Early oseltamivir therapy improves the outcome in critically ill patients with influenza: a propensity analysis

• Published in: Intensive care medicine Vol. 44; no. 2; pp. 257 - 260
• Main Authors: Hernu, Romain, Chroboczek, Tomasz, Madelaine, Thomas, Casalegno, Jean-Sebastien, Lina, Bruno, Cour, Martin, Argaud, Laurent
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-02-2018; Springer; Springer Nature B.V; Springer Verlag
• Subjects: Aged; Analysis; Anesthesiology; Antiviral Agents - therapeutic use; Care and treatment; Critical Care Medicine; Critical Illness; Emergency Medicine; Female; Humans; Influenza; Influenza A; Influenza A Virus, H1N1 Subtype; Influenza, Human - drug therapy; Intensive; Letter; Life Sciences; Male; Medicine; Medicine & Public Health; Middle Aged; Oseltamivir; Oseltamivir - therapeutic use; Pain Medicine; Patient outcomes; Pediatrics; Pneumology/Respiratory System; Treatment Outcome; France; General & Internal Medicine
• ISSN: 0342-4642; 1432-1238
• DOI: 10.1007/s00134-017-4953-3

Influenza affects between two and three million people worldwide each year, with complications responsible for a significant number of excess hospitalizations in intensive care units (ICUs) [1]. Since the newsworthy 2009 A(H1N1) pandemic (pdm), publications about influenza in ICUs remain scarce, with crucial outstanding issues on prognosis factors including the timing of antiviral treatments [2, 3, 4, 5]. Here, we present a multicenter prospective study of critically ill influenza-infected patients aimed to identify prognosis factors associated with death.This study was conducted from December 2008 to April 2013 in the 12 polyvalent ICUs from the Lyon catchment area (France). All adult patients admitted with microbiologically confirmed influenza infection were included. Following univariate comparisons, the independent contribution of patients’ characteristics to in-hospital mortality was analyzed by backward stepwise multivariate analysis in a logistic regression model...