Cocaine-induced adaptations in D1 and D2 accumbens projection neurons (a dichotomy not necessarily synonymous with direct and indirect pathways)

Highlights ► Cocaine-induced adaptations in nucleus accumbens (NAc) contribute to relapse. ► Projection neurons in NAc are D1 or D2 dopamine receptor-expressing. ► D1 and D2 cell types in NAc are not synonymous with direct/indirect pathways. ► NAc neurons show cocaine-induced changes in synaptic pla...

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Bibliographic Details
Published in:	Current opinion in neurobiology Vol. 23; no. 4; pp. 546 - 552
Main Authors:	Smith, Rachel J, Lobo, Mary Kay, Spencer, Sade, Kalivas, Peter W
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-08-2013
Subjects:	Adaptation, Physiological - drug effects Animals Cocaine - pharmacology Neural Pathways - drug effects Neural Pathways - metabolism Neurology Nucleus Accumbens - cytology Nucleus Accumbens - drug effects Nucleus Accumbens - metabolism Psychiatry Receptors, Dopamine D1 - metabolism Receptors, Dopamine D2 - metabolism
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Summary:	Highlights ► Cocaine-induced adaptations in nucleus accumbens (NAc) contribute to relapse. ► Projection neurons in NAc are D1 or D2 dopamine receptor-expressing. ► D1 and D2 cell types in NAc are not synonymous with direct/indirect pathways. ► NAc neurons show cocaine-induced changes in synaptic plasticity. ► New technologies examine involvement of D1 and/or D2 projection neurons.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1
ISSN:	0959-4388 1873-6882
DOI:	10.1016/j.conb.2013.01.026