Protein tyrosine phosphatases as potential therapeutic targets

Protein tyrosine phosphorylation is a key regulatory process in virtually all aspects of cellular functions. Dysregulation of protein tyrosine phosphorylation is a major cause of human diseases, such as cancers, diabetes, autoimmune disorders, and neurological diseases. Indeed, protein tyrosine phos...

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Bibliographic Details
Published in:	Acta pharmacologica Sinica Vol. 35; no. 10; pp. 1227 - 1246
Main Authors:	He, Rong-jun, Yu, Zhi-hong, Zhang, Ruo-yu, Zhang, Zhong-yin
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01-10-2014 Nature Publishing Group
Subjects:	2型糖尿病 Animals Biomedical and Life Sciences Biomedicine Drug Discovery - methods Humans Immunology Internal Medicine Medical Microbiology Pharmacology/Toxicology Phosphorylation - drug effects Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - therapeutic use Protein Tyrosine Phosphatases - antagonists & inhibitors Protein Tyrosine Phosphatases - metabolism Review Vaccine 促分裂原活化蛋白激酶治疗自身免疫性疾病药物发现蛋白酪氨酸磷酸化蛋白酪氨酸磷酸酶骨髓性白血病 PTP1B Fas associated phosphatase-1 phosphatases of regenerating liver-1 CDC25 mitogen-activated protein kinase phosphatases lymphoid-specific tyrosine phosphatase low molecular weight PTPs striatal enriched tyrosine phosphatases drug target protein tyrosine phosphatases Src homology phosphotyrosyl phosphatase 2 CD45 antigen
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