Therapeutic Targeting of Oncogenic Tyrosine Phosphatases

Protein tyrosine phosphatases (PTP) are exciting and novel targets for cancer drug discovery that work in concert with protein tyrosine kinases (PTK) in controlling cellular homeostasis. Given the activating role that some PTKs play in initiating growth factor-mediated cellular processes, PTPs are u...

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Bibliographic Details
Published in:	Cancer research (Chicago, Ill.) Vol. 77; no. 21; pp. 5701 - 5705
Main Authors:	Frankson, Rochelle, Yu, Zhi-Hong, Bai, Yunpeng, Li, Qinglin, Zhang, Ruo-Yu, Zhang, Zhong-Yin
Format:	Journal Article
Language:	English
Published:	United States American Association for Cancer Research, Inc 01-11-2017
Subjects:	1-Phosphatidylinositol 3-kinase AKT protein Animals Antineoplastic Agents - therapeutic use Autoimmune diseases Cancer Carcinogenesis - drug effects Carcinogenesis - genetics Drug discovery Extracellular signal-regulated kinase Homeostasis Homology Humans JNK protein Kinases Liver Metabolic disorders Molecular Targeted Therapy - methods Mutation Neoplasms - drug therapy Neoplasms - enzymology Neoplasms - genetics NF-κB protein Oncogenes - genetics Phosphatase Phosphorylation Protein Tyrosine Phosphatases - antagonists & inhibitors Protein Tyrosine Phosphatases - genetics Protein Tyrosine Phosphatases - metabolism Protein-tyrosine kinase PTEN protein Regulators Signal Transduction - drug effects Signal Transduction - genetics Src protein Therapeutic targets
Online Access:	Get full text
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