 year: 2004 ident: 10.1016/j.celrep.2015.03.043_bib36 article-title: A role for long-lived radicals (LLR) in radiation-induced mutation and persistent chromosomal instability: counteraction by ascorbate and RibCys but not DMSO publication-title: Mutat. Res. doi: 10.1016/j.mrfmmm.2004.03.011 contributor: fullname: Waldren – volume: 19 start-page: R152 issue: R2 year: 2010 ident: 10.1016/j.celrep.2015.03.043_bib13 article-title: Large non-coding RNAs: missing links in cancer? publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddq353 contributor: fullname: Huarte – volume: 318 start-page: 798 year: 2007 ident: 10.1016/j.celrep.2015.03.043_bib4 article-title: Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends publication-title: Science doi: 10.1126/science.1147182 contributor: fullname: Azzalin – volume: 129 start-page: 693 year: 2007 ident: 10.1016/j.celrep.2015.03.043_bib41 article-title: Perinucleolar targeting of the inactive X during S phase: evidence for a role in the maintenance of silencing publication-title: Cell doi: 10.1016/j.cell.2007.03.036 contributor: fullname: Zhang – volume: 752 start-page: 84 year: 2013 ident: 10.1016/j.celrep.2015.03.043_bib15 article-title: Non-targeted effects of ionising radiation-Implications for low dose risk publication-title: Mutat. Res. doi: 10.1016/j.mrrev.2012.12.001 contributor: fullname: Kadhim – volume: 20 start-page: 2223 year: 2006 ident: 10.1016/j.celrep.2015.03.043_bib9 article-title: A novel role for Xist RNA in the formation of a repressive nuclear compartment into which genes are recruited when silenced publication-title: Genes Dev. doi: 10.1101/gad.380906 contributor: fullname: Chaumeil – volume: 293 start-page: 481 year: 1993 ident: 10.1016/j.celrep.2015.03.043_bib1 article-title: Characterization of a full-length cDNA encoding human liver S-adenosylmethionine synthetase: tissue-specific gene expression and mRNA levels in hepatopathies publication-title: Biochem. J. doi: 10.1042/bj2930481 contributor: fullname: Alvarez – volume: 43 start-page: 621 year: 2011 ident: 10.1016/j.celrep.2015.03.043_bib14 article-title: Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters publication-title: Nat. Genet. doi: 10.1038/ng.848 contributor: fullname: Hung – volume: 14 start-page: 103 year: 2007 ident: 10.1016/j.celrep.2015.03.043_bib29 article-title: Transcriptional noise and the fidelity of initiation by RNA polymerase II publication-title: Nat. Struct. Mol. Biol. doi: 10.1038/nsmb0207-103 contributor: fullname: Struhl – volume: 7 start-page: e50329 year: 2012 ident: 10.1016/j.celrep.2015.03.043_bib11 article-title: NADP+ binding to the regulatory subunit of methionine adenosyltransferase II increases intersubunit binding affinity in the hetero-trimer publication-title: PLoS ONE doi: 10.1371/journal.pone.0050329 contributor: fullname: González – volume: 13 start-page: 119 year: 2013 ident: 10.1016/j.celrep.2015.03.043_bib24 article-title: Differential expression of long non-coding RNAs during genotoxic stress-induced apoptosis in HeLa and MCF-7 cells publication-title: Clin. Exp. Med. doi: 10.1007/s10238-012-0181-x contributor: fullname: Özgür – volume: 329 start-page: 689 year: 2010 ident: 10.1016/j.celrep.2015.03.043_bib34 article-title: Long noncoding RNA as modular scaffold of histone modification complexes publication-title: Science doi: 10.1126/science.1192002 contributor: fullname: Tsai – volume: 7 start-page: 206 year: 2012 ident: 10.1016/j.celrep.2015.03.043_bib3 article-title: Radiation resistance due to high expression of miR-21 and G2/M checkpoint arrest in breast cancer cells publication-title: Radiat. Oncol. doi: 10.1186/1748-717X-7-206 