Carriers of Rare Missense Variants in IFIH1 Are Protected from Psoriasis

• Published in: Journal of investigative dermatology Vol. 130; no. 12; pp. 2768 - 2772
• Main Authors: Li, Yonghong, Liao, Wilson, Cargill, Michele, Chang, Monica, Matsunami, Nori, Feng, Bing-Jian, Poon, Annie, Callis-Duffin, Kristina P., Catanese, Joseph J., Bowcock, Anne M., Leppert, Mark F., Kwok, Pui-Yan, Krueger, Gerald G., Begovich, Ann B.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01-12-2010; Nature Publishing Group; Elsevier Limited
• Subjects: Adult; Autoimmunity - genetics; Biological and medical sciences; DEAD-box RNA Helicases - genetics; Dermatology; Female; Genetic Predisposition to Disease - epidemiology; Heterozygote; Humans; Interferon-Induced Helicase, IFIH1; Male; Medical sciences; Mutation, Missense; Polymorphism, Single Nucleotide; Psoriasis - epidemiology; Psoriasis - genetics; Psoriasis. Parapsoriasis. Lichen; Risk Factors; Psoriasis; Dermatology; Skin disease
• ISSN: 0022-202X; 1523-1747
• DOI: 10.1038/jid.2010.214

Testing of ∼25,000 putative functional single-nucleotide polymorphisms (SNPs) across the human genome in a genetic association study has identified three psoriasis genes, IL12B, IL23R, and IL13. We now report evidence for the association of psoriasis risk with missense SNPs in the interferon induced with helicase C domain 1 gene (IFIH1). The rare alleles of two independent SNPs were associated with decreased risk of psoriasis—rs35667974 (Ile923Val): odds ratio (OR) for minor allele carriers is 0.43, P=2.36 × 10−5 (2,098 cases vs. 1,748 controls); and rs10930046 (His460Arg): OR for minor allele carriers is 0.51, P=6.47 × 10−4 (2,098 cases vs. 1,744 controls). Compared to noncarriers, carriers of the 923Val and/or 460Arg variants were protected from psoriasis (OR=0.46, P=5.56 × 10−8). To our knowledge, these results suggest that IFIH1 is a previously unreported psoriasis gene.