The effect of early versus delayed challenge after vaccination in controlling SHIV 89.6P infection

Abstract We sought to determine how effectively a CD8+ T cell inducing vaccine controls SHIV-89.6P infection in rhesus macaques at a range of challenge times post-vaccination. To this end, twenty eight Mamu-A⁎01+ rhesus macaques were given replication incompetent human serotype 5 adenovirus vector e...

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Bibliographic Details
Published in:	Virology (New York, N.Y.) Vol. 381; no. 1; pp. 75 - 80
Main Authors:	Chavez, Leslie L, Davenport, Miles P, Shiver, John W, Tussey, Lynda G, Cox, Kara S, Bachinsky, Margaret, Wang, Fubao, Huang, Lingyi, Schleif, William A, Davies, Mary-Ellen, Tang, Aimin, Casimiro, Danilo R, Perelson, Alan S, Ribeiro, Ruy M
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 10-11-2008
Subjects:	Adenovirus Animals CD4-Positive T-Lymphocytes - immunology CD8 CD8-Positive T-Lymphocytes - immunology Challenge time Delayed response HIV Humans Infectious Disease Macaca mulatta Macaca mulatta - immunology Modeling SAIDS Vaccines - immunology Simian Acquired Immunodeficiency Syndrome - immunology Simian Acquired Immunodeficiency Syndrome - prevention & control Simian Acquired Immunodeficiency Syndrome - virology Simian Immunodeficiency Virus - genetics Simian Immunodeficiency Virus - immunology Time Factors Vaccination Vaccine Viral Load Challenge time Delayed response Vaccine HIV Modeling CD8
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