contributor: fullname: Anastasov – volume: 276 start-page: 25309 year: 2001 ident: 10.1016/j.celrep.2015.03.043_bib32 article-title: Set domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M101914200 contributor: fullname: Tachibana – volume: 129 start-page: 1311 year: 2007 ident: 10.1016/j.celrep.2015.03.043_bib26 article-title: Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs publication-title: Cell doi: 10.1016/j.cell.2007.05.022 contributor: fullname: Rinn – volume: 25 start-page: 1086 year: 2013 ident: 10.1016/j.celrep.2015.03.043_bib37 article-title: Long non-coding RNA ANRIL (CDKN2B-AS) is induced by the ATM-E2F1 signaling pathway publication-title: Cell. Signal. doi: 10.1016/j.cellsig.2013.02.006 contributor: fullname: Wan – volume: 15 start-page: 1507 year: 2001 ident: 10.1016/j.celrep.2015.03.043_bib40 article-title: The role of c-Myb and Sp1 in the up-regulation of methionine adenosyltransferase 2A gene expression in human hepatocellular carcinoma publication-title: FASEB J. doi: 10.1096/fj.01-0040com contributor: fullname: Yang – volume: 53 start-page: 277 year: 2014 ident: 10.1016/j.celrep.2015.03.043_bib22 article-title: The histone H3 lysine 9 methyltransferases G9a and GLP regulate polycomb repressive complex 2-mediated gene silencing publication-title: Mol. Cell doi: 10.1016/j.molcel.2013.12.005 contributor: fullname: Mozzetta – volume: 8 start-page: 296 year: 2013 ident: 10.1016/j.celrep.2015.03.043_bib30 article-title: Changes in circulating microRNAs after radiochemotherapy in head and neck cancer patients publication-title: Radiat. Oncol. doi: 10.1186/1748-717X-8-296 contributor: fullname: Summerer – volume: 10 start-page: 228 year: 2008 ident: 10.1016/j.celrep.2015.03.043_bib27 article-title: Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II publication-title: Nat. Cell Biol. doi: 10.1038/ncb1685 contributor: fullname: Schoeftner – volume: 86 start-page: 10179 year: 2014 ident: 10.1016/j.celrep.2015.03.043_bib28 article-title: Methylsorb: a simple method for quantifying DNA methylation using DNA-gold affinity interactions publication-title: Anal. Chem. doi: 10.1021/ac502214z contributor: fullname: Sina – volume: 22 start-page: 1372 year: 2012 ident: 10.1016/j.celrep.2015.03.043_bib6 article-title: Triplexator: detecting nucleic acid triple helices in genomic and transcriptomic data publication-title: Genome Res. doi: 10.1101/gr.130237.111 contributor: fullname: Buske – volume: 13 start-page: 51 year: 1997 ident: 10.1016/j.celrep.2015.03.043_bib16 article-title: Consensus nomenclature for the mammalian methionine adenosyltransferase genes and gene products publication-title: Trends Genet. doi: 10.1016/S0168-9525(97)01013-5 contributor: fullname: Kotb – volume: 43 start-page: 904 year: 2011 ident: 10.1016/j.celrep.2015.03.043_bib38 article-title: Molecular mechanisms of long noncoding RNAs publication-title: Mol. Cel1 doi: 10.1016/j.molcel.2011.08.018 contributor: fullname: Wang – volume: 12 start-page: 2675 year: 2013 ident: 10.1016/j.celrep.2015.03.043_bib7 article-title: Polycomb repressive complex 2 contributes to DNA double-strand break repair publication-title: Cell Cycle doi: 10.4161/cc.25795 contributor: fullname: Campbell – volume: 4 start-page: 296 year: 2009 ident: 10.1016/j.celrep.2015.03.043_bib21 article-title: Long antisense non-coding RNAs function to direct epigenetic complexes that regulate transcription in human cells publication-title: Epigenetics doi: 10.4161/epi.4.5.9282 contributor: fullname: Morris – volume: 5 start-page: 15 year: 2014 ident: 10.1016/j.celrep.2015.03.043_bib10 article-title: The emerging role of triple helices in RNA biology