Aortic Arch Replacement Using Selective Cerebral Perfusion

• Published in: The Annals of thoracic surgery Vol. 83; no. 2; pp. S796 - S798
• Main Authors: Kazui, Teruhisa, MD, PhD, Yamashita, Katsushi, MD, PhD, Washiyama, Naoki, MD, PhD, Terada, Hitoshi, MD, PhD, Bashar, Abul Hasan Muhammad, MBBS, PhD, Suzuki, Kazuchika, MD, PhD, Suzuki, Takayasu, MD
• Format: Journal Article Conference Proceeding
• Language: English
• Published: New York, NY Elsevier Inc 01-02-2007; Elsevier Science
• Subjects: Adult; Aged; Aged, 80 and over; Aneurysm, Dissecting - complications; Aneurysm, Dissecting - surgery; Aorta, Thoracic - surgery; Aortic Aneurysm - complications; Aortic Aneurysm - surgery; Biological and medical sciences; Blood Vessel Prosthesis Implantation - adverse effects; Blood Vessel Prosthesis Implantation - mortality; Brain - blood supply; Cardiothoracic Surgery; Female; Heart-Assist Devices; Hospital Mortality; Humans; Male; Medical Records; Medical sciences; Middle Aged; Nervous System Diseases - etiology; Perfusion - methods; Prognosis; Retrospective Studies; Stroke - complications; Surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the heart; Surgery of the respiratory system; Time Factors; Treatment; Respiratory disease; Perfusion; Aortic arch; Surgery; Replacement; Thorax; Encephalon
• ISSN: 0003-4975; 1552-6259
• DOI: 10.1016/j.athoracsur.2006.10.082

Background The present study was conducted to report our clinical experience with aortic arch replacement using selective cerebral perfusion (SCP) and determine the independent predictors of in-hospital mortality and neurologic outcome. Methods We studied 472 consecutive patients who underwent aortic arch replacement using SCP between January 1986 and February 2006. All operations were performed with the aid of hypothermic extracorporeal circulation, SCP, and in most cases, systemic circulatory arrest for open distal anastomosis. The etiology of aortic diseases included acute aortic dissection in 126 patients (27%), chronic aortic dissection in 102 (21%), and degenerative aneurysm in 245 (52%). Total arch replacement was performed in 420 patients (89%). Mean SCP time was 88 ± 32 minutes. Results The overall in-hospital mortality was 9.3%, but it dropped significantly to 4.1% in the most recent 266 patients. Independent predictors of in-hospital mortality were early series, renal/mesenteric ischemia, pump time, increasing age, chronic renal dysfunction, history of cerebrovascular accident (CVA), and previous ascending or arch operation. Overall postoperative temporary and permanent neurologic dysfunction were 4.7% and 3.2%, respectively. A history of CVA was the only predictor of temporary neurologic dysfunction, whereas CVA and pump time were independent predictors of permanent neurologic dysfunction. SCP time had no significant correlation with in-hospital mortality and neurologic outcome. Conclusions SCP facilitates complicated aortic arch replacement, resulting in a reduction of mortality and morbidity for arch aneurysms or dissections.