publication-title: Wiley Interdiscip. Rev. RNA doi: 10.1002/wrna.1194 contributor: fullname: Conrad – volume: 7 start-page: 288 year: 2010 ident: 10.1016/j.celrep.2015.03.043_bib31 article-title: Polycomb group proteins set the stage for early lineage commitment publication-title: Cell Stem Cell doi: 10.1016/j.stem.2010.08.004 contributor: fullname: Surface – volume: 50 start-page: 3585 year: 2014 ident: 10.1016/j.celrep.2015.03.043_bib8 article-title: Molecular inversion probe-based SPR biosensing for specific, label-free and real-time detection of regional DNA methylation publication-title: Chem. Commun. (Camb.) doi: 10.1039/C3CC49607D contributor: fullname: Carrascosa – volume: 9 start-page: 596 year: 2009 ident: 10.1016/j.celrep.2015.03.043_bib23 article-title: Assessing cancer risks of low-dose radiation publication-title: Nat. Rev. Cancer doi: 10.1038/nrc2677 contributor: fullname: Mullenders – volume: 39 start-page: D146 year: 2011 ident: 10.1016/j.celrep.2015.03.043_bib2 article-title: lncRNAdb: a reference database for long noncoding RNAs publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkq1138 contributor: fullname: Amaral – volume: 469 start-page: 343 year: 2011 ident: 10.1016/j.celrep.2015.03.043_bib18 article-title: The Polycomb complex PRC2 and its mark in life publication-title: Nature doi: 10.1038/nature09784 contributor: fullname: Margueron – volume: 50 start-page: 155 year: 2011 ident: 10.1016/j.celrep.2015.03.043_bib25 article-title: Low-dose irradiation causes rapid alterations to the proteome of the human endothelial cell line EA.hy926 publication-title: Radiat. Environ. Biophys. doi: 10.1007/s00411-010-0342-9 contributor: fullname: Pluder – volume: 306 start-page: 2242 year: 2004 ident: 10.1016/j.celrep.2015.03.043_bib5 article-title: Global identification of human transcribed sequences with genome tiling arrays publication-title: Science doi: 10.1126/science.1103388 contributor: fullname: Bertone – volume: 73 start-page: 265 year: 1997 ident: 10.1016/j.celrep.2015.03.043_bib19 article-title: S-adenosylmethionine synthesis: molecular mechanisms and clinical implications publication-title: Pharmacol. Ther. doi: 10.1016/S0163-7258(96)00197-0 contributor: fullname: Mato – volume: 454 start-page: 126 year: 2008 ident: 10.1016/j.celrep.2015.03.043_bib39 article-title: Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription publication-title: Nature doi: 10.1038/nature06992 contributor: fullname: Wang
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Snippet	Exposure to low dose irradiation causes transiently elevated expression of a long ncRNA PARTICLE (Gene PARTICL- 'Promoter of MAT2A-Antisense RadiaTion Induced... Exposure to low-dose irradiation causes transiently elevated expression of the long ncRNA PARTICLE (gene PARTICLE, promoter of MAT2A-antisense...
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SubjectTerms	Carcinoma, Squamous Cell - radiotherapy Cell Line Chromatin Immunoprecipitation DNA Methylation - genetics DNA Methylation - radiation effects Electrophoretic Mobility Shift Assay Gene Expression Regulation - radiation effects Head and Neck Neoplasms - radiotherapy Humans Immunoblotting In Situ Hybridization Methionine Adenosyltransferase - biosynthesis Methionine Adenosyltransferase - genetics Oligonucleotide Array Sequence Analysis Radiation, Ionizing RNA, Long Noncoding - biosynthesis RNA, Long Noncoding - genetics Squamous Cell Carcinoma of Head and Neck Surface Plasmon Resonance
Title	PARTICLE - a triplex-forming long ncRNA regulates locus specific methylation in response to low dose irradiation